Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells

  • Authors:
    • Ji Hoon Song
    • Dahae Lee
    • Seoung Rak Lee
    • Jae Sik Yu
    • Tae Su Jang
    • Joo‑Won Nam
    • Ki Hyun Kim
    • Ki Sung Kang
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea, College of Korean Medicine, Gacheon University, Seongnam, Gyeonggi 13120, Republic of Korea, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea, Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon 25354, Republic of Korea, College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea
  • Pages: 5982-5987
    |
    Published online on: February 8, 2018
       https://doi.org/10.3892/mmr.2018.8582
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A phytochemical investigation of the MeOH extracts from mulberries (the fruit of Morus alba L.) led to the identification of six heterocyclic compounds (1‑6). These compounds were screened to detect whether they protected pancreatic INS‑1 cells from streptozotocin (STZ)‑induced cytotoxicity. Compound 3 was the most effective at preventing STZ‑induced cytotoxicity and the production of reactive oxygen species (ROS) in INS‑1 cells. In addition, compound 3 effectively prevented apoptosis induced by STZ in INS‑1 cells. Compound 3 also prevented STZ‑mediated cleavage of caspase‑8, caspase‑3 and poly (ADP‑ribose) polymerase and increased the expression of B‑cell lymphoma‑2 (Bcl‑2), an anti‑apoptotic Bcl‑2 family protein. In conclusion, the results of the present study indicate that compound 3 extracted from the fruit of M. alba was highly effective in preventing type 1 diabetes mellitus and may be a novel treatment option.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Pantalone KM, Hobbs TM, Wells BJ, Kong SX, Kattan MW, Bouchard J, Yu C, Sakurada B, Milinovich A, Weng W, et al: Clinical characteristics, complications, comorbidities and treatment patterns among patients with type 2 diabetes mellitus in a large integrated health system. BMJ Open Diabetes Res Care. 3:e0000932015. View Article : Google Scholar : PubMed/NCBI

2 

Constantino MI, Molyneaux L, Limacher-Gisler F, Al-Saeed A, Luo C, Wu T, Twigg SM, Yue DK and Wong J: Long-term complications and mortality in young-onset diabetes: Type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care. 36:3863–3869. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Emerging Risk Factors Collaboration, ; Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, et al: Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Lancet. 375:2215–2222. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Rother KI: Diabetes treatment-bridging the divide. N Engl J Med. 356:1499–1501. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Malik VS, Popkin BM, Bray GA, Després JP and Hu FB: Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation. 121:1356–1364. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ripsin CM, Kang H and Urban RJ: Management of blood glucose in type 2 diabetes mellitus. Am Fam Physician. 79:29–36. 2009.PubMed/NCBI

7 

Khan MA, Rahman AA, Islam S, Khandokhar P, Parvin S, Islam MB, Hossain M, Rashid M, Sadik G, Nasrin S, et al: A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae). BMC Res Notes. 6:242013. View Article : Google Scholar : PubMed/NCBI

8 

Oki T, Kobayashi M, Nakamura T, Okuyama A, Masuda M, Shiratsuchi H and Suda I: Changes in radical-scavenging activity and components of mulberry fruit during maturation. J Food Sci. 71:C18–C22. 2006. View Article : Google Scholar

9 

Pawlowska AM, Oleszek W and Braca A: Quali-quantitative analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits. J Agric Food Chem. 56:3377–3380. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Guo C, Li R, Zheng N, Xu L, Liang T and He Q: Anti-diabetic effect of ramulus mori polysaccharides, isolated from Morus alba L., on STZ-diabetic mice through blocking inflammatory response and attenuating oxidative stress. Int Immunopharmacol. 16:93–99. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ren C, Zhang Y, Cui W, Lu G, Wang Y, Gao H, Huang L and Mu Z: A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin. Int J Biol Macromol. 72:951–959. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Zelová H, Hanáková Z, Čermáková Z, Šmejkal K, Dalĺ Acqua S, Babula P, Cvačka J and Hošek J: Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra. J Nat Prod. 77:1297–1303. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yan F and Zheng X: Anthocyanin-rich mulberry fruit improves insulin resistance and protects hepatocytes against oxidative stress during hyperglycemia by regulating AMPK/ACC/mTOR pathway. J Funct Foods. 30:270–281. 2017. View Article : Google Scholar

14 

Jiao Y, Wang X, Jiang X, Kong F, Wang S and Yan C: Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats. J Ethnopharmacol. 199:119–127. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Kim KH, Lee IK, Park KM, Kim WK and Lee KR: Isolation of γ-Lactam Alkaloids from the Macrolepiota neomastoidea. Bullet Korean Che Soc. 29:1591–1593. 2008. View Article : Google Scholar

16 

Bateman L, Breeden SW and O'Leary P: New chiral diamide ligands: Synthesis and application in allylic alkylation. Tetrahedron: Asymmet. 19:391–396. 2008. View Article : Google Scholar

17 

Kim MR, Lee SK, Kim CS, Kim KS and Moon DC: Phytochemical constituents of Carpesium macrocephalum FR-et SAV. Arch Pharm Res. 27:1029–1033. 2004. View Article : Google Scholar

18 

Podea PV, Toşa MI, Paizs C and Irimie FD: Chemoenzymatic preparation of enantiopure L-benzofuranyl- and L-benzo[b]thiophenyl alanines. Tetrahedron: Asymmet. 19:500–511. 2008. View Article : Google Scholar

19 

Lee SR, Park JY, Yu JS, Lee SO, Ryu JY, Choi SZ, Kang KS, Yamabe N and Kim KH: Odisolane, a novel oxolane derivative, and antiangiogenic constituents from the fruits of mulberry (Morus alba L.). J Agric Food Chem. 64:3804–3809. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Siu J, Baxendale IR and Ley SV: Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines. Org Biomol Chem. 2:160–167. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Chen F, Xiong H, Wang J, Ding X, Shu G and Mei Z: Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic rats. J Ethnopharmacol. 149:729–736. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Mythili MD, Vyas R, Akila G and Gunasekaran S: Effect of streptozotocin on the ultrastructure of rat pancreatic islets. Microsc Res Tech. 63:274–281. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Saini KS, Thompson C, Winterford CM, Walker NI and Cameron DP: Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line, INS-1. Biochem Mol Biol Int. 39:1229–1236. 1996.PubMed/NCBI

24 

Kasono K, Yasu T, Kakehashi A, Kinoshita N, Tamemoto H, Namai K, Ohno R, Ueba H, Kuroki M, Ishikawa S and Kawakami M: Nicorandil improves diabetes and rat islet beta-cell damage induced by streptozotocin in vivo and in vitro. Eur J Endocrinol. 151:277–285. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Lee D, Kim KH, Lee J, Hwang GS, Lee HL, Hahm DH, Huh CK, Lee SC, Lee S and Kang KS: Protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells. J Pharm Pharmacol. 69:875–883. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Song JH, Lee D, Lee SR, Yu JS, Jang TS, Nam JW, Kim KH and Kang KS: Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells. Mol Med Rep 17: 5982-5987, 2018.
APA
Song, J.H., Lee, D., Lee, S.R., Yu, J.S., Jang, T.S., Nam, J. ... Kang, K.S. (2018). Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells. Molecular Medicine Reports, 17, 5982-5987. https://doi.org/10.3892/mmr.2018.8582
MLA
Song, J. H., Lee, D., Lee, S. R., Yu, J. S., Jang, T. S., Nam, J., Kim, K. H., Kang, K. S."Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells". Molecular Medicine Reports 17.4 (2018): 5982-5987.
Chicago
Song, J. H., Lee, D., Lee, S. R., Yu, J. S., Jang, T. S., Nam, J., Kim, K. H., Kang, K. S."Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells". Molecular Medicine Reports 17, no. 4 (2018): 5982-5987. https://doi.org/10.3892/mmr.2018.8582
Copy and paste a formatted citation
x
Spandidos Publications style
Song JH, Lee D, Lee SR, Yu JS, Jang TS, Nam JW, Kim KH and Kang KS: Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells. Mol Med Rep 17: 5982-5987, 2018.
APA
Song, J.H., Lee, D., Lee, S.R., Yu, J.S., Jang, T.S., Nam, J. ... Kang, K.S. (2018). Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells. Molecular Medicine Reports, 17, 5982-5987. https://doi.org/10.3892/mmr.2018.8582
MLA
Song, J. H., Lee, D., Lee, S. R., Yu, J. S., Jang, T. S., Nam, J., Kim, K. H., Kang, K. S."Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells". Molecular Medicine Reports 17.4 (2018): 5982-5987.
Chicago
Song, J. H., Lee, D., Lee, S. R., Yu, J. S., Jang, T. S., Nam, J., Kim, K. H., Kang, K. S."Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells". Molecular Medicine Reports 17, no. 4 (2018): 5982-5987. https://doi.org/10.3892/mmr.2018.8582
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team