Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats

  • Authors:
    • Linqiang Zhou
    • Chenglin Liu
    • Zhong Wang
    • Haitao Shen
    • Zunjia Wen
    • Dongdong Chen
    • Qing Sun
    • Gang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5684-5691
    |
    Published online on: February 21, 2018
       https://doi.org/10.3892/mmr.2018.8624
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pannexins serve an important role in the regulation of extracellular neuronal regenerative currents and cellular signal transduction of glial cells; however, the effects of pannexins in various cerebrovascular diseases have not been reported. The present study focused on the expression and influence of pannexins in a rat model of intracerebral hemorrhage (ICH), and confirmed that pannexins (including Pannexin‑1, Pannexin‑2 and Pannexin‑3) are expressed in rat brain tissues. However, only the expression of Pannexin‑1 was significantly increased and peaked 48 h post‑ICH. Following treatment with carbenoxolone (CBX), which is an inhibitor of Pannexin‑1, apoptosis and neuronal degeneration in the brain tissues around the ICH hematoma decreased. The extent of secondary brain injury due to ICH was also alleviated. Compared with rats in the ICH‑only group, recovery of neurocognitive functions improved significantly in the CBX‑treated groups. Results from the present study suggested that the upregulation of Pannexin‑1 expression may be involved in apoptosis and degeneration of neurons in the rat brain following ICH, and may contribute to subsequent cognitive dysfunction.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Broderick JP, Brott T, Tomsick T, Miller R and Huster G: Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg. 78:188–191. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Zhang LF, Yang J, Hong Z, Yuan GG, Zhou BF, Zhao LC, Huang YN, Chen J and Wu YF; Collaborative Group of China Multicenter Study of Cardiovascular Epidemiology, : Proportion of different subtypes of stroke in China. Stroke. 34:2091–2096. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Qureshi AI, Ling GS, Khan J, Suri MF, Miskolczi L, Guterman LR and Hopkins LN: Quantitative analysis of injured, necrotic and apoptotic cells in a new experimental model of intracerebral hemorrhage. Crit Care Med. 29:152–157. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Rincon F and Mayer SA: Novel therapies for intracerebral hemorrhage. Curr Opin Crit Care. 10:94–100. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Hossain MI, Kamaruddin MA and Cheng HC: Aberrant regulation and function of Src family tyrosine kinases: Their potential contributions to glutamate-induced neurotoxicity. Clin Exp Pharmacol Physiol. 39:684–691. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Panchin Y, Kelmanson I, Matz M, Lukyanov K, Usman N and Lukyanov S: A ubiquitous family of putative gap junction molecules. Curr Biol. 10:R473–R474. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Zoidl G, Petrasch-Parwez E, Ray A, Meier C, Bunse S, Habbes HW, Dahl G and Dermietzel R: Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus. Neuroscience. 146:9–16. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Iglesias R, Dahl G, Qiu F, Spray DC and Scemes E: Pannexin 1: The molecular substrate of astrocyte ‘hemichannels’. J Neurosci. 29:7092–7097. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Thompson RJ, Jackson MF, Olah ME, Rungta RL, Hines DJ, Beazely MA, MacDonald JF and MacVicar BA: Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science. 322:1555–1559. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Zhang L, Deng T, Sun Y, Liu K, Yang Y and Zheng X: Role for nitric oxide in permeability of hippocampal neuronal hemichannels during oxygen glucose deprivation. J Neurosci Res. 86:2281–2291. 2008. View Article : Google Scholar : PubMed/NCBI

11 

de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff HJ, Stanton PK and Rozental R: Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke. 36:2232–2237. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Madry C, Haglerød C and Attwell D: The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells. Brain. 133:3755–3763. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Weilinger NL, Tang PL and Thompson RJ: Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases. J Neurosci. 32:12579–12588. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Liew HK, Pang CY, Hsu CW, Wang MJ, Li TY, Peng HF, Kuo JS and Wang JY: Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats. J Neuroinflammation. 9:132012. View Article : Google Scholar : PubMed/NCBI

15 

Okauchi M, Hua Y, Keep RF, Morgenstern LB, Schallert T and Xi G: Deferoxamine treatment for intracerebral hemorrhage in aged rats: Therapeutic time window and optimal duration. Stroke. 41:375–382. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Gareri P, Condorelli D, Belluardo N, Russo E, Loiacono A, Barresi V, Trovato-Salinaro A, Mirone MB, Ferreri IG and De Sarro G: Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs). Neuropharmacology. 47:1205–1216. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Chen G, Li Q, Feng D, Hu T, Fang Q and Wang Z: Expression of NR2B in different brain regions and effect of NR2B antagonism on learning deficits after experimental subarachnoid hemorrhage. Neuroscience. 231:136–144. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Wang Y, Gao A, Xu X, Dang B, You W, Li H, Yu Z and Chen G: The neuroprotection of lysosomotropic agents in experimental subarachnoid hemorrhage probably involving the apoptosis pathway triggering by cathepsins via chelating intralysosomal iron. Mol Neurobiol. 52:64–77. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Friedrich V, Flores R and Sehba FA: Cell death starts early after subarachnoid hemorrhage. Neurosci Lett. 512:6–11. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Bruzzone R, Hormuzdi SG, Barbe MT, Herb A and Monyer H: Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci USA. 100:pp. 13644–13649. 2003; View Article : Google Scholar : PubMed/NCBI

21 

Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, et al: Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis. Nature. 467:863–867. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Balami JS and Buchan AM: Complications of intracerebral haemorrhage. Lancet Neurol. 11:101–118. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Xi G, Hua Y, Bhasin RR, Ennis SR, Keep RF and Hoff JT: Mechanisms of edema formation after intracerebral hemorrhage: Effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke. 32:2932–2938. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Castillo J, Dávalos A, Naveiro J and Noya M: Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke. Stroke. 27:1060–1065. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Qureshi AI, Ali Z, Suri MF, Shuaib A, Baker G, Todd K, Guterman LR and Hopkins LN: Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: An in vivo microdialysis study. Crit Care Med. 31:1482–1489. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Mailly F, Marin P, Israël M, Glowinski J and Prémont J: Increase in external glutamate and NMDA receptor activation contribute to H2O2-induced neuronal apoptosis. J Neurochem. 73:1181–1188. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Thompson RJ, Zhou N and MacVicar BA: Ischemia opens neuronal gap junction hemichannels. Science. 312:924–927. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Turpie AG and Thomson TJ: Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut. 6:591–594. 1965. View Article : Google Scholar : PubMed/NCBI

29 

Traub RD, Whittington MA, Buhl EH, LeBeau FE, Bibbig A, Boyd S, Cross H and Baldeweg T: A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of and perhaps initiating, seizures. Epilepsia. 42:153–170. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Carlen PL, Skinner F, Zhang L, Naus C, Kushnir M and Perez VJ: The role of gap junctions in seizures. Brain Res Brain Res Rev. 32:235–241. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Ma W, Hui H, Pelegrin P and Surprenant A: Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther. 328:409–418. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou L, Liu C, Wang Z, Shen H, Wen Z, Chen D, Sun Q and Chen G: Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats. Mol Med Rep 17: 5684-5691, 2018.
APA
Zhou, L., Liu, C., Wang, Z., Shen, H., Wen, Z., Chen, D. ... Chen, G. (2018). Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats. Molecular Medicine Reports, 17, 5684-5691. https://doi.org/10.3892/mmr.2018.8624
MLA
Zhou, L., Liu, C., Wang, Z., Shen, H., Wen, Z., Chen, D., Sun, Q., Chen, G."Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats". Molecular Medicine Reports 17.4 (2018): 5684-5691.
Chicago
Zhou, L., Liu, C., Wang, Z., Shen, H., Wen, Z., Chen, D., Sun, Q., Chen, G."Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats". Molecular Medicine Reports 17, no. 4 (2018): 5684-5691. https://doi.org/10.3892/mmr.2018.8624
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou L, Liu C, Wang Z, Shen H, Wen Z, Chen D, Sun Q and Chen G: Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats. Mol Med Rep 17: 5684-5691, 2018.
APA
Zhou, L., Liu, C., Wang, Z., Shen, H., Wen, Z., Chen, D. ... Chen, G. (2018). Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats. Molecular Medicine Reports, 17, 5684-5691. https://doi.org/10.3892/mmr.2018.8624
MLA
Zhou, L., Liu, C., Wang, Z., Shen, H., Wen, Z., Chen, D., Sun, Q., Chen, G."Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats". Molecular Medicine Reports 17.4 (2018): 5684-5691.
Chicago
Zhou, L., Liu, C., Wang, Z., Shen, H., Wen, Z., Chen, D., Sun, Q., Chen, G."Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats". Molecular Medicine Reports 17, no. 4 (2018): 5684-5691. https://doi.org/10.3892/mmr.2018.8624
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team