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Article Open Access

Identification of COMMD1 as a novel lamin A binding partner

  • Authors:
    • Zhiwen Jiang
    • Weichun Chen
    • Jing Zhou
    • Qi Peng
    • Huiling Zheng
    • Yuan Yuan
    • Hongjing Cui
    • Wei Zhao
    • Xuerong Sun
    • Zhongjun Zhou
    • Xinguang Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Aging Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China, Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1790-1796
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/mmr.2019.10419
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Abstract

Lamin A, which is encoded by the LMNA gene, regulates gene expression and genome stability through interactions with a variety of proteins. Mutations in LMNA lead to a diverse set of inherited human diseases, collectively referred to as laminopathies. To gain insight into the protein interactions of lamin A, a yeast two‑hybrid screen was conducted using the carboxy‑terminus of lamin A. The screen identified copper metabolism MURR1 domain‑containing 1 (COMMD1) as a novel lamin A binding partner. Colocalization experiments using fluorescent confocal microscopy revealed that COMMD1 colocalized with lamin A in 293 cells. Furthermore, the COMMD1‑lamin A protein interaction was also demonstrated in co‑immunoprecipitation experiments. Collectively, the present study demonstrated a physical interaction between COMMD1 and lamin A, which may aid to elucidate the mechanisms of lamin A in the aging process.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Z, Chen W, Zhou J, Peng Q, Zheng H, Yuan Y, Cui H, Zhao W, Sun X, Zhou Z, Zhou Z, et al: Identification of COMMD1 as a novel lamin A binding partner. Mol Med Rep 20: 1790-1796, 2019.
APA
Jiang, Z., Chen, W., Zhou, J., Peng, Q., Zheng, H., Yuan, Y. ... Liu, X. (2019). Identification of COMMD1 as a novel lamin A binding partner. Molecular Medicine Reports, 20, 1790-1796. https://doi.org/10.3892/mmr.2019.10419
MLA
Jiang, Z., Chen, W., Zhou, J., Peng, Q., Zheng, H., Yuan, Y., Cui, H., Zhao, W., Sun, X., Zhou, Z., Liu, X."Identification of COMMD1 as a novel lamin A binding partner". Molecular Medicine Reports 20.2 (2019): 1790-1796.
Chicago
Jiang, Z., Chen, W., Zhou, J., Peng, Q., Zheng, H., Yuan, Y., Cui, H., Zhao, W., Sun, X., Zhou, Z., Liu, X."Identification of COMMD1 as a novel lamin A binding partner". Molecular Medicine Reports 20, no. 2 (2019): 1790-1796. https://doi.org/10.3892/mmr.2019.10419
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Z, Chen W, Zhou J, Peng Q, Zheng H, Yuan Y, Cui H, Zhao W, Sun X, Zhou Z, Zhou Z, et al: Identification of COMMD1 as a novel lamin A binding partner. Mol Med Rep 20: 1790-1796, 2019.
APA
Jiang, Z., Chen, W., Zhou, J., Peng, Q., Zheng, H., Yuan, Y. ... Liu, X. (2019). Identification of COMMD1 as a novel lamin A binding partner. Molecular Medicine Reports, 20, 1790-1796. https://doi.org/10.3892/mmr.2019.10419
MLA
Jiang, Z., Chen, W., Zhou, J., Peng, Q., Zheng, H., Yuan, Y., Cui, H., Zhao, W., Sun, X., Zhou, Z., Liu, X."Identification of COMMD1 as a novel lamin A binding partner". Molecular Medicine Reports 20.2 (2019): 1790-1796.
Chicago
Jiang, Z., Chen, W., Zhou, J., Peng, Q., Zheng, H., Yuan, Y., Cui, H., Zhao, W., Sun, X., Zhou, Z., Liu, X."Identification of COMMD1 as a novel lamin A binding partner". Molecular Medicine Reports 20, no. 2 (2019): 1790-1796. https://doi.org/10.3892/mmr.2019.10419
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