Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review)

World Health Organization (WHO), . Cancer. simplehttps://www.who.int/health-topics/cancer#tab=tab_1

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144:1941–1953. 2019. View Article : Google Scholar : PubMed/NCBI

Fidler MM, Bray F and Soerjomataram I: The global cancer burden and human development: A review. Scand J Public Health. 46:27–36. 2018. View Article : Google Scholar : PubMed/NCBI

Du X, Khan AR, Fu M, Ji J, Yu A and Zhai G: Current development in the formulations of non-injection administration of paclitaxel. Int J Pharm. 542:242–252. 2018. View Article : Google Scholar : PubMed/NCBI

Reshma PL, Unnikrishnan BS, Preethi GU, Syama HP, Archana MG, Remya K, Shiji R, Sreekutty J and Sreelekha TT: Overcoming drug-resistance in lung cancer cells by paclitaxel loaded galactoxyloglucan nanoparticles. Int J Biol Macromol. 136:266–274. 2019. View Article : Google Scholar : PubMed/NCBI

Nakamura F, Seino M, Suzuki Y, Sakaki H, Sudo T, Ohta T, Tsutsumi S and Nagase S: Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: A case report and review of the literature. J Med Case Rep. 13:3282019. View Article : Google Scholar : PubMed/NCBI

Lan YQ, Wu RP, Huang XB, Wang XL, Zhong DT, Huang CY and Song JT: Paclitaxel, oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in patients with recurrent or metastatic gastric cancer. Tumori. 104:22–29. 2018. View Article : Google Scholar : PubMed/NCBI

Sofias AM, Dunne M, Storm G and Allen C: The battle of ‘nano’ paclitaxel. Adv Drug Deliv Rev. 122:20–30. 2017. View Article : Google Scholar : PubMed/NCBI

Emami F, Banstola A, Vatanara A, Lee S, Kim JO, Jeong JH and Yook S: Doxorubicin and Anti-PD-L1 antibody conjugated gold nanoparticles for colorectal cancer photochemotherapy. Mol Pharm. 16:1184–1199. 2019. View Article : Google Scholar : PubMed/NCBI

Abdel-Rashid RS, Omar SM, Teiama MS, Khairy A, Magdy M and Anis B: Fabrication of gold nanoparticles in absence of surfactant as in vitro carrier of plasmid DNA. Int J Nanomed. 14:8399–8408. 2019. View Article : Google Scholar

Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW and Penn JS: Targeted imaging of VCAM-1 mRNA in a mouse model of laser-induced choroidal neovascularization using antisense hairpin-DNA-functionalized gold-nanoparticles. Mol Pharm. 15:5514–5520. 2018. View Article : Google Scholar : PubMed/NCBI

Chan KP, Chao SH and Kah JCY: Universal mRNA translation enhancement with gold nanoparticles conjugated to oligonucleotides with a Poly(T) sequence. ACS Appl Mater Interfaces. 10:5203–5212. 2018. View Article : Google Scholar : PubMed/NCBI

Cragg GM: Paclitaxel (Taxol): A success story with valuable lessons for natural product drug discovery and development. Med Res Rev. 18:315–331. 1998. View Article : Google Scholar : PubMed/NCBI

Khanna C, Rosenberg M and Vail DM: A review of paclitaxel and novel formulations including those suitable for use in dogs. J Vet Intern Med. 29:1006–1012. 2015. View Article : Google Scholar : PubMed/NCBI

Ettinger DS, Wood DE, Aggarwal C, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, et al: NCCN guidelines insights: Non-small cell lung cancer, version 1.2020. J Natl Compr Canc Netw. 17:1464–1472. 2019. View Article : Google Scholar : PubMed/NCBI

Goetz MP, Gradishar WJ, Anderson BO, Abraham J, Aft R, Allison KH, Blair SL, Burstein HJ, Dang C, Elias AD, et al: NCCN guidelines insights: Breast cancer, version 3.2018. J Natl Compr Canc Netw. 17:118–126. 2019. View Article : Google Scholar : PubMed/NCBI

Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, et al: NCCN guidelines insights: Colon cancer, version 2.2018. J Natl Compr Canc Netw. 16:359–369. 2018. View Article : Google Scholar : PubMed/NCBI

Ajani JA, D'Amico TA, Almhanna K, Bentrem DJ, Chao J, Das P, Denlinger CS, Fanta P, Farjah F, Fuchs CS, et al: Gastric Cancer, Version 3.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 14:1286–1312. 2016. View Article : Google Scholar : PubMed/NCBI

Zhu L and Chen L: Progress in research on paclitaxel and tumor immunotherapy. Cell Mol Biol Lett. 24:402019. View Article : Google Scholar : PubMed/NCBI

Spitz DR, Dornfeld KJ, Krishnan K and Giusthe D: Oxidative stress in cancer biology and therapy. Humana Press; 2012, View Article : Google Scholar

Hsiao JR, Leu SF and Huang BM: Apoptotic mechanism of paclitaxel-induced cell death in human head and neck tumor cell lines. J Oral Pathol Med. 38:188–197. 2009. View Article : Google Scholar : PubMed/NCBI

Honore S, Kamath K, Braguer D, Horwitz SB, Wilson L, Briand C and Jordan MA: Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res. 64:4957–4964. 2004. View Article : Google Scholar : PubMed/NCBI

Abu Samaan TM, Samec M, Liskova A, Kubatka P and Büsselberg D: Paclitaxel's mechanistic and clinical effects on breast cancer. Biomolecules. 9:7892019. View Article : Google Scholar

Ai B, Bie Z, Zhang S and Li A: Paclitaxel targets VEGF-mediated angiogenesis in ovarian cancer treatment. Am J Cancer Res. 6:1624–1635. 2016.PubMed/NCBI

Nakajima T, Elovaara E, Gonzalez FJ, Gelboin HV, Raunio H, Pelkonen O, Vainio H and Aoyama T: Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem Res Toxicol. 7:891–896. 1994. View Article : Google Scholar : PubMed/NCBI

van Eijk M, Boosman RJ, Schinkel AH, Huitema ADR and Beijnen JH: Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: Relevance for resistance to taxanes. Cancer Chemother Pharmacol. 84:487–499. 2019. View Article : Google Scholar : PubMed/NCBI

Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, Vogel V, Klaus B, Nadler W, Rösli C, et al: CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat Med. 22:278–287. 2016. View Article : Google Scholar : PubMed/NCBI

Němcová-Fürstová V, Kopperová D, Balušíková K, Ehrlichová M, Brynychová M, Václavíková R, Daniel P, Souček P and Kovář J: Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters. Toxicol Appl Pharmacol. 310:215–228. 2016. View Article : Google Scholar : PubMed/NCBI

Njiaju UO, Gamazon ER, Gorsic LK, Delaney SM, Wheeler HE, Im HK and Dolan ME: Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel. Pharmacogenet Genomics. 22:498–507. 2012. View Article : Google Scholar : PubMed/NCBI

Cao X, Hou J, An Q, Assaraf YG and Wang X: Towards the overcoming of anticancer drug resistance mediated by p53 mutations. Drug Resist Updat. 49:1006712019. View Article : Google Scholar : PubMed/NCBI

Xu JH, Hu SL, Shen GD and Shen G: Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy. Cancer Cell Int. 16:132016. View Article : Google Scholar : PubMed/NCBI

Boraschi D, Italiani P, Palomba R, Decuzzi P, Duschl A, Fadeel B and Moghimi SM: Nanoparticles and innate immunity: New perspectives on host defence. Semin Immunol. 34:33–51. 2017. View Article : Google Scholar : PubMed/NCBI

Primard C, Rochereau N, Luciani E, Genin C, Delair T, Paul S and Verrier B: Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells. Biomaterials. 31:6060–6068. 2010. View Article : Google Scholar : PubMed/NCBI

Ashour AE, Badran M, Kumar A, Hussain T, Alsarra IA and Yassin AEB: Physical PEGylation enhances the cytotoxicity of 5-fluorouracil-loaded PLGA and PCL nanoparticles. Int J Nanomedicine. 14:9259–9273. 2019. View Article : Google Scholar : PubMed/NCBI

Yang S and Gao H: Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy. Pharmacol Res. 126:97–108. 2017. View Article : Google Scholar : PubMed/NCBI

Wang Y, Xie Y, Li J, Peng ZH, Sheinin Y, Zhou J and Oupický D: Tumor-penetrating nanoparticles for enhanced anticancer activity of combined photodynamic and hypoxia-activated therapy. ACS Nano. 11:2227–2238. 2017. View Article : Google Scholar : PubMed/NCBI

Banstola A, Pham TT, Jeong JH and Yook S: Polydopamine-tailored paclitaxel-loaded polymeric microspheres with adhered NIR-controllable gold nanoparticles for chemo-phototherapy of pancreatic cancer. Drug Deliv. 26:629–640. 2019. View Article : Google Scholar : PubMed/NCBI

Zhao L, Bi D, Qi X, Guo Y, Yue F, Wang X and Han M: Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy. Nanotechnology. 30:2551012019. View Article : Google Scholar : PubMed/NCBI

Li W, Cao Z, Liu R, Liu L, Li H, Li X, Chen Y, Lu C and Liu Y: AuNPs as an important inorganic nanoparticle applied in drug carrier systems. Artif Cells Nanomed Biotech. 47:4222–4233. 2019. View Article : Google Scholar

Das P, Fatehbasharzad P, Colombo M, Fiandra L and Prosperi D: Multifunctional magnetic gold nanomaterials for cancer. Trends Biotech. 37:995–1010. 2019. View Article : Google Scholar

Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE and Tamarkin L: Colloidal gold: A novel nanoparticle vector for tumor directed drug delivery. Drug Deliv. 11:169–183. 2004. View Article : Google Scholar : PubMed/NCBI

Hale SJM, Perrins RD, Garci A CE, Pace A, Peral U, Patel KR, Robinson A, Williams P, Ding Y, Saito G, et al: DM1 loaded ultrasmall gold nanoparticles display significant efficacy and improved tolerability in murine models of hepatocellular carcinoma. Bioconjug Chem. 30:703–713. 2019. View Article : Google Scholar : PubMed/NCBI

Govindaraju S, Roshini A, Lee MH and Yun K: Kaempferol conjugated gold nanoclusters enabled efficient for anticancer therapeutics to A549 lung cancer cells. Int J Nanomedicine. 14:5147–5157. 2019. View Article : Google Scholar : PubMed/NCBI

Zhang X, Liu Y, Luo L, Li L, Xing S, Yin T, Bian K, Zhu R and Gao D: A chemo-photothermal synergetic antitumor drug delivery system: Gold nanoshell coated wedelolactone liposome. Mater Sci Eng C Mater Biol Appl. 101:505–512. 2019. View Article : Google Scholar : PubMed/NCBI

Tortiglione C and de la Fuente JM: Synthesis of gold nanoparticles for gene silencing. Methods Mol Biol. 1974:203–214. 2019. View Article : Google Scholar : PubMed/NCBI

Wang J, Thomas M, Lin P, Cheng JX, Matei DE and Wei A: siRNA delivery using dithiocarbamate-anchored oligonucleotides on gold nanorods. Bioconjug Chem. 30:443–453. 2019. View Article : Google Scholar : PubMed/NCBI

Ye W, Li H, Li X, Fan X, Jin Q and Ji J: mRNA guided intracellular self-assembly of DNA-gold nanoparticle conjugates as a precise trigger to up-regulate cell apoptosis and activate photothermal therapy. Bioconjug Chem. 30:1763–1772. 2019. View Article : Google Scholar : PubMed/NCBI

Talamantez-Lyburn S, Brown P, Hondrogiannis N, Ratliff J, Wicks SL, Nana N, Zheng Z, Rosenzweig Z, Hondrogiannis E, Devadas MS and Ehrlich ES: Gold nanoparticles loaded with cullin-5 DNA increase sensitivity to 17-AAG in cullin-5 deficient breast cancer cells. Int J of Pharm. 564:281–292. 2019. View Article : Google Scholar

Liu B, Cao W, Qiao G, Yao S, Pan S, Wang L, Yue C, Ma L, Liu Y and Cui D: Effects of gold nanoprism-assisted human PD-L1 siRNA on both gene down-regulation and photothermal therapy on lung cancer. Acta Biomater. 99:307–319. 2019. View Article : Google Scholar : PubMed/NCBI

Sukumar UK, Bose RJC, Malhotra M, Babikir HA, Afjei R, Robinson E, Zeng Y, Chang E, Habte F, Sinclair R, et al: Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide. Biomaterials. 218:1193422019. View Article : Google Scholar : PubMed/NCBI

Zhang J, Zhao T, Han F, Hu Y and Li Y: Photothermal and gene therapy combined with immunotherapy to gastric cancer by the gold nanoshell-based system. J Nanobiotechnology. 17:802019. View Article : Google Scholar : PubMed/NCBI

Chen X, Han W, Zhao XAO, Tang W and Wang F: Epirubicin-loaded marine carrageenan oligosaccharide capped gold nanoparticle system for pH-triggered anticancer drug release. Sci Rep. 9:67542019. View Article : Google Scholar : PubMed/NCBI

Pedrosa P, Corvo ML, Margarida FS, Martins P, Carvalheiro MC, Costa PM, Martins C, Martins LMDRS, Baptista PV and Fernandes AR: Targeting cancer resistance via multifunctional gold nanoparticles. Int J Mol Sci. 20:55102019. View Article : Google Scholar

Cryer AM, Chan C, Eftychidou A, Maksoudian C, Mahesh M, Tetley TD, Spivey AC and Thorley AJ: Tyrosine kinase inhibitor gold nanoconjugates for the treatment of non-small cell lung cancer. ACS App Mat Interfaces. 11:16336–16346. 2019. View Article : Google Scholar

Zhang H, Cui W, Qu X, Wu H, Qu L, Zhang X, Mäkilä E, Salonen J, Zhu Y, Yang Z, et al: Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression. Proc Nat Acad Sci USA. 116:7744–7749. 2019. View Article : Google Scholar : PubMed/NCBI

Paris JL, Villaverde G, Gómez-Graña S and Vallet-Regí M: Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy. Acta Biomater. 101:459–468. 2020. View Article : Google Scholar : PubMed/NCBI

Gasparri AM, Sacch A, Basso V, Cortesi F, Freschi M, Rrapaj E, Bellone M, Casorati G, Dellabona P, Mondino A, et al: Boosting interleukin-12 antitumor activity and synergism with immunotherapy by targeted delivery with isoDGR-tagged nanogold. Small. 15:e19034622019. View Article : Google Scholar : PubMed/NCBI

Barman S, Das G, Gupta V, Mondal P, Jana B, Bhunia D, Khan J, Mukherjee D and Ghos S: Dual-arm nanocapsule targets neuropilin-1 receptor and microtubule: A potential nanomedicine platform. Mol Pharm. 16:2522–2531. 2019. View Article : Google Scholar : PubMed/NCBI

Cruz E and Kayser V: Synthesis and enhanced cellular uptake in vitro of Anti-HER2 multifunctional gold nanoparticles. Cancers (Basel). 11:8702019. View Article : Google Scholar

Groysbeck N, Stoessel A, Donzeau M, da Silva EC, Lehmann M, Strub JM, Cianferani S, Dembélé K and Zuber G: Synthesis and biological evaluation of 2.4 nm thiolate-protected gold nanoparticles conjugated to Cetuximab for targeting glioblastoma cancer cells via the EGFR. Nanotechnology. 30:184005. 2019. View Article : Google Scholar : PubMed/NCBI

Yi Y, Kim HJ, Zheng M, Mi P, Naito M, Kim BS, Min HS, Hayash K, Perche F, Toh K, et al: Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J Control Release. 295:268–277. 2019. View Article : Google Scholar : PubMed/NCBI

Lee YJ, Song K, Cha SH, Cho S, Kim YS and Park Y: Sesquiterpenoids from Tussilago farfara flower bud extract for the eco-friendly synthesis of silver and gold nanoparticles possessing antibacterial and anticancer activities. Nanomaterials (Basel). 9:8192019. View Article : Google Scholar

Boomi P, Ganesan RM, Poorani G, Gurumallesh Prabu H, Ravikumar S and Jeyakanthan J: Biological synergy of greener gold nanoparticles by using Coleus aromaticus leaf extract. Mater Sci Eng C Mater Biol Appl. 99:202–210. 2019. View Article : Google Scholar : PubMed/NCBI

Vijayan R, Joseph S and Mathew B: Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties. Artif Cells Nanomed Biotechnol. 46:861–871. 2018. View Article : Google Scholar : PubMed/NCBI

Aljabali AAA, Akkam Y, Al Zoubi MS, Al-Batayneh KM, Al-Trad B, Abo Alrob O, Alkilany AM, Benamara M and Evans DJ: Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity. Nanomaterials (Basel). 8:1742018. View Article : Google Scholar

Xu L, Li W, Shi Q, Li H, Yang Z, Liao D, Li L, Yang X and Zhang J: Synthesis of mulberry leaf extract mediated gold nanoparticles and their ameliorative effect on Aluminium intoxicated and diabetic retinopathy in rats during perinatal life. J Photochem Photobiol B. 196:1115022019. View Article : Google Scholar : PubMed/NCBI

Ke Y, Al Aboody MS, Alturaiki W, Alsagaby SA, Alfaiz FA, Veeraraghavan VP and Mickymaray S: Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa). Artif Cells Nanomed Biotechnol. 47:1938–1946. 2019. View Article : Google Scholar : PubMed/NCBI

Vijayan R, Joseph S and Mathew B: Anticancer, antimicrobial, antioxidant, and catalytic activities of green-synthesized silver and gold nanoparticles using Bauhinia purpurea leaf extract. Bioprocess Biosyst Eng. 42:305–319. 2019. View Article : Google Scholar : PubMed/NCBI

Bao QY, Zhang N, Geng DD, Xue GW, Merritt M, Zhang C and Ding Y: The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating paclitaxel-conjugated gold nanoparticles. Int J Pharm. 477:408–415. 2014. View Article : Google Scholar : PubMed/NCBI

Ding Y, Zhou YY, Chen H, Geng DD, Wu DY, Hong J, Shen WB, Hang TG and Zhang C: The performance of thiol-terminated PEG-paclitaxel-conjugated gold nanoparticles. Biomaterials. 34:10217–10227. 2013. View Article : Google Scholar : PubMed/NCBI

Gibson JD, Khanal BP and Zubarev ER: Paclitaxel-functionalized gold nanoparticles. J Am Chem Soc. 129:11653–11661. 2007. View Article : Google Scholar : PubMed/NCBI

Vemuri SK, Banala RR, Mukherjee S, Uppula P, Gpv S, A V GR and T M: Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies. Mater Sci Eng C Mater Biol Appl. 99:417–429. 2019. View Article : Google Scholar : PubMed/NCBI

Li F, Zhou XF, Zhou HY, Jia JB, Li LW, Zhai SM and Yan B: Reducing both Pgp overexpression and drug efflux with anti-cancer gold-paclitaxel nanoconjugates. PLoS One. 11:e01600422016. View Article : Google Scholar : PubMed/NCBI

Zhong J, Yang S, Wen L and Xing D: Imaging-guided photoacoustic drug release and synergistic chemo-photoacoustic therapy with paclitaxel-containing nanoparticles. J Control Release. 226:77–87. 2016. View Article : Google Scholar : PubMed/NCBI

Farboudi A, Nouri A, Shirinzad S, Sojoudi P, Davaran S, Akrami M and Irani M: Synthesis of magnetic gold coated poly (epsilon-caprolactonediol) based polyurethane/poly(N-isopropylacrylamide)-grafted-chitosan core-shell nanofibers for controlled release of paclitaxel and 5-FU. Int J Biol Macromol. 150:1130–1140. 2020. View Article : Google Scholar : PubMed/NCBI

Heo DN, Yang DH, Moon HJ, Lee JB, Bae MS, Lee SC, Lee WJ, Sun IC and Kwon IK: Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy. Biomaterial. 33:856–866. 2012. View Article : Google Scholar

Paciotti GF, Zhao JL, Cao SG, Brodie PG, Tamarkin L, Huhta M, Myer LD, Friedman J and Kingston DG: Synthesis and evaluation of paclitaxel-loaded gold nanoparticles for tumor-targeted drug delivery. Bioconjug Chem. 27:2646–2657. 2016. View Article : Google Scholar : PubMed/NCBI

Liaskoni A, Angelopoulou A, Voulgari E, Popescu MT, Tsitsilianis C and Avgoustakis K: Paclitaxel controlled delivery using a pH-responsive functional-AuNP/block-copolymer vesicular nanocarrier composite system. Eur J Pharm Sci. 117:177–186. 2018. View Article : Google Scholar : PubMed/NCBI

Manivasagan P, Bharathiraja S, Bui NQ, Lim IG and Oh JH: Paclitaxel-loaded chitosan oligosaccharide-stabilized gold nanoparticles as novel agents for drug delivery and photoacoustic imaging of cancer cells. Int J Pharm. 511:367–379. 2016. View Article : Google Scholar : PubMed/NCBI

Peralta DV, Heidari Z, Dash S and Tarr MA: Hybrid paclitaxel and gold nanorod-loaded human serum albumin nanoparticles for simultaneous chemotherapeutic and photothermal therapy on 4T1 breast cancer cells. ACS Appl Mater Interfaces. 7:7101–7111. 2015. View Article : Google Scholar : PubMed/NCBI

Gupta S, Stafford RJ, Javadi S, Ozkan E, Ensor JE, Wright KC, Elliot AM, Jian Y, Serda RE, Dixon KA, et al: Effects of near-infrared laser irradiation of biodegradable microspheres containing hollow gold nanospheres and paclitaxel administered intraarterially in a rabbit liver tumor model. J Vasc Interv Radiol. 23:553–561. 2012. View Article : Google Scholar : PubMed/NCBI

Zhu HY, Han WL, Gan Y, Li QF, Li XL, Shao LL, Zhu D and Guo HW: Combined modality therapy based on hybrid gold nanostars coated with temperature sensitive liposomes to overcome paclitaxel-resistance in hepatic carcinoma. Pharmaceutics. 11:6832019. View Article : Google Scholar

England CG, Miller MC, Kuttan A, Trent JO and Frieboes HB: Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles. Eur J Pharm Biopharm. 92:120–129. 2015. View Article : Google Scholar : PubMed/NCBI

Pandey PC, Pandey G and Narayan RJ: Polyethylenimine-mediated synthetic insertion of gold nanoparticles into mesoporous silica nanoparticles for drug loading and biocatalysis. Biointerphases. 12:0110052017. View Article : Google Scholar : PubMed/NCBI

Wang Q, Zhang X, Sun Y, Wang L, Ding L, Zhu WH, Di W and Duan YR: Gold-caged copolymer nanoparticles as multimodal synergistic photodynamic/photothermal/chemotherapy platform against lethality androgen-resistant prostate cancer. Biomaterials. 212:73–86. 2019. View Article : Google Scholar : PubMed/NCBI

Yahyaei B and Pourali P: One step conjugation of some chemotherapeutic drugs to the biologically produced gold nanoparticles and assessment of their anticancer effects. Sci Rep. 9:102422019. View Article : Google Scholar : PubMed/NCBI

Wu J, Liu Y, Tang YX, Wang SJ, Wang CY, Li YJ, Su XD, Tian JH, Tian Y, Pan J, et al: Synergistic chemo-photothermal therapy of breast cancer by mesenchymal stem cell-encapsulated yolk-shell GNR@HPMO-PTX nanospheres. ACS Appl Mater Interfaces. 8:17927–17935. 2016. View Article : Google Scholar : PubMed/NCBI

You J, Wang Z, Du Y, Yuan H, Zhang P, Zhou J, Liu F, Li C and Hu F: Specific tumor delivery of paclitaxel using glycolipid-like polymer micelles containing gold nanospheres. Biomaterials. 34:4510–4519. 2013. View Article : Google Scholar : PubMed/NCBI

Pardridge WM: The blood-brain barrier, bottleneck in brain drug development. NeuroRx. 2:3–14. 2005. View Article : Google Scholar : PubMed/NCBI

Sonavane G, Tomoda K and Makino K: Biodistribution of colloidal gold nanoparticles after intravenous administration, effect of particle size. Colloids Surf B Biointerfaces. 66:274–280. 2008. View Article : Google Scholar : PubMed/NCBI

Khongkow M, Yata T, Boonrungsiman S, Ruktanonchai UR, Graham D and Namdee K: Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood-brain barrier penetration. Sci Rep. 9:82782019. View Article : Google Scholar : PubMed/NCBI

Zhang Y, Walker JB, Minic Z, Liu F, Goshgarian H and Mao G: Transporter protein and drug-conjugated gold nanoparticles capable of bypassing the blood-brain barrier. Sci Rep. 6:257942016. View Article : Google Scholar : PubMed/NCBI

Singh N, Nayak J, Sahoo SK and Kumar R: Glutathione conjugated superparamagnetic Fe₃O₄-Au core shell nanoparticles for pH controlled release of DOX. Mater Sci Eng C Mater Biol App. 100:453–465. 2019. View Article : Google Scholar

Gao W, Xu K, Ji L and Tang B: Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation and apoptosis in HL7702 cells. Toxicol Lett. 205:86–95. 2011. View Article : Google Scholar : PubMed/NCBI

Coradeghini R, Gioria S, García CP, Nativo P, Franchini F, Gilliland D, Ponti J and Rossi F: Size-dependent toxicity and cell interaction mechanisms of gold nanoparticles on mouse fibroblasts. Toxicol Lett. 217:205–216. 2013. View Article : Google Scholar : PubMed/NCBI

Favi PM, Gao M, Johana Sepúlveda Arango L, Ospina SP, Morales M, Pavon JJ and Webster TJ: Shape and surface effects on the cytotoxicity of nanoparticles: Gold nanospheres versus gold nanostars. J Biomed Mater Res A. 103:3449–3462. 2015. View Article : Google Scholar : PubMed/NCBI

Feng ZV, Gunsolus IL, Qiu TA, Hurley KR, Nyberg LH, Frew H, Johnson KP, Vartanian AM, Jacob LM, Lohse SE, et al: Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria. Chem Sci. 6:5186–5196. 2015. View Article : Google Scholar : PubMed/NCBI

Gorain B, Choudhury H, Pandey M and Kesharwani P: Paclitaxel loaded vitamin E-TPGS nanoparticles for cancer therapy. Mater Sci Eng C Mater Biol Appl. 91:868–880. 2018. View Article : Google Scholar : PubMed/NCBI

Kundranda MN and Niu J: Albumin-bound paclitaxel in solid tumors: Clinical development and future directions. Drug Des Devel Ther. 9:3767–3777. 2015. View Article : Google Scholar : PubMed/NCBI