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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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April-2019 Volume 19 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1

  • Authors:
    • Zhisheng Wang
    • Jiayun Zhang
    • Songlan Zhang
    • Shifang Yan
    • Zihui Wang
    • Chao Wang
    • Xiaojiang Zhang
  • View Affiliations / Copyright

    Affiliations: Medical Department of Shandong Medical College, Shandong 250002, P.R. China, Department of Cardiology, Staff Hospital of Hebei GEO University, Hebei 050031, P.R. China, Second Department of Internal Medicine, People's Hospital of Shizhong District, Shandong 250002, P.R. China, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, P.R. China, Department of Cardiology, People's Hospital of Mancheng District, Hebei 071000, P.R. China, Department of Cardiology, People's Hospital of Zouping County, Shandong 256200, P.R. China
  • Pages: 3298-3304
    |
    Published online on: February 25, 2019
       https://doi.org/10.3892/mmr.2019.9983
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Abstract

Atherosclerosis is a chronic disease characterized by the accumulation of lipids and fibrous elements in the large arteries, which is the principal cause of coronary artery disease. Dysregulated exosomal microRNA (miRNA) levels in serum have been identified in patients with various diseases, including CAD. In the present study, nine candidate miRNAs were detected in the plasma exosome from 42 patients with coronary atherosclerosis, and a higher expression of miR‑30e and miR‑92a was identified in patients. Following bioinformatics analysis and confirmation through immunoblotting, it was demonstrated that ATP binding cassette (ABC)A1 is a direct target of miR‑30e, and miR‑92a. Furthermore, a negative correlation was identified between plasma miR‑30e and ABCA1, or miR‑30e and cholesterol. Thus, the results of the present study suggest that the miR‑30e level in exosomes from serum may have the potential to be a novel diagnostic biomarker for coronary atherosclerosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Zhang J, Zhang S, Yan S, Wang Z, Wang C and Zhang X: MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. Mol Med Rep 19: 3298-3304, 2019.
APA
Wang, Z., Zhang, J., Zhang, S., Yan, S., Wang, Z., Wang, C., & Zhang, X. (2019). MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. Molecular Medicine Reports, 19, 3298-3304. https://doi.org/10.3892/mmr.2019.9983
MLA
Wang, Z., Zhang, J., Zhang, S., Yan, S., Wang, Z., Wang, C., Zhang, X."MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1". Molecular Medicine Reports 19.4 (2019): 3298-3304.
Chicago
Wang, Z., Zhang, J., Zhang, S., Yan, S., Wang, Z., Wang, C., Zhang, X."MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1". Molecular Medicine Reports 19, no. 4 (2019): 3298-3304. https://doi.org/10.3892/mmr.2019.9983
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Zhang J, Zhang S, Yan S, Wang Z, Wang C and Zhang X: MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. Mol Med Rep 19: 3298-3304, 2019.
APA
Wang, Z., Zhang, J., Zhang, S., Yan, S., Wang, Z., Wang, C., & Zhang, X. (2019). MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. Molecular Medicine Reports, 19, 3298-3304. https://doi.org/10.3892/mmr.2019.9983
MLA
Wang, Z., Zhang, J., Zhang, S., Yan, S., Wang, Z., Wang, C., Zhang, X."MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1". Molecular Medicine Reports 19.4 (2019): 3298-3304.
Chicago
Wang, Z., Zhang, J., Zhang, S., Yan, S., Wang, Z., Wang, C., Zhang, X."MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1". Molecular Medicine Reports 19, no. 4 (2019): 3298-3304. https://doi.org/10.3892/mmr.2019.9983
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