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Expression of autophagy‑associated proteins in rat dental irreversible pulpitis

  • Authors:
    • Shengcai Qi
    • Jun Qian
    • Fubo Chen
    • Peng Zhou
    • Jing Yue
    • Fengqin Tang
    • Yiming Zhang
    • Shiqiang Gong
    • Guangwei Shang
    • Chun Cui
    • Yuanzhi Xu
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Jiangsu Key Laboratory of Oral Diseases, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2749-2757
    |
    Published online on: February 7, 2019
       https://doi.org/10.3892/mmr.2019.9944
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Abstract

Autophagy serves an important role in numerous diseases, as well as in infection and inflammation. Irreversible pulpitis (IP) is one of the most common inflammatory endodontic diseases, and autophagy has been reported to regulate IP in vitro. However, the level of autophagy in the IP pathogenic process in vivo remains unknown. The aim of the current study was, thus, to investigate the levels of autophagy‑associated proteins in rats with IP in vivo. A rat dental IP model was successfully constructed, and five different time points (0, 1, 3, 5 and 7 days) were investigated. The levels of the autophagy‑related 5 (ATG5), ATG7, light chain 3 (LC3) and Beclin‑1 proteins exhibited a time‑dependent increase in rats with IP, whereas the levels of mammalian target of rapamycin and p62/sequestosome 1 were decreased. In addition, the levels of ATG proteins were specifically increased in odontoblasts and microvascular endothelial cells in pulpitis tissue. Based on these findings, autophagy may serve an important role in IP, and the present study data provide a new insight into the IP pathogenesis and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Qi S, Qian J, Chen F, Zhou P, Yue J, Tang F, Zhang Y, Gong S, Shang G, Cui C, Cui C, et al: Expression of autophagy‑associated proteins in rat dental irreversible pulpitis. Mol Med Rep 19: 2749-2757, 2019.
APA
Qi, S., Qian, J., Chen, F., Zhou, P., Yue, J., Tang, F. ... Xu, Y. (2019). Expression of autophagy‑associated proteins in rat dental irreversible pulpitis. Molecular Medicine Reports, 19, 2749-2757. https://doi.org/10.3892/mmr.2019.9944
MLA
Qi, S., Qian, J., Chen, F., Zhou, P., Yue, J., Tang, F., Zhang, Y., Gong, S., Shang, G., Cui, C., Xu, Y."Expression of autophagy‑associated proteins in rat dental irreversible pulpitis". Molecular Medicine Reports 19.4 (2019): 2749-2757.
Chicago
Qi, S., Qian, J., Chen, F., Zhou, P., Yue, J., Tang, F., Zhang, Y., Gong, S., Shang, G., Cui, C., Xu, Y."Expression of autophagy‑associated proteins in rat dental irreversible pulpitis". Molecular Medicine Reports 19, no. 4 (2019): 2749-2757. https://doi.org/10.3892/mmr.2019.9944
Copy and paste a formatted citation
x
Spandidos Publications style
Qi S, Qian J, Chen F, Zhou P, Yue J, Tang F, Zhang Y, Gong S, Shang G, Cui C, Cui C, et al: Expression of autophagy‑associated proteins in rat dental irreversible pulpitis. Mol Med Rep 19: 2749-2757, 2019.
APA
Qi, S., Qian, J., Chen, F., Zhou, P., Yue, J., Tang, F. ... Xu, Y. (2019). Expression of autophagy‑associated proteins in rat dental irreversible pulpitis. Molecular Medicine Reports, 19, 2749-2757. https://doi.org/10.3892/mmr.2019.9944
MLA
Qi, S., Qian, J., Chen, F., Zhou, P., Yue, J., Tang, F., Zhang, Y., Gong, S., Shang, G., Cui, C., Xu, Y."Expression of autophagy‑associated proteins in rat dental irreversible pulpitis". Molecular Medicine Reports 19.4 (2019): 2749-2757.
Chicago
Qi, S., Qian, J., Chen, F., Zhou, P., Yue, J., Tang, F., Zhang, Y., Gong, S., Shang, G., Cui, C., Xu, Y."Expression of autophagy‑associated proteins in rat dental irreversible pulpitis". Molecular Medicine Reports 19, no. 4 (2019): 2749-2757. https://doi.org/10.3892/mmr.2019.9944
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