Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2022 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2022 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation

  • Authors:
    • Ye Kuang
    • Chuanmei Peng
    • Yulin Dong
    • Jia Wang
    • Fanbin Kong
    • Xiaoqing Yang
    • Yang Wang
    • Hui Gao
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory, Yan'An Hospital, Kunming, Yunnan 650000, P.R. China
    Copyright: © Kuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 195
    |
    Published online on: April 14, 2022
       https://doi.org/10.3892/mmr.2022.12711
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute myeloid leukemia (AML) is a type of hematological malignancy caused by uncontrolled clonal proliferation of hematopoietic stem cells. The special energy metabolism mode of AML relying on oxidative phosphorylation is different from the traditional ‘Warburg effect’. However, its mechanism is not clear. In the present study, it was demonstrated that the mRNA expression levels of NADH dehydrogenase subunit 1, 4 and 5 (ND1, ND4 and ND5) were upregulated in AML samples from The Cancer Genome Atlas database using the limma package in the R programming language. Reverse transcription‑quantitative PCR and ELISA were used to verify the upregulation of ND1, ND4 and ND5 in clinical samples. Pan‑cancer analysis revealed that the expression of ND1 was upregulated only in AML, ND2 was upregulated only in AML and thymoma, and ND4 was upregulated only in AML and kidney chromophobe. In the present study, it was demonstrated that silencing of ND1/4/5 could inhibit the proliferation of AML cells in transplanted tumor of nude mice. Additionally, it was found that oxidative phosphorylation and energy metabolism of AML cells were decreased after silencing of ND1/4/5. In conclusion, the present study suggested that ND1/4/5 may be involved in the regulation of oxidative phosphorylation metabolism in AML as a potential cancer‑promoting factor.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

De Kouchkovsky I and Abdul-Hay M: Acute myeloid leukemia: A comprehensive review and 2016 update. Blood Cancer J. 6:e4412016. View Article : Google Scholar : PubMed/NCBI

2 

Thol F and Ganser A: Treatment of relapsed acute myeloid leukemia. Curr Treat Options Oncol. 21:662020. View Article : Google Scholar : PubMed/NCBI

3 

Čolović N, Denčić-Fekete M, Peruničić M and Jurišić V: Clinical characteristics and treatment outcome of hypocellular acute myeloid leukemia based on WHO classification. Indian J Hematol Blood Transfus. 36:59–63. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Feng L, Li Y, Li Y, Jiang Y, Wang N, Yuan D and Fan J: Whole exome sequencing detects CHST3 mutation in patient with acute promyelocytic leukemia: A case report. Medicine (Baltimore). 97:e122142018. View Article : Google Scholar : PubMed/NCBI

5 

Chen X and Cherian S: Acute myeloid leukemia immunophenotyping by flow cytometric analysis. Clin Lab Med. 37:753–769. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Gorczyca W, Sun ZY, Cronin W, Li X, Mau S and Tugulea S: Immunophenotypic pattern of myeloid populations by flow cytometry analysis. Methods Cell Biol. 103:221–266. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Matsuo T, Kuriyama K, Miyazaki Y, Yoshida S, Tomonaga M, Emi N, Kobayashi T, Miyawaki S, Matsushima T, Shinagawa K, et al: Japan adult leukemia study group. The percentage of myeloperoxidase-positive blast cells is a strong independent prognostic factor in acute myeloid leukemia, even in the patients with normal karyotype. Leukemia. 17:1538–1543. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Lee YJ, Huang YT, Kim SJ, Maloy M, Tamari R, Giralt SA, Papadopoulos EB, Jakubowski AA and Papanicolaou GA: Adenovirus viremia in adult CD34(+) selected hematopoietic cell transplant recipients: Low incidence and high clinical impact. Biol Blood Marrow Transplant. 22:174–178. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Yang JJ, Park TS and Wan TS: Recurrent cytogenetic abnormalities in acute myeloid leukemia. Methods Mol Biol. 1541:223–245. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Kishtagari A, Levine RL and Viny AD: Driver mutations in acute myeloid leukemia. Curr Opin Hematol. 27:49–57. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Jurisić V, Pavlović S, Colović N, Djordjevic V, Bunjevacki V, Janković G and Colović M: Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia. J Genet. 88:149–152. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Jurisic V, Radenkovic S and Konjevic G: The actual role of LDH as tumor marker, biochemical and clinical aspects. Adv Exp Med Biol. 867:115–124. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Kavianpour M, Ahmadzadeh A, Shahrabi S and Saki N: Significance of oncogenes and tumor suppressor genes in AML prognosis. Tumour Biol. 37:10041–10052. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Liberti MV and Locasale JW: The warburg effect: How does it benefit cancer cells? Trends Biochem Sci. 41:211–218. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Vaupel P, Schmidberger H and Mayer A: The warburg effect: Essential part of metabolic reprogramming and central contributor to cancer progression. Int J Radiat Biol. 95:912–919. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Xu XD, Shao SX, Jiang HP, Cao YW, Wang YH, Yang XC, Wang YL, Wang XS and Niu HT: Warburg effect or reverse warburg effect? A review of cancer metabolism. Oncol Res Treat. 38:117–122. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, et al: Mubritinib targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia. Cancer Cell. 36:84–99. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Herst PM and Berridge MV: Cell surface oxygen consumption: A major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochim Biophys Acta. 1767:170–177. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip ANA, et al: An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 24:1036–1046. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Toth A, Meyrat A, Stoldt S, Santiago R, Wenzel D, Jakobs S, von Ballmoos C and Ott M: Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes. Proc Natl Acad Sci USA. 117:2412–2421. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Li T and Le A: Glutamine metabolism in cancer. Adv Exp Med Biol. 1063:13–32. 2018. View Article : Google Scholar : PubMed/NCBI

22 

van der Bliek AM, Sedensky MM and Morgan PG: Cell biology of the mitochondrion. Genetics. 207:843–871. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Hardeland R: Melatonin and the electron transport chain. Cell Mol Life Sci. 74:3883–3896. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Tatarková Z, Kuka S, Račay P, Lehotský J, Dobrota D, Mištuna D and Kaplán P: Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart. Physiol Res. 60:281–289. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Ji Y, Liang M, Zhang J, Zhang M, Zhu J, Meng X, Zhang S, Gao M, Zhao F, Wei QP, et al: Mitochondrial haplotypes may modulate the phenotypic manifestation of the LHON-associated ND1 G3460A mutation in Chinese families. J Hum Genet. 59:134–40. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Rezvani Z, Didari E, Arastehkani A, Ghodsinejad V, Aryani O, Kamalidehghan B and Houshmand M: Fifteen novel mutations in the mitochondrial NADH dehydrogenase subunit 1, 2, 3, 4, 4L, 5 and 6 genes from Iranian patients with Leber's hereditary optic neuropathy (LHON). Mol Biol Rep. 40:6837–6841. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Nguyen L, Martens JWM, Van Hoeck A and Cuppen E: Pan-cancer landscape of homologous recombination deficiency. Nat Commun. 11:55842020. View Article : Google Scholar : PubMed/NCBI

28 

Blum A, Wang P and Zenklusen JC: SnapShot: TCGA-analyzed tumors. Cell. 173:5302018. View Article : Google Scholar : PubMed/NCBI

29 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 33:451–458. 1976. View Article : Google Scholar : PubMed/NCBI

30 

O'Donnell MR, Tallman MS, Abboud CN, Altman JK, Appelbaum FR, Arber DA, Attar E, Borate U, Coutre SE, Damon LE, et al: Acute myeloid leukemia, version 2.2013. J Natl Compr Canc Netw. 11:1047–1055. 2013. View Article : Google Scholar : PubMed/NCBI

31 

du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, et al: Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 18:e30004112020. View Article : Google Scholar : PubMed/NCBI

32 

Riemondy KA, Sheridan RM, Gillen A, Yu Y, Bennett CG and Hesselberth JR: valr: Reproducible genome interval analysis in R. F1000Res. 6:10252017. View Article : Google Scholar : PubMed/NCBI

33 

Mangiola S, Doyle MA and Papenfuss AT: Interfacing Seurat with the R tidy universe. Bioinformatics. 24:btab4042021. View Article : Google Scholar

34 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

35 

R Core Team R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2019. https://www.R-project.org/

36 

Hu K: Become competent in generating RNA-Seq heat maps in one day for novices without prior R experience. Methods Mol Biol. 2239:269–303. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45W:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Muz B, de la Puente P, Azab F and Azab AK: The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckl). 3:83–92. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Hassan C, Afshinnekoo E, Li S, Wu S and Mason CE: Genetic and epigenetic heterogeneity and the impact on cancer relapse. Exp Hematol. 54:26–30. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Jiang Z, Bahr T, Zhou C, Jin T, Chen H, Song S, Ikeno Y, Tian H and Bai Y: Diagnostic value of circulating cell-free mtDNA in patients with suspected thyroid cancer: ND4/ND1 ratio as a new potential plasma marker. Mitochondrion. 55:145–153. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Liu ZW, Guo ZJ, Chu AL, Zhang Y, Liang B, Guo X, Chai T, Song R, Hou G and Yuan JJ: High incidence of coding gene mutations in mitochondrial DNA in esophageal cancer. Mol Med Rep. 16:8537–8541. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Payen VL, Brisson L, Dewhirst MW and Sonveaux P: Common responses of tumors and wounds to hypoxia. Cancer J. 21:75–87. 2015. View Article : Google Scholar : PubMed/NCBI

44 

de Bièvre C and Dujon B: Organisation of the mitochondrial genome of Trichophyton rubrum III. DNA sequence analysis of the NADH dehydrogenase subunits 1, 2, 3, 4, 5 and the cytochrome b gene. Curr Genet. 35:30–35. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Cardol P, Lapaille M, Minet P, Franck F, Matagne RF and Remacle C: ND3 and ND4L subunits of mitochondrial complex I, both nucleus encoded in Chlamydomonas reinhardtii, are required for activity and assembly of the enzyme. Eukaryot Cell. 5:1460–1467. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Zhang C, Liu T, Luo P, Gao L, Liao X, Ma L, Jiang Z, Liu D, Yang Z, Jiang Q, et al: Near-infrared oxidative phosphorylation inhibitor integrates acute myeloid leukemia-targeted imaging and therapy. Sci Adv. 7:eabb61042021. View Article : Google Scholar : PubMed/NCBI

47 

Carter JL, Hege K, Kalpage HA, Edwards H, Hüttemann M, Taub JW and Ge Y: Targeting mitochondrial respiration for the treatment of acute myeloid leukemia. Biochem Pharmacol. 182:1142532020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kuang Y, Peng C, Dong Y, Wang J, Kong F, Yang X, Wang Y and Gao H: NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation. Mol Med Rep 25: 195, 2022.
APA
Kuang, Y., Peng, C., Dong, Y., Wang, J., Kong, F., Yang, X. ... Gao, H. (2022). NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation. Molecular Medicine Reports, 25, 195. https://doi.org/10.3892/mmr.2022.12711
MLA
Kuang, Y., Peng, C., Dong, Y., Wang, J., Kong, F., Yang, X., Wang, Y., Gao, H."NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation". Molecular Medicine Reports 25.6 (2022): 195.
Chicago
Kuang, Y., Peng, C., Dong, Y., Wang, J., Kong, F., Yang, X., Wang, Y., Gao, H."NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation". Molecular Medicine Reports 25, no. 6 (2022): 195. https://doi.org/10.3892/mmr.2022.12711
Copy and paste a formatted citation
x
Spandidos Publications style
Kuang Y, Peng C, Dong Y, Wang J, Kong F, Yang X, Wang Y and Gao H: NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation. Mol Med Rep 25: 195, 2022.
APA
Kuang, Y., Peng, C., Dong, Y., Wang, J., Kong, F., Yang, X. ... Gao, H. (2022). NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation. Molecular Medicine Reports, 25, 195. https://doi.org/10.3892/mmr.2022.12711
MLA
Kuang, Y., Peng, C., Dong, Y., Wang, J., Kong, F., Yang, X., Wang, Y., Gao, H."NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation". Molecular Medicine Reports 25.6 (2022): 195.
Chicago
Kuang, Y., Peng, C., Dong, Y., Wang, J., Kong, F., Yang, X., Wang, Y., Gao, H."NADH dehydrogenase subunit 1/4/5 promotes survival of acute myeloid leukemia by mediating specific oxidative phosphorylation". Molecular Medicine Reports 25, no. 6 (2022): 195. https://doi.org/10.3892/mmr.2022.12711
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team