Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

Kim,Kwangkho; Kwon,Ohman; Ryu,Tae  Young; Jung,Cho‑Rok; Kim,Janghwan; Min,Jeong‑Ki; Kim,Dae‑Soo; Son,Mi‑Young; Cho,Hyun‑Soo

doi:10.3892/mmr.2019.10431

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

Authors:
- Kwangkho Kim
- Ohman Kwon
- Tae Young Ryu
- Cho‑Rok Jung
- Janghwan Kim
- Jeong‑Ki Min
- Dae‑Soo Kim
- Mi‑Young Son
- Hyun‑Soo Cho
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Affiliations: Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
Published online on: June 26, 2019 https://doi.org/10.3892/mmr.2019.10431
Pages: 1569-1574
Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Short‑chain fatty acids (SCFAs; butyrate, propionate and acetate) are metabolites derived from the gut microbiota via dietary fiber fermentation. In colon cancer, treatment with SCFAs, mainly butyrate and propionate, suppresses cell proliferation, migration and invasion. Furthermore, although sodium butyrate is known to induce cell apoptosis in lung cancer, the anticancer effects of sodium propionate (SP) on lung cancer are not well understood. In the present study, SP treatment induced cell cycle arrest, especially in the G2/M phase, and cell apoptosis in the H1299 and H1703 lung cancer cell lines. As determined by reverse transcription‑quantitative PCR and western blotting, Survivin and p21 expression levels were significantly affected by SP treatment, suggesting that SP treatment suppressed cell proliferation in these lung cancer cell lines. Thus, it was proposed that the SP‑mediated regulation of Survivin and p21 in lung cancer may be applicable to lung cancer therapy.

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