Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury

  • Authors:
    • Xinxin Guo
    • Xueshu Tao
    • Qing Tong
    • Tiecheng Li
    • Daosong Dong
    • Bohan Zhang
    • Mengnan Zhao
    • Tao Song
  • View Affiliations / Copyright

    Affiliations: Department of Pain Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110000, P.R. China, Department of Scientific Research, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China, Department of Anesthesiology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1279-1287
    |
    Published online on: June 6, 2019
       https://doi.org/10.3892/mmr.2019.10368
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Obesity is associated with increased sensitivity to pain, including neuropathic pain, but the precise mechanisms are not fully understood. Recent evidence has revealed that AMP‑activated protein kinase (AMPK) in the central nervous system (CNS) regulates the neuropeptide calcitonin gene‑related peptide (CGRP), a principal neurotransmitter of the class C nerve fiber, which serves an important role in initiating and maintaining neuropathic pain. AMPK has been demonstrated to be downregulated in the CNS in obesity. The present study hypothesized that obesity may lead to increased sensitivity to neuropathic pain by downregulating AMPK and upregulating CGRP expression levels in the CNS. Sprague‑Dawley rats consuming a high‑fat diet (HF) for 12 weeks developed obesity; they exhibited significantly decreased levels of phospho (p)‑AMPK and increased CGRP expression levels in the spinal cord (SC) and dorsal root ganglion (DRG), respectively, compared with rats consuming a low‑fat (LF) diet. HF‑fed rats that underwent spared nerve injury (SNI) also exhibited lower p‑AMPK and higher CGRP expression levels in the SC and DRG, compared with the corresponding LF‑diet rats. The 50% paw withdrawal threshold (PWT; as measured by Von Frey testing) was significantly lower in HF‑fed compared with LF‑fed rats, with or without SNI. Through intrathecal treatment, the AMPK activator 5‑aminoimidazole‑4‑carboxamide riboside (AICAR) or the CGRP antagonist CGRP8‑37 decreased CGRP expression levels and increased the 50% PWT; however, the AMPK inhibitor dorsomorphin augmented CGRP expression levels and further reduced the 50% PWT in HF‑fed rats, but not LF‑fed rats, with or without SNI. The results indicated that blocking the AMPK‑CGRP pathway may enhance neuropathic pain in HF‑induced obesity, with or without nerve injury. Targeting AMPK in the CNS may be a novel strategy for the prevention and treatment of obesity‑associated neuropathic pain.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM and Leibel RL: Obesity Pathogenesis: An endocrine society scientific statement. Endocr Rev. 38:267–296. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Roane DS and Porter JR: Nociception and opioid-induced analgesia in lean (Fa/-) and obese (fa/fa) Zucker rats. Physiol Behav. 38:215–218. 1986. View Article : Google Scholar : PubMed/NCBI

3 

Croci T and Zarini E: Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats. Br J Pharmacol. 150:559–566. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Iannitti T, Graham A and Dolan S: Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity. Exp Physiol. 97:1236–1245. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Wang J, Zhang Q, Zhao L, Li D, Fu Z and Liang L: Down-regulation of PPARα in the spinal cord contributes to augmented peripheral inflammation and inflammatory hyperalgesia in diet-induced obese rats. Neuroscience. 278:165–178. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Y, Song C, Li H, Hou J and Li D: Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARα. Mol Med Rep. 13:5309–5316. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hozumi J, Sumitani M, Matsubayashi Y, Abe H, Oshima Y, Chikuda H, Takeshita K and Yamada Y: Relationship between neuropathic pain and obesity. Pain Res Manag. 2016:24879242016. View Article : Google Scholar : PubMed/NCBI

8 

Kim M and Tian R: Targeting AMPK for cardiac protection: Opportunities and challenges. J Mol Cell Cardiol. 51:548–553. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kialka M, Doroszewska K, Janeczko M and Milewicz T: Metformin-new potential medicine in pain treatment? Przegl Lek. 74:81–83. 2017.(In Polish). PubMed/NCBI

10 

Price TJ, Das V and Dussor G: Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain. Curr Drug Targets. 17:908–920. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Asiedu MN, Dussor G and Price TJ: Targeting AMPK for the alleviation of pathological pain. Exp Suppl. 107:257–285. 2016.PubMed/NCBI

12 

Yang YJ, Hu L, Xia YP, Jiang CY, Miao C, Yang CQ, Yuan M and Wang L: Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. J Neuroinflammation. 13:842016. View Article : Google Scholar : PubMed/NCBI

13 

Fei W, Tian DR, Tso P and Han JS: Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue. Peptides. 35:23–30. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Song T, Lv LY, Xu J, Tian ZY, Cui WY, Wang QS, Qu G and Shi XM: Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: Role of AMP-activated protein kinase pathway. Exp Biol Med (Maywood). 236:1427–1436. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Chaplan SR, Bach FW, Pogrel JW, Chung JM and Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 53:55–63. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Decosterd I and Woolf CJ: Spared nerve injury: An animal model of persistent peripheral neuropathic pain. Pain. 87:149–158. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Storkson RV, Kjorsvik A, Tjolsen A and Hole K: Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods. 65:167–172. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Kanai Y, Nakazato E, Fujiuchi A, Hara T and Imai A: Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats. Neuropharmacology. 49:977–84. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Rossi HL, Luu AK, DeVilbiss JL and Recober A: Obesity increases nociceptive activation of the trigeminal system. Eur J Pain. 17:649–653. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Baron R, Binder A and Wasner G: Neuropathic pain: Diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 9:807–819. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Gavini CK, Bookout AL, Bonomo R, Gautron L, Lee S and Mansuy-Aubert V: Liver X receptors protect dorsal root ganglia from obesity-induced endoplasmic reticulum stress and mechanical allodynia. Cell Rep. 25:271–277 e4. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Price TJ and Dussor G: AMPK: An emerging target for modification of injury-induced pain plasticity. Neurosci Lett 557 Pt A. 9–18. 2013. View Article : Google Scholar

23 

Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, et al: Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain. 7:702011. View Article : Google Scholar : PubMed/NCBI

24 

Melemedjian OK, Tillu DV, Asiedu MN, Mandell EK, Moy JK, Blute VM, Taylor CJ, Ghosh S and Price TJ: BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Mol Pain. 9:122013. View Article : Google Scholar : PubMed/NCBI

25 

Maixner DW, Yan X, Gao M, Yadav R and Weng HR: Adenosine monophosphate-activated protein kinase regulates interleukin-1beta expression and glial glutamate transporter function in rodents with neuropathic pain. Anesthesiology. 122:1401–1413. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Ren H, Jin H, Jia Z, Ji N and Luo F: Pulsed Radiofrequency Applied to the Sciatic Nerve Improves Neuropathic Pain by Down-regulating The Expression of Calcitonin Gene-related Peptide in the Dorsal Root Ganglion. Int J Med Sci. 15:153–160. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Pezet S and McMahon SB: Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci. 29:507–538. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Lee SE and Kim JH: Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat. Neurosci Res. 58:245–249. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Sun RQ, Lawand NB and Willis WD: The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin. Pain. 104:201–208. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Hu P, Bembrick AL, Keay KA and McLachlan EM: Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve. Brain Behav Immun. 21:599–616. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Vincent HK and Taylor AG: Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes. 30:400–418. 2006. View Article : Google Scholar

32 

Natoli R, Fernando N, Dahlenburg T, Jiao H, Aggio-Bruce R, Barnett NL, Chao de la Barca JM, Tcherkez G, Reynier P, Fang J, Chu-Tan JA, et al: Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment. Mol Vis. 24:201–217. 2018.PubMed/NCBI

33 

Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A and Garg R: The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J Clin Endocrinol Metab. 86:355–362. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Kiasalari Z, Rahmani T, Mahmoudi N, Baluchnejadmojarad T and Roghani M: Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation. Biomed Pharmacothe. 86:654–661. 2017. View Article : Google Scholar

35 

Siotto M, Aprile I, Simonelli I, Pazzaglia C, Ventriglia M, Santoro M and Padua L: An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain. J Neural Transm (Vienna). 124:1557–1566. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Zhao B, Pan Y, Wang Z, Tan Y and Song X: Intrathecal administration of tempol reduces chronic constriction injury-induced neuropathic pain in rats by increasing SOD activity and inhibiting NGF expression. Cell Mol Neurobiol. 36:893–906. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Lee SG, Wu HM, Lee CG, Oh CS, Chung SW and Kim SG: Binge alcohol intake after hypergravity stress sustainably decreases AMPK and transcription factors necessary for hepatocyte survival. Alcohol Clin Exp Res. 41:76–86. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Shi L, Zhang T, Zhou Y, Zeng X, Ran L, Zhang Q, Zhu J and Mi M: Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway. Endocrine. 50:378–389. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Reyes C, Leyland KM, Peat G, Cooper C, Arden NK and Prieto-Alhambra D: Ass-ociation between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study. Arthritis Rheumatol. 68:1869–1875. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Fischer K, PrzepieraBędzak H, Sawicki M, Walecka A, Brzosko I and Brzosko M: Serum Interleukin-23 in polish patients with systemic lupus erythematosus: Association with lupus nephritis, obesity, and peripheral vascular disease. Mediators Inflamm. 2017:94014322017. View Article : Google Scholar : PubMed/NCBI

41 

Dario AB, Ferreira ML, Refshauge KM, Lima TS, Ordoñana JR and Ferreira PH: The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: A systematic review of twin studies. Spine J. 15:1106–1117. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Gallagher HC, Gallagher RM, Butler M, Buggy DJ and Henman MC: Venlafaxine for neuropathic pain in adults. Cochrane Database Syst Rev. 8:CD0110912015.

43 

Hozumi J, Sumitani M, Matsubayashi Y, Abe H, Oshima Y, Chikuda H, Takeshita K and Yamada Y: Relationship between neuropathic pain and obesity. Pain Res Manag. 2016:24879242016. View Article : Google Scholar : PubMed/NCBI

44 

Bruun JM, Stallknecht B, Helge JW and Richelsen B: Interleukin-18 in plasma and adipose tissue: Effects of obesity, insulin resistance and weght loss. EurJ Endocrinl. 157:465–471. 2007. View Article : Google Scholar

45 

Wisse BE: The inflammatory syndrome: The role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol. 15:2792–2800. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Barisione M, Carlini F, Gradaschi R, Camerini G and Adami GF: Body weight at developmental age in siblings born to mothers before and after surgically induced weight loss. Surg Obes Relat Dis. 8:387–391. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo X, Tao X, Tong Q, Li T, Dong D, Zhang B, Zhao M and Song T: Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury. Mol Med Rep 20: 1279-1287, 2019.
APA
Guo, X., Tao, X., Tong, Q., Li, T., Dong, D., Zhang, B. ... Song, T. (2019). Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury. Molecular Medicine Reports, 20, 1279-1287. https://doi.org/10.3892/mmr.2019.10368
MLA
Guo, X., Tao, X., Tong, Q., Li, T., Dong, D., Zhang, B., Zhao, M., Song, T."Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury". Molecular Medicine Reports 20.2 (2019): 1279-1287.
Chicago
Guo, X., Tao, X., Tong, Q., Li, T., Dong, D., Zhang, B., Zhao, M., Song, T."Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury". Molecular Medicine Reports 20, no. 2 (2019): 1279-1287. https://doi.org/10.3892/mmr.2019.10368
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Tao X, Tong Q, Li T, Dong D, Zhang B, Zhao M and Song T: Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury. Mol Med Rep 20: 1279-1287, 2019.
APA
Guo, X., Tao, X., Tong, Q., Li, T., Dong, D., Zhang, B. ... Song, T. (2019). Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury. Molecular Medicine Reports, 20, 1279-1287. https://doi.org/10.3892/mmr.2019.10368
MLA
Guo, X., Tao, X., Tong, Q., Li, T., Dong, D., Zhang, B., Zhao, M., Song, T."Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury". Molecular Medicine Reports 20.2 (2019): 1279-1287.
Chicago
Guo, X., Tao, X., Tong, Q., Li, T., Dong, D., Zhang, B., Zhao, M., Song, T."Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury". Molecular Medicine Reports 20, no. 2 (2019): 1279-1287. https://doi.org/10.3892/mmr.2019.10368
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team