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Review

Oxidative CaMKII as a potential target for inflammatory disease (Review)

  • Authors:
    • Jingjing Qu
    • Quanhui Mei
    • Ruichao Niu
  • View Affiliations / Copyright

    Affiliations: Department of Lung Cancer and Gastroenterology, Hunan Cancer Hospital, Affiliated Tumor Hospital of Xiangya Medical School of Central South University, Changsha, Hunan 410008, P.R. China, Department of Intensive Care Unit, The First People's Hospital of Changde City, Changde, Hunan 410005, P.R. China, Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 863-870
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    Published online on: May 29, 2019
       https://doi.org/10.3892/mmr.2019.10309
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Abstract

CaMKII is a calcium‑activated kinase, proved to be modulated by oxidation. Currently, the oxidative activation of CaMKII exists in several models of asthma, chronic rhinosinusitis with nasal polyps, cardiovascular disease, diabetes mellitus, acute ischemic stroke and cancer. Oxidized CaMKII (ox‑CaMKII) may be important in several of these diseases. The present review examines the mechanism underlying the oxidative activation of CaMKII and summarizes the current findings associated with the function of ox‑CaMKII in inflammatory diseases. Taken together, the findings of this review aim to improve current understanding of the function of ox‑CaMKII and provide novel insights for future research.
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Copy and paste a formatted citation
Spandidos Publications style
Qu J, Mei Q and Niu R: Oxidative CaMKII as a potential target for inflammatory disease (Review). Mol Med Rep 20: 863-870, 2019.
APA
Qu, J., Mei, Q., & Niu, R. (2019). Oxidative CaMKII as a potential target for inflammatory disease (Review). Molecular Medicine Reports, 20, 863-870. https://doi.org/10.3892/mmr.2019.10309
MLA
Qu, J., Mei, Q., Niu, R."Oxidative CaMKII as a potential target for inflammatory disease (Review)". Molecular Medicine Reports 20.2 (2019): 863-870.
Chicago
Qu, J., Mei, Q., Niu, R."Oxidative CaMKII as a potential target for inflammatory disease (Review)". Molecular Medicine Reports 20, no. 2 (2019): 863-870. https://doi.org/10.3892/mmr.2019.10309
Copy and paste a formatted citation
x
Spandidos Publications style
Qu J, Mei Q and Niu R: Oxidative CaMKII as a potential target for inflammatory disease (Review). Mol Med Rep 20: 863-870, 2019.
APA
Qu, J., Mei, Q., & Niu, R. (2019). Oxidative CaMKII as a potential target for inflammatory disease (Review). Molecular Medicine Reports, 20, 863-870. https://doi.org/10.3892/mmr.2019.10309
MLA
Qu, J., Mei, Q., Niu, R."Oxidative CaMKII as a potential target for inflammatory disease (Review)". Molecular Medicine Reports 20.2 (2019): 863-870.
Chicago
Qu, J., Mei, Q., Niu, R."Oxidative CaMKII as a potential target for inflammatory disease (Review)". Molecular Medicine Reports 20, no. 2 (2019): 863-870. https://doi.org/10.3892/mmr.2019.10309
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