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Review Open Access

Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review)

  • Authors:
    • Tao Wei
    • Hongshu Sui
    • Yanping Su
    • Wanjing Cheng
    • Yunhua Liu
    • Zilin He
    • Qingchao Ji
    • Changlong Xu
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, Shandong 271000, P.R. China, Reproductive Medical Center, Nanning Second People's Hospital, Nanning, Guangxi Zhuang Autonomous Region 530031, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4992-5002
    |
    Published online on: October 16, 2020
       https://doi.org/10.3892/mmr.2020.11607
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Abstract

Cystic fibrosis (CF) is a chronic disease causing severe impairment to the respiratory system and digestive tracts. Currently, CF is incurable. As an autosomal recessive disorder, the morbidity of CF is significantly higher among Caucasians of European descent, whereas it is less pervasive among African and Asian populations. The disease is caused by identical mutations (homozygosity) or different mutations (heterozygosity) of an autosomal recessive mutation at position 7q31.2‑q31.1 of chromosome 7. Diagnostic criteria and guidelines work concurrently with laboratory detection to facilitate precise CF detection. With technological advances, the understanding of CF pathogenesis has reached an unprecedented level, allowing for increasingly precise carrier screening, more effective early stage CF intervention and improved prognostic outcomes. These advances significantly increase the life quality and expectancy of patients with CF. Given the numerous improvements in the field of CF, the current review summarized the technical advances in the study of the molecular mechanisms underlying CF, as well as how these improvements facilitate the clinical outcomes of CF. Furthermore, challenges and obstacles to overcome are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Wei T, Sui H, Su Y, Cheng W, Liu Y, He Z, Ji Q and Xu C: Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review). Mol Med Rep 22: 4992-5002, 2020.
APA
Wei, T., Sui, H., Su, Y., Cheng, W., Liu, Y., He, Z. ... Xu, C. (2020). Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review). Molecular Medicine Reports, 22, 4992-5002. https://doi.org/10.3892/mmr.2020.11607
MLA
Wei, T., Sui, H., Su, Y., Cheng, W., Liu, Y., He, Z., Ji, Q., Xu, C."Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review)". Molecular Medicine Reports 22.6 (2020): 4992-5002.
Chicago
Wei, T., Sui, H., Su, Y., Cheng, W., Liu, Y., He, Z., Ji, Q., Xu, C."Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review)". Molecular Medicine Reports 22, no. 6 (2020): 4992-5002. https://doi.org/10.3892/mmr.2020.11607
Copy and paste a formatted citation
x
Spandidos Publications style
Wei T, Sui H, Su Y, Cheng W, Liu Y, He Z, Ji Q and Xu C: Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review). Mol Med Rep 22: 4992-5002, 2020.
APA
Wei, T., Sui, H., Su, Y., Cheng, W., Liu, Y., He, Z. ... Xu, C. (2020). Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review). Molecular Medicine Reports, 22, 4992-5002. https://doi.org/10.3892/mmr.2020.11607
MLA
Wei, T., Sui, H., Su, Y., Cheng, W., Liu, Y., He, Z., Ji, Q., Xu, C."Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review)". Molecular Medicine Reports 22.6 (2020): 4992-5002.
Chicago
Wei, T., Sui, H., Su, Y., Cheng, W., Liu, Y., He, Z., Ji, Q., Xu, C."Research advances in molecular mechanisms underlying the pathogenesis of cystic fibrosis: From technical improvement to clinical applications (Review)". Molecular Medicine Reports 22, no. 6 (2020): 4992-5002. https://doi.org/10.3892/mmr.2020.11607
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