Panax ginseng components and the pathogenesis of Alzheimer's disease (Review)

Razgonova,Mayya Petrovna; Veselov,Valery Vyacheslavovich; Zakharenko,Alexander Mikhailovich; Golokhvast,Kirill Sergeyevich; Nosyrev,Alexander Evgenyevich; Cravotto,Giancarlo; Tsatsakis,Aristidis; Spandidos,Demetrios A.

doi:10.3892/mmr.2019.9972

Panax ginseng components and the pathogenesis of Alzheimer's disease (Review)

Authors:
- Mayya Petrovna Razgonova
- Valery Vyacheslavovich Veselov
- Alexander Mikhailovich Zakharenko
- Kirill Sergeyevich Golokhvast
- Alexander Evgenyevich Nosyrev
- Giancarlo Cravotto
- Aristidis Tsatsakis
- Demetrios A. Spandidos
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Affiliations: SEC Nanotechnology, Far Eastern Federal University, Vladivostok 690950, Russia, Center of Bioanalytical Investigation and Molecular Design, I.M. Sechenov First Moscow State Medical University, Moscow 119048, Russia, Department of Drug Science and Technology, University of Turin, Turin 10125, Italy, Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Greece
Published online on: February 19, 2019 https://doi.org/10.3892/mmr.2019.9972
Pages: 2975-2998
Copyright: © Razgonova et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ginseng is one of the main representatives of traditional Chinese medicine and presents a wide range of pharmacological actions. Ginsenosides are the main class of active compounds found in ginseng. They demonstrate unique biological activity and medicinal value, namely anti-tumour, anti‑inflammatory and antioxidant properties, as well as anti-apoptotic properties. Increasing levels of stress in life are responsible for the increased incidence of nervous system diseases. Neurological diseases create a huge burden on the lives and health of individuals. In recent years, studies have indicated that ginsenosides play a pronounced positive role in the prevention and treatment of neurological diseases. Nevertheless, research is still at an early stage of development, and the complex mechanisms of action involved remain largely unknown. This review aimed to shed light into what is currently known about the mechanisms of action of ginsenosides in relation to Alzheimer's disease. Scientific material and theoretical bases for the treatment of nervous system diseases with purified Panax ginseng extracts are also discussed.

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