Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review)

Wang,Zhiguang; Dong,Jianyu; Zhao,Qiaojiajie; Ying,Ying; Zhang,Lijie; Zou,Junrong; Zhao,Shuqi; Wang,Jiuju; Zhao,Yuan; Jiang,Shanshan

doi:10.3892/mmr.2020.11580

Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review)

Authors:
- Zhiguang Wang
- Jianyu Dong
- Qiaojiajie Zhao
- Ying Ying
- Lijie Zhang
- Junrong Zou
- Shuqi Zhao
- Jiuju Wang
- Yuan Zhao
- Shanshan Jiang
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Affiliations: Frontier Institute of Science and Technology, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, P.R. China, Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710000, P.R. China , Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University Medical College, Nanchang, Jiangxi 330006, P.R. China , Institute of Urology, The First Affiliated Hospital of Gan'nan Medical University, Ganzhou, Jiangxi 341001, P.R. China
Published online on: October 11, 2020 https://doi.org/10.3892/mmr.2020.11580
Pages: 4475-4484
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paclitaxel is a potent antineoplastic agent, but poor solubility and resistance have limited its use. Gold nanoparticles (AuNPs) are widely studied as drug carriers because they can be engineered to prevent drug insolubility, carry nucleic acid payloads for gene therapy, target specific tumor cell lines, modulate drug release and amplify photothermal therapy. Consequently, the conjugation of paclitaxel with AuNPs to improve antiproliferative and pro‑apoptotic potency may enable improved clinical outcomes. There are currently a number of different AuNPs under development, including simple drug or nucleic acid carriers and targeted AuNPs that are designed to deliver therapeutic payloads to specific cells. The current study reviewed previous research on AuNPs and the development of AuNP‑based paclitaxel delivery.

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