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Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response

  • Authors:
    • Jun Ma
    • Daorong Hou
    • Zhiqing Wei
    • Jianguo Zhu
    • Hua Lu
    • Zheng Li
    • Xiefeng Wang
    • Yingbin Li
    • Guanqun Qiao
    • Ning Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Vascular Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Radiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1621-1628
    |
    Published online on: June 20, 2019
       https://doi.org/10.3892/mmr.2019.10407
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Abstract

The inflammatory response plays a vital role in cerebral aneurysm (CA) formation and progression. Tanshinone  IIA (Tan IIA) is one of the major active components of Chinese medicine Danshen (Salvia miltiorrhiza Bunge) and is widely used for the treatment of cardiovascular diseases, due to its anti‑inflammatory effects. The aim of the present study was to investigate whether Tan IIA can attenuate CA formation in rat models, and determine its underlying mechanisms. CAs were induced in rats surgically and through high‑salt diet treatments. The Tan IIA‑treated group displayed relatively mild symptoms, as compared with the control group. Tan IIA treatment reduced macrophage infiltration and nuclear factor (NF)‑κB activation in aneurysmal walls. Next, lipopolysaccharide (LPS)‑stimulated RAW 264.7 murine macrophage cells were used to examine the anti‑inflammatory effects of Tan IIA on macrophages. It was found that Tan IIA reversed LPS‑induced differentiation of RAW 264.7 cells and suppressed NF‑κB pathway activation. In conclusion, these findings demonstrated that Tan IIA can suppress CA formation by inhibiting inflammatory responses in macrophages.
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1 

Vlak MHM, Algra A, Brandenburg R and Rinkel GJ: Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis. Lancet Neurol. 10:626–636. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Baron EP: Headache, cerebral aneurysms, and the use of triptans and ergot derivatives. Headache. 55:739–747. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Bowles E: Cerebral aneurysm and aneurysmal subarachnoid haemorrhage. Nurs Stand. 28:52–59. 2014. View Article : Google Scholar : PubMed/NCBI

4 

van Gijn J, Kerr RS and Rinkel GJ: Subarachnoid haemorrhage. Lancet. 369:306–318. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Pera J, Korostynski M, Krzyszkowski T, Czopek J, Slowik A, Dziedzic T, Piechota M, Stachura K, Moskala M, Przewlocki R and Szczudlik A: Gene expression profiles in human ruptured and unruptured intracranial aneurysms: What is the role of inflammation? Stroke. 41:224–231. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Hosaka K and Hoh BL: Inflammation and cerebral aneurysms. Transl Stroke Res. 5:190–198. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Tuttolomondo A, Di Sciacca R, Di Raimondo D, Pedone C, La Placa S, Pinto A and Licata G: Effects of clinical and laboratory variables and of pretreatment with cardiovascular drugs in acute ischaemic stroke: A retrospective chart review from the GIFA study. Int J Cardiol. 151:318–322. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Di Raimondo D, Tuttolomondo A, Buttà C, Miceli S, Licata G and Pinto A: Effects of ACE-inhibitors and angiotensin receptor blockers on inflammation. Curr Pharm Des. 18:4385–4413. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Licata G, Tuttolomondo A, Corrao S, Di Raimondo D, Fernandez P, Caruso C, Avellone G and Pinto A: Immunoinflammatory activation during the acute phase of lacunar and non-lacunar ischemic stroke: Association with time of onset and diabetic state. Int J Immunopathol Pharmacol. 19:639–646. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, Ishibashi R, Nozaki K, Morishita R and Hashimoto N: NF-kappaB is a key mediator of cerebral aneurysm formation. Circulation. 116:2830–2840. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Moriwaki T, Takagi Y, Sadamasa N, Aoki T, Nozaki K and Hashimoto N: Impaired progression of cerebral aneurysms in interleukin-1β-deficient mice. Stroke. 37:900–905. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Aoki T, Kataoka H, Morimoto M, Nozaki K and Hashimoto N: Macrophage-derived matrix metalloproteinase-2 and −9 promote the progression of cerebral aneurysms in rats. Stroke. 38:162–169. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Zhang M, Qian Y and Tang A: Research progress of pharmacologic actions of TanshinoneIIA. Med Recapitulate. 16:2661–2664. 2010.

14 

Wang X: Progress of pharmacological research and clinical application of Tanshinone II A. Guang Ming J Chin Med. 26:1514–1517. 2011.

15 

Hosaka K, Downes DP, Nowicki KW and Hoh BL: Modified murine intracranial aneurysm model: Aneurysm formation and rupture by elastase and hypertension. J Neurointerv Surg. 6:474–479. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Toth M, Sohail A and Fridman R: Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography. Methods Mol Biol. 878:121–135. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Li Y, Gu B, Liu J, Xiong X, Zhou C and Wu G: Research progress of Tanshinone II A. Li ShiZhen Med Materia Med Res. 21:1770–1772. 2010.

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Jin UH, Suh SJ, Chang HW, Son JK, Lee SH, Son KH, Chang YC and Kim CH: Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J Cell Biochem. 104:15–26. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Hartley JW, Evans LH, Green KY, Naghashfar Z, Macias AR, Zerfas PM and Ward JM: Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line. Retrovirology. 5:12008. View Article : Google Scholar : PubMed/NCBI

21 

Saxena RK, Vallyathan V and Lewis DM: Evidence for lipopolysaccharide-induced differentiation of RAW264.7 murine macrophage cell line into dendritic like cells. J Biosci. 28:129–134. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Jou LD, Lee DH, Morsi H and Mawad ME: Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery. AJNR Am J Neuroradiol. 29:1761–1767. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Chalouhi N, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Koch WJ and Dumont AS: Biology of intracranial aneurysms: Role of inflammation. J Cereb Blood Flow Metab. 32:1659–1676. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Starke RM, Raper DM, Ding D, Chalouhi N, Owens GK, Hasan DM, Medel R and Dumont AS: Tumor necrosis factor-α modulates cerebral aneurysm formation and rupture. Transl Stroke Res. 5:269–277. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Starke RM, Chalouhi N, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Koch WJ and Dumont AS: The role of oxidative stress in cerebral aneurysm formation and rupture. Curr Neurovasc Res. 10:247–255. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Tang FT, Cao Y, Wang TQ, Wang LJ, Guo J, Zhou XS, Xu SW, Liu WH, Liu PQ and Huang HQ: Tanshinone IIA attenuates atherosclerosis in ApoE(−/-) mice through down-regulation of scavenger receptor expression. Eur J Pharmacol. 650:275–284. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Ji X, Tan BK, Zhu YC, Linz W and Zhu YZ: Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats. Life Sci. 73:1413–1426. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Ren ZH, Tong YH, Xu W, Ma J and Chen Y: Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression. Phytomedicine. 17:212–218. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M, Mobashery S, Sakamoto A and Hashimoto T: Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab. 29:1547–1558. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Jin D, Sheng J, Yang X and Gao B: Matrix metalloproteinases and tissue inhibitors of metalloproteinases expression in human cerebral ruptured and unruptured aneurysm. Surg Neurol. 68 (Suppl):S11–S16. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Nuki Y, Matsumoto MM, Tsang E, Young WL, van Rooijen N, Kurihara C and Hashimoto T: Roles of macrophages in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab. 29:495–503. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Pannu H, Kim DH, Guo D, King TM, Van Ginhoven G, Chin T, Chang K, Qi Y, Shete S and Milewicz DM: The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. J Neurosurg. 105:418–423. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Fujiwara N and Kobayashi K: Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 4:281–286. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Hou D, Wei Z, Zhu J, Lu H, Li Z, Wang X, Li Y, Qiao G, Liu N, Liu N, et al: Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Mol Med Rep 20: 1621-1628, 2019.
APA
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z. ... Liu, N. (2019). Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Molecular Medicine Reports, 20, 1621-1628. https://doi.org/10.3892/mmr.2019.10407
MLA
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z., Wang, X., Li, Y., Qiao, G., Liu, N."Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response". Molecular Medicine Reports 20.2 (2019): 1621-1628.
Chicago
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z., Wang, X., Li, Y., Qiao, G., Liu, N."Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response". Molecular Medicine Reports 20, no. 2 (2019): 1621-1628. https://doi.org/10.3892/mmr.2019.10407
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Hou D, Wei Z, Zhu J, Lu H, Li Z, Wang X, Li Y, Qiao G, Liu N, Liu N, et al: Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Mol Med Rep 20: 1621-1628, 2019.
APA
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z. ... Liu, N. (2019). Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Molecular Medicine Reports, 20, 1621-1628. https://doi.org/10.3892/mmr.2019.10407
MLA
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z., Wang, X., Li, Y., Qiao, G., Liu, N."Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response". Molecular Medicine Reports 20.2 (2019): 1621-1628.
Chicago
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z., Wang, X., Li, Y., Qiao, G., Liu, N."Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response". Molecular Medicine Reports 20, no. 2 (2019): 1621-1628. https://doi.org/10.3892/mmr.2019.10407
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