Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2022 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2022 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway

  • Authors:
    • Jie Cai
    • Zhenhua Sun
    • Lili Zhang
    • Hongrui Xu
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 193
    |
    Published online on: April 6, 2022
       https://doi.org/10.3892/mmr.2022.12709
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The liver is a crucial digestive organ of humans and in charge of detoxification. Acute hepatic injury is an aggressive type of hepatic disease and its harmful effect cannot be ignored. The present study examined the role and mechanism of stress‑associated endoplasmic reticulum protein 1 (SERP1) in acute hepatic injury. Mice were injected intraperitoneally with D‑galactosamine/lipopolysaccharide (LPS) and rat hepatocytes were induced by LPS to establish an acute hepatic injury model. Tissue lesions were observed by H&E staining, and biomarkers of hepatic injury in the serum were examined. Western blotting, immunohistochemistry and reverse transcription‑quantitative PCR were performed to assess SERP1 expression in tissues and hepatocytes. A SERP1 overexpression plasmid was constructed to evaluate the role of SERP1 in inflammation, apoptosis, endoplasmic reticulum stress (ERS) and the GSK3β/β‑catenin/T‑cell factor (TCF)/lymphoid enhancing factor (LEF) signaling pathway. In addition, a GSK3β overexpression plasmid was constructed to investigate the role of GSK3β/β‑catenin signal activation. Additionally, the present study investigated whether SERP1 regulated the endoplasmic reticulum via this pathway. In the present study, reliable animal and cellular hepatic injury models were established and verified. SERP1 overexpression reduced the expression of inflammatory factors, apoptosis‑related proteins and ERS‑related proteins, as well as the expression of proteins related to GSK3β/β‑catenin/TCF/LEF signaling pathways. A GSK3β overexpression plasmid was constructed and it was revealed that GSK3β overexpression could reverse the effects of SERP1 overexpression in aforementioned aspects. This suggested that the activation of the GSK3β/β‑catenin/TCF/LEF signaling pathway may be required for the regulation of SERP1. In conclusion, SERP1 regulated ERS via the GSK3β/β‑catenin/TCF/LEF signaling pathway, thereby reducing inchoate acute hepatic injury.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Wu G, Win S, Than TA, Chen P and Kaplowitz N: Gut microbiota and liver injury (I)-acute liver injury. Adv Exp Med Biol. 1238:23–37. 2020. View Article : Google Scholar : PubMed/NCBI

2 

He GW, Günther C, Kremer AE, Thonn V, Amann K, Poremba C, Neurath MF, Wirtz S and Becker C: PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut. 66:716–723. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Hassan A and Fontana RJ: The diagnosis and management of idiosyncratic drug-induced liver injury. Liver Int. 39:31–41. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Katarey D and Verma S: Drug-induced liver injury. Clin Med (Lond). 16 (Suppl 6):s104–s109. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hosseini N, Shor J and Szabo G: Alcoholic hepatitis: A review. Alcohol Alcohol. 54:408–16. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Zhao RH, Shi Y, Zhao H, Wu W and Sheng JF: Acute-on-chronic liver failure in chronic hepatitis B: An update. Expert Rev Gastroenterol Hepatol. 12:341–350. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Guzel E, Arlier S, Guzeloglu-Kayisli O, Tabak MS, Ekiz T, Semerci N, Larsen K, Schatz F, Lockwood CJ and Kayisli UA: Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology. Int J Mol Sci. 18:7922017. View Article : Google Scholar : PubMed/NCBI

8 

Fernández A, Ordóñez R, Reiter RJ, González-Gallego J and Mauriz JL: Melatonin and endoplasmic reticulum stress: Relation to autophagy and apoptosis. J Pineal Res. 59:292–307. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Oakes SA and Papa FR: The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 10:173–194. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Song M and Cubillos-Ruiz JR: Endoplasmic reticulum stress responses in intratumoral immune cells: Implications for cancer immunotherapy. Trends Immunol. 40:128–141. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Yilmaz E: Endoplasmic reticulum stress and obesity. Adv Exp Med Biol. 960:261–276. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Lebeaupin C, Vallée D, Hazari Y, Hetz C, Chevet E and Bailly-Maitre B: Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. J Hepatol. 69:927–947. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Zhao YF, Gao Y, Wu XF, Wang JG and Duan LX: Protective effect of earthworm active ingredients against endoplasmic reticulum stress-induced acute liver injury in mice. Zhongguo Zhong Yao Za Zhi. 42:1183–1188. 2017.(In Chinese). PubMed/NCBI

14 

Wang S, Luan J and Lv X: Inhibition of endoplasmic reticulum stress attenuated ethanol-induced exosomal miR-122 and Acute liver injury in mice. Alcohol Alcohol. 54:465–471. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Faria D, Lentze N, Almaça J, Luz S, Alessio L, Tian Y, Martins JP, Cruz P, Schreiber R, Rezwan M, et al: Regulation of ENaC biogenesis by the stress response protein SERP1. Pflugers Arch. 463:819–827. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Jung S, Hyun J, Nah J, Han J, Kim SH, Park J, Oh Y, Gwon Y, Moon S, Jo DG and Jung YK: SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions. Sci Signal. 13:eaax89492020. View Article : Google Scholar : PubMed/NCBI

17 

Hori O, Miyazaki M, Tamatani T, Ozawa K, Takano K, Okabe M, Ikawa M, Hartmann E, Mai P, Stern DM, et al: Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Mol Cell Biol. 26:4257–4267. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Zhang L, Ren F, Zhang X, Wang X, Shi H, Zhou L, Zheng S, Chen Y, Chen D, Li L, et al: Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. Dis Model Mech. 9:799–809. 2016.PubMed/NCBI

19 

Ren F, Zhou L, Zhang X, Wen T, Shi H, Xie B, Li Z, Chen D, Wang Z and Duan Z: Endoplasmic reticulum stress-activated glycogen synthase kinase 3β aggravates liver inflammation and hepatotoxicity in mice with acute liver failure. Inflammation. 38:1151–1165. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ren F, Yang B, Zhang X, Wen T, Wang X, Yin J, Piao Z, Zheng S, Zhang J, Chen Y, et al: Role of endoplasmic reticulum stress in D-GalN/LPS-induced acute liver failure. Zhonghua Gan Zang Bing Za Zhi. 22:364–368. 2014.(In Chinese). PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Cao P, Sun J, Sullivan MA, Huang X, Wang H, Zhang Y, Wang N and Wang K: Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. Int J Biol Macromol. 111:1133–1139. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Trefts E, Gannon M and Wasserman DH: The liver. Curr Biol. 27:R1147–R1151. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Jühling F, Oudot MA, Virzì A, Bandiera S, Jamey C, Meszaros G, et al: Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis c virus-infected cells and liver to identify pathways associated with disease development. Gastroenterology. 157:537–551.e9. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Kleiner DE: Drug-induced liver injury: The hepatic pathologist's approach. Gastroenterol Clin North Am. 46:273–296. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I and Rela M: COVID-19 and the liver. J Hepatol. 73:1231–1240. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Li R, Yang W, Yin Y, Zhang P, Wang Y and Tao K: Protective role of 4-Octyl itaconate in murine LPS/D-GalN-induced acute liver failure via inhibiting inflammation, oxidative stress, and apoptosis. Oxid Med Cell Longev. 2021:99320992021.PubMed/NCBI

28 

Pan CW, Yang SX, Pan ZZ, Zheng B, Wang JZ, Lu GR, Xue ZX and Xu CL: Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway. Oncotarget. 8:41202–41210. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, et al: Endoplasmic reticulum chaperone glucose-regulated protein 94 is essential for proinsulin handling. Diabetes. 68:747–760. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Yi S, Chen K, Zhang L, Shi W, Zhang Y, Niu S, Jia M, Cong B and Li Y: Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways. Front Cell Neurosci. 13:1902019. View Article : Google Scholar : PubMed/NCBI

31 

Macen JL, Upton C, Nation N and McFadden G: SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation. Virology. 195:348–363. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Gao M, Yu T, Liu D, Shi Y, Yang P, Zhang J, Wang J, Liu Y and Zhang X: Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1. Clin Sci (Lond). 135:347–365. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Junyuan Z, Hui X, Chunlan H, Junjie F, Qixiang M, Yingying L, Lihong L, Xingpeng W and Yue Z: Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. Pancreatology. 18:742–752. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Li W, Cao T, Luo C, Cai J, Zhou X, Xiao X and Liu S: Crosstalk between ER stress, NLRP3 inflammasome, and inflammation. Appl Microbiol Biotechnol. 104:6129–6140. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Sankrityayan H, Oza MJ, Kulkarni YA, Mulay SR and Gaikwad AB: ER stress response mediates diabetic microvascular complications. Drug Discov Today. 24:2247–2257. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Wu Z, Wang H, Fang S and Xu C: Roles of endoplasmic reticulum stress and autophagy on H2O2-induced oxidative stress injury in HepG2 cells. Mol Med Rep. 18:4163–4174. 2018.PubMed/NCBI

37 

Song J, Zhang Q, Wang S, Yang F, Chen Z, Dong Q, Ji Q, Yuan X and Ren D: Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts. J Cell Physiol. 233:9473–9487. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Li W, Li W, Leng Y, Xiong Y and Xia Z: Ferroptosis is involved in diabetes myocardial ischemia/reperfusion injury through endoplasmic reticulum stress. DNA Cell Biol. 39:210–225. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Shen H, Ming Y, Xu C, Xu Y, Zhao S and Zhang Q: Deregulation of long noncoding RNA (TUG1) contributes to excessive podocytes apoptosis by activating endoplasmic reticulum stress in the development of diabetic nephropathy. J Cell Physiol. Jan 22–2019.(Epub ahead of print). View Article : Google Scholar

40 

Wang Z, Yin F, Xu J, Zhang T, Wang G, Mao M, Wang Z, Sun W, Han J, Yang M, et al: CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma. J Exp Clin Cancer Res. 38:442019. View Article : Google Scholar : PubMed/NCBI

41 

Fu Y, Cai J, Xi M and He Y, Zhao Y, Zheng Y, Zhang Y, Xi J and He Y: Neuroprotection effect of astragaloside IV from 2-DG-induced endoplasmic reticulum stress. Oxid Med Cell Longev. 2020:97820622020. View Article : Google Scholar : PubMed/NCBI

42 

Liu XJ, Wei J, Shang YH, Huang HC and Lao FX: Modulation of AβPP and GSK3β by endoplasmic reticulum stress and involvement in Alzheimer's disease. J Alzheimers Dis. 57:1157–1170. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cai J, Sun Z, Zhang L and Xu H: SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway. Mol Med Rep 25: 193, 2022.
APA
Cai, J., Sun, Z., Zhang, L., & Xu, H. (2022). SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway. Molecular Medicine Reports, 25, 193. https://doi.org/10.3892/mmr.2022.12709
MLA
Cai, J., Sun, Z., Zhang, L., Xu, H."SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway". Molecular Medicine Reports 25.6 (2022): 193.
Chicago
Cai, J., Sun, Z., Zhang, L., Xu, H."SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway". Molecular Medicine Reports 25, no. 6 (2022): 193. https://doi.org/10.3892/mmr.2022.12709
Copy and paste a formatted citation
x
Spandidos Publications style
Cai J, Sun Z, Zhang L and Xu H: SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway. Mol Med Rep 25: 193, 2022.
APA
Cai, J., Sun, Z., Zhang, L., & Xu, H. (2022). SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway. Molecular Medicine Reports, 25, 193. https://doi.org/10.3892/mmr.2022.12709
MLA
Cai, J., Sun, Z., Zhang, L., Xu, H."SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway". Molecular Medicine Reports 25.6 (2022): 193.
Chicago
Cai, J., Sun, Z., Zhang, L., Xu, H."SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway". Molecular Medicine Reports 25, no. 6 (2022): 193. https://doi.org/10.3892/mmr.2022.12709
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team