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Article Open Access

TRP‑2 mediates coat color pigmentation in sheep skin

  • Authors:
    • Linli Xue
    • Yanan Li
    • Bingling Zhao
    • Tianzhi Chen
    • Yanjun Dong
    • Ruiwen Fan
    • Jingwei Li
    • Haidong Wang
    • Xiaoyan He
  • View Affiliations / Copyright

    Affiliations: College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi 030801, P.R. China, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5869-5877
    |
    Published online on: February 6, 2018
       https://doi.org/10.3892/mmr.2018.8563
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Abstract

Tyrosinase‑related protein 2 (TRP‑2) is one of the most important members of the tyrosinase family, and is a key enzyme involved in melanin biosynthesis. In the present study, a skin transcriptome profile, immunohistochemistry, western blotting and reverse transcription‑quantitative polymerase chain reaction were used to investigate TRP‑2 expression in sheep with different coat colors, namely, black, white and black‑white. TRP‑2 was overexpressed in melanocytes in order to study the effect of TRP‑2 on melanin production. Results revealed differing TRP‑2 levels in sheep of different coat colors and in various parts of the coat with different colors in the same sheep. TRP‑2 expression levels in dark‑colored areas were significantly increased compared with light‑colored areas in piebald sheep. TRP‑2 overexpression may regulate melanogenesis and significantly increase melanogenesis associated transcription factor expression in vitro. Therefore, TRP‑2 may affect melanin production in sheep, and different expression levels determine coat color. The results may provide novel approaches for developing therapeutic strategies for skin diseases associated with pigmentation disorders.
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Copy and paste a formatted citation
Spandidos Publications style
Xue L, Li Y, Zhao B, Chen T, Dong Y, Fan R, Li J, Wang H and He X: TRP‑2 mediates coat color pigmentation in sheep skin. Mol Med Rep 17: 5869-5877, 2018.
APA
Xue, L., Li, Y., Zhao, B., Chen, T., Dong, Y., Fan, R. ... He, X. (2018). TRP‑2 mediates coat color pigmentation in sheep skin. Molecular Medicine Reports, 17, 5869-5877. https://doi.org/10.3892/mmr.2018.8563
MLA
Xue, L., Li, Y., Zhao, B., Chen, T., Dong, Y., Fan, R., Li, J., Wang, H., He, X."TRP‑2 mediates coat color pigmentation in sheep skin". Molecular Medicine Reports 17.4 (2018): 5869-5877.
Chicago
Xue, L., Li, Y., Zhao, B., Chen, T., Dong, Y., Fan, R., Li, J., Wang, H., He, X."TRP‑2 mediates coat color pigmentation in sheep skin". Molecular Medicine Reports 17, no. 4 (2018): 5869-5877. https://doi.org/10.3892/mmr.2018.8563
Copy and paste a formatted citation
x
Spandidos Publications style
Xue L, Li Y, Zhao B, Chen T, Dong Y, Fan R, Li J, Wang H and He X: TRP‑2 mediates coat color pigmentation in sheep skin. Mol Med Rep 17: 5869-5877, 2018.
APA
Xue, L., Li, Y., Zhao, B., Chen, T., Dong, Y., Fan, R. ... He, X. (2018). TRP‑2 mediates coat color pigmentation in sheep skin. Molecular Medicine Reports, 17, 5869-5877. https://doi.org/10.3892/mmr.2018.8563
MLA
Xue, L., Li, Y., Zhao, B., Chen, T., Dong, Y., Fan, R., Li, J., Wang, H., He, X."TRP‑2 mediates coat color pigmentation in sheep skin". Molecular Medicine Reports 17.4 (2018): 5869-5877.
Chicago
Xue, L., Li, Y., Zhao, B., Chen, T., Dong, Y., Fan, R., Li, J., Wang, H., He, X."TRP‑2 mediates coat color pigmentation in sheep skin". Molecular Medicine Reports 17, no. 4 (2018): 5869-5877. https://doi.org/10.3892/mmr.2018.8563
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