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Article

Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip

  • Authors:
    • De Li
    • Hui Wang
    • Ji‑Ye He
    • Cheng‑Long Wang
    • Wei‑Jia Feng
    • Chao Shen
    • Jun‑Feng Zhu
    • Dong‑Liang Wang
    • Xiao‑Dong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Xin‑Hua Hospital, Shanghai Jiao‑Tong University School of Medicine, Shanghai 200092, P.R. China
  • Pages: 2808-2816
    |
    Published online on: January 30, 2019
       https://doi.org/10.3892/mmr.2019.9910
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Abstract

Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder characterized by progressive joint soreness and limited mobility. The aim of the present study was to investigate the pathological changes and inflammatory infiltration in the hypertrophic synovium of the hip joint associated with the progression of DDH. Synovial biopsies in the hip joint are obtained from patients with moderate DDH and severe DDH during surgery. These biopsies are processed for histological and immunohistochemical (IHC) analysis and investigation of the pathological processes in a synovium, including types of inflammatory cell infiltration, synovial angiogenesis and fibrosis, neuron endings and neuropeptide invasion. Correlation analysis was performed between the mean optical density (MOD) of each antibody, and Harris hip score (HHS) and visual analogue score (VAS) using the Spearman correlation test. Chronic inflammation in the synovium was observed via the positive IHC staining of inflammatory cells, such as T cells, B cells, macrophages and leukocytes. Excessive staining of vimentin and α smooth muscle actin in the synovium of severe DDH represented significant fibrosis and angiogenesis. These targets were also significantly correlated with HHS in severe DDH. The MOD levels of CD68 (indicators of macrophage) indicated apparent correlations with HHS and VAS in patients with severe DDH. The labels of nerve fibers and pain transmission indicators were as follows: Neurofilament‑200 and substance P. Calcitonin gene‑related peptide was upregulated in the synovium of severe DDH in contrast to that in the synovium of moderate DDH. The MOD levels of NF‑200, SP and CGRP were correlated with VAS in severe DDH. The pathology of DDH includes chronic inflammatory cell infiltration corresponding with nerve fibers and fibroblastic proliferation, which might contribute to arthritis progression and joint soreness in DDH.
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1 

Lisle R, Boekelaar M, Stannage K and Whitewood C: Delayed diagnosis of developmental dislocation of the hip: The Western Australian experience. ANZ J Surg. 82:612–615. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Shi D, Dai J, Zhu P, Qin J, Zhu L, Zhu H, Zhao B, Qiu X, Xu Z, Chen D, et al: Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: A case-control study in Han Chinese. Arthritis Res Ther. 13:R272011. View Article : Google Scholar : PubMed/NCBI

3 

Sangal RB, Waryasz GR and Schiller JR: Femoroacetabular impingement: A review of current concepts. R I Med J (2013). 97:33–38. 2014.PubMed/NCBI

4 

Alzaharani A, Bali K, Gudena R, Railton P, Ponjevic D, Matyas JR and Powell JN: The innervation of the human acetabular labrum and hip joint: An anatomic study. BMC Musculoskelet Disord. 15:412014. View Article : Google Scholar : PubMed/NCBI

5 

Henak CR, Abraham CL, Anderson AE, Maas SA, Ellis BJ, Peters CL and Weiss JA: Patient-specific analysis of cartilage and labrum mechanics in human hips with acetabular dysplasia. Osteoarthritis Cartilage. 22:210–217. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Haversath M, Hanke J, Landgraeber S, Herten M, Zilkens C, Krauspe R and Jäger M: The distribution of nociceptive innervation in the painful hip: A histological investigation. Bone Joint J 95-B. 770–776. 2013. View Article : Google Scholar

7 

Nakajima T, Ohtori S, Inoue G, Koshi T, Yamamoto S, Nakamura J, Takahashi K and Harada Y: The characteristics of dorsal-root ganglia and sensory innervation of the hip in rats. J Bone Joint Surg Br. 90:254–257. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Henrotin Y, Lambert C and Richette P: Importance of synovitis in osteoarthritis: Evidence for the use of glycosaminoglycans against synovial inflammation. Semin Arthritis Rheum. 43:579–587. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Henrotin Y, Pesesse L and Lambert C: Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis. Ther Adv Musculoskelet Dis. 6:20–34. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Shirai C, Ohtori S, Kishida S, Harada Y and Moriya H: The pattern of distribution of PGP 9.5 and TNF-alpha immunoreactive sensory nerve fibers in the labrum and synovium of the human hip joint. Neurosci Lett. 450:18–22. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Takeshita M, Nakamura J, Ohtori S, Inoue G, Orita S, Miyagi M, Ishikawa T and Takahashi K: Sensory innervation and inflammatory cytokines in hypertrophic synovia associated with pain transmission in osteoarthritis of the hip: A case-control study. Rheumatology (Oxford). 51:1790–1795. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Beckmann J, Schubert J, Morhenn HG, Grau V, Schnettler R and Lips KS: Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis. Cell Tissue Res. 359:465–477. 2015. View Article : Google Scholar : PubMed/NCBI

13 

de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, Huizinga TW and Kloppenburg M: Synovial inflammation, immune cells and their cytokines in osteoarthritis: A review. Osteoarthritis Cartilage. 20:1484–1499. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kim YS, Kim JM, Lee YG, Hong OK, Kwon HS and Ji JH: Intercellular adhesion molecule-1 (ICAM-1, CD54) is increased in adhesive capsulitis. J Bone Joint Surg Am. 95:e181–e188. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hand GC, Athanasou NA, Matthews T and Carr AJ: The pathology of frozen shoulder. J Bone Joint Surg Br. 89:928–932. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Wang H, Zhang X, He JY, Zheng XF, Li D, Li Z, Zhu JF, Shen C, Cai GQ and Chen XD: Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip. Arthritis Res Ther. 17:42015. View Article : Google Scholar : PubMed/NCBI

17 

Crowe JF, Mani VJ and Ranawat CS: Total hip replacement in congenital dislocation and dysplasia of the hip. J Bone Joint Surg Am. 61:15–23. 1979. View Article : Google Scholar : PubMed/NCBI

18 

Hart DJ and Spector TD: The classification and assessment of osteoarthritis. Baillieres Clin Rheumatol. 9:407–432. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Cashman JP, Round J, Taylor G and Clarke NM: The natural history of developmental dysplasia of the hip after early supervised treatment in the Pavlik harness. A prospective, longitudinal follow-up. J Bone Joint Surg Br. 84:418–425. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Nakamura S, Ninomiya S and Nakamura T: Primary osteoarthritis of the hip joint in Japan. Clin Orthop Relat Res. 190–196. 1989.PubMed/NCBI

21 

Rondelet B, Kerbaul F, Motte S, van Beneden R, Remmelink M, Brimioulle S, McEntee K, Wauthy P, Salmon I, Ketelslegers JM and Naeije R: Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. Circulation. 107:1329–1335. 2003. View Article : Google Scholar : PubMed/NCBI

22 

O'Neill TW, Parkes MJ, Maricar N, Marjanovic EJ, Hodgson R, Gait AD, Cootes TF, Hutchinson CE and Felson DT: Synovial tissue volume: A treatment target in knee osteoarthritis (OA). Ann Rheum Dis. 75:84–90. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Liu-Bryan R: Synovium and the innate inflammatory network in osteoarthritis progression. Curr Rheumatol Rep. 15:3232013. View Article : Google Scholar : PubMed/NCBI

24 

Adães S, Mendonça M, Santos TN, Castro-Lopes JM, Ferreira-Gomes J and Neto FL: Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis. Arthritis Res Ther. 16:R102014. View Article : Google Scholar : PubMed/NCBI

25 

Daghestani HN, Pieper CF and Kraus VB: Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis. Arthritis Rheumatol. 67:956–965. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Zhang RX, Ren K and Dubner R: Osteoarthritis pain mechanisms: Basic studies in animal models. Osteoarthritis Cartilage. 21:1308–1315. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Wakamatsu K, Nanki T, Miyasaka N, Umezawa K and Kubota T: Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther. 7:R1348–R1359. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Laragione T and Gulko PS: Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10. Mol Med. 18:1009–1017. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Mifková A, Kodet O, Szabo P, Kučera J, Dvořánková B, André S, Koripelly G, Gabius HJ, Lehn JM and Smetana K Jr: Synthetic polyamine BPA-C8 inhibits TGF-β1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro. Chembiochem. 15:1465–1470. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Minton K: Extracellular matrix: Preconditioning the ECM for fibrosis. Nat Rev Mol Cell Biol. 15:766–767. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Shinde AV and Frangogiannis NG: Fibroblasts in myocardial infarction: A role in inflammation and repair. J Mol Cell Cardiol. 70:74–82. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Leech MT and Morand EF: Fibroblasts and synovial immunity. Curr Opin Pharmacol. 13:565–569. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Sobel K, Tham M, Stark HJ, Stammer H, Prätzel-Wunder S, Bickenbach JR and Boukamp P: Wnt-3a-activated human fibroblasts promote human keratinocyte proliferation and matrix destruction. Int J Cancer. 136:2786–2798. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Kägebein D, Gutjahr M, Große C, Vogel AB, Rödel J and Knittler MR: Chlamydia trachomatis-infected epithelial cells and fibroblasts retain the ability to express surface-presented major histocompatibility complex class I molecules. Infect Immun. 82:993–1006. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Scanzello CR and Goldring SR: The role of synovitis in osteoarthritis pathogenesis. Bone. 51:249–257. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Nigrovic PA and Lee DM: Synovial mast cells: Role in acute and chronic arthritis. Immunol Rev. 217:19–37. 2007. View Article : Google Scholar : PubMed/NCBI

37 

da Silva EZ, Jamur MC and Oliver C: Mast cell function: A new vision of an old cell. J Histochem Cytochem. 62:698–738. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li D, Wang H, He JY, Wang CL, Feng WJ, Shen C, Zhu JF, Wang DL and Chen XD: Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip. Mol Med Rep 19: 2808-2816, 2019.
APA
Li, D., Wang, H., He, J., Wang, C., Feng, W., Shen, C. ... Chen, X. (2019). Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip. Molecular Medicine Reports, 19, 2808-2816. https://doi.org/10.3892/mmr.2019.9910
MLA
Li, D., Wang, H., He, J., Wang, C., Feng, W., Shen, C., Zhu, J., Wang, D., Chen, X."Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip". Molecular Medicine Reports 19.4 (2019): 2808-2816.
Chicago
Li, D., Wang, H., He, J., Wang, C., Feng, W., Shen, C., Zhu, J., Wang, D., Chen, X."Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip". Molecular Medicine Reports 19, no. 4 (2019): 2808-2816. https://doi.org/10.3892/mmr.2019.9910
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Wang H, He JY, Wang CL, Feng WJ, Shen C, Zhu JF, Wang DL and Chen XD: Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip. Mol Med Rep 19: 2808-2816, 2019.
APA
Li, D., Wang, H., He, J., Wang, C., Feng, W., Shen, C. ... Chen, X. (2019). Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip. Molecular Medicine Reports, 19, 2808-2816. https://doi.org/10.3892/mmr.2019.9910
MLA
Li, D., Wang, H., He, J., Wang, C., Feng, W., Shen, C., Zhu, J., Wang, D., Chen, X."Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip". Molecular Medicine Reports 19.4 (2019): 2808-2816.
Chicago
Li, D., Wang, H., He, J., Wang, C., Feng, W., Shen, C., Zhu, J., Wang, D., Chen, X."Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip". Molecular Medicine Reports 19, no. 4 (2019): 2808-2816. https://doi.org/10.3892/mmr.2019.9910
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