Open Access

lncRNA ATXN8OS promotes breast cancer by sequestering miR‑204

  • Authors:
    • Zhen Deng
    • Huayu Cai
    • Liying Lin
    • Lingfeng Zhu
    • Weizhen Wu
    • Shunliang Yang
    • Jinquan Cai
    • Jianming Tan
  • View Affiliations

  • Published online on: June 6, 2019     https://doi.org/10.3892/mmr.2019.10367
  • Pages: 1057-1064
  • Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer (BC) is a common malignancy among women and the leading cause of female cancer mortality worldwide. In recent years, increasing evidence has shown that long non‑coding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs) in human cancer and that they are involved in many biological processes, including proliferation, migration, apoptosis and invasion. In the present study, the biological function and molecular mechanism of ataxin 8 opposite strand (ATXN8OS) in BC tissue and cell lines were investigated. It was found that ATXN8OS was markedly up‑regulated in BC tissue and cell lines, and that its level of overexpression was inversely linked with the overall survival rate of patients with BC. Knockdown of ATXN8OS inhibited proliferation, viability and invasion in the human MCF7 and MDA‑MB‑231 BC cell lines. In addition, microRNA‑204 (miR‑204) was negatively associated with the expression of ATXN8OS in BC tissues and cell lines. A luciferase assay demonstrated a direct binding site for miR‑204 within ATXN8OS, and inhibition of miR‑204 stimulated the tumour‑promoting effect of ATXN8OS on BC cells. In conclusion, the present study suggested that ATXN8OS acts as a tumour promoter by sequestering miR‑204 during the development of BC, therefore providing a mechanistic insight which may facilitate the diagnosis and treatment of BC.
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August-2019
Volume 20 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Deng Z, Cai H, Lin L, Zhu L, Wu W, Yang S, Cai J and Tan J: lncRNA ATXN8OS promotes breast cancer by sequestering miR‑204. Mol Med Rep 20: 1057-1064, 2019
APA
Deng, Z., Cai, H., Lin, L., Zhu, L., Wu, W., Yang, S. ... Tan, J. (2019). lncRNA ATXN8OS promotes breast cancer by sequestering miR‑204. Molecular Medicine Reports, 20, 1057-1064. https://doi.org/10.3892/mmr.2019.10367
MLA
Deng, Z., Cai, H., Lin, L., Zhu, L., Wu, W., Yang, S., Cai, J., Tan, J."lncRNA ATXN8OS promotes breast cancer by sequestering miR‑204". Molecular Medicine Reports 20.2 (2019): 1057-1064.
Chicago
Deng, Z., Cai, H., Lin, L., Zhu, L., Wu, W., Yang, S., Cai, J., Tan, J."lncRNA ATXN8OS promotes breast cancer by sequestering miR‑204". Molecular Medicine Reports 20, no. 2 (2019): 1057-1064. https://doi.org/10.3892/mmr.2019.10367