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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2021 Volume 24 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 825
Published online on: 24 September 2021

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Article Open Access

Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis

Wenjing Fei, Wei Jiao, Xiaoyan Feng, Xufeng Chen, Yuhai Wang
Article Number: 824
Published online on: 24 September 2021

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Article Open Access

PPARγ attenuates hepatic inflammation and oxidative stress of non‑alcoholic steatohepatitis via modulating the miR‑21‑5p/SFRP5 pathway

Xiying Zhang, Fang Deng, Yuping Zhang, Xiaohong Zhang, Jianfei Chen, Youzhao Jiang
Article Number: 823
Published online on: 24 September 2021

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Article Open Access

Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells

Xiaohong Ni, Yongjiang Feng, Xiangwei Fu
Article Number: 822
Published online on: 24 September 2021

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Article Open Access

Ginsenoside Rk1 protects human melanocytes from H2O2‑induced oxidative injury via regulation of the PI3K/AKT/Nrf2/HO‑1 pathway

Jian Xiong, Jianing Yang, Kai Yan, Jing Guo
Article Number: 821
Published online on: 24 September 2021

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Article Open Access

Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2

Yujing Huang, Ying Liu, Jing Huang, Lu Gao, Zhenggang Wu, Lu Wang, Lin Fan
Article Number: 820
Published online on: 24 September 2021

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Article Open Access

HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation

Jinhai Chang, Xuguang Hu, Jinniang Nan, Xianghua Zhang, Xintian Jin
Article Number: 819
Published online on: 22 September 2021

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Article Open Access

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Shuang Zhang, Sihan Lin, Qiaofei Tang, Zhiyong Yan
Article Number: 818
Published online on: 22 September 2021

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Article Open Access

NUAK2 silencing inhibits the proliferation, migration and epithelial‑to‑mesenchymal transition of cervical cancer cells via upregulating CYFIP2

Yuxia Li, Xiaohui Song, Liping Liu, Lei Yue
Article Number: 817
Published online on: 22 September 2021

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Retraction Open Access

[Retracted] Downregulation of caspase‑3 alleviates Mycoplasma pneumoniae‑induced apoptosis in alveolar epithelial cells

Shan Shi, Xiaolei Liu, Haibo Li
Article Number: 816
Published online on: 22 September 2021

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Article Open Access

Exosomes in serum‑free cultures of THP‑1 macrophages infected with Mycobacterium tuberculosis

Fantahun Biadglegne, Phil Rademacher, Yarúa Gabriela Jaimes De Sulbaran, Brigitte König, Arne C. Rodloff, Ulrike Zedler, Anca Dorhoi, Ulrich Sack
Article Number: 815
Published online on: 22 September 2021

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Article Open Access

NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells

Weidang Xie, Wei Huang, Shumin Cai, Hui Chen, Weijun Fu, Zhongqing Chen, Yanan Liu
Article Number: 814
Published online on: 22 September 2021

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Article Open Access

Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen

Jianxiong Wu, Hongjun Zhang, Rulin Deng, Lifeng Xing, Mingwu Hu, Xiaoling Fu
Article Number: 813
Published online on: 20 September 2021

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Article Open Access

miR‑125a‑5p reverses epithelial‑mesenchymal transition and restores drug sensitivity by negatively regulating TAFAZZIN signaling in breast cancer

Dongmei Li, Limei Chen, Xiaofang Zhang, Yanhua Wang, Chuansheng Huang, Jianglong Li, Feilong He, Wenxing He
Article Number: 812
Published online on: 20 September 2021

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Article Open Access

Silencing circ‑BIRC6 inhibits the proliferation, invasion, migration and epithelial‑mesenchymal transition of bladder cancer cells by targeting the miR‑495‑3p/XBP1 signaling axis

Lei Zhou, Bingzhi Wang, Yichuan Zhang, Kun Yao, Bin Liu
Article Number: 811
Published online on: 20 September 2021

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Retraction Open Access

[Retracted] MicroRNA‑338‑3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo

Xinyu Li, Zhihong Li, Guiyun Yang, Zhenxiang Pan
Article Number: 810
Published online on: 20 September 2021

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Correction Open Access

[Corrigendum] FOXO3a‑mediated suppression of the self‑renewal capacity of sphere‑forming cells derived from the ovarian cancer SKOV3 cell line by 7‑difluoromethoxyl‑5,4’‑di‑n‑octyl genistein

Yingxia Ning, Chaoyuan Luo, Kaiqun Ren, Meifang Quan, Jianguo Cao
Article Number: 809
Published online on: 17 September 2021

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Correction Open Access

[Corrigendum] Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte‑like cells in dimethylnitrosamine‑induced liver cirrhosis in mice

Yan Xiang, Bing-Yao Pang, Yuan Zhang, Qiao-Ling Xie, Ying Zhu, Ai-Jing Leng, Long-Qing Lu, Hai-Long Chen
Article Number: 808
Published online on: 17 September 2021

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Article

JMJD3 deficiency alleviates lipopolysaccharide‑induced acute lung injury by inhibiting alveolar epithelial ferroptosis in a Nrf2‑dependent manner

Junwei Peng, Bin Fan, Chuanming Bao, Chen Jing
Article Number: 807
Published online on: 17 September 2021

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Article Open Access

Upregulation of miR‑335 exerts protective effects against sepsis‑induced myocardial injury

Xian Long, Yongpan Huang, Jianbin He, Xiang Zhang, Yan Zhou, Yingmin Wei, Ying Tang, Lijing Liu
Article Number: 806
Published online on: 17 September 2021

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Article Open Access

Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy

Xueyi Zhu, Yuxue Cao, Mingyue Su, Mengmeng Chen, Congcong Li, La Yi, Jingjing Qin, Wuniqiemu Tulake, Fangzhou Teng, Yuanyuan Zhong, Weifeng Tang, Shiyuan Wang, Jingcheng Dong
Article Number: 805
Published online on: 17 September 2021

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Correction Open Access

[Corrigendum] Murine and Chinese cobra venom‑derived nerve growth factor stimulate chondrogenic differentiation of BMSCs in vitro: A comparative study

Zhikang Miao, Zhenhui Lu, Shixing Luo, Danqing Lei, Yi He, Huayu Wu, Jinmin Zhao, Li Zheng
Article Number: 804
Published online on: 16 September 2021

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Article

Novel compound heterozygous mutations in CYP1B1 identified in a Chinese family with developmental glaucoma

Suping Cai, Daren Zhang, Xiaodong Jiao, Tingting Wang, Mengjie Fan, Yun Wang, James Fielding Hejtmancik, Xuyang Liu
Article Number: 803
Published online on: 15 September 2021

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Article Open Access

Triamcinolone acetonide modulates TGF‑β2‑induced angiogenic and tissue‑remodeling effects in cultured human retinal pigment epithelial cells

Chih-Cheng Hsiao, Yo-Chen Chang, Yu-Ting Hsiao, Po-Han Chen, Ming-Chu Hsieh, Wen-Chuan Wu, Ying-Hsien Kao
Article Number: 802
Published online on: 14 September 2021

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Article Open Access

Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice

Yan Li, Duoduo Zhang, Lan Li, Yuli Han, Xianan Dong, Liu Yang, Xuewang Li, Weizu Li, Weiping Li
Article Number: 801
Published online on: 14 September 2021

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Article Open Access

PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer

Rujun Chen, Chan Sheng, Ruyue Ma, Liwen Zhang, Lina Yang, Yaping Chen
Article Number: 800
Published online on: 14 September 2021

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Article Open Access

α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway

Jiang Tao Zhou, Kai Da Ren, Jing Hou, Jie Chen, Guan'e Yang
Article Number: 799
Published online on: 14 September 2021

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Article Open Access

Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR‑331‑3p/TGF‑βR1 axis in pre‑eclampsia

Li Shan, Xiaofei Hou
Article Number: 798
Published online on: 14 September 2021

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Article Open Access

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells

Ying Xie, Ran Chen, Liujia Yan, Zhangjun Jia, Guangshu Liang, Qin Wang
Article Number: 797
Published online on: 14 September 2021

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Article Open Access

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway

Cheng Qian, Qiang Liu
Article Number: 796
Published online on: 13 September 2021

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Article Open Access

Exosomal‑miR‑1184 derived from mesenchymal stem cells alleviates cisplatin‑associated acute kidney injury Corrigendum in /10.3892/mmr.2022.12757

Jinshi Zhang, Wenfang He, Danna Zheng, Qiang He, Mingming Tan, Juan Jin
Article Number: 795
Published online on: 13 September 2021

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Article

Knockdown of lncRNA PVT1 inhibits the proliferation and accelerates the apoptosis of colorectal cancer cells via the miR‑761/MAPK1 axis

Yujing Liu, Yongyou Wu, Zhu Zhu, Jiangbo Gong, Wenhuan Dou
Article Number: 794
Published online on: 13 September 2021

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Article Open Access

MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1

Zhibiao Zhong, Weilan Su, Hongmei Chen
Article Number: 793
Published online on: 10 September 2021

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Article

Rab6c is a new target of miR‑218 that can promote the progression of bladder cancer

Long He, Xiang Pan, Xialu Wang, Yuhua Cao, Peng Chen, Cheng Du, Daifa Huang
Article Number: 792
Published online on: 10 September 2021

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Article Open Access

Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model

Han Li, Dong Peng, Shi-Jie Zhang, Yang Zhang, Qi Wang, Li Guan
Article Number: 791
Published online on: 10 September 2021

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Article Open Access

Amelioration of alcohol‑induced gastric mucosa damage by oral administration of food‑polydeoxyribonucleotides

Jonghwan Kim, Soyoung Chun, Seul-Ong Ohk, Sanghoon Kim, Juwan Kim, Sungoh Lee, Hangyu Kim, Sujong Kim
Article Number: 790
Published online on: 09 September 2021

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Article Open Access

Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer

Yijun Zhang, Shumei Yan, Yan Li, Jiangbo Zhang, Yuan Luo, Pengcheng Li, Yuanzhong Yang, Yong Li, Yuhua Huang, Enhua Wang
Article Number: 789
Published online on: 09 September 2021

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Review Open Access

Effects of miRNAs, lncRNAs and circRNAs on osteoporosis as regulatory factors of bone homeostasis (Review)

Zhichao Li, Haipeng Xue, Guoqing Tan, Zhanwang Xu
Article Number: 788
Published online on: 09 September 2021

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Article Open Access

Schizandrin A induces the apoptosis and suppresses the proliferation, invasion and migration of gastric cancer cells by activating endoplasmic reticulum stress

Huachao Pu, Qian Qian, Fuli Wang, Minjie Gong, Xinguo Ge
Article Number: 787
Published online on: 09 September 2021

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Article Open Access

circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR‑199‑3p expression

Yu Sun, Guangtao Ma, Hongtao Xiang, Xiaomin Wang, Hanmei Wang, Yan Zhang, Fuzhong Qie, Chenlong Li
Article Number: 786
Published online on: 08 September 2021

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Article Open Access

Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1

Xiumei Wen, Beihui He, Xing Tang, Bin Wang, Zhiyun Chen
Article Number: 785
Published online on: 08 September 2021

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Article

Long non‑coding RNA FGD5‑AS1/microRNA‑133a‑3p upregulates aquaporin 1 to decrease the inflammatory response in LPS‑induced sepsis

Yuru Chu, Xu Wang, Naihao Yu, Yali Li, Jianying Kan
Article Number: 784
Published online on: 07 September 2021

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Article Open Access

Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells

Junjun Wei, Liangliang Chen, Duidui Wang, Li Tang, Zhenhua Xie, Weifeng Chen, Shuwei Zhang, Guobin Weng
Article Number: 783
Published online on: 07 September 2021

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Article Open Access

lncRNA TPT1‑AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion

Hao Li, Jing Jin, Jianchun Xian, Wei Wang
Article Number: 782
Published online on: 07 September 2021

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Article Open Access

LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR‑1281 and TRIM65

Haidong Lv, Dixia Zhou, Guoqing Liu
Article Number: 781
Published online on: 07 September 2021

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Article Open Access

Long non‑coding RNA ZSCAN16‑AS1 promotes the malignant properties of hepatocellular carcinoma by decoying microRNA‑451a and consequently increasing ATF2 expression

Chaohua Lv, Qingsong Wan, Chengxiang Shen, Hongsheng Wu, Bin Zhou, Weiwei Wang
Article Number: 780
Published online on: 07 September 2021

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Article Open Access

Paeonol alleviates lipopolysaccharide‑induced hepatocytes injury through alteration of mitochondrial function and NF‑κB translocation

Shouzhu Xu, Jie Xu, Ting Hao, Yu Yan, Shihao Zhang, Aihong Li, Chuandao Shi, Qiling Liu, Jing Zhao
Article Number: 779
Published online on: 07 September 2021

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Article Open Access

Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 activation through autophagy inhibition

Hao Pan, Lin Niu, Yihao Wu, Liuying Chen, Xiaowei Zhou, Yan Zhao
Article Number: 778
Published online on: 07 September 2021

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Article Open Access

miR221 regulates TGF-β1-induced HSC activation through inhibiting autophagy by directly targeting LAMP2

Ran Cheng, Hao Xu, Yang Hong
Article Number: 777
Published online on: 07 September 2021

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Article Open Access

Protective effect of parecoxib sodium against ischemia reperfusion‑induced intestinal injury

Mei Li, Zhi Zheng
Article Number: 776
Published online on: 07 September 2021

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Article Open Access

Phillygenin inhibits the inflammation and apoptosis of pulmonary epithelial cells by activating PPARγ signaling via downregulation of MMP8

Yufeng Lin, Peng Yang
Article Number: 775
Published online on: 06 September 2021

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Article Open Access

ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model

Renfeng Qiu, Shuxiao Chen, Peixian Gao, Kun Luo, Xuedong Feng, Hai Yuan, Xuejun Wu, Gang Li
Article Number: 774
Published online on: 06 September 2021

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Article Open Access

Remote ischemic post‑conditioning alleviates ischemia/reperfusion‑induced intestinal injury via the ERK signaling pathway‑mediated RAGE/HMGB axis

Lei Mi, Nan Zhang, Jiyun Wan, Ming Cheng, Jianping Liao, Xiao Zheng
Article Number: 773
Published online on: 06 September 2021

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Article Open Access

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy

Cuixiang Xu, Xiaoyan Huang, Yubin Huang, Xiao Liu, Min Wu, Jianhua Wang, Xianglong Duan
Article Number: 772
Published online on: 06 September 2021

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Article Open Access

miR‑486‑5p suppresses gastric cancer cell growth and migration through downregulation of fibroblast growth factor 9

Weiwei Wei, Chunyu Liu, Rongrong Yao, Qingyun Tan, Qingdong Wang, Hao Tian
Article Number: 771
Published online on: 03 September 2021

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Article Open Access

Expression of atrial‑fetal light chains in cultured human cardiomyocytes after chemical ischemia‑reperfusion injury

Marta Banaszkiewicz, Agnieszka Olejnik, Anna Krzywonos‑Zawadzka, Kornela Hałucha, Iwona Bil‑Lula
Article Number: 770
Published online on: 03 September 2021

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Article Open Access

Lycium barbarum polysaccharide protects ARPE‑19 cells against H2O2‑induced oxidative stress via the Nrf2/HO‑1 pathway

Ran Liang, Qi Zhao, Qing Zhu, Xin He, Mingjun Gao, Yiru Wang
Article Number: 769
Published online on: 03 September 2021

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Review Open Access

Overview of the molecular mechanisms contributing to the formation of cancer‑associated adipocytes (Review)

Yunpeng Tang, Wenkai Zhang, Tianqiang Sheng, Xi He, Xiangyang Xiong
Article Number: 768
Published online on: 03 September 2021

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Article Open Access

Parallel evaluation of cell‑based phage display panning strategies: Optimized selection and depletion steps result in AML blast‑binding consensus antibodies

Theresa Weber, Sibylle Pscherer, Ulrike Gamerdinger, Andrea Teigler‑Schlegel, Natalja Rutz, Wolfgang Blau, Mathias Rummel, Stefan Gattenlöhner, Mehmet Kemal Tur
Article Number: 767
Published online on: 03 September 2021

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Article Open Access

Regulation of the PTEN/PI3K/AKT pathway in RCC using the active compounds of natural products in vitro

Xue Wang, Zhenhua Xie, Zhongguan Lou, Yulu Chen, Shuaishuai Huang, Yu Ren, Guobin Weng, Shuwei Zhang
Article Number: 766
Published online on: 03 September 2021

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Article Open Access

Silencing of PFKFB3 protects podocytes against high glucose‑induced injury by inducing autophagy

Zhengming Zhu, Qingsheng Liu, Jianshi Sun, Ziyang Bao, Weiwei Wang
Article Number: 765
Published online on: 03 September 2021

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Article Open Access

High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells

Baosheng Han, Jianzhong Wang, Jiawei Wu, Fang Yan, Yaru Wang, Jun Li
Article Number: 764
Published online on: 03 September 2021

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Article Open Access

Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal‑induced macrophages via inhibiting the Akt/mTOR signaling pathway

Mengqi Sun, Yun Ye, Yilan Huang, Wenxian Yin, Zhaolan Yu, Shurong Wang
Article Number: 763
Published online on: 03 September 2021

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Long non‑coding RNA HAND2‑AS1/miR‑106a/PTEN axis re‑sensitizes cisplatin‑resistant ovarian cells to cisplatin treatment

Lijun Li, Li Li, Lian Hu, Ting Li, Dan Xie, Xiaoliu Liu
Article Number: 762
Published online on: 02 September 2021

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Ribosomal RNA‑depleted RNA sequencing reveals the pathogenesis of refractory Mycoplasma pneumoniae pneumonia in children

Feng Huang, Huifeng Fan, Diyuan Yang, Junsong Zhang, Tingting Shi, Dongwei Zhang, Gen Lu
Article Number: 761
Published online on: 02 September 2021

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Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma

Tianling Ding, Jie Hao
Article Number: 760
Published online on: 02 September 2021

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Effect of N‑terminal region of human parvovirus B19‑VP1 unique region on cardiac injury in naïve mice

Kuo-Chuan Hung, Zi-Yun Huang, Jia Le Yow, Tsai-Ching Hsu, Bor-Show Tzang
Article Number: 759
Published online on: 02 September 2021

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Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling

Ruihong Yuan, Xiaoming Dai, Yisong Li, Chunshan Li, Liu Liu
Article Number: 758
Published online on: 02 September 2021

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LINC00238 inhibits hepatic carcinoma progression by activating TMEM106C‑mediated apoptosis pathway

Caihua Jiang, Feng Li, Meng Yang, Jianping Duan, Jianming Lai, Shulun Sun, Shaohua Fan
Article Number: 757
Published online on: 02 September 2021

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Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke

Jin Wang, Zun Zhang, Shaojing Fu, Xiaojie Li, Xinhui Li, Shaobin Wang, Lihe Yuan
Article Number: 756
Published online on: 02 September 2021

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Gycyrrhizic acid alleviates atherosclerotic lesions in rats with diabetes mellitus

Yaodong Zhao, Wei Li, Daimin Zhang
Article Number: 755
Published online on: 02 September 2021

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Atrial natriuretic peptide protects vertebral endplate chondrocytes against H2O2‑induced apoptosis and oxidative stress through activation of the Nrf2/HO‑1 signaling pathway

Feiping He, Jingying Gai, Jun Wang, Lei Tang, Yifeng Liu, Qingchun Feng
Article Number: 754
Published online on: 01 September 2021

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MicroRNA‑502‑3p promotes Mycobacterium tuberculosis survival in macrophages by modulating the inflammatory response by targeting ROCK1

Fang Liu, Zhen Dong, Yuefu Lin, Haibo Yang, Pingping Wang, Yongxia Zhang
Article Number: 753
Published online on: 01 September 2021

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miR‑32‑5p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1

Peng Yuan, Chaofeng Tang, Bendong Chen, Peng Lei, Jianjun Song, Guojun Xin, Zuozheng Wang, Yongfeng Hui, Weijie Yao, Genwang Wang, Guozhong Zhao
Article Number: 752
Published online on: 31 August 2021

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[Retracted] Downregulation of matrix metalloproteinase 9 by small interfering RNA inhibits the tumor growth of ovarian epithelial carcinoma in vitro and in vivo

Fengjun Guo, Jingyan Tian, Manhua Cui, Meiru Fang, Lin Yang
Article Number: 751
Published online on: 31 August 2021

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Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model

Min Yuan, Guoqing Jing, Qian Kong, Tingqian Ming, Xuemin Song, Xiaojing Wu
Article Number: 750
Published online on: 31 August 2021

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NEAT1 silencing alleviates pulmonary arterial smooth muscle cell migration and proliferation under hypoxia through regulation of miR‑34a‑5p/KLF4 in vitro

Xiuli Dou, Yuxiao Ma, Yijie Qin, Qinglin Dong, Shouwei Zhang, Rui Tian, Mingyu Pan
Article Number: 749
Published online on: 31 August 2021

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Knockdown of MIR9‑3HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR‑498 via EP300

Fang Li, Ying Liang, Pian Ying
Article Number: 748
Published online on: 31 August 2021

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Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway

Chao Liu, Xiao-Lin Huang, Jian-Ping Liang, Xu Zhong, Zi-Feng Wei, Li-Xue Dai, Jun Wang
Article Number: 747
Published online on: 27 August 2021

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Involvement of autophagy in diosgenin‑induced megakaryocyte differentiation in human erythroleukemia cells

Dima Diab, Aline Pinon, Catherine Ouk, Rouba Hage‑Sleiman, Mona Diab‑Assaf, Bertrand Liagre, David Yannick Leger
Article Number: 746
Published online on: 27 August 2021

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Review

SLC26A6 and NADC‑1: Future direction of nephrolithiasis and calculus‑related hypertension research (Review)

Xingyue Yang, Shun Yao, Jiaxing An, Hai Jin, Hui Wang, Biguang Tuo
Article Number: 745
Published online on: 26 August 2021

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O‑GlcNAcylation contributes to intermittent hypoxia‑associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways

Xueling Guo, Yan Deng, Linghui Zhan, Jin Shang, Huiguo Liu
Article Number: 744
Published online on: 25 August 2021

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Silencing the lncRNA NORAD inhibits EMT of head and neck squamous cell carcinoma stem cells via miR‑26a‑5p

Weiming Hu, Yong Zhao, Lizhong Su, Zuliang Wu, Wenjing Jiang, Xiaoze Jiang, Ming Liu
Article Number: 743
Published online on: 25 August 2021

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Alteration of immune profiles is associated with pulmonary function and symptoms in patients with chronic obstructive pulmonary disease

Sixiang Li, Shuang Zhao, Zhenru Wu, Fangfang Wang, Weimin Li
Article Number: 742
Published online on: 24 August 2021

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Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice

Wei Zhao, Li Chen, Heng Zhou, Chunyan Deng, Qizhen Han, Yonghua Chen, Qing Wu, Shanshan Li
Article Number: 741
Published online on: 24 August 2021

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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