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Article

Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas

  • Authors:
    • Fan Wang
    • Honghong Li
    • Yin Lou
    • Juan Xie
    • Dongsheng Cao
    • Xueying Huang
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Anatomy, Anhui Medical University, Hefei, Anhui 230601, P.R. China
  • Pages: 2825-2830
    |
    Published online on: January 24, 2019
       https://doi.org/10.3892/mmr.2019.9895
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Abstract

Infantile hemangiomas (IH) are the most common infantile neoplasms and are characterized by initial proliferation during infancy and subsequent spontaneous regression within the next 5‑10 years, frequently leaving fibrous fat residues. However, the specific mechanisms underlying the differentiation of hemangioma stem cells (HemSCs) into adipocytes are not clear. The purpose of the present study was to investigate the effect of insulin‑like growth factor I (IGF‑1) on HemSCs from patients with IH and to determine the signaling mechanisms involved. Treatment of HemSCs with IGF‑1 led to upregulation of the protein expression levels of peroxisome proliferator‑activated receptor‑γ (PPARγ). By contrast, inhibition of the IGF‑1 receptor (IGF‑1R) or phosphoinositide 3‑kinase (PI3K) activity decreased the expression of PPARγ, in addition to that of CCAAT/enhancer‑binding protein (C/EBP)α, C/EBPβ, and adiponectin. IGF‑1 upregulated the expression of phosphorylated RAC‑α serine/threonine‑protein kinase in IH cells, whereas a specific PI3K inhibitor or IGF‑1R antibody blocked this effect. These results indicated that IGF‑1 is a pro‑proliferative and pro‑lipogenic factor in IH HemSCs. Taken together, these findings indicated that IGF‑1 is able to upregulate PPARγ by activating the IGF‑1R and PI3K pathways, thereby accelerating lipogenesis and enhancing IH HemSC adipogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Li H, Lou Y, Xie J, Cao D and Huang X: Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas. Mol Med Rep 19: 2825-2830, 2019.
APA
Wang, F., Li, H., Lou, Y., Xie, J., Cao, D., & Huang, X. (2019). Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas. Molecular Medicine Reports, 19, 2825-2830. https://doi.org/10.3892/mmr.2019.9895
MLA
Wang, F., Li, H., Lou, Y., Xie, J., Cao, D., Huang, X."Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas". Molecular Medicine Reports 19.4 (2019): 2825-2830.
Chicago
Wang, F., Li, H., Lou, Y., Xie, J., Cao, D., Huang, X."Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas". Molecular Medicine Reports 19, no. 4 (2019): 2825-2830. https://doi.org/10.3892/mmr.2019.9895
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Li H, Lou Y, Xie J, Cao D and Huang X: Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas. Mol Med Rep 19: 2825-2830, 2019.
APA
Wang, F., Li, H., Lou, Y., Xie, J., Cao, D., & Huang, X. (2019). Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas. Molecular Medicine Reports, 19, 2825-2830. https://doi.org/10.3892/mmr.2019.9895
MLA
Wang, F., Li, H., Lou, Y., Xie, J., Cao, D., Huang, X."Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas". Molecular Medicine Reports 19.4 (2019): 2825-2830.
Chicago
Wang, F., Li, H., Lou, Y., Xie, J., Cao, D., Huang, X."Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas". Molecular Medicine Reports 19, no. 4 (2019): 2825-2830. https://doi.org/10.3892/mmr.2019.9895
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