[Corrigendum] Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte‑like cells in dimethylnitrosamine‑induced liver cirrhosis in mice

Xiang,Yan; Pang,Bing-Yao; Zhang,Yuan; Xie,Qiao-Ling; Zhu,Ying; Leng,Ai-Jing; Lu,Long-Qing; Chen,Hai-Long

doi:10.3892/mmr.2021.12448

November-2021 Volume 24 Issue 5

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Correction Open Access

[Corrigendum] Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte‑like cells in dimethylnitrosamine‑induced liver cirrhosis in mice

Authors:
- Yan Xiang
- Bing-Yao Pang
- Yuan Zhang
- Qiao-Ling Xie
- Ying Zhu
- Ai-Jing Leng
- Long-Qing Lu
- Hai-Long Chen
View Affiliations / Copyright

Affiliations: Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China

Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 808
|
Published online on: September 17, 2021

https://doi.org/10.3892/mmr.2021.12448
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Mol Med Rep 15: [Related article:] 613-626, 2017; DOI: 10.3892/mmr.2016.6083

Following the publication of the above article, an interested reader to the authors’ attention that there appeared to be several duplications of data panels featured within Fig. 1,Fig. 2,Fig. 3. After having consulted their original data, the authors have realized that a number of the data panels were inadvertently assembled incorrectly in these figures.

Figure 1.

Comparison of liver histology in mice with DMN-induced liver cirrhosis. Mice were injected with DMN or normal saline for 4 weeks. Following 4 weeks of DMN treatment, mice were subsequently treated with YGD or HGF for a further 4 weeks. Liver tissues were stained with (A) hematoxylin and eosin and (B) Masson's trichrome. Liver damage induced by DMN was alleviated by YGD or HGF treatment. Magnification, ×100; scale bar=200 µm. YGD, Yi Guan Jian decoction; HGF, hepatocyte growth factor; DMN, dimethylnitrosamine; C, control; M, model; NC, negative control; W, week.

Figure 2.

DMN and YGD regulate the differentiation of BMSCs into hepatocytes and biliary epithelial cells. Mice were injected with DMN or normal saline for 4 weeks. Following 4 weeks of DMN treatment, mice were treated with YGD or HGF for a further 4 weeks. (A) The expression of CD90 (green, top row) and Alb (red, middle row) was detected by immunofluorescence, with the co-localization analyzed by merging these images (bottom row). (B) The expression of CD90 (green, top row) and CK18 (red, middle row) was detected by immunofluorescence, with the co-localization analyzed by merging these images (bottom row). Expression and co-localization was increased by DMN injection and further increased by YGD treatment. Magnification, ×60. YGD, Yi Guan Jian decoction; HGF, hepatocyte growth factor; DMN, dimethylnitrosamine; CD, cluster of differentiation; Alb, Albumin; CK18, cytokeratin 18; C, control; M, model; W, week.

Figure 3.

DMN, YGD and HGF regulate the expression of α-SMA, CXCR4, ERK1/2, NF-κB p65 and β-catenin. Mice were injected with DMN or normal saline for 4 weeks. Following 4 weeks of DMN treatment, mice were treated with YGD or HGF for a further 4 weeks. Liver sections were stained for (A) α-SMA (B) CXCR4. (C) ERK1/2.

The corrected versions of Fig. 1A (showing the correct data for the NC-2W and NC-4W experiments), Fig. 1B (including the correct data for the C-4W, M-2W, NC-2W and NC-4W experiments), Fig. 2 (showing the correct data for the YGD-2W experiment), Fig. 3A (NC-3W data panel corrected), Fig. 3B (HGF-1W and NC-3W data panels corrected) and Fig. 3C (C-4W data panel corrected) are shown on the next four pages. All these corrections were approved by all authors. The authors regret that these errors were not resolved before the publication of the paper, thank the Editor of Molecular Medicine Reports for granting them the opportunity to publish this corrigendum, and apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte‑like cells in dimethylnitrosamine‑induced liver cirrhosis in mice

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