Open Access

Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response

  • Authors:
    • Jun Ma
    • Daorong Hou
    • Zhiqing Wei
    • Jianguo Zhu
    • Hua Lu
    • Zheng Li
    • Xiefeng Wang
    • Yingbin Li
    • Guanqun Qiao
    • Ning Liu
  • View Affiliations

  • Published online on: June 20, 2019     https://doi.org/10.3892/mmr.2019.10407
  • Pages: 1621-1628
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The inflammatory response plays a vital role in cerebral aneurysm (CA) formation and progression. Tanshinone  IIA (Tan IIA) is one of the major active components of Chinese medicine Danshen (Salvia miltiorrhiza Bunge) and is widely used for the treatment of cardiovascular diseases, due to its anti‑inflammatory effects. The aim of the present study was to investigate whether Tan IIA can attenuate CA formation in rat models, and determine its underlying mechanisms. CAs were induced in rats surgically and through high‑salt diet treatments. The Tan IIA‑treated group displayed relatively mild symptoms, as compared with the control group. Tan IIA treatment reduced macrophage infiltration and nuclear factor (NF)‑κB activation in aneurysmal walls. Next, lipopolysaccharide (LPS)‑stimulated RAW 264.7 murine macrophage cells were used to examine the anti‑inflammatory effects of Tan IIA on macrophages. It was found that Tan IIA reversed LPS‑induced differentiation of RAW 264.7 cells and suppressed NF‑κB pathway activation. In conclusion, these findings demonstrated that Tan IIA can suppress CA formation by inhibiting inflammatory responses in macrophages.
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August-2019
Volume 20 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ma J, Hou D, Wei Z, Zhu J, Lu H, Li Z, Wang X, Li Y, Qiao G, Liu N, Liu N, et al: Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Mol Med Rep 20: 1621-1628, 2019
APA
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z. ... Liu, N. (2019). Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response. Molecular Medicine Reports, 20, 1621-1628. https://doi.org/10.3892/mmr.2019.10407
MLA
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z., Wang, X., Li, Y., Qiao, G., Liu, N."Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response". Molecular Medicine Reports 20.2 (2019): 1621-1628.
Chicago
Ma, J., Hou, D., Wei, Z., Zhu, J., Lu, H., Li, Z., Wang, X., Li, Y., Qiao, G., Liu, N."Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response". Molecular Medicine Reports 20, no. 2 (2019): 1621-1628. https://doi.org/10.3892/mmr.2019.10407