Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro

  • Authors:
    • Ronghuan He
    • Wenlun Han
    • Yanjun Hu
    • Xijing Chen
    • Xiaoling Hu
    • Yimin Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China, Department of Nephrology, Tongde Hospital of Zhejiang, Hangzhou, Zhejiang 310012, P.R. China
  • Pages: 1306-1312
    |
    Published online on: June 5, 2019
       https://doi.org/10.3892/mmr.2019.10338
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

17β‑estradiol (E2) and aquaporin 2 (AQP2) are associated with endometrial receptivity, and E2 directly regulates AQP2 expression in endometrial cancer cells. The present study aimed to investigate the role of AQP2 in embryo implantation. Normal endometrial samples were collected at the Women's Hospital (Hangzhou, China) from women seeking in vitro fertilization and embryo transfer; women with endometrial abnormalities were excluded from the study. Samples were categorized into early‑mid proliferative, late proliferative, early secretory, mid‑secretory and late secretory phase groups, according to the menstrual cycle. The mRNA and protein expression levels of AQP2 were assessed in normal human endometrium in response to E2 via reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. The effects of AQP2 on spheroid attachment were assessed using an in vitro co‑culture assay with small interfering (si)RNA against AQP2. The highest expression levels of AQP2 were observed in the late proliferative and mid‑secretory phases, with the lowest levels detected in the early proliferative and late secretory phases. In addition, treatment with 10‑9 or 10‑7 M E2 for 24 h upregulated AQP2 in the cultured endometrium. Knockdown of AQP2 by siRNA significantly decreased JAr spheroid attachment; however, this effect was significantly reversed when AQP2 siRNA‑transfected cells were treated with 10‑7 M E2. The results of the present study suggested that AQP2 expression levels in human endometrium may be mediated by estrogen, and low AQP2 expression levels may be a potential cause of impaired uterine receptivity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Adamson GD, Tabangin M, Macaluso M and Mouzon J: The number of babies born globaylly after treatment with the assisted reproductive technologies (ART). Fertil Steril. 100:S422013. View Article : Google Scholar

2 

Paulson RJ, Hatch IE, Lobo RA and Sauer MV: Cumulative conception and live birth rates after oocyte donation: Implications regarding endometrial receptivity. Hum Reprod. 12:835–839. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Absalan F, Ghannadi A and Kazerooni M: Reproductive outcome following thawed embryo transfer in management of ovarian hyperstimulation syndrome. J Reprod Infertil. 14:133–137. 2013.PubMed/NCBI

4 

Li MQ and Jin LP: Ovarian stimulation for in vitro fertilization alters the protein profile expression in endometrial secretion. Int J Clin Exp Pathol. 6:1964–1971. 2013.PubMed/NCBI

5 

Davar R, Janati S, Mohseni F, Khabazkhoob M and Asgari S: A comparison of the effects of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles: A randomized clinical trial. J Reprod Infertil. 17:97–103. 2016.PubMed/NCBI

6 

Kara M, Kutlu T, Sofuoglu K, Devranoglu B and Cetinkaya T: Association between serum estradiol level on the hCG administration day and IVF-ICSI outcome. Iran J Reprod Med. 10:53–58. 2012.PubMed/NCBI

7 

Arslan M, Bocca S, Arslan EO, Duran HE, Stadtmauer L and Oehninger S: Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation. J Assist Reprod Genet. 24:111–117. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Ullah K, Rahman TU, Pan HT, Guo MX, Dong XY, Liu J, Jin LY, Cheng Y, Ke ZH, Ren J, et al: Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium. J Mol Endocrinol. 59:105–119. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Dominguez F, Garrido-Gomez T, Lopez JA, Camafeita E, Quinonero A, Pellicer A and Simón C: Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin 1 and annexin A2 as differentially regulated. Hum Reprod. 24:2607–2617. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Huang HF, He RH, Sun CC, Zhang Y, Meng QX and Ma YY: Function of aquaporins in female and male reproductive systems. Hum Reprod Update. 12:785–795. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Zhu C, Jiang Z, Bazer FW, Johnson GA, Burghardt RC and Wu G: Aquaporins in the female reproductive system of mammals. Front Biosci (Landmark Ed). 20:838–871. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Day RE, Kitchen P, Owen DS, Bland C, Marshall L, Conner AC, Bill RM and Conner MT: Human aquaporins: regulators of transcellular water flow. Biochim Biophys Acta. 1840:1492–1506. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Aralla M, Borromeo V, Groppetti D, Secchi C, Cremonesi F and Arrighi S: A collaboration of aquaporins handles water transport in relation to the estrous cycle in the bitch uterus. Theriogenology. 72:310–321. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Skowronski MT, Skowronska A and Nielsen S: Fluctuation of aquaporin 1, 5, and 9 expression in the pig oviduct during the estrous cycle and early pregnancy. J Histochem Cytochem. 59:419–427. 2011. View Article : Google Scholar : PubMed/NCBI

15 

He RH, Sheng JZ, Luo Q, Jin F, Wang B, Qian YL, Zhou CY, Sheng X and Huang HF: Aquaporin-2 expression in human endometrium correlates with serum ovarian steroid hormones. Life Sci. 79:423–429. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Hildenbrand A, Lalitkumar L, Nielsen S, Gemzell-Danielsson K and Stavreus-Evers A: Expression of aquaporin 2 in human endometrium. Fertil Steril. 86:1452–1458. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, He RH, Liu AX, Wang TT, Leung PC, et al: Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab. 96:E1399–E1408. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Noyes RW, Hertig AT and Rock J: Dating the endometrial biopsy. Am J Obstet Gynecol. 122:262–263. 1975. View Article : Google Scholar : PubMed/NCBI

19 

Horne AW, King AE, Shaw E, McDonald SE, Williams AR, Saunders PT and Critchley HO: Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy. J Clin Endocrinol Metab. 94:5146–5154. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F and Sasaki S: Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature. 361:549–552. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Schefe JH, Lehmann KE, Buschmann IR, Unger T and Funke-Kaiser H: Quantitative real-time RT-PCR data analysis: Current concepts and the novel ‘gene expression's CT difference’ formula. J Mol Med (Berl). 84:901–910. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Hohn HP, Linke M and Denker HW: Adhesion of trophoblast to uterine epithelium as related to the state of trophoblast differentiation: In vitro studies using cell lines. Mol Reprod Dev. 57:135–145. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Uchida H, Maruyama T, Ohta K, Ono M, Arase T, Kagami M, Oda H, Kajitani T, Asada H and Yoshimura Y: Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation. Hum Reprod. 22:2615–2622. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Liu Y, Kodithuwakku SP, Ng PY, Chai J, Ng EH, Yeung WS, Ho PC and Lee KF: Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: An in vitro co-culture study. Hum Reprod. 25:479–490. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Marsh EE, Shaw ND, Klingman KM, Tiamfook-Morgan TO, Yialamas MA, Sluss PM and Hall JE: Estrogen levels are higher across the menstrual cycle in African-American women compared with Caucasian women. J Clin Endocrinol Metab. 96:3199–3206. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Hannan NJ, Paiva P, Dimitriadis E and Salamonsen LA: Models for study of human embryo implantation: Choice of cell lines? Biol Reprod. 82:235–245. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Nishida M: The Ishikawa cells from birth to the present. Hum Cell. 15:104–117. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Apps R, Murphy SP, Fernando R, Gardner L, Ahad T and Moffett A: Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology. 127:26–39. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Heneweer C, Schmidt M, Denker HW and Thie M: Molecular mechanisms in uterine epithelium during trophoblast binding: The role of small GTPase RhoA in human uterine Ishikawa cells. J Exp Clin Assist Reprod. 2:42005. View Article : Google Scholar : PubMed/NCBI

31 

Zhang D, Xu G, Zhang R, Zhu Y, Gao H, Zhou C, Sheng J and Huang H: Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. Reprod Fertil Dev. 28:499–506. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Smith SK: Regulation of angiogenesis in the endometrium. Trends Endocrinol Metab. 12:147–151. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Gupta SC, Kim JH, Prasad S and Aggarwal BB: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 29:405–434. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Klinge CM, Jernigan SC, Mattingly KA, Risinger KE and Zhang J: Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. J Mol Endocrinol. 33:387–410. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Chai J, Lee KF, Ng EH, Yeung WS and Ho PC: Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: Studies on natural and stimulated cycles. Fertil Steril. 96:764–768. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Yu Ng EH, Yeung WS, Yee Lan Lau E, So WW and Ho PC: High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles. Hum Reprod. 15:250–255. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Forman R, Fries N, Testart J, Belaisch-Allart J, Hazout A and Frydman R: Evidence for an adverse effect of elevated serum estradiol concentrations on embryo implantation. Fertil Steril. 49:118–122. 1988. View Article : Google Scholar : PubMed/NCBI

38 

Fossum GT, Davidson A and Paulson RJ: Ovarian hyperstimulation inhibits embryo implantation in the mouse. J In Vitro Fert Embryo Transf. 6:7–10. 1989. View Article : Google Scholar : PubMed/NCBI

39 

Noci I, Borri P, Coccia ME, Criscuoli L, Scarselli G, Messeri G, Paglierani M, Moncini D and Taddei G: Hormonal patterns, steroid receptors and morphological pictures of endometrium in hyperstimulated IVF cycles. Eur J Obstet Gynecol Reprod Biol. 75:215–220. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Kalem Z, Kalem MN and Gurgan T: Methods for endometrial preparation in frozen-thawed embryo transfer cycles. J Turk Ger Gynecol Assoc. 17:168–172. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Valbuena D, Jasper M, Remohi J, Pellicer A and Simon C: Ovarian stimulation and endometrial receptivity. Hum Reprod (2 Suppl 14). S107–S111. 1999. View Article : Google Scholar

42 

Xu LZ, Gao MZ, Yao LH, Liang AJ, Zhao XM and Sun ZG: Effect of high ovarian response on the expression of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) in peri-implantation endometrium in IVF women. Int J Clin Exp Pathol. 8:8902–8911. 2015.PubMed/NCBI

43 

Rashidi B, Soleimani Rad JI, Roshangar L and Alizadeh Miran R: Evaluation of pinopodes expression on the mouse endometrium immediately before implantation by treatment with HMG/HCG and sildenafil citrate administration. Iran J Basic Med Sci. 15:1091–1096. 2012.PubMed/NCBI

44 

Cheema MU, Irsik DL, Wang Y, Miller-Little W, Hyndman KA, Marks ES, Frøkiær J, Boesen EI and Norregaard R: Estradiol regulates AQP2 expression in the collecting duct: A novel inhibitory role for estrogen receptor alpha. Am J Physiol Renal Physiol. 309:F305–F317. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Chenette PE, Sauer MV and Paulson RJ: Very high serum estradiol levels are not detrimental to clinical outcome of in vitro fertilization. Fertil Steril. 54:858–863. 1990. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He R, Han W, Hu Y, Chen X, Hu X and Zhu Y: AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro. Mol Med Rep 20: 1306-1312, 2019.
APA
He, R., Han, W., Hu, Y., Chen, X., Hu, X., & Zhu, Y. (2019). AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro. Molecular Medicine Reports, 20, 1306-1312. https://doi.org/10.3892/mmr.2019.10338
MLA
He, R., Han, W., Hu, Y., Chen, X., Hu, X., Zhu, Y."AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro". Molecular Medicine Reports 20.2 (2019): 1306-1312.
Chicago
He, R., Han, W., Hu, Y., Chen, X., Hu, X., Zhu, Y."AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro". Molecular Medicine Reports 20, no. 2 (2019): 1306-1312. https://doi.org/10.3892/mmr.2019.10338
Copy and paste a formatted citation
x
Spandidos Publications style
He R, Han W, Hu Y, Chen X, Hu X and Zhu Y: AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro. Mol Med Rep 20: 1306-1312, 2019.
APA
He, R., Han, W., Hu, Y., Chen, X., Hu, X., & Zhu, Y. (2019). AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro. Molecular Medicine Reports, 20, 1306-1312. https://doi.org/10.3892/mmr.2019.10338
MLA
He, R., Han, W., Hu, Y., Chen, X., Hu, X., Zhu, Y."AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro". Molecular Medicine Reports 20.2 (2019): 1306-1312.
Chicago
He, R., Han, W., Hu, Y., Chen, X., Hu, X., Zhu, Y."AQP2 is regulated by estradiol in human endometrium and is associated with spheroid attachment in vitro". Molecular Medicine Reports 20, no. 2 (2019): 1306-1312. https://doi.org/10.3892/mmr.2019.10338
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team