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Article Open Access

miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression

  • Authors:
    • Fulin Liu
    • Kejia Wu
    • Wanrong Wu
    • Yurou Chen
    • Hanshu Wu
    • Hui Wang
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: The First Department of Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5627-5634
    |
    Published online on: February 2, 2018
       https://doi.org/10.3892/mmr.2018.8558
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Abstract

Pre-eclampsia (PE) is a common but complex condition that can occur in pregnancy. It is estimated to affect 3-8% of pregnancies worldwide. PE development is thought to be multifactorial and to involve the dysregulation of microRNA (miR) expression. However, the precise mechanisms of PE development remain unclear. The present study aimed to illustrate the association between miR‑203 expression and PE development in samples of human placenta collected from mothers with (n=18) and without (n=20) PE. It was demonstrated that miR‑203 expression was significantly increased in the PE placenta compared with the normal placenta samples, while the expression of vascular endothelial growth factor A (VEGFA) was decreased. In vitro experiments revealed that miR‑203 overexpression significantly downregulated VEGFA expression and inhibited the proliferation, migration and invasion ability of HTR‑8/SVneo cells. Suppression of miR‑203 expression alleviated these effects. A luciferase reporter assay confirmed the interaction of the 3'‑untranslated region of VEGFA with miR‑203. Thus, miR‑203 may have significant contribution to the development of PE by targeting VEGFA in the human placenta and may have potential as a biomarker or therapeutic target in the treatment of PE.
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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Wu K, Wu W, Chen Y, Wu H, Wang H and Zhang W: miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression. Mol Med Rep 17: 5627-5634, 2018.
APA
Liu, F., Wu, K., Wu, W., Chen, Y., Wu, H., Wang, H., & Zhang, W. (2018). miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression. Molecular Medicine Reports, 17, 5627-5634. https://doi.org/10.3892/mmr.2018.8558
MLA
Liu, F., Wu, K., Wu, W., Chen, Y., Wu, H., Wang, H., Zhang, W."miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression". Molecular Medicine Reports 17.4 (2018): 5627-5634.
Chicago
Liu, F., Wu, K., Wu, W., Chen, Y., Wu, H., Wang, H., Zhang, W."miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression". Molecular Medicine Reports 17, no. 4 (2018): 5627-5634. https://doi.org/10.3892/mmr.2018.8558
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Wu K, Wu W, Chen Y, Wu H, Wang H and Zhang W: miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression. Mol Med Rep 17: 5627-5634, 2018.
APA
Liu, F., Wu, K., Wu, W., Chen, Y., Wu, H., Wang, H., & Zhang, W. (2018). miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression. Molecular Medicine Reports, 17, 5627-5634. https://doi.org/10.3892/mmr.2018.8558
MLA
Liu, F., Wu, K., Wu, W., Chen, Y., Wu, H., Wang, H., Zhang, W."miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression". Molecular Medicine Reports 17.4 (2018): 5627-5634.
Chicago
Liu, F., Wu, K., Wu, W., Chen, Y., Wu, H., Wang, H., Zhang, W."miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression". Molecular Medicine Reports 17, no. 4 (2018): 5627-5634. https://doi.org/10.3892/mmr.2018.8558
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