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Article

lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis

  • Authors:
    • Tongqiang He
    • Yuan Qiao
    • Yanxiang Lv
    • Jun Wang
    • Rui Hu
    • Yinli Cao
  • View Affiliations / Copyright

    Affiliations: Obstetrics and Gynecology Intensive Care Unit, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China, Department of Obstetrics, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China
  • Pages: 1451-1458
    |
    Published online on: June 5, 2019
       https://doi.org/10.3892/mmr.2019.10350
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Abstract

Preeclampsia (PE) is a complication of pregnancy, and a leading cause of maternal mortality and morbidity worldwide. Recently, the dysregulation of long non‑coding RNAs (lncRNAs) has been reported to contribute to the pathogenesis and progression of PE. This study aimed to examine the alterations in the lncRNA family with sequence similarity 99 member A (FAM99A) in PE and its effects on trophoblasts. The results of reverse transcription‑quantitative PCR indicated that the expression levels of FAM99A were downregulated in placental tissues from women with severe PE compared with in those from controls. A Transwell invasion assay and wound healing assay revealed that overexpression of FAM99A promoted invasion and migration of HTR‑8/SVneo cells; conversely, knockdown of FAM99A suppressed the invasive and migratory abilities of HTR‑8/SVneo cells. Flow cytometry demonstrated that FAM99A overexpression induced a decrease in the apoptotic rate of cells, whereas knockdown of FAM99A increased the apoptotic rate of HTR‑8/SVneo cells. Western blot analysis revealed that overexpression of FAM99A decreased the protein expression levels of cleaved caspase‑3, cleaved caspase‑9 and Bax, and increased Bcl‑2 protein expression, whereas knockdown of FAM99A had the opposite effects on these protein levels. Overexpression of FAM99A also decreased caspase‑3 activity in HTR‑8/SVneo cells; however, knockdown of FAM99A increased caspase‑3 activity. In addition, overexpression of FAM99A enhanced Wnt/β‑catenin signaling activity, whereas FAM99A knockdown exerted an inhibitory effect on the Wnt/β‑catenin signaling activity in HTR‑8/SVneo cells. In conclusion, these results indicated that FAM99A may serve a role in modulating the functions of trophoblasts, partially via targeting Wnt/β‑catenin signaling.
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1 

Kurtz WS, Glueck CJ, Hutchins RK, Sisk RA and Wang P: Retinal artery and vein thrombotic occlusion during pregnancy: Markers for familial thrombophilia and adverse pregnancy outcomes. Clin Ophthalmol. 10:935–938. 2016.PubMed/NCBI

2 

Powe CE, Levine RJ and Karumanchi SA: Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 123:2856–2869. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Gao L, Qi HB, Kamana KC, Zhang XM, Zhang H and Baker PN: Excessive autophagy induces the failure of trophoblast invasion and vasculature: Possible relevance to the pathogenesis of preeclampsia. J Hypertens. 33:106–117. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Salomon C, Yee SW, Mitchell MD and Rice GE: The possible role of extravillous trophoblast-derived exosomes on the uterine spiral arterial remodeling under both normal and pathological conditions. Biomed Res Int. 2014:6931572014. View Article : Google Scholar : PubMed/NCBI

5 

Saito S and Nakashima A: A review of the mechanism for poor placentation in early-onset preeclampsia: The role of autophagy in trophoblast invasion and vascular remodeling. J Reprod Immunol. 101-102:80–88. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Hung TH, Chen SF, Lo LM, Li MJ, Yeh YL and Hsieh TT: Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PLoS One. 7:e409572012. View Article : Google Scholar : PubMed/NCBI

7 

Sharp AN, Heazell AE, Crocker IP and Mor G: Placental apoptosis in health and disease. Am J Reprod Immunol. 64:159–169. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Wieczorek E and Reszka E: mRNA, microRNA and lncRNA as novel bladder tumor markers. Clin Chim Acta. 477:141–153. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Freedman JE and Miano JM; National Heart, Lung, and Blood Institute Workshop Participants, : Challenges and opportunities in linking long noncoding RNAs to cardiovascular, lung, and blood diseases. Arterioscler Thromb Vasc Biol. 37:21–25. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Tian L, Zheng F, Li Z, Wang H, Yuan H, Zhang X, Ma Z, Li X, Gao X and Wang B: miR-148a-3p regulates adipocyte and osteoblast differentiation by targeting lysine-specific demethylase 6b. Gene. 627:32–39. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Y, Zou Y, Wang W, Zuo Q, Jiang Z, Sun M, De W and Sun L: Down-regulated long non-coding RNA MEG3 and its effect on promoting apoptosis and suppressing migration of trophoblast cells. J Cell Biochem. 116:542–550. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Chen H, Meng T, Liu X, Sun M, Tong C, Liu J, Wang H and Du J: Long non-coding RNA MALAT-1 is downregulated in preeclampsia and regulates proliferation, apoptosis, migration and invasion of JEG-3 trophoblast cells. Int J Clin Exp Pathol. 8:12718–12727. 2015.PubMed/NCBI

13 

Zuo Q, Huang S, Zou Y, Xu Y, Jiang Z, Zou S, Xu H and Sun L: The Lnc RNA SPRY4-IT1 modulates trophoblast cell invasion and migration by affecting the epithelial-mesenchymal transition. Sci Rep. 6:371832016. View Article : Google Scholar : PubMed/NCBI

14 

He X, He Y, Xi B, Zheng J, Zeng X, Cai Q, Ouyang Y, Wang C, Zhou X, Huang H, et al: LncRNAs expression in preeclampsia placenta reveals the potential role of LncRNAs contributing to preeclampsia pathogenesis. PLoS One. 8:e814372013. View Article : Google Scholar : PubMed/NCBI

15 

Peng L, Liu Z, Xiao J, Tu Y, Wan Z, Xiong H, Li Y and Xiao W: MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/β-catenin signaling pathway. Oncol Rep. 38:301–308. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Tranquilli AL, Brown MA, Zeeman GG, Dekker G and Sibai BM: The definition of severe and early-onset preeclampsia. Statements from the international society for the study of hypertension in pregnancy (ISSHP). Pregnancy Hypertens. 3:44–47. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Graham CH, Hawley TS, Hawley RG, MacDougall JR, Kerbel RS, Khoo N and Lala PK: Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res. 206:204–211. 1993. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

McAninch D, Roberts CT and Bianco-Miotto T: Mechanistic insight into long noncoding RNAs and the placenta. Int J Mol Sci. 18:E13712017. View Article : Google Scholar : PubMed/NCBI

20 

Zou Y, Jiang Z, Yu X, Sun M, Zhang Y, Zuo Q, Zhou J, Yang N, Han P, Ge Z, et al: Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo. PLoS One. 8:e795982013. View Article : Google Scholar : PubMed/NCBI

21 

Song X, Rui C, Meng L, Zhang R, Shen R, Ding H, Li J, Li J and Long W: Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q. Oncotarget. 8:7637–7646. 2017.PubMed/NCBI

22 

Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi CS, Buhimschi IA, Bukowski R, Guller S, Paidas M and Huang Y: H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget. 7:38398–38407. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Liu X, Chen H, Kong W, Zhang Y, Cao L, Gao L and Zhou R: Down-regulated long non-coding RNA-ATB in preeclampsia and its effect on suppressing migration, proliferation, and tube formation of trophoblast cells. Placenta. 49:80–87. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Xu Y, Ge Z, Zhang E, Zuo Q, Huang S, Yang N, Wu D, Zhang Y, Chen Y, Xu H, et al: The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3. Cell Death Dis. 8:e31042017. View Article : Google Scholar : PubMed/NCBI

25 

Xu H, Sun Q, Lu L, Luo F, Zhou L, Liu J, Cao L, Wang Q, Xue J, Yang Q, et al: MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-κB, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. Toxicol Lett. 280:171–180. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Petry CJ, Koulman A, Lu L, Jenkins B, Furse S, Prentice P, Matthews L, Hughes IA, Acerini CL, Ong KK and Dunger DB: Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: A cohort study. Reprod Biol Endocrinol. 16:822018. View Article : Google Scholar : PubMed/NCBI

27 

Petry CJ, Sanz Marcos N, Pimentel G, Hayes MG, Nodzenski M, Scholtens DM, Hughes IA, Acerini CL, Ong KK, Lowe WL Jr and Dunger DB: Associations between fetal imprinted genes and maternal blood pressure in pregnancy. Hypertension. 68:1459–1466. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Freitag N, Tirado-González I, Barrientos G, Herse F, Thijssen VL, Weedon-Fekjær SM, Schulz H, Wallukat G, Klapp BF, Nevers T, et al: Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia. Proc Natl Acad Sci USA. 110:11451–11456. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Palei AC, Spradley FT, Warrington JP, George EM and Granger JP: Pathophysiology of hypertension in pre-eclampsia: A lesson in integrative physiology. Acta Physiol (Oxf). 208:224–233. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Hoppler S and Kavanagh CL: Wnt signalling: Variety at the core. J Cell Sci. 120:385–393. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Krishnamurthy N and Kurzrock R: Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors. Cancer Treat Rev. 62:50–60. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Nusse R and Clevers H: Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 169:985–999. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Zhuang B, Luo X, Rao H, Li Q, Liu X and Qi H: Expression and significance of SATB1 and wnt/β-catenin signaling molecule in the placenta of preeclampsia. Zhonghua Fu Chan Ke Za Zhi. 50:283–290. 2015.(In Chinese). PubMed/NCBI

34 

Zhuang B, Luo X, Rao H, Li Q, Shan N, Liu X and Qi H: Oxidative stress-induced C/EBPβ inhibits β-catenin signaling molecule involving in the pathology of preeclampsia. Placenta. 36:839–846. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Kumar P, Thirkill TL, Ji J, Monte LH and Douglas GC: Differential effects of sodium butyrate and lithium chloride on rhesus monkey trophoblast differentiation. PLoS One. 10:e01350892015. View Article : Google Scholar : PubMed/NCBI

36 

Yang Y, Wang Y, Liang Q, Yao L, Gu S and Bai X: MiR-338-5p promotes inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via targeting SPRY1. J Cell Biochem. 118:2295–2301. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He T, Qiao Y, Lv Y, Wang J, Hu R and Cao Y: lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Mol Med Rep 20: 1451-1458, 2019.
APA
He, T., Qiao, Y., Lv, Y., Wang, J., Hu, R., & Cao, Y. (2019). lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Molecular Medicine Reports, 20, 1451-1458. https://doi.org/10.3892/mmr.2019.10350
MLA
He, T., Qiao, Y., Lv, Y., Wang, J., Hu, R., Cao, Y."lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis". Molecular Medicine Reports 20.2 (2019): 1451-1458.
Chicago
He, T., Qiao, Y., Lv, Y., Wang, J., Hu, R., Cao, Y."lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis". Molecular Medicine Reports 20, no. 2 (2019): 1451-1458. https://doi.org/10.3892/mmr.2019.10350
Copy and paste a formatted citation
x
Spandidos Publications style
He T, Qiao Y, Lv Y, Wang J, Hu R and Cao Y: lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Mol Med Rep 20: 1451-1458, 2019.
APA
He, T., Qiao, Y., Lv, Y., Wang, J., Hu, R., & Cao, Y. (2019). lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Molecular Medicine Reports, 20, 1451-1458. https://doi.org/10.3892/mmr.2019.10350
MLA
He, T., Qiao, Y., Lv, Y., Wang, J., Hu, R., Cao, Y."lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis". Molecular Medicine Reports 20.2 (2019): 1451-1458.
Chicago
He, T., Qiao, Y., Lv, Y., Wang, J., Hu, R., Cao, Y."lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis". Molecular Medicine Reports 20, no. 2 (2019): 1451-1458. https://doi.org/10.3892/mmr.2019.10350
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