Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis

  • Authors:
    • Wenqing Wu
    • Ge Peng
    • Fan Yang
    • Yue Zhang
    • Zhenzhen Mu
    • Xiuping Han
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Atopy (Allergy) Research Center, Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo 1138642, Japan
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1761-1771
    |
    Published online on: June 20, 2019
       https://doi.org/10.3892/mmr.2019.10405
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by intense itching and recurrent eczematous lesions. Sulforaphane is known to attenuate oxidative stress, and tissue or cell damage in cerebral ischemia, brain inflammation and intracerebral hemorrhage. In the present study, a 2,4‑dinitrochlorobenzene (DNCB)‑induced AD mouse model was developed, and ear thickness, dermatitis score, eosinophil count, mast cell infiltration, and serum IgE levels were measured in DNCB‑induced AD and sulforaphane‑treated groups to demonstrate the therapeutic effects of sulforaphane. AD symptoms of DNCB‑induced mice were attenuated by sulforaphane treatment compared with those of negative control mice; furthermore, eosinophil count, mast cell infiltration and serum IgE levels were also reduced by sulforaphane treatment in DNCB‑induced AD mice. Western blot assays revealed that the expression levels of nuclear factor‑E2‑related factor 2 (Nrf2) and heme oxygenase-1 (HO‑1), which exhibit oxidation resistance, were increased by sulforaphane treatment in DNCB‑induced AD mice. The present study suggested that sulforaphane exerted a therapeutic effect in the AD mouse model through the activation of the Nrf2/HO‑1 axis as well as the suppression of Janus kinase 1/STAT3 signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bieber T: Atopic dermatitis. N Engl J Med. 358:1483–1494. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Weidinger S and Novak N: Atopic dermatitis. Lancet. 387:1109–1122. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Werfel T, Schwerk N, Hansen G and Kapp A: The diagnosis and graded therapy of atopic dermatitis. Dtsch Arztebl Int. 111:509–520. 2014.PubMed/NCBI

4 

Gęgotek A and Skrzydlewska E: The role of transcription factor Nrf2 in skin cells metabolism. Arch Dermatol Res. 307:385–396. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ji H and Li XK: Oxidative stress in atopic dermatitis. Oxid Med Cell Longev. 2016:27214692016. View Article : Google Scholar : PubMed/NCBI

6 

Rojo de la Vega M, Krajisnik A, Zhang DD and Wondrak GT: Targeting NRF2 for improved skin barrier function and photoprotection: Focus on the achiote-derived apocarotenoid bixin. Nutrients. 9:E13712017. View Article : Google Scholar : PubMed/NCBI

7 

Gruber F, Ornelas CM, Karner S, Narzt MS, Nagelreiter IM, Gschwandtner M, Bochkov V and Tschachler E: Nrf2 deficiency causes lipid oxidation, inflammation and matrix-protease expression in DHA supplemented and UVA irradiated skin fibroblasts. Free Radic Biol Med. 88:439–451. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Guerrero-Beltrán CE, Calderón-Oliver M, Pedraza-Chaverri J and Chirino YI: Protective effect of sulforaphane against oxidative stress: Recent advances. Exp Toxicol Pathol. 64:503–508. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Mathew ST, Bergström P and Hammarsten O: Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation. Toxicol Appl Pharmacol. 276:188–194. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kumar KJ, Yang HL, Tsai YC, Hung PC, Chang SH, Lo HW, Shen PC, Chen SC, Wang HM, Wang SY, et al: Lucidone protects human skin keratinocytes against free radical-induced oxidative damage and inflammation through the up-regulation of HO-1/Nrf2 antioxidant genes and down-regulation of NF-κB signaling pathway. Food Chem Toxicol. 59:55–66. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Furue M, Chiba T, Tsuji G, Ulzii D, Kido-Nakahara M, Nakahara T and Kadono T: Atopic dermatitis: Immune deviation, barrier dysfunction, IgE autoreactivity and new therapies. Allergol Int. 66:398–403. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Kiiski V, Karlsson O, Remitz A and Reitamo S: High serum total IgE predicts poor long-term outcome in atopic dermatitis. Acta Derm Venereol. 95:943–947. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Lucae S, Schmid-Grendelmeier P, Wüthrich B, Kraft D, Valenta R and Linhart B: IgE responses to exogenous and endogenous allergens in atopic dermatitis patients under long-term systemic cyclosporine A treatment. Allergy. 71:115–118. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Altrichter S, Kriehuber E, Moser J, Valenta R, Kopp T and Stingl G: Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis. J Invest Dermatol. 128:2232–2239. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Liu FT, Goodarzi H and Chen HY: IgE, mast cells, and eosinophils in atopic dermatitis. Clin Rev Allergy Immunol. 41:298–310. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Elovic A, Wong DT, Weller PF, Matossian K and Galli SJ: Expression of transforming growth factors-alpha and beta 1 messenger RNA and product by eosinophils in nasal polyps. J Allergy Clin Immunol. 93:864–869. 1994. View Article : Google Scholar : PubMed/NCBI

17 

Kato A, Chustz RT, Ogasawara T, Kulka M, Saito H, Schleimer RP and Matsumoto K: Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells. J Immunol. 182:7233–7243. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Ushida Y, Suganuma H and Hashimoto K: Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation. J Nutr Biochem. 39:134–144. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Yan B, Ma Z, Shi S, Hu Y, Ma T, Rong G and Yang J: Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation. Mol Med Rep. 15:4005–4014. 2017. View Article : Google Scholar : PubMed/NCBI

20 

O'Connor JC, Lawson MA, André C, Moreau M, Lestage J, Castanon N, Kelley KW and Dantzer R: Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry. 14:511–522. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Peng G, Mu Z, Cui L, Liu P, Wang Y, Wu W and Han X: Anti-IL-33 antibody has a therapeutic effect in an atopic dermatitis murine model induced by 2, 4-dinitrochlorobenzene. Inflammation. 41:154–163. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

David Boothe W, Tarbox JA and Tarbox MB: Atopic dermatitis: Pathophysiology. Adv Exp Med Biol. 1027:21–37. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Briganti S and Picardo M: Antioxidant activity, lipid peroxidation and skin diseases. What's new. J Eur Acad Dermatol Venereol. 17:663–669. 2010. View Article : Google Scholar

25 

Yang L, Palliyaguru DL and Kensler TW: Frugal chemoprevention: Targeting Nrf2 with foods rich in sulforaphane. Semin Oncol. 43:146–153. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Ruiz S, Pergola PE, Zager RA and Vaziri ND: Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int. 83:1029–1041. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Lawal AO: Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways. Toxicol Lett. 270:88–95. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Prasad KN: Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer's disease. Mech Ageing Dev. 153:41–47. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Schäfer M, Farwanah H, Willrodt AH, Huebner AJ, Sandhoff K, Roop D, Hohl D, Bloch W and Werner S: Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med. 4:364–379. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Choi JH, Jin SW, Han EH, Park BH, Kim HG, Khanal T, Hwang YP, Do MT, Lee HS, Chung YC, et al: Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1. Phytomedicine. 21:1053–1061. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Saw CL, Huang MT, Liu Y, Khor TO, Conney AH and Kong AN: Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol Carcinog. 50:479–486. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Chaiprasongsuk A, Lohakul J, Soontrapa K, Sampattavanich S, Akarasereenont P and Panich U: Activation of Nrf2 reduces UVA-mediated MMP-1 upregulation via MAPK/AP-1 signaling cascades: The photoprotective effects of sulforaphane and hispidulin. J Pharmacol Exp Ther. 360:388–398. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Migdal C, Botton J, El Ali Z, Azoury ME, Guldemann J, Giménez-Arnau E, Lepoittevin JP, Kerdine-Römer S and Pallardy M: Reactivity of chemical sensitizers toward amino acids in cellulo plays a role in the activation of the Nrf2-ARE pathway in human monocyte dendritic cells and the THP-1 cell line. Toxicol Sci. 133:259–274. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Emter R, van der Veen JW, Adamson G, Ezendam J, van Loveren H and Natsch A: Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events. Toxicol In Vitro. 27:2225–2232. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Welsch K, Holstein J, Laurence A and Ghoreschi K: Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors. Eur J Immunol. 47:1096–1107. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Jin W, Huang W, Chen L, Jin M, Wang Q, Gao Z and Jin Z: Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-inflammatory responses in DNCB-induced atopic dermatitis model mice. Int J Mol Sci. 19:E39732018. View Article : Google Scholar : PubMed/NCBI

37 

Abe Y and Tanaka N: The Hedgehog signaling networks in lung cancer: The mechanisms and roles in tumor progression and implications for cancer therapy. Biomed Res Int. 2016:79692862016. View Article : Google Scholar : PubMed/NCBI

38 

Chu J, Wang X, Bi H, Li L, Ren M and Wang J: Dihydromyricetin relieves rheumatoid arthritis symptoms and suppresses expression of pro-inflammatory cytokines via the activation of Nrf2 pathway in rheumatoid arthritis model. Int Immunopharmacol. 59:174–180. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Roy R, Dagher A, Butterfield C and Moses MA: ADAM12 is a novel regulator of tumor angiogenesis via STAT3 signaling. Mol Cancer Res. 15:1608–1622. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Choi JK, Jang YH, Lee S, Lee SR, Choi YA, Jin M, Choi JH, Park JH, Park PH, Choi H, et al: Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes. Food Chem Toxicol. 110:142–150. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Pastore S, Giustizieri ML, Mascia F, Giannetti A, Kaushansky K and Girolomoni G: Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor. J Invest Dermatol. 115:1134–1143. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Mashiko S, Bouguermouh S, Rubio M, Baba N, Bissonnette R and Sarfati M: Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis. J Allergy Clin Immunol. 136:351–359.e1. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Mu Z, Zhao Y, Liu X, Chang C and Zhang J: Molecular biology of atopic dermatitis. Clin Rev Allergy Immunol. 47:193–218. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y and Kawabe T: Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflammation Res. 58:705–715. 2009. View Article : Google Scholar

45 

Ma YY, Yang MQ, Wang CF, Ding J and Li JY: Inhibiting mast cell degranulation by HO-1 affects dendritic cell maturation in vitro. Inflamm Res. 63:527–537. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Zink A, Gensbaur A, Zirbs M, Seifert F, Suarez IL, Mourantchanian V, Weidinger S, Mempel M, Ring J and Ollert M: Targeting IgE in severe atopic dermatitis with a combination of immunoadsorption and omalizumab. Acta Derm Venereol. 96:72–76. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Park G, Oh DS, Lee MG, Lee CE and Kim YU: 6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway. Toxicol Appl Pharmacol. 310:51–59. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Kiehl P, Falkenberg K, Vogelbruch M and Kapp A: Tissue eosinophilia in acute and chronic atopic dermatitis: A morphometric approach using quantitative image analysis of immunostaining. Br J Dermatol. 145:720–729. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Ajith Y, Dimri U, Gopalakrishnan A, Madhesh E, Jhambh R, Joshi V and Devi G: Th1/Th2 immune responses and oxidative stress in caprine flea allergy dermatitis. Parasite Immunol. 39:2017. View Article : Google Scholar : PubMed/NCBI

50 

Werfel T, Allam JP, Biedermann T, Eyerich K, Gilles S, Guttman-Yassky E, Hoetzenecker W, Knol E, Simon HU, Wollenberg A, et al: Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Allergy Clin Immunol. 138:336–349. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu W, Peng G, Yang F, Zhang Y, Mu Z and Han X: Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis. Mol Med Rep 20: 1761-1771, 2019.
APA
Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., & Han, X. (2019). Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis. Molecular Medicine Reports, 20, 1761-1771. https://doi.org/10.3892/mmr.2019.10405
MLA
Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., Han, X."Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis". Molecular Medicine Reports 20.2 (2019): 1761-1771.
Chicago
Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., Han, X."Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis". Molecular Medicine Reports 20, no. 2 (2019): 1761-1771. https://doi.org/10.3892/mmr.2019.10405
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Peng G, Yang F, Zhang Y, Mu Z and Han X: Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis. Mol Med Rep 20: 1761-1771, 2019.
APA
Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., & Han, X. (2019). Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis. Molecular Medicine Reports, 20, 1761-1771. https://doi.org/10.3892/mmr.2019.10405
MLA
Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., Han, X."Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis". Molecular Medicine Reports 20.2 (2019): 1761-1771.
Chicago
Wu, W., Peng, G., Yang, F., Zhang, Y., Mu, Z., Han, X."Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO‑1 axis". Molecular Medicine Reports 20, no. 2 (2019): 1761-1771. https://doi.org/10.3892/mmr.2019.10405
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team