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Article Open Access

Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data

  • Authors:
    • Wei Zhong
    • Lianzhi Dai
    • Jing Liu
    • Song Zhou
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, Fujian 363000, P.R. China, Medical Department, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, Fujian 363000, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5744-5753
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    Published online on: February 12, 2018
       https://doi.org/10.3892/mmr.2018.8594
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Abstract

Cholangiocarcinoma (CCA) is characterized by delayed diagnosis and poor survival rate. Research efforts have focused on novel diagnostic technologies for this type of cancer. Transcriptomic microarray technology is a useful research strategy for investigating the molecular properties of CCA. The objective of the present study was to identify candidate biomarkers with high potential for clinical application in CCA using a meta‑analysis‑based approach. Gene expression profiles of CCA were downloaded from the Gene Expression Omnibus database for integrated analysis. All differentially expressed genes (DEGs) were analyzed by Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Protein‑protein interaction (PPI) networks were further constructed, hub proteins were identified and functional modules were extracted. Following integrated analysis of the seven eligible datasets (428 cases and 46 controls), a set of 1,080 DEGs was identified, including 710 upregulated and 370 downregulated genes. Functional enrichment analysis demonstrated that ‘chromosome organization’ was a significantly enriched GO term in the biological process category. ‘DNA replication’, ‘influenza A’, and ‘lysosome’ were the top three significantly enriched KEGG pathways. Furthermore, PPI network analysis indicated that the significant hub proteins were histone deacetylase 1, cullin‑associated NEDD8‑dissociated protein 1, ubiquitin D, early growth response protein 1 and glycogen synthase kinase 3β. The majority of these proteins are involved in CCA. These results provided a set of targets that may help researchers to clarify further the underlying mechanisms of CCA tumorigenesis.
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View References

1 

de Groen PC, Gores GJ, LaRusso NF, Gunderson LL and Nagorney DM: Biliary tract cancers. N Engl J Med. 341:1368–1378. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Tyson GL and El-Serag HB: Risk factors for cholangiocarcinoma. Hepatology. 54:173–184. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Rizvi S and Gores GJ: Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology. 145:1215–1229. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Saha SK, Zhu AX, Fuchs CS and Brooks GA: Forty-year trends in cholangiocarcinoma incidence in the U.S.: Intrahepatic disease on the rise. Oncologist. 21:594–599. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG and Ganesan K: Cholangiocarcinoma: Classification, diagnosis, staging, imaging features, and management. Abdom Radiol (NY). 42:1637–1649. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Khuntikeo N, Chamadol N, Yongvanit P, Loilome W, Namwat N, Sithithaworn P, Andrews RH, Petney TN, Promthet S, Thinkhamrop K, et al: Cohort profile: Cholangiocarcinoma screening and care program (CASCAP). BMC Cancer. 15:4592015. View Article : Google Scholar : PubMed/NCBI

7 

Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, et al: Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma. Cancer Discov. 7:1116–1135. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kayhanian H, Smyth EC and Braconi C: Emerging molecular targets and therapy for cholangiocarcinoma. World J Gastrointest Oncol. 9:268–280. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sia D, Hoshida Y, Villanueva A, Roayaie S, Ferrer J, Tabak B, Peix J, Sole M, Tovar V, Alsinet C, et al: Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology. 144:829–840. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Seok JY, Na DC, Woo HG, Roncalli M, Kwon SM, Yoo JE, Ahn EY, Kim GI, Choi JS, Kim YB and Park YN: A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition. Hepatology. 55:1776–1786. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Murakami Y, Kubo S, Tamori A, Itami S, Kawamura E, Iwaisako K, Ikeda K, Kawada N, Ochiya T and Taguchi YH: Comprehensive analysis of transcriptome and metabolome analysis in intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Sci Rep. 5:162942015. View Article : Google Scholar : PubMed/NCBI

12 

Andersen JB, Spee B, Blechacz BR, Avital I, Komuta M, Barbour A, Conner EA, Gillen MC, Roskams T, Roberts LR, et al: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology. 142:1021–1031.e15. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, et al: Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatology. 56:1792–1803. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Seol MA, Chu IS, Lee MJ, Yu GR, Cui XD, Cho BH, Ahn EK, Leem SH, Kim IH and Kim DG: Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma. BMC Cancer. 11:782011. View Article : Google Scholar : PubMed/NCBI

15 

Sulpice L, Desille M, Turlin B, Fautrel A, Boudjema K, Clément B and Coulouarn C: Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma. Genom Data. 7:229–232. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Xia J, Gill EE and Hancock RE: NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data. Nat Protoc. 10:823–844. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Xia J, Benner MJ and Hancock RE: NetworkAnalyst-integrative approaches for protein-protein interaction network analysis and visual exploration. Nucleic Acids Res. 42(Web Server Issue): W167–W174. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Breuer K, Foroushani AK, Laird MR, Chen C, Sribnaia A, Lo R, Winsor GL, Hancock RE, Brinkman FS and Lynn DJ: InnateDB: Systems biology of innate immunity and beyond-recent updates and continuing curation. Nucleic Acids Res. 41(Database Issue): D1228–D1233. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Orchard S, Kerrien S, Abbani S, Aranda B, Bhate J, Bidwell S, Bridge A, Briganti L, Brinkman FS, Cesareni G, et al: Protein interaction data curation: The International Molecular Exchange (IMEx) consortium. Nat Methods. 9:345–350. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A, et al: IntAct: An open source molecular interaction database. Nucleic Acids Res. 32(Database Issue): D452–D455. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Licata L, Briganti L, Peluso D, Perfetto L, Iannuccelli M, Galeota E, Sacco F, Palma A, Nardozza AP, Santonico E, et al: MINT, the molecular interaction database: 2012 update. Nucleic Acids Res. 40(Database Issue): D857–D861. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU and Eisenberg D: The database of interacting proteins: 2004 update. Nucleic Acids Res. 32(Database Issue): D449–D451. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Isserlin R, El-Badrawi RA and Bader GD: The biomolecular interaction network database in PSI-MI 2.5. Database (Oxford). 2011:baq0372011. View Article : Google Scholar : PubMed/NCBI

26 

Chatr-Aryamontri A, Breitkreutz BJ, Oughtred R, Boucher L, Heinicke S, Chen D, Stark C, Breitkreutz A, Kolas N, O'Donnell L, et al: The BioGRID interaction database: 2015 update. Nucleic Acids Res. 43(Database Issue): D470–D478. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Blechacz B, Komuta M, Roskams T and Gores GJ: Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol. 8:512–522. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Hass HG, Nehls O, Jobst J, Frilling A, Vogel U and Kaiser S: Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis. World J Gastroenterol. 14:2501–2510. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Sulpice L, Rayar M, Desille M, Turlin B, Fautrel A, Boucher E, Llamas-Gutierrez F, Meunier B, Boudjema K, Clément B and Coulouarn C: Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma. Hepatology. 58:1992–2000. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Tongtawee T, Kaewpitoon SJ, Loyd R, Chanvitan S, Leelawat K, Praditpol N, Jujinda S and Kaewpitoon N: High expression of matrix metalloproteinase-11 indicates poor prognosis in human cholangiocarcinoma. Asian Pac J Cancer Prev. 16:3697–3701. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Huang QX, Cui JY, Ma H, Jia XM, Huang FL and Jiang LX: Screening of potential biomarkers for cholangiocarcinoma by integrated analysis of microarray data sets. Cancer Gene Ther. 23:48–53. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Sawanyawisuth K, Wongkham C, Araki N, Zhao Q, Riggins GJ and Wongkham S: Serial analysis of gene expression reveals promising therapeutic targets for liver fluke-associated cholangiocarcinoma. Asian Pac J Cancer Prev. 13 Suppl:S89–S93. 2012.

33 

Batmunkh E, Tátrai P, Szabó E, Lódi C, Holczbauer A, Páska C, Kupcsulik P, Kiss A, Schaff Z and Kovalszky I: Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma. Hum Pathol. 38:1508–1515. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Wang H, Jiang S, Zhang Y, Pan K, Xia J and Chen M: High expression of thymosin beta 10 predicts poor prognosis for hepatocellular carcinoma after hepatectomy. World J Surg Oncol. 12:2262014. View Article : Google Scholar : PubMed/NCBI

35 

Zhang X, Ren D, Guo L, Wang L, Wu S, Lin C, Ye L, Zhu J, Li J, Song L, et al: Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer. Breast Cancer Res. 19:152017. View Article : Google Scholar : PubMed/NCBI

36 

Mattu S, Fornari F, Quagliata L, Perra A, Angioni MM, Petrelli A, Menegon S, Morandi A, Chiarugi P, Ledda-Columbano GM, et al: The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. J Hepatol. 64:891–898. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Fan K, Li N, Qi J, Yin P, Zhao C, Wang L, Li Z and Zha X: Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer. Cell Signal. 26:2801–2808. 2014. View Article : Google Scholar : PubMed/NCBI

38 

You J, Shi X, Liang H, Ye J, Wang L, Han H, Fang H, Kang W and Wang T: Cystathionine-γ-lyase promotes process of breast cancer in association with STAT3 signaling pathway. Oncotarget. 8:65677–65686. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Nakagawa S, Okabe H, Sakamoto Y, Hayashi H, Hashimoto D, Yokoyama N, Sakamoto K, Kuroki H, Mima K, Nitta H, et al: Enhancer of zeste homolog 2 (EZH2) promotes progression of cholangiocarcinoma cells by regulating cell cycle and apoptosis. Ann Surg Oncol. 20 Suppl 3:S667–S675. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Giussani M, Merlino G, Cappelletti V, Tagliabue E and Daidone MG: Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression. Semin Cancer Biol. 35:3–10. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Kuo DS, Labelle-Dumais C and Gould DB: COL4A1 and COL4A2 mutations and disease: Insights into pathogenic mechanisms and potential therapeutic targets. Hum Mol Genet. 21:R97–R110. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Razumilava N and Gores GJ: Cholangiocarcinoma. Lancet. 383:2168–2179. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Morine Y, Shimada M, Iwahashi S, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J and Miyake H: Role of histone deacetylase expression in intrahepatic cholangiocarcinoma. Surgery. 151:412–419. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhong W, Dai L, Liu J and Zhou S: Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data. Mol Med Rep 17: 5744-5753, 2018.
APA
Zhong, W., Dai, L., Liu, J., & Zhou, S. (2018). Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data. Molecular Medicine Reports, 17, 5744-5753. https://doi.org/10.3892/mmr.2018.8594
MLA
Zhong, W., Dai, L., Liu, J., Zhou, S."Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data". Molecular Medicine Reports 17.4 (2018): 5744-5753.
Chicago
Zhong, W., Dai, L., Liu, J., Zhou, S."Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data". Molecular Medicine Reports 17, no. 4 (2018): 5744-5753. https://doi.org/10.3892/mmr.2018.8594
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong W, Dai L, Liu J and Zhou S: Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data. Mol Med Rep 17: 5744-5753, 2018.
APA
Zhong, W., Dai, L., Liu, J., & Zhou, S. (2018). Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data. Molecular Medicine Reports, 17, 5744-5753. https://doi.org/10.3892/mmr.2018.8594
MLA
Zhong, W., Dai, L., Liu, J., Zhou, S."Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data". Molecular Medicine Reports 17.4 (2018): 5744-5753.
Chicago
Zhong, W., Dai, L., Liu, J., Zhou, S."Cholangiocarcinoma‑associated genes identified by integrative analysis of gene expression data". Molecular Medicine Reports 17, no. 4 (2018): 5744-5753. https://doi.org/10.3892/mmr.2018.8594
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