Open Access

Isatin inhibits the invasion of human neuroblastoma SH‑SY5Y cells, based on microarray analysis

  • Authors:
    • Li Zhang
    • Wenyan Sun
    • Yi Cao
    • Lin Hou
    • Chuanxia Ju
    • Xuefeng Wang
  • View Affiliations

  • Published online on: June 12, 2019     https://doi.org/10.3892/mmr.2019.10378
  • Pages: 1700-1706
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Neuroblastoma is the fourth most common type of extracranial malignant solid tumor in children. Isatin had been demonstrated to have inhibitory effects on neuroblastoma tumors in vivo and in vitro. The aim of the present study was to investigate the molecular mechanism related to the anti‑invasion effect of isatin on SH‑SY5Y cells using microarray analysis. The microarray data identified a number of genes to be differentially upregulated or downregulated between isatin‑treated cells and untreated controls. A large number of these genes were associated with the mTOR signaling pathway. The differentially expressed genes involved in the mTOR signaling pathway were verified further, as well as their downstream genes associated with autophagy. The results of the present study provided an insight into the potential inhibitory mechanism of isatin on neuroblastoma metastasis.
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August-2019
Volume 20 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Sun W, Cao Y, Hou L, Ju C and Wang X: Isatin inhibits the invasion of human neuroblastoma SH‑SY5Y cells, based on microarray analysis. Mol Med Rep 20: 1700-1706, 2019.
APA
Zhang, L., Sun, W., Cao, Y., Hou, L., Ju, C., & Wang, X. (2019). Isatin inhibits the invasion of human neuroblastoma SH‑SY5Y cells, based on microarray analysis. Molecular Medicine Reports, 20, 1700-1706. https://doi.org/10.3892/mmr.2019.10378
MLA
Zhang, L., Sun, W., Cao, Y., Hou, L., Ju, C., Wang, X."Isatin inhibits the invasion of human neuroblastoma SH‑SY5Y cells, based on microarray analysis". Molecular Medicine Reports 20.2 (2019): 1700-1706.
Chicago
Zhang, L., Sun, W., Cao, Y., Hou, L., Ju, C., Wang, X."Isatin inhibits the invasion of human neuroblastoma SH‑SY5Y cells, based on microarray analysis". Molecular Medicine Reports 20, no. 2 (2019): 1700-1706. https://doi.org/10.3892/mmr.2019.10378