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Article

Interleukin‑33 promotes obstructive renal injury via macrophages

  • Authors:
    • Yanlei Li
    • Jing Liu
    • Ting Yu
    • Bingdi Yan
    • Hongjun Li
  • View Affiliations / Copyright

    Affiliations: Health Management Medical Center, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
  • Pages: 1353-1362
    |
    Published online on: June 3, 2019
       https://doi.org/10.3892/mmr.2019.10324
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Abstract

Chronic kidney disease is the outcome of most kidney diseases, and renal fibrosis is a pathological process involved in the progression of these disorders. The role of interleukin (IL)‑33 was previously investigated in fibrotic disorders affecting various organs, including liver, lungs and heart; however, its role in renal fibrosis remains unclear. Previous studies have demonstrated that macrophages are involved in obstructive renal injury. In the present study, the roles of IL‑33 and macrophages on renal fibrosis were investigated using a mouse model of unilateral ureteral obstruction (UUO). Compared with non‑obstructed kidneys, the expression levels of IL‑33 and its receptor, interleukin 1 receptor like 1, increased after UUO. Furthermore, the infiltration of macrophages and the degree of renal fibrosis increased after treatment with IL‑33. Additionally, the expression level of arginase‑1, a marker of M2 macrophages, increased in renal tissue. After depletion of macrophages, the administration of exogenous IL‑33 was not sufficient to reverse the reduction in fibrosis caused by elimination of these cells. Collectively, the present results suggested that IL‑33 promoted renal fibrosis in UUO‑induced renal injury by regulating macrophage polarization.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu J, Yu T, Yan B and Li H: Interleukin‑33 promotes obstructive renal injury via macrophages. Mol Med Rep 20: 1353-1362, 2019.
APA
Li, Y., Liu, J., Yu, T., Yan, B., & Li, H. (2019). Interleukin‑33 promotes obstructive renal injury via macrophages. Molecular Medicine Reports, 20, 1353-1362. https://doi.org/10.3892/mmr.2019.10324
MLA
Li, Y., Liu, J., Yu, T., Yan, B., Li, H."Interleukin‑33 promotes obstructive renal injury via macrophages". Molecular Medicine Reports 20.2 (2019): 1353-1362.
Chicago
Li, Y., Liu, J., Yu, T., Yan, B., Li, H."Interleukin‑33 promotes obstructive renal injury via macrophages". Molecular Medicine Reports 20, no. 2 (2019): 1353-1362. https://doi.org/10.3892/mmr.2019.10324
Copy and paste a formatted citation
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Spandidos Publications style
Li Y, Liu J, Yu T, Yan B and Li H: Interleukin‑33 promotes obstructive renal injury via macrophages. Mol Med Rep 20: 1353-1362, 2019.
APA
Li, Y., Liu, J., Yu, T., Yan, B., & Li, H. (2019). Interleukin‑33 promotes obstructive renal injury via macrophages. Molecular Medicine Reports, 20, 1353-1362. https://doi.org/10.3892/mmr.2019.10324
MLA
Li, Y., Liu, J., Yu, T., Yan, B., Li, H."Interleukin‑33 promotes obstructive renal injury via macrophages". Molecular Medicine Reports 20.2 (2019): 1353-1362.
Chicago
Li, Y., Liu, J., Yu, T., Yan, B., Li, H."Interleukin‑33 promotes obstructive renal injury via macrophages". Molecular Medicine Reports 20, no. 2 (2019): 1353-1362. https://doi.org/10.3892/mmr.2019.10324
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