Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability

  • Authors:
    • Wei Zhang
    • Jie Zhang
    • Lei Cheng
    • Haosheng Ni
    • Bo You
    • Ying Shan
    • Lili Bao
    • Di Wu
    • Ting Zhang
    • Huijun Yue
    • Jing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5921-5927
    |
    Published online on: February 26, 2018
       https://doi.org/10.3892/mmr.2018.8634
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Abnormal angiogenesis and vascular permeability is important for the formation of nasal polyps (NPs). Increasing evidence has indicated that exosomes serve a vital role in modulating angiogenesis and vascular permeability. A disintegrin and metalloprotease 10 (ADAM10), an important type of proteinase that is overexpressed in various diseases, can influence angiogenesis and vascular permeability and has been observed in healthy nasal exosomes. To the best of our knowledge, the expression levels and the function of ADAM10 in NLF‑derived exosomes from NPs has not been demonstrated previously. In order to determine the influence of exosomes derived from nasal lavage fluid (NLF) on angiogenesis and vascular permeability, 25 nasal polyp patients and 15 healthy volunteers were enrolled in the present study. NLF was collected from all of the subjects. Exosomes were isolated from NLF, visualized under transmission electron microscope and identified using western blot analysis. The effect of exosomes on human umbilical vein endothelial cells (HUVECs) was measured by tube formation and permeability assays in vitro. The expression of exosomal ADAM10 was also analyzed by western blotting. NLF‑derived exosomes from NPs influenced proliferation, tube formation and the permeability of HUVECs. ADAM10 was highly expressed in NLF‑derived exosomes from NPs when compared with healthy volunteers. Thus, NLF‑derived exosomes from NPs promoted angiogenesis and vascular permeability, which may be associated with abundant ADAM10 in NP exosomes.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, et al: EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 50:1–12. 2012.PubMed/NCBI

2 

Wang C, Lou H, Wang X, Wang Y, Fan E, Li Y, Wang H, Bachert C and Zhang L: Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 135:922–929.e6. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Coste A, Rateau JG, Roudot-Thoraval F, Chapelin C, Gilain L, Poron F, Peynegre R, Bernaudin JF and Escudier E: Increased epithelial cell proliferation in nasal polyps. Arch Otolaryngol Head Neck Surg. 122:432–436. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Yukitatsu Y, Hata M, Yamanegi K, Yamada N, Ohyama H, Nakasho K, Kojima Y, Oka H, Tsuzuki K, Sakagami M and Terada N: Decreased expression of VE-cadherin and claudin-5 and increased phosphorylation of VE-cadherin in vascular endothelium in nasal polyps. Cell Tissue Res. 352:647–657. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Gosepath J, Brieger J, Lehr HA and Mann WJ: Expression, localization, and significance of vascular permeability/vascular endothelial growth factor in nasal polyps. Am J Rhinol. 19:7–13. 2005.PubMed/NCBI

6 

Record M, Subra C, Silvente-Poirot S and Poirot M: Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol. 81:1171–1182. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Kulshreshtha A, Ahmad T, Agrawal A and Ghosh B: Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation. J Allergy Clin Immunol. 131:1194–1203, 1203.e1-e14. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Honegger A, Schilling D, Bastian S, Sponagel J, Kuryshev V, Sültmann H, Scheffner M, Hoppe-Seyler K and Hoppe-Seyler F: Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 11:e10047122015. View Article : Google Scholar : PubMed/NCBI

9 

You B, Cao X, Shao X, Ni H, Shi S, Shan Y, Gu Z and You Y: Clinical and biological significance of HAX-1 overexpression in nasopharyngeal carcinoma. Oncotarget. 7:12505–12524. 2016. View Article : Google Scholar : PubMed/NCBI

10 

You Y, Shan Y, Chen J, Yue H, You B, Shi S, Li X and Cao X: Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis. Cancer Sci. 106:1669–1677. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Nakayama A: Proteomic analysis of urinary exosomes. Rinsho Byori. 62:684–691. 2014.(In Japanese). PubMed/NCBI

12 

Näslund TI, Paquin-Proulx D, Paredes PT, Vallhov H, Sandberg JK and Gabrielsson S: Exosomes from breast milk inhibit HIV-1 infection of dendritic cells and subsequent viral transfer to CD4+ T cells. AIDS. 28:171–180. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Lässer C, O'Neil SE, Ekerljung L, Ekström K, Sjöstrand M and Lötvall J: RNA-containing exosomes in human nasal secretions. Am J Rhinol Allergy. 25:89–93. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Choi EB, Hong SW, Kim DK, Jeon SG, Kim KR, Cho SH, Gho YS, Jee YK and Kim YK: Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis. Allergy. 69:517–526. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Lässer C, O'Neil SE, Shelke GV, Sihlbom C, Hansson SF, Gho YS, Lundbäck B and Lötvall J: Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation. J Transl Med. 14:1812016. View Article : Google Scholar : PubMed/NCBI

16 

Sampey GC, Saifuddin M, Schwab A, Barclay R, Punya S, Chung MC, Hakami RM, Zadeh MA, Lepene B, Klase ZA, et al: Exosomes from HIV-1-infected cells stimulate production of pro-inflammatory cytokines through trans-activating response (TAR) RNA. J Biol Chem. 291:1251–1266. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Wang X, Gu H, Qin D, Yang L, Huang W, Essandoh K, Wang Y, Caldwell CC, Peng T, Zingarelli B and Fan GC: Exosomal miR-223 contributes to mesenchymal stem cell-elicited cardioprotection in polymicrobial sepsis. Sci Rep. 5:137212015. View Article : Google Scholar : PubMed/NCBI

18 

Lee SL, Rouhi P, Dahl Jensen L, Zhang D, Ji H, Hauptmann G, Ingham P and Cao Y: Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci USA. 106:pp. 19485–19490. 2009; View Article : Google Scholar : PubMed/NCBI

19 

Kalani A, Kamat PK, Chaturvedi P, Tyagi SC and Tyagi N: Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia. Life Sci. 107:1–7. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Isozaki T, Rabquer BJ, Ruth JH, Haines GK III and Koch AE: ADAM-10 is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis. Arthritis Rheum. 65:98–108. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Blobel CP: Metalloprotease-disintegrins: Links to cell adhesion and cleavage of TNF alpha and Notch. Cell. 90:589–592. 1997. View Article : Google Scholar : PubMed/NCBI

22 

You B, Shan Y, Shi S, Li X and You Y: Effects of ADAM10 upregulation on progression, migration and prognosis of nasopharyngeal carcinoma. Cancer Sci. 106:1506–1514. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Chueh HW, Park SK, Hur DY and Bae WY: Expression profile of ADAM10 and ADAM17 in allergic rhinitis. Int Forum Allergy Rhinol. 5:1036–1041. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P and Reiss K: ADAM10 regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res. 102:1192–1201. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Donners MM, Wolfs IM, Olieslagers S, Mohammadi-Motahhari Z, Tchaikovski V, Heeneman S, van Buul JD, Caolo V, Molin DG, Post MJ and Waltenberger J: A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. Arterioscler Thromb Vasc Biol. 30:2188–2195. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Reiss K, Cornelsen I, Husmann M, Gimpl G and Bhakdi S: Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity. J Biol Chem. 286:26931–26942. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Howarth PH, Persson CG, Meltzer EO, Jacobson MR, Durham SR and Silkoff PE: Objective monitoring of nasal airway inflammation in rhinitis. J Allergy Clin Immunol. 115 3 Suppl 1:S414–S441. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–659. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Romancino DP, Paterniti G, Campos Y, De Luca A, Di Felice V, d'Azzo A and Bongiovanni A: Identification and characterization of the nano-sized vesicles released by muscle cells. FEBS Lett. 587:1379–1384. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Hellquist HB: Nasal polyps update. Histopathology. Allergy Asthma Proc. 17:pp. 237–242. 1996; View Article : Google Scholar : PubMed/NCBI

31 

Slavin RG: Nasal polyps and sinusitis. Clin Allergy Immunol. 16:295–309. 2002.PubMed/NCBI

32 

Watanabe K and Komatsuzaki A: Ultrastructural findings of capillaries in nasal polyps. Rhinology. 30:49–56. 1992.PubMed/NCBI

33 

Higginbotham JN, Demory BM, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ and Coffey RJ: Amphiregulin exosomes increase cancer cell invasion. Curr Biol. 21:779–786. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Hood JL, San RS and Wickline SA: Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 71:3792–3801. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Martinez-Bravo MJ, Wahlund CJ, Qazi KR, Moulder R, Lukic A, Rådmark O, Lahesmaa R, Grunewald J, Eklund A and Gabrielsson S: Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules. J Allergy Clin Immunol. 139:1186–1194. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Zhu M, Li Y, Shi J, Feng W, Nie G and Zhao Y: Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation. Small. 8:404–412. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Bashratyan R, Sheng H, Regn D, Rahman MJ and Dai YD: Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice. Eur J Immunol. 43:2588–2597. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Dreymueller D, Uhlig S and Ludwig A: ADAM-family metalloproteinases in lung inflammation: Potential therapeutic targets. Am J Physiol Lung Cell Mol Physiol. 308:L325–L343. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Erbek SS, Erinanc H, Erbek S, Topal O and Kiyici H: Expression of a disintegrin and metalloproteinase 33 protein in nasal polyposis: An immunohistochemical study. Am J Rhinol Allergy. 24:79–82. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Erbek SS, Hizal E, Erinanc H and Erbek S: Expression of a disintegrin and metalloproteinase 8 by inflammatory cells in nasal polyps. Am J Rhinol Allergy. 27:1512013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Zhang J, Cheng L, Ni H, You B, Shan Y, Bao L, Wu D, Zhang T, Yue H, Yue H, et al: A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability. Mol Med Rep 17: 5921-5927, 2018.
APA
Zhang, W., Zhang, J., Cheng, L., Ni, H., You, B., Shan, Y. ... Chen, J. (2018). A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability. Molecular Medicine Reports, 17, 5921-5927. https://doi.org/10.3892/mmr.2018.8634
MLA
Zhang, W., Zhang, J., Cheng, L., Ni, H., You, B., Shan, Y., Bao, L., Wu, D., Zhang, T., Yue, H., Chen, J."A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability". Molecular Medicine Reports 17.4 (2018): 5921-5927.
Chicago
Zhang, W., Zhang, J., Cheng, L., Ni, H., You, B., Shan, Y., Bao, L., Wu, D., Zhang, T., Yue, H., Chen, J."A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability". Molecular Medicine Reports 17, no. 4 (2018): 5921-5927. https://doi.org/10.3892/mmr.2018.8634
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Zhang J, Cheng L, Ni H, You B, Shan Y, Bao L, Wu D, Zhang T, Yue H, Yue H, et al: A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability. Mol Med Rep 17: 5921-5927, 2018.
APA
Zhang, W., Zhang, J., Cheng, L., Ni, H., You, B., Shan, Y. ... Chen, J. (2018). A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability. Molecular Medicine Reports, 17, 5921-5927. https://doi.org/10.3892/mmr.2018.8634
MLA
Zhang, W., Zhang, J., Cheng, L., Ni, H., You, B., Shan, Y., Bao, L., Wu, D., Zhang, T., Yue, H., Chen, J."A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability". Molecular Medicine Reports 17.4 (2018): 5921-5927.
Chicago
Zhang, W., Zhang, J., Cheng, L., Ni, H., You, B., Shan, Y., Bao, L., Wu, D., Zhang, T., Yue, H., Chen, J."A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability". Molecular Medicine Reports 17, no. 4 (2018): 5921-5927. https://doi.org/10.3892/mmr.2018.8634
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team