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Article

Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets

  • Authors:
    • Liying Liu
    • Siqi Wang
    • Chunyuan Cen
    • Shuyi Peng
    • Yan Chen
    • Xin Li
    • Nan Diao
    • Qian Li
    • Ling Ma
    • Ping Han
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Advanced Application Team, GE Healthcare, Shanghai 201203, P.R. China
  • Pages: 1901-1914
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/mmr.2019.10414
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor with rapid progression and poor prognosis. In the present study, 11 high‑quality microarray datasets, comprising 334 tumor samples and 151 non‑tumor samples from the Gene Expression Omnibus, were screened, and integrative meta‑analysis of expression data was used to identify gene signatures that differentiate between PDAC and normal pancreatic tissues. Following the identification of differentially expressed genes (DEGs), two‑way hierarchical clustering analysis was performed for all DEGs using the gplots package in R software. Hub genes were then determined through protein‑protein interaction network analysis using NetworkAnalyst. In addition, functional annotation and pathway enrichment analyses of all DEGs were conducted in the Database for Annotation, Visualization, and Integrated Discovery. The expression levels and Kaplan‑Meier analysis of the top 10 upregulated and downregulated genes were verified in The Cancer Genome Atlas. A total of 1,587 DEGs, including 1,004 upregulated and 583 downregulated genes, were obtained by comparing PDAC with normal tissues. Of these, hematological and neurological expressed 1, integrin subunit α2 (ITGA2) and S100 calcium‑binding protein A6 (S100A6) were the top upregulated genes, and kinesin family member 1A, Dymeclin and β‑secretase 1 were the top downregulated genes. Reverse transcription‑quantitative PCR was performed to examine the expression levels of S100A6, KRT19 and GNG7, and the results suggested that S100A6 was significantly upregulated in PDAC compared with normal pancreatic tissues. ITGA2 overexpression was significantly associated with shorter overall survival times, whereas family with sequence similarity 46 member C overexpression was strongly associated with longer overall survival times. In addition, network‑based meta‑analysis confirmed growth factor receptor‑bound protein 2 and histone deacetylase 5 as pivotal hub genes in PDAC compared with normal tissue. In conclusion, the results of the present meta‑analysis identified PDAC‑related gene signatures, providing new perspectives and potential targets for PDAC diagnosis and treatment.
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1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Crane CH, Varadhachary GR, Yordy JS, Staerkel GA, Javle MM, Safran H, Haque W, Hobbs BD, Krishnan S, Fleming JB, et al: Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: Correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol. 29:3037–3043. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N and Depinho RA: Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 20:1218–1249. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H and Kleeff J: Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages. PLoS Med. 7:e10002672010. View Article : Google Scholar : PubMed/NCBI

5 

Stratton MR, Campbell PJ and Futreal PA: The cancer genome. Nature. 458:719–724. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, et al: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 321:1801–1806. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Nagata K, Horinouchi M, Saitou M, Higashi M, Nomoto M, Goto M and Yonezawa S: Mucin expression profile in pancreatic cancer and the precursor lesions. J Hepatobiliary Pancreat Surg. 14:243–254. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Sausen M, Phallen J, Adleff V, Jones S, Leary RJ, Barrett MT, Anagnostou V, Parpart-Li S, Murphy D, Kay Li Q, et al: Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. Nat Commun. 6:76862015. View Article : Google Scholar : PubMed/NCBI

9 

Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ and Kern SE: Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57:1731–1734. 1997.PubMed/NCBI

10 

Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D and DePinho RA: Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 20:3130–3146. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Fong ZV and Winter JM: Biomarkers in pancreatic cancer: Diagnostic, prognostic, and predictive. Cancer J. 18:530–538. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Poruk KE, Gay DZ, Brown K, Mulvihill JD, Boucher KM, Scaife CL, Firpo MA and Mulvihill SJ: The clinical utility of CA 19-9 in pancreatic adenocarcinoma: Diagnostic and prognostic updates. Curr Mol Med. 13:340–351. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Kim SM, Kwon IJ, Myoung H, Lee JH and Lee SK: Identification of human papillomavirus (HPV) subtype in oral cancer patients through microarray technology. Eur Arch Otorhinolaryngol. 275:535–543. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Gunel T, Hosseini MK, Gumusoglu E, Kisakesen HI, Benian A and Aydinli K: Expression profiling of maternal plasma and placenta microRNAs in preeclamptic pregnancies by microarray technology. Placenta. 52:77–85. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Qiao X, Wang H, Wang X, Zhao B and Liu J: Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas. Balkan J Med Genet. 19:5–16. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Li G, Li X, Yang M, Xu L, Deng S and Ran L: Prediction of biomarkers of oral squamous cell carcinoma using microarray technology. Sci Rep. 7:421052017. View Article : Google Scholar : PubMed/NCBI

17 

Li J, Chen Z, Tian L, Zhou C, He MY, Gao Y, Wang S, Zhou F, Shi S, Feng X, et al: LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma. Gut. 63:1700–1710. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Ramasamy A, Mondry A, Holmes CC and Altman DG: Key issues in conducting a meta-analysis of gene expression microarray datasets. PLoS Med. 5:e1842008. View Article : Google Scholar : PubMed/NCBI

19 

Rung J and Brazma A: Reuse of public genome-wide gene expression data. Nat Rev Genet. 14:89–99. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Wang S, Jin F, Fan W, Liu F, Zou Y, Hu X, Xu H and Han P: Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes. Sci Rep. 7:117412017. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Xia Q and Lin J: Identification of the potential oncogenes in glioblastoma based on bioinformatic analysis and elucidation of the underlying mechanisms. Oncol Rep. 40:715–725. 2018.PubMed/NCBI

22 

Xiao W, Pacyna-Gengelbach M, Schluns K, An Q, Gao Y, Cheng S and Petersen I: Differentially expressed genes associated with human lung cancer. Oncol Rep. 14:229–234. 2005.PubMed/NCBI

23 

Tang F, He Z, Lei H, Chen Y, Lu Z, Zeng G and Wang H: Identification of differentially expressed genes and biological pathways in bladder cancer. Mol Med Rep. 17:6425–6434. 2018.PubMed/NCBI

24 

Peng C, Ma W, Xia W and Zheng W: Integrated analysis of differentially expressed genes and pathways in triplenegative breast cancer. Mol Med Rep. 15:1087–1094. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Sun W, Ma X, Shen J, Yin F, Wang C and Cai Z: Bioinformatics analysis of differentially expressed pathways related to the metastatic characteristics of osteosarcoma. Int J Mol Med. 38:466–474. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, et al: Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 69:7385–7392. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Tang Y, Zhang Z, Tang Y, Chen X and Zhou J: Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis. Oncol Lett. 16:2453–2461. 2018.PubMed/NCBI

28 

Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: AJCC Cancer Staging Manual. 8th. Springer International Publishing; New York, NY: 2017, View Article : Google Scholar

29 

Xia J, Fjell CD, Mayer ML, Pena OM, Wishart DS and Hancock RE: INMEX-a web-based tool for integrative meta-analysis of expression data. Nucleic Acids Res. 41:W63–W70. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Johnson WE, Li C and Rabinovic A: Adjusting batch effects in microarray expression data using empirical bayes methods. Biostatistics. 8:118–127. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Cochran WG: The combination of estimates from different experiments. Biometrics. 10:101–129. 1954. View Article : Google Scholar

32 

Marot G, Foulley JL, Mayer CD and Jaffrézic F: Moderated effect size and P-value combinations for microarray meta-analyses. Bioinformatics. 25:2692–2699. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Breuer K, Foroushani AK, Laird MR, Chen C, Sribnaia A, Lo R, Winsor GL, Hancock RE, Brinkman FS and Lynn DJ: InnateDB: Systems biology of innate immunity and beyond-recent updates and continuing curation. Nucleic Acids Res. 41:D1228–D1233. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Badea L, Herlea V, Dima SO, Dumitrascu T and Popescu I: Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology. 55:2016–2027. 2008.PubMed/NCBI

36 

Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z and Wang L: FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell. 16:259–266. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Zhang G, Schetter A, He P, Funamizu N, Gaedcke J, Ghadimi BM, Ried T, Hassan R, Yfantis HG, Lee DH, et al: DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma. PLos One. 7:e315072012. View Article : Google Scholar : PubMed/NCBI

38 

Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, et al: Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res. 19:4983–4993. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Donahue TR, Tran LM, Hill R, Li Y, Kovochich A, Calvopina JH, Patel SG, Wu N, Hindoyan A, Farrell JJ, et al: Integrative survival-based molecular profiling of human pancreatic cancer. Clin Cancer Res. 18:1352–1363. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M, Lemoine NR and Brentnall TA: Molecular analysis of precursor lesions in familial pancreatic cancer. PLos One. 8:e548302013. View Article : Google Scholar : PubMed/NCBI

41 

Park M, Kim M, Hwang D, Park M, Kim WK, Kim SK, Shin J, Park ES, Kang CM, Paik YK and Kim H: Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas. Mod Pathol. 27:580–593. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Lunardi S, Jamieson NB, Lim SY, Griffiths KL, Carvalho-Gaspar M, Al-Assar O, Yameen S, Carter RC, McKay CJ, Spoletini G, et al: IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget. 5:11064–11080. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Janky R, Binda MM, Allemeersch J, Van den Broeck A, Govaere O, Swinnen JV, Roskams T, Aerts S and Topal B: Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma. BMC Cancer. 16:6322016. View Article : Google Scholar : PubMed/NCBI

44 

Jha PK, Vijay A, Sahu A and Ashraf MZ: Comprehensive gene expression meta-analysis and integrated bioinformatic approaches reveal shared signatures between thrombosis and myeloproliferative disorders. Sci Rep. 6:370992016. View Article : Google Scholar : PubMed/NCBI

45 

Wang X, Ning Y and Guo X: Integrative meta-analysis of differentially expressed genes in osteoarthritis using microarray technology. Mol Med Rep. 12:3439–3445. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Han H, Bearss DJ, Browne LW, Calaluce R, Nagle RB and Von Hoff DD: Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray. Cancer Res. 62:2890–2896. 2002.PubMed/NCBI

47 

Lu KH, Patterson AP, Wang L, Marquez RT, Atkinson EN, Baggerly KA, Ramoth LR, Rosen DG, Liu J, Hellstrom I, et al: Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res. 10:3291–3300. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Laughlin KM, Luo D, Liu C, Shaw G, Warrington KH Jr, Qiu J, Yachnis AT and Harrison JK: Hematopoietic- and neurologic-expressed sequence 1 expression in the murine GL261 and high-grade human gliomas. Pathol Oncol Res. 15:437–444. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Zhang C, Xu B, Lu S, Zhao Y and Liu P: HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity. Mol Cancer. 16:902017. View Article : Google Scholar : PubMed/NCBI

50 

Varisli L, Ozturk BE, Akyuz GK and Korkmaz KS: HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells. J Cell Biochem. 116:170–178. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Ramirez NE, Zhang Z, Madamanchi A, Boyd KL, O'Rear LD, Nashabi A, Li Z, Dupont WD, Zijlstra A and Zutter MM: The α2β1 integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest. 121:226–237. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Robertson JH, Yang SY, Winslet MC and Seifalian AM: Functional blocking of specific integrins inhibit colonic cancer migration. Clin Exp Metastasis. 26:769–780. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Shimoyama S, Gansauge F, Gansauge S, Oohara T and Beger HG: Altered expression of extracellular matrix molecules and their receptors in chronic pancreatitis and pancreatic adenocarcinoma in comparison with normal pancreas. Int J Pancreatol. 18:227–234. 1995.PubMed/NCBI

54 

Li Y, Wagner ER, Yan Z, Wang Z, Luther G, Jiang W, Ye J, Wei Q, Wang J, Zhao L, et al: The calcium-binding protein S100A6 accelerates human osteosarcoma growth by promoting cell proliferation and inhibiting osteogenic differentiation. Cell Physiol Biochem. 37:2375–2392. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Wang XH, Zhang LH, Zhong XY, Xing XF, Liu YQ, Niu ZJ, Peng Y, Du H, Zhang GG, Hu Y, et al: S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. Am J Pathol. 177:586–597. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Maelandsmo GM, Florenes VA, Mellingsaeter T, Hovig E, Kerbel RS and Fodstad O: Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma. Int J Cancer. 74:464–469. 1997. View Article : Google Scholar : PubMed/NCBI

57 

He X, Xu X, Khan AQ and Ling W: High expression of S100A6 predicts unfavorable prognosis of lung squamous cell cancer. Med Sci Monit. 23:5011–5017. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Ohuchida K, Mizumoto K, Ishikawa N, Fujii K, Konomi H, Nagai E, Yamaguchi K, Tsuneyoshi M and Tanaka M: The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target. Clin Cancer Res. 11:7785–7793. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Kuick R and Hanash S: Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 63:2649–2657. 2003.PubMed/NCBI

60 

Okada Y, Yamazaki H, Sekine-Aizawa Y and Hirokawa N: The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell. 81:769–780. 1995. View Article : Google Scholar : PubMed/NCBI

61 

De S, Cipriano R, Jackson MW and Stark GR: Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. Cancer Res. 69:8035–8042. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, et al: Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma. Int J Oncol. 37:695–705. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Brait M, Loyo M, Rosenbaum E, Ostrow KL, Markova A, Papagerakis S, Zahurak M, Goodman SM, Zeiger M, Sidransky D, et al: Correlation between BRAF mutation and promoter methylation of TIMP3, RARbeta2 and RASSF1A in thyroid cancer. Epigenetics. 7:710–719. 2012. View Article : Google Scholar : PubMed/NCBI

64 

Osipovich AB, Jennings JL, Lin Q, Link AJ and Ruley HE: Dyggve-Melchior-Clausen syndrome: Chondrodysplasia resulting from defects in intracellular vesicle traffic. Proc Natl Acad Sci U S A. 105:16171–16176. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Dimitrov A, Paupe V, Gueudry C, Sibarita JB, Raposo G, Vielemeyer O, Gilbert T, Csaba Z, Attie-Bitach T, Cormier-Daire V, et al: The gene responsible for Dyggve-Melchior-Clausen syndrome encodes a novel peripheral membrane protein dynamically associated with the Golgi apparatus. Hum Mol Genet. 18:440–453. 2009. View Article : Google Scholar : PubMed/NCBI

66 

Shi Z, Hong Y, Zhang K, Wang J, Zheng L, Zhang Z, Hu Z, Han X, Han Y, Chen T, et al: BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model. Biochim Biophys Acta Mol Basis Dis. 1863:2398–2407. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Yi X, Hao Y, Xia N, Wang J, Quintero M, Li D and Zhou F: Sensitive and continuous screening of inhibitors of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) at single SPR chips. Anal Chem. 85:3660–3666. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Chen Q, Liu X, Xu L, Wang Y, Wang S, Li Q, Huang Y and Liu T: Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion. Oncol Rep. 35:1916–1924. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Dong J, Wang R, Ren G, Li X, Wang J, Sun Y, Liang J, Nie Y, Wu K, Feng B, et al: HMGA2-FOXL2 axis regulates metastases and epithelial-to-mesenchymal transition of chemoresistant gastric cancer. Clin Cancer Res. 23:3461–3473. 2017. View Article : Google Scholar : PubMed/NCBI

70 

Yao H, Yang Z, Liu Z, Miao X, Yang L, Li D, Zou Q and Yuan Y: Glypican-3 and KRT19 are markers associating with metastasis and poor prognosis of pancreatic ductal adenocarcinoma. Cancer Biomark. 17:397–404. 2016. View Article : Google Scholar : PubMed/NCBI

71 

Dugnani E, Sordi V, Pellegrini S, Chimienti R, Marzinotto I, Pasquale V, Liberati D, Balzano G, Doglioni C, Reni M, et al: Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome. Pancreatology. 18:945–953. 2018. View Article : Google Scholar : PubMed/NCBI

72 

Li CF, Chuang IC, Liu TT, Chen KC, Chen YY, Fang FM, Li SH, Chen TJ, Yu SC, Lan J and Huang HY: Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors. Oncotarget. 7:49986–49997. 2016.PubMed/NCBI

73 

Caba O, Irigoyen A, Jimenez-Luna C, Benavides M, Ortuño FM, Gallego J, Rojas I, Guillen-Ponce C, Torres C, Aranda E and Prados J: Identification of gene expression profiling associated with erlotinib-related skin toxicity in pancreatic adenocarcinoma patients. Toxicol Appl Pharmacol. 311:113–116. 2016. View Article : Google Scholar : PubMed/NCBI

74 

Wintgens JP, Wichert SP, Popovic L, Rossner MJ and Wehr MC: Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays. Cell Mol Life Sci. 76:1185–1199. 2019. View Article : Google Scholar : PubMed/NCBI

75 

Dharmawardana PG, Peruzzi B, Giubellino A, Burke TR Jr and Bottaro DP: Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy. Anticancer Drugs. 17:13–20. 2006. View Article : Google Scholar : PubMed/NCBI

76 

Liang C, Xu Y, Ge H, Xing B, Li G, Li G and Wu J: miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis. Oncotarget. 8:107543–107557. 2017. View Article : Google Scholar : PubMed/NCBI

77 

Birchmeier C, Birchmeier W, Gherardi E and Vande Woude GF: Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 4:915–925. 2003. View Article : Google Scholar : PubMed/NCBI

78 

Wang X, Lu X, Zhang T, Wen C, Shi M, Tang X, Chen H, Peng C, Li H, Fang Y, et al: mir-329 restricts tumor growth by targeting grb2 in pancreatic cancer. Oncotarget. 7:21441–21453. 2016.PubMed/NCBI

79 

Witt O, Deubzer HE, Milde T and Oehme I: HDAC family: What are the cancer relevant targets? Cancer Lett. 277:8–21. 2009. View Article : Google Scholar : PubMed/NCBI

80 

Milde T, Oehme I, Korshunov A, Kopp-Schneider A, Remke M, Northcott P, Deubzer HE, Lodrini M, Taylor MD, von Deimling A, et al: HDAC5 and HDAC9 in medulloblastoma: Novel markers for risk stratification and role in tumor cell growth. Clin Cancer Res. 16:3240–3252. 2010. View Article : Google Scholar : PubMed/NCBI

81 

Li A, Liu Z, Li M, Zhou S, Xu Y, Xiao Y and Yang W: HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer. Oncotarget. 7:37966–37978. 2016.PubMed/NCBI

82 

Klieser E, Urbas R, Stättner S, Primavesi F, Jäger T, Dinnewitzer A, Mayr C, Kiesslich T, Holzmann K, Di Fazio P, et al: Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome. Hum Pathol. 65:41–52. 2017. View Article : Google Scholar : PubMed/NCBI

83 

He P, Liang J, Shao T, Guo Y, Hou Y and Li Y: HDAC5 promotes colorectal cancer cell proliferation by up-regulating DLL4 expression. Int J Clin Exp Med. 8:6510–6516. 2015.PubMed/NCBI

84 

Ozdağ H, Teschendorff AE, Ahmed AA, Hyland SJ, Blenkiron C, Bobrow L, Veerakumarasivam A, Burtt G, Subkhankulova T, Arends MJ, et al: Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics. 7:902006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Wang S, Cen C, Peng S, Chen Y, Li X, Diao N, Li Q, Ma L, Han P, Han P, et al: Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets. Mol Med Rep 20: 1901-1914, 2019.
APA
Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X. ... Han, P. (2019). Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets. Molecular Medicine Reports, 20, 1901-1914. https://doi.org/10.3892/mmr.2019.10414
MLA
Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X., Diao, N., Li, Q., Ma, L., Han, P."Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets". Molecular Medicine Reports 20.2 (2019): 1901-1914.
Chicago
Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X., Diao, N., Li, Q., Ma, L., Han, P."Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets". Molecular Medicine Reports 20, no. 2 (2019): 1901-1914. https://doi.org/10.3892/mmr.2019.10414
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Wang S, Cen C, Peng S, Chen Y, Li X, Diao N, Li Q, Ma L, Han P, Han P, et al: Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets. Mol Med Rep 20: 1901-1914, 2019.
APA
Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X. ... Han, P. (2019). Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets. Molecular Medicine Reports, 20, 1901-1914. https://doi.org/10.3892/mmr.2019.10414
MLA
Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X., Diao, N., Li, Q., Ma, L., Han, P."Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets". Molecular Medicine Reports 20.2 (2019): 1901-1914.
Chicago
Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X., Diao, N., Li, Q., Ma, L., Han, P."Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets". Molecular Medicine Reports 20, no. 2 (2019): 1901-1914. https://doi.org/10.3892/mmr.2019.10414
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