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Article

Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia

  • Authors:
    • Fayez Hamam
    • Ahmed Eldalo
    • Qasem Abdallah
    • Ibrahim Al‑Deeb
    • Saleh Alzahrani
    • Abdullah Alwagdani
    • Ahmed Alotaibi
    • Abdel-Rahman Nasr
    • Yaser Gouda
    • Khaled Mohamed

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Makkah 21974, Kingdom of Saudi Arabia, Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Makkah 21974, Kingdom of Saudi Arabia, Department of Pharmacognosy, College of Pharmacy, Taif University, Taif, Makkah 21974, Kingdom of Saudi Arabia, Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
  • Pages: 6059-6067
    |
    Published online on: February 15, 2018
       https://doi.org/10.3892/mmr.2018.8607
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Abstract

Huernia Sp. Nov. aff. Boleana, Apocynaceae, grows in the high mountains of southwest Saudi Arabia and is widely used as a remedy for the treatment of diabetes. The present study investigated the anti‑inflammatory, wound healing and inhibitory effects on migration of Huernia Sp. Nov. aff. Boleana. The anti‑inflammatory effect was assessed in mice using formalin‑induced edema. Wound healing effects were assessed in rats using a circular excision wound model. An in vitro ʻscratch’ test was used to investigate the inhibitory effects on melanoma cell (B16‑F10) migration. The anti‑inflammatory effects of total extract, hexane and chloroform fractions were greater or equal to indomethacin (control). The relatively non‑polar fractions (hexane and chloroform) exhibited higher anti‑inflammatory activities compared with the aqueous fraction. The percentage of wound contraction among animals treated with the plant extract was higher compared with the control; however, this difference was not statistically significant (P>0.05). The total plant extract increased wound healing by inhibiting the inflammatory response, promoting angiogenesis, and significantly promoting the proliferation of fibroblasts, particularly on days 7 and 14 post‑wounding. Furthermore, the plant extract promoted wound repair via the enhancement of collagen synthesis, and complete epithelization with well‑formed and differentiated epithelial tissues. The in vitro ʻscratch’ test indicated the inhibitory effects of this plant on melanoma cell migration in a dose‑dependent manner. The present study indicated that Huernia Sp. Nov. aff. Boleana may have potential as an anti‑inflammatory, wound-healing and migration-inhibiting ethno medicine.
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Copy and paste a formatted citation
Spandidos Publications style
Hamam F, Eldalo A, Abdallah Q, Al‑Deeb I, Alzahrani S, Alwagdani A, Alotaibi A, Nasr A, Gouda Y, Mohamed K, Mohamed K, et al: Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia. Mol Med Rep 17: 6059-6067, 2018.
APA
Hamam, F., Eldalo, A., Abdallah, Q., Al‑Deeb, I., Alzahrani, S., Alwagdani, A. ... Mohamed, K. (2018). Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia. Molecular Medicine Reports, 17, 6059-6067. https://doi.org/10.3892/mmr.2018.8607
MLA
Hamam, F., Eldalo, A., Abdallah, Q., Al‑Deeb, I., Alzahrani, S., Alwagdani, A., Alotaibi, A., Nasr, A., Gouda, Y., Mohamed, K."Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia". Molecular Medicine Reports 17.4 (2018): 6059-6067.
Chicago
Hamam, F., Eldalo, A., Abdallah, Q., Al‑Deeb, I., Alzahrani, S., Alwagdani, A., Alotaibi, A., Nasr, A., Gouda, Y., Mohamed, K."Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia". Molecular Medicine Reports 17, no. 4 (2018): 6059-6067. https://doi.org/10.3892/mmr.2018.8607
Copy and paste a formatted citation
x
Spandidos Publications style
Hamam F, Eldalo A, Abdallah Q, Al‑Deeb I, Alzahrani S, Alwagdani A, Alotaibi A, Nasr A, Gouda Y, Mohamed K, Mohamed K, et al: Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia. Mol Med Rep 17: 6059-6067, 2018.
APA
Hamam, F., Eldalo, A., Abdallah, Q., Al‑Deeb, I., Alzahrani, S., Alwagdani, A. ... Mohamed, K. (2018). Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia. Molecular Medicine Reports, 17, 6059-6067. https://doi.org/10.3892/mmr.2018.8607
MLA
Hamam, F., Eldalo, A., Abdallah, Q., Al‑Deeb, I., Alzahrani, S., Alwagdani, A., Alotaibi, A., Nasr, A., Gouda, Y., Mohamed, K."Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia". Molecular Medicine Reports 17.4 (2018): 6059-6067.
Chicago
Hamam, F., Eldalo, A., Abdallah, Q., Al‑Deeb, I., Alzahrani, S., Alwagdani, A., Alotaibi, A., Nasr, A., Gouda, Y., Mohamed, K."Pharmacological activities of a novel plant species, Huernia Sp. Nov. aff. Boleana growing in the high mountains of southwest Saudi Arabia". Molecular Medicine Reports 17, no. 4 (2018): 6059-6067. https://doi.org/10.3892/mmr.2018.8607
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