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RING finger protein 10 is a potential drug target for diabetic vascular complications

  • Authors:
    • Siyu Li
    • Guiquan Yu
    • Wei Huang
    • Ruiyu Wang
    • Peng Pu
    • Ming Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 931-938
    |
    Published online on: June 6, 2019
       https://doi.org/10.3892/mmr.2019.10358
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Abstract

Vascular remodeling induced by long‑term hyperglycaemia is the main pathological process in diabetic vascular complications. Thus, vascular remodeling may be a potential therapeutic target in diabetes mellitus (DM) with macrovascular disease. The present study aimed to investigate the effect of RING finger protein 10 (RNF10) on vascular remodeling under conditions of chronic hyperglycaemia stimulation. We found that overexpression of RNF10 clearly decreased intimal thickness and attenuated vascular remodeling in DM. TUNEL staining showed that apoptosis was clearly inhibited, an effect that may be mediated by decreases in Bcl‑2 protein expression. Quantitative analysis demonstrated that overexpression of RNF10 could suppress inflammation by reducing the levels of TNF‑α, and MCP‑1 mRNA and NF‑κB protein. Meanwhile, overexpression of RNF10 prevented vascular smooth muscle cell (VSMC) hyperproliferation through the downregulation of cyclin D1 and CDK4 proteins. Notably, short hairpin RNF10 (shRNF10) greatly aggravated the pathological responses of diabetic vascular remodeling. These outcomes revealed that the differential expression of RNF10 had a completely opposite effect on vascular damage under hyperglycaemia, further displaying the core function of RNF10 in regulating vascular remodeling induced by diabetes. Consequently, RNF10 could be a novel target for the treatment of diabetic vascular complications.
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Copy and paste a formatted citation
Spandidos Publications style
Li S, Yu G, Huang W, Wang R, Pu P and Chen M: RING finger protein 10 is a potential drug target for diabetic vascular complications. Mol Med Rep 20: 931-938, 2019.
APA
Li, S., Yu, G., Huang, W., Wang, R., Pu, P., & Chen, M. (2019). RING finger protein 10 is a potential drug target for diabetic vascular complications. Molecular Medicine Reports, 20, 931-938. https://doi.org/10.3892/mmr.2019.10358
MLA
Li, S., Yu, G., Huang, W., Wang, R., Pu, P., Chen, M."RING finger protein 10 is a potential drug target for diabetic vascular complications". Molecular Medicine Reports 20.2 (2019): 931-938.
Chicago
Li, S., Yu, G., Huang, W., Wang, R., Pu, P., Chen, M."RING finger protein 10 is a potential drug target for diabetic vascular complications". Molecular Medicine Reports 20, no. 2 (2019): 931-938. https://doi.org/10.3892/mmr.2019.10358
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Yu G, Huang W, Wang R, Pu P and Chen M: RING finger protein 10 is a potential drug target for diabetic vascular complications. Mol Med Rep 20: 931-938, 2019.
APA
Li, S., Yu, G., Huang, W., Wang, R., Pu, P., & Chen, M. (2019). RING finger protein 10 is a potential drug target for diabetic vascular complications. Molecular Medicine Reports, 20, 931-938. https://doi.org/10.3892/mmr.2019.10358
MLA
Li, S., Yu, G., Huang, W., Wang, R., Pu, P., Chen, M."RING finger protein 10 is a potential drug target for diabetic vascular complications". Molecular Medicine Reports 20.2 (2019): 931-938.
Chicago
Li, S., Yu, G., Huang, W., Wang, R., Pu, P., Chen, M."RING finger protein 10 is a potential drug target for diabetic vascular complications". Molecular Medicine Reports 20, no. 2 (2019): 931-938. https://doi.org/10.3892/mmr.2019.10358
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