Open Access

Significant association between GPR50 hypomethylation and AD in males

  • Authors:
    • Weihua Chen
    • Huihui Ji
    • Liping Li
    • Chunshuang Xu
    • Ting Zou
    • Wei Cui
    • Shujun Xu
    • Xiaohui Zhou
    • Shiwei Duan
    • Qinwen Wang
  • View Affiliations

  • Published online on: June 6, 2019     https://doi.org/10.3892/mmr.2019.10366
  • Pages: 1085-1092
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease. G protein coupled receptor 50 (GPR50) is a candidate gene for AD. The present study was designed to determine the association between GPR50 methylation and AD. The methylation levels of the GPR50 promoter in 51 patients with AD and 61 healthy controls were determined by bisulfite pyrophosphate sequencing. All participants were Han Chinese, living in Ningbo. It was identified that the GPR50 promoter methylation level was significantly decreased in the male AD group compared with the male control group (9.15 vs. 16.67%, P=0.002). In addition, it was observed that the GPR50 methylation levels of the females was significantly increased compared with that of males in both the patients with AD and the healthy control group (AD patient group: 33.00 vs. 9.15%, P<0.0001; healthy control group: 29.41 vs. 16.67%, P<0.0001). This may be explained by the fact that GPR50 is located on the X chromosome. In addition, GPR50 methylation was positively correlated with plasma cholinesterase levels in female patients with AD (r=0.489, P=0.039). The present study demonstrated that hypomethylation of the GPR50 promoter in peripheral blood may be a potential biomarker for the diagnosis of AD in Chinese Han males.
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August-2019
Volume 20 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen W, Ji H, Li L, Xu C, Zou T, Cui W, Xu S, Zhou X, Duan S, Wang Q, Wang Q, et al: Significant association between GPR50 hypomethylation and AD in males. Mol Med Rep 20: 1085-1092, 2019.
APA
Chen, W., Ji, H., Li, L., Xu, C., Zou, T., Cui, W. ... Wang, Q. (2019). Significant association between GPR50 hypomethylation and AD in males. Molecular Medicine Reports, 20, 1085-1092. https://doi.org/10.3892/mmr.2019.10366
MLA
Chen, W., Ji, H., Li, L., Xu, C., Zou, T., Cui, W., Xu, S., Zhou, X., Duan, S., Wang, Q."Significant association between GPR50 hypomethylation and AD in males". Molecular Medicine Reports 20.2 (2019): 1085-1092.
Chicago
Chen, W., Ji, H., Li, L., Xu, C., Zou, T., Cui, W., Xu, S., Zhou, X., Duan, S., Wang, Q."Significant association between GPR50 hypomethylation and AD in males". Molecular Medicine Reports 20, no. 2 (2019): 1085-1092. https://doi.org/10.3892/mmr.2019.10366