Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation

  • Authors:
    • Tao Hu
    • Shan‑Shan Li
    • Min‑Nan Lu
    • Li Zhang
    • Bo Chen
    • Rui Mao
    • Rong Mei
    • Ya‑Xin Tan
    • Shan Li
    • Yan‑Bin Xiyang
  • View Affiliations / Copyright

    Affiliations: Institute of Neuroscience, Basic Medical College, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Basic Medical College, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Experiment Center for Medical Science Research, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Editorial Department of Journal of Kunming Medical University, Kunming, Yunnan 650500, P.R. China, School of Stomatology, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Department of Neurology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China
  • Pages: 2002-2011
    |
    Published online on: June 20, 2019
       https://doi.org/10.3892/mmr.2019.10406
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Voltage‑gated sodium channel β2 (Navβ2), as an unconventional substrate of β‑site amyloid precursor protein cleaving enzyme 1, is involved in regulating the neuronal surface expression of sodium channels. A previous study demonstrated that knockdown of Navβ2 protected neurons and induced spatial cognition improvement by partially reducing pathological amyloidogenic processing of amyloid precursor protein (APP) in aged APP/presenilin 1 (PS1) transgenic mice. The present study aimed to investigate whether Navβ2 knockdown altered APP metabolism via regulation of the Aβ‑degrading enzyme neprilysin (NEP). APPswe/PS1ΔE9 mice (APP/PS1 transgenic mice with a C57BL/6J genetic background) carrying a Navβ2‑knockdown mutation (APP/PS1/Navβ2‑kd) or without Navβ2 knockdown (APP/PS1) were used for cell culture and further analysis. The present results demonstrated that in APP/PS1 mouse‑derived neurons, Navβ2 knockdown partially reversed the reduction in pathological APP cleavage, and the recovery of neurite extension and neuron area. Additionally, Navβ2 knockdown increased NEP activity and levels, and the levels of intracellular domain fragment binding to the NEP promoter. The present findings suggested that knockdown of Navβ2 reversed the APP/PS1 mutation‑induced deficiency in amyloid β degradation by regulating NEP.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Jia J, Wei C, Chen S, Li F, Tang Y, Qin W, Zhao L, Jin H, Xu H, Wang F, et al: The cost of Alzheimer's disease in China and re-estimation of costs worldwide. Alzheimers Dement. 14:483–491. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Yiannopoulou KG and Papageorgiou SG: Current and future treatments for Alzheimer's disease. Ther Adv Neurol Disord. 6:19–33. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Chu J, Li JG, Hoffman NE, Madesh M and Praticò D: Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway. J Neurochem. 133:432–439. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Esler WP and Wolfe MS: A portrait of Alzheimer secretases-new features and familiar faces. Science. 293:1449–1454. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Glenner GG and Wong CW: Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 120:885–890. 1984. View Article : Google Scholar : PubMed/NCBI

6 

Agostinho P, Pliássova A, Oliveira CR and Cunha RA: Localization and trafficking of amyloid-β protein precursor and secretases: Impact on Alzheimer's disease. J Alzheimers Dis. 45:329–347. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ashe KH and Zahs KR: Probing the biology of Alzheimer's disease in mice. Neuron. 66:631–645. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Sakono M and Zako T: Amyloid oligomers: Formation and toxicity of Abeta oligomers. FEBS J. 277:1348–1358. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Liu LJ, Leung KH, Chan DS, Wang YT, Ma DL and Leung CH: Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell Death Dis. 5:e12932014. View Article : Google Scholar : PubMed/NCBI

10 

Ito M, Tanaka T, Toita A, Uchiyama N, Kokubo H, Morishita N, Klein MG, Zou H, Murakami M, Kondo M, et al: Discovery of 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea derivatives as novel and selective cyclin-dependent kinase 12 (CDK12) inhibitors. J Med Chem. 61:7710–7728. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Ma DL, Lin S, Wang W, Yang C and Leung CH: Luminescent chemosensors by using cyclometalated iridium(iii) complexes and their applications. Chem Sci. 8:878–889. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Dhar Malhotra J, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS and Isom LL: Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation. 103:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Vijayaragavan K, Powell AJ, Kinghorn IJ and Chahine M: Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na (v) 1.8 voltage-gated sodium channel. Biochem Biophys Res Commun. 319:531–540. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Bechtold DA and Smith KJ: Sodium-mediated axonal degeneration in inflammatory demyelinating disease. J Neurol Sci. 233:27–35. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Waxman SG: Axonal conduction and injury in multiple sclerosis: The role of sodium channels. Nat Rev Neurosci. 7:932–941. 2006. View Article : Google Scholar : PubMed/NCBI

16 

O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB and Isom LL: Loss of Na+ channel beta2 subunits is neuroprotective in amouse model of multiple sclerosis. Mol Cell Neurosci. 40:143–155. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ III, Kazen-Gillespie KA, et al: Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci USA. 99:17072–17077. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I and Isom LL: Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci. 26:7984–7994. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ and Kovacs DM: BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol. 9:755–764. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P and Nukina N: beta subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. Biol Chem. 280:23009–23017. 2005. View Article : Google Scholar

21 

Kim DY, Ingano LA, Carey BW, Pettingell WH and Kovacs DM: Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. J Biol Chem. 280:23251–23261. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Huth T, Schmidt-Neuenfeldt K, Rittger A, Saftig P, Reiss K and Alzheimer C: Non-proteolytic effect of beta-site APP cleaving enzyme 1 (BACE1) on sodium channel function. Neurobiol Dis. 33:282–289. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al: Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci. 33:7020–7026. 2013. View Article : Google Scholar : PubMed/NCBI

24 

XiYang YB, Wang YC, Zhao Y, Ru J, Lu BT, Zhang YN, Wang NC, Hu WY, Liu J, Yang JW, et al: Sodium channel-voltage-gated-beta 2 plays a vital role in brain aging associated with synaptic plasticity and expression of COX5A and FGF-2. Mol Neurobiol. 53:955–967. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Hu T, Xiao Z, Mao R, Chen B, Lu MN, Tong J, Mei R, Li SS, Xiao ZC, Zhang LF and Xiyang YB: Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing. Oncotarget. 8:99284–99295. 2017. View Article : Google Scholar : PubMed/NCBI

26 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals, . Guide for the Care and Use of Laboratory Animals. 8th. National Academies Press; Washington, DC: 2011

27 

Hu T, Li YS, Chen B, Chang YF, Liu GC, Hong Y, Chen HL and Xiyang YB: Elevated glucose-6-phosphate dehydrogenase expression in the cervical cancer cases is associated with the cancerigenic event of high-risk human papillomaviruses. Exp Bio Med (Maywood). 240:1287–1297. 2015. View Article : Google Scholar

28 

Grimm MO, Mett J, Stahlmann CP, Grösgen S, Haupenthal VJ, Blümel T, Hundsdörfer B, Zimmer VC, Mylonas NT, Tanila H, et al: APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression. Front Aging Neurosci. 7:772015. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Hu T, Chang YF, Xiao Z, Mao R, Tong J, Chen B, Liu GC, Hong Y, Chen HL, Kong SY, et al: miR-1 inhibits progression of high-risk papillomavirus-associated human cervical cancer by targeting G6PD. Oncotarget. 7:86103–86116. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Zuccato C, Belyaev N, Conforti P, Ooi L, Tartari M, Papadimou E, MacDonald M, Fossale E, Zeitlin S, Buckley N and Cattaneo E: Wide spread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. J Neurosci. 27:6972–6983. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Belyaev ND, Nalivaeva NN, Makova NZ and Turner AJ: Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: Implications for Alzheimer disease. EMBO Rep. 10:94–100. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Kerridge C, Kozlova DI, Nalivaeva NN and Turner AJ: Hypoxia affects neprilysin expression through caspase activation and an APP intracellular domain-dependent Mechanism. Front Neurosci. 9:4262015. View Article : Google Scholar : PubMed/NCBI

34 

Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B and Lannfelt L: A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet. 1:345–347. 1992. View Article : Google Scholar : PubMed/NCBI

35 

Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I and Selkoe DJ: Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360:672–674. 1992. View Article : Google Scholar : PubMed/NCBI

36 

Felsenstein KM, Hunihan LW and Roberts SB: Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation. Nat Genet. 6:251–255. 1994. View Article : Google Scholar : PubMed/NCBI

37 

Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D and Ward PJ: Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science. 248:1122–1124. 1990. View Article : Google Scholar : PubMed/NCBI

38 

Lichtenthaler SF: α-secretase in Alzheimer's disease: Molecular identity, regulation and therapeutic potential. J Neurochem. 116:10–21. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Hardy J and Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science. 297:353–356. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Xie Z and Xu Z: General anesthetics and β-amyloid protein. Prog Neuropsychopharmacol Biol Psychiatry. 47:140–146. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Nalivaeva NN, Beckett C, Belyaev ND and Turner AJ: Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J Neurochem. 120 (Suppl 1):S167–S185. 2012. View Article : Google Scholar

42 

Nalivaeva NN, Belyaev ND, Kerridge C and Turner AJ: Amyloid- clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease. Front Aging Neurosci. 6:2352014. View Article : Google Scholar : PubMed/NCBI

43 

Marr RA and Spencer BJ: NEP-like endopeptidases and Alzheimer's disease. Curr Alzheimer Res. 7:223–229. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Pacheco-Quinto J and Eckman EA: Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes. J Biol Chem. 288:5606–5615. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Miners JS, Baig S, Palmer J, Palmer LE, Kehoe PG and Love S: Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol. 18:240–252. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Turner AJ, Brown CD, Carson JA and Barnes K: The neprilysin family in health and disease. Adv Exp Med Biol. 477:229–240. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Turner AJ, Isaac RE and Coates D: The neprilysin (NEP) family of zinc metalloendopeptidases: Genomics and function. Bioessays. 23:261–269. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Selkoe DJ: Preventing Alzheimer's disease. Science. 337:1488–1492. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Pluta R, Jabłoński M, Ułamek-Kozioł M, Kocki J, Brzozowska J, Januszewski S, Furmaga-Jabłońska W, Bogucka-Kocka A, Maciejewski R and Czuczwar SJ: Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes. Mol Neurobiol. 48:500–515. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Li C, Booze RM and Hersh LB: Tissue-specific expression of rat neutral endopeptidase (neprilysin) mRNAs. J Biol Chem. 270:5723–5728. 1995. View Article : Google Scholar : PubMed/NCBI

51 

Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D'Adamio L, Shen J, Müller U, et al: Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron. 46:541–554. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM and Turner AJ: The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem. 285:41443–41454. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Kerridge C, Belyaev ND, Nalivaeva NN and Turner AJ: The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain. J Neurochem. 130:419–431. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Li S, Wang X, Ma QH, Yang WL, Zhang XG, Dawe GS and Xiao ZC: Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway. Sci Rep. 6:393202016. View Article : Google Scholar : PubMed/NCBI

55 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Hébert SS and De Strooper B: Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci. 32:199–206. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Lukiw WJ: Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport. 18:297–300. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Liu W, Liu C, Yin B and Peng XZ: Functions of miR-9 and miR-9* during aging in SAMP8 mice and their possible mechanisms. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 37:253–258. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu T, Li SS, Lu MN, Zhang L, Chen B, Mao R, Mei R, Tan YX, Li S, Xiyang YB, Xiyang YB, et al: Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation. Mol Med Rep 20: 2002-2011, 2019.
APA
Hu, T., Li, S., Lu, M., Zhang, L., Chen, B., Mao, R. ... Xiyang, Y. (2019). Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation. Molecular Medicine Reports, 20, 2002-2011. https://doi.org/10.3892/mmr.2019.10406
MLA
Hu, T., Li, S., Lu, M., Zhang, L., Chen, B., Mao, R., Mei, R., Tan, Y., Li, S., Xiyang, Y."Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation". Molecular Medicine Reports 20.2 (2019): 2002-2011.
Chicago
Hu, T., Li, S., Lu, M., Zhang, L., Chen, B., Mao, R., Mei, R., Tan, Y., Li, S., Xiyang, Y."Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation". Molecular Medicine Reports 20, no. 2 (2019): 2002-2011. https://doi.org/10.3892/mmr.2019.10406
Copy and paste a formatted citation
x
Spandidos Publications style
Hu T, Li SS, Lu MN, Zhang L, Chen B, Mao R, Mei R, Tan YX, Li S, Xiyang YB, Xiyang YB, et al: Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation. Mol Med Rep 20: 2002-2011, 2019.
APA
Hu, T., Li, S., Lu, M., Zhang, L., Chen, B., Mao, R. ... Xiyang, Y. (2019). Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation. Molecular Medicine Reports, 20, 2002-2011. https://doi.org/10.3892/mmr.2019.10406
MLA
Hu, T., Li, S., Lu, M., Zhang, L., Chen, B., Mao, R., Mei, R., Tan, Y., Li, S., Xiyang, Y."Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation". Molecular Medicine Reports 20.2 (2019): 2002-2011.
Chicago
Hu, T., Li, S., Lu, M., Zhang, L., Chen, B., Mao, R., Mei, R., Tan, Y., Li, S., Xiyang, Y."Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation". Molecular Medicine Reports 20, no. 2 (2019): 2002-2011. https://doi.org/10.3892/mmr.2019.10406
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team