Open Access

Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)

  • Authors:
    • Wei Yang
    • Jianhui Huang
    • Hui Wu
    • Yuqing Wang
    • Zhiyin Du
    • Yuanbo Ling
    • Weizhuo Wang
    • Qian Wu
    • Wenbin Gao
  • View Affiliations

  • Published online on: October 16, 2020     https://doi.org/10.3892/mmr.2020.11608
  • Pages: 4967-4980
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Muscle atrophy is a severe clinical problem involving the loss of muscle mass and strength that frequently accompanies the development of numerous types of cancer, including pancreatic, lung and gastric cancers. Cancer cachexia is a multifactorial syndrome characterized by a continuous decline in skeletal muscle mass that cannot be reversed by conventional nutritional therapy. The pathophysiological characteristic of cancer cachexia is a negative protein and energy balance caused by a combination of factors, including reduced food intake and metabolic abnormalities. Numerous necessary cellular processes are disrupted by the presence of abnormal metabolites, which mediate several intracellular signaling pathways and result in the net loss of cytoplasm and organelles in atrophic skeletal muscle during various states of cancer cachexia. Currently, the clinical morbidity and mortality rates of patients with cancer cachexia are high. Once a patient enters the cachexia phase, the consequences are difficult to reverse and the treatment methods for cancer cachexia are very limited. The present review aimed to summarize the recent discoveries regarding the pathogenesis of cancer cachexia‑induced muscle atrophy and provided novel ideas for the comprehensive treatment to improve the prognosis of affected patients.
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December-2020
Volume 22 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yang W, Huang J, Wu H, Wang Y, Du Z, Ling Y, Wang W, Wu Q and Gao W: Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review). Mol Med Rep 22: 4967-4980, 2020
APA
Yang, W., Huang, J., Wu, H., Wang, Y., Du, Z., Ling, Y. ... Gao, W. (2020). Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review). Molecular Medicine Reports, 22, 4967-4980. https://doi.org/10.3892/mmr.2020.11608
MLA
Yang, W., Huang, J., Wu, H., Wang, Y., Du, Z., Ling, Y., Wang, W., Wu, Q., Gao, W."Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)". Molecular Medicine Reports 22.6 (2020): 4967-4980.
Chicago
Yang, W., Huang, J., Wu, H., Wang, Y., Du, Z., Ling, Y., Wang, W., Wu, Q., Gao, W."Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)". Molecular Medicine Reports 22, no. 6 (2020): 4967-4980. https://doi.org/10.3892/mmr.2020.11608