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Article

Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing

  • Authors:
    • Jung Oh Kim
    • Kee Ook Lee
    • Hyun Woo Kim
    • Han Sung Park
    • Jinkwon Kim
    • Jung Hoon Sung
    • Doyeun Oh
    • Ok Joon Kim
    • Nam Keun Kim
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Gyeonggi 13488, Republic of Korea, Department of Neurology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, Gyeonggi 13496, Republic of Korea, Department of Cardiology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, Gyeonggi 13496, Republic of Korea, Department of Internal Medicine, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, Gyeonggi 13496, Republic of Korea
  • Pages: 1973-1983
    |
    Published online on: February 5, 2020
       https://doi.org/10.3892/mmr.2020.10975
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Abstract

Silent brain infarction (SBI) is a cerebral infarction identified through brain imaging. In particular, studies have shown that the presence of SBI in elderly patients increases their risk of cognitive dysfunction, impairment and dementia. However, little research has been published on the relevance of SBI to these risks for the Korean population. The association between potassium voltage‑gated channel subfamily Q member 2 (KCNQ2), transcription factor 4 (TCF4) and regulator of G‑protein signaling 18 (RGS18) genotypes and SBI were investigated using whole‑exome sequencing and PCR restriction fragment length polymorphism (RFLP) analysis. The study population included 407 patients with SBI (171 males) and 401 control subjects (172 males). Genotyping was performed using PCR RFLP. Interestingly, TCF4 rs9957668T>C polymorphisms were associated with SBI prevalence [TT vs. CC: adjusted odds ratio (AOR), 1.815, 95% confidence intervals (CI), 1.202‑2.740; TT vs. TC+CC: AOR, 1.492, 95% CI, 1.066‑2.088; TT+TC vs. CC: AOR, 1.454, 95% CI, 1.045‑2.203]. The combination of KCNQ2 rs73146513A>G and TCF4 rs9957668T>C genotypes was associated with increasing SBI prevalence (AG/CC: AOR, 3.719, 95% CI, 1.766‑7.833; AA/CC: AOR, 3.201, 95% CI, 1.387‑7.387). The present study showed that TCF4 rs9957668T>C polymorphisms may be risk factors for SBI. Therefore, the TCF4 rs9957668T>C polymorphism may serve as a biomarker for increased risk of SBI in the Korean population.
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View References

1 

Kim SH, Shin DW, Yun JM, Lee JE, Lim JS, Cho BL, Kwon HM and Park JH: Kidney dysfunction and silent brain infarction in generally healthy adults. J Neurol Sci. 379:89–93. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Cho Y, Kim JO, Lee JH, Park HM, Jeon YJ, Oh SH, Bae J, Park YS, Kim OJ and Kim NK: Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction. PLoS One. 10:e01152952015. View Article : Google Scholar : PubMed/NCBI

3 

Nakaguchi H, Matsuno A, Okubo T and Hoya K: Relationship between silent brain infarction and amount of daily coffee consumption in middle age. J Stroke Cerebrovasc Dis. 25:1678–1682. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, et al: Silent brain infarction and risk of future stroke: A systematic review and meta-analysis. Stroke. 47:719–725. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hong SH, Park HM, Ahn JY, Kim OJ, Hwang TS, Oh D and Kim NK: ACE I/D polymorphism in Korean patients with ischemic stroke and silent brain infarction. Acta Neurol Scand. 117:244–249. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Jeon YJ, Kim OJ, Kim SY, Oh SH, Oh D, Kim OJ, Shin BS and Kim NK: Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk. Arterioscler Thromb Vasc Biol. 33:420–430. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Kim MH, Moon JS, Park SY, An SA, Kim OJ, Kim NK and Oh SH: Different risk factor profiles between silent brain infarction and symptomatic lacunar infarction. Eur Neurol. 65:250–256. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Kim OJ, Lee JH, Choi JK, Oh SH, Hong SH, Oh D and Kim NK: Association between tumor necrosis factor-alpha (−308G→A and −238G→A) polymorphisms and homocysteine levels in patients with ischemic strokes and silent brain infarctions. Cerebrovasc Dis. 30:483–490. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Oh SH, Kim NK, Kim SH, Kim JK, Kim HS, Kim WC and Kim OJ: The prevalence and risk factor analysis of silent brain infarction in patients with first-ever ischemic stroke. J Neurol Sci. 293:97–101. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Park SY, An SA, Lee HB, Kim Y, Kim NK, Kim SH, Kim OJ and Oh SH: Different impact of hyperhomocysteinemia on cerebral small vessel ischemia and cervico-cerebral atherosclerosis in non-stroke individuals. Thromb Res. 131:e12–e16. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Kunikata H, Aizawa N, Kudo M, Mugikura S, Nitta F, Morimoto R, Iwakura Y, Ono Y, Satoh F, Takahashi H, et al: Relationship of ocular microcirculation, measured by laser speckle flowgraphy, and silent brain infarction in primary aldosteronism. PLoS One. 10:e01174522015. View Article : Google Scholar : PubMed/NCBI

12 

Kwon HS, Kim YS, Park HH, Choi H, Lee KY, Lee YJ, Heo SH, Chang DI and Koh SH: Increased VEGF and decreased SDF-1α in patients with silent brain infarction are associated with better prognosis after first-ever acute lacunar stroke. J Stroke Cerebrovasc Dis. 24:704–710. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Fanning JP, Wong AA and Fraser JF: The epidemiology of silent brain infarction: A systematic review of population-based cohorts. BMC Med. 12:1192014. View Article : Google Scholar : PubMed/NCBI

14 

Hoefler G: Next-generation sequencing in diagnostics and clinical research. Pathobiology. 84:289–291. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Malhotra S, Singh S and Sarkar S: Whole genome variant analysis in three ethnically diverse Indians. Genes Genomics. 40:497–510. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Zare F, Dow M, Monteleone N, Hosny A and Nabavi S: An evaluation of copy number variation detection tools for cancer using whole exome sequencing data. BMC Bioinformatics. 18:2862017. View Article : Google Scholar : PubMed/NCBI

17 

Duan H, Peng J, Kessi M and Yin F: De novo KCNQ2 mutation in one case of epilepsy of infancy with migrating focal seizures that evolved to infantile spasms. Child Neurol Open. 5:2329048X187677382018. View Article : Google Scholar : PubMed/NCBI

18 

Wei X, Zhang Y, Yin B, Wen J, Cheng J and Fu X: The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia. PLoS One. 13:e01921222018. View Article : Google Scholar : PubMed/NCBI

19 

Bonham LW, Evans DS, Liu Y, Cummings SR, Yaffe K and Yokoyama JS: Neurotransmitter pathway genes in cognitive decline during aging: Evidence for GNG4 and KCNQ2 genes. Am J Alzheimers Dis Other Demen. 33:153–165. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Goodwill AG, Fu L, Noblet JN, Casalini ED, Sassoon D, Berwick ZC, Kassab GS, Tune JD and Dick GM: KV7 channels contribute to paracrine, but not metabolic or ischemic, regulation of coronary vascular reactivity in swine. Am J Physiol Heart Circ Physiol. 310:H693–H704. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Ng FL, Davis AJ, Jepps TA, Harhun MI, Yeung SY, Wan A, Reddy M, Melville D, Nardi A, Khong TK, et al: Expression and function of the K+ channel KCNQ genes in human arteries. Br J Pharmacol. 162:42–53. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Spagnoli C, Salerno GG, Iodice A, Frattini D, Pisani F and Fusco C: KCNQ2 encephalopathy: A case due to a de novo deletion. Brain Dev. 40:65–68. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Kolligs FT, Nieman MT, Winer I, Hu G, Van Mater D, Feng Y, Smith IM, Wu R, Zhai Y, Cho KR, et al: ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell. 1:145–155. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Henthorn P, McCarrick-Walmsley R and Kadesch T: Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor. Nucleic Acids Res. 18:6781990. View Article : Google Scholar : PubMed/NCBI

25 

de Pontual L, Mathieu Y, Golzio C, Rio M, Malan V, Boddaert N, Soufflet C, Picard C, Durandy A, Dobbie A, et al: Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome. Hum Mutat. 30:669–676. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Amiel J, Rio M, de Pontual L, Redon R, Malan V, Boddaert N, Plouin P, Carter NP, Lyonnet S, Munnich A, et al: Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. Am J Hum Genet. 80:988–993. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL and Clarke MF: Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 276:915–923. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, et al: RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes. Biochem J. 359:109–118. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Alshbool FZ, Karim ZA, Vemana HP, Conlon C, Lin OA and Khasawneh FT: The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis. Biochem Biophys Res Commun. 462:378–382. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Louwette S, Van Geet C and Freson K: Regulators of G protein signaling: Role in hematopoiesis, megakaryopoiesis and platelet function. J Thromb Haemost. 10:2215–2222. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Kim JO, Jeon YJ, Kim OJ, Oh SH, Kim HS, Shin BS, Oh D, Kim EJ, Cho YK and Kim NK: Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction. Mol Med Rep. 9:2459–2466. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Cingolani P, Platts A, Wang L, Coon M, Nguyen T, Wang L, Land SJ, Lu X and Ruden DM: A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin). 6:80–92. 2012. View Article : Google Scholar : PubMed/NCBI

33 

1000 Genomes Project Consortium, ; Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, et al: A global reference for human genetic variation. Nature. 526:68–74. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Lin DY, Hu Y and Huang BE: Simple and efficient analysis of disease association with missing genotype data. Am J Hum Genet. 82:444–452. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Vermeer SE, Den Heijer T, Koudstaal PJ, Oudkerk M, Hofman A and Breteler MM; Rotterdam Scan Study, : Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 34:392–396. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Kim MN, Kim JO, Lee SM, Park H, Lee JH, Rim KS, Hwang SG and Kim NK: Variation in the Dicer and RAN genes are associated with survival in patients with hepatocellular carcinoma. PLoS One. 11:e01622792016. View Article : Google Scholar : PubMed/NCBI

37 

Kanzaki T, Uju Y, Sekine K, Ishii Y, Yoshimi T, Yasui R, Yasukawa A, Sato M, Okamoto S, Hisaoka T, et al: Increased silent brain infarction accompanied with high prevalence of diabetes and dyslipidemia in psychiatric inpatients: A cross-sectional study. Prim Care Companion CNS Disord. 2015 Mar 26;2015 (Epub ahead of print). doi: 10.4088/PCC.14m01713. View Article : Google Scholar : PubMed/NCBI

38 

Quednow BB, Brzózka MM and Rossner MJ: Transcription factor 4 (TCF4) and schizophrenia: Integrating the animal and the human perspective. Cell Mol Life Sci. 71:2815–2835. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Rao BS, Tharigopala A, Rachapalli SR, Rajagopal R and Soumittra N: Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study. Indian J Ophthalmol. 65:931–935. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Sepp M, Vihma H, Nurm K, Urb M, Page SC, Roots K, Hark A, Maher BJ, Pruunsild P and Timmusk T: The intellectual disability and schizophrenia associated transcription factor TCF4 is regulated by neuronal activity and protein kinase A. J Neurosci. 37:10516–10527. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim JO, Lee KO, Kim HW, Park HS, Kim J, Sung JH, Oh D, Kim OJ and Kim NK: Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing. Mol Med Rep 21: 1973-1983, 2020.
APA
Kim, J.O., Lee, K.O., Kim, H.W., Park, H.S., Kim, J., Sung, J.H. ... Kim, N.K. (2020). Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing. Molecular Medicine Reports, 21, 1973-1983. https://doi.org/10.3892/mmr.2020.10975
MLA
Kim, J. O., Lee, K. O., Kim, H. W., Park, H. S., Kim, J., Sung, J. H., Oh, D., Kim, O. J., Kim, N. K."Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing". Molecular Medicine Reports 21.4 (2020): 1973-1983.
Chicago
Kim, J. O., Lee, K. O., Kim, H. W., Park, H. S., Kim, J., Sung, J. H., Oh, D., Kim, O. J., Kim, N. K."Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing". Molecular Medicine Reports 21, no. 4 (2020): 1973-1983. https://doi.org/10.3892/mmr.2020.10975
Copy and paste a formatted citation
x
Spandidos Publications style
Kim JO, Lee KO, Kim HW, Park HS, Kim J, Sung JH, Oh D, Kim OJ and Kim NK: Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing. Mol Med Rep 21: 1973-1983, 2020.
APA
Kim, J.O., Lee, K.O., Kim, H.W., Park, H.S., Kim, J., Sung, J.H. ... Kim, N.K. (2020). Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing. Molecular Medicine Reports, 21, 1973-1983. https://doi.org/10.3892/mmr.2020.10975
MLA
Kim, J. O., Lee, K. O., Kim, H. W., Park, H. S., Kim, J., Sung, J. H., Oh, D., Kim, O. J., Kim, N. K."Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing". Molecular Medicine Reports 21.4 (2020): 1973-1983.
Chicago
Kim, J. O., Lee, K. O., Kim, H. W., Park, H. S., Kim, J., Sung, J. H., Oh, D., Kim, O. J., Kim, N. K."Association between KCNQ2, TCF4 and RGS18 polymorphisms and silent brain infarction based on whole‑exome sequencing". Molecular Medicine Reports 21, no. 4 (2020): 1973-1983. https://doi.org/10.3892/mmr.2020.10975
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