Open Access

Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/lpr mice

  • Authors:
    • Tianhong Xie
    • Huiqiang Liu
    • Ping Li
  • View Affiliations

  • Published online on: May 4, 2022     https://doi.org/10.3892/mmr.2022.12727
  • Article Number: 211
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CD138+ T cells, the majority of which are CD4 and CD8 double‑negative (DN) T cells, contribute to the production of anti‑dsDNA antibodies in a CD4 receptor‑dependent way to promote the development of systemic lupus erythematosus (SLE). Accumulation of CD138+ T cells in the spleen of MRL/lpr mice was significantly reduced by prednisone. Reduced expression of CD138 in DN T cells induced by prednisone treatment alleviated the accumulation of DN T cells in MRL/lpr mice. The frequency of CD138+ cells in CD4+ T cells of prednisone‑treated MRL/lpr mice was also significantly reduced, which subsequently contributed to reduced production of anti‑dsDNA antibody in the prednisone‑treated MRL/lpr mice. Additionally, prednisone significantly reduced serum IgG and IgG subsets and simultaneously increased IgM secretion in serum. This suggested that glucocorticoids played a protective role during SLE treatment in MRL/lpr mice by promoting the production of IgM. The present study provides new insights into the mechanism of glucocorticoid for the treatment of SLE.

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Copy and paste a formatted citation
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Spandidos Publications style
Xie T, Liu H and Li P: Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/<em>lpr</em> mice. Mol Med Rep 25: 211, 2022
APA
Xie, T., Liu, H., & Li, P. (2022). Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/<em>lpr</em> mice. Molecular Medicine Reports, 25, 211. https://doi.org/10.3892/mmr.2022.12727
MLA
Xie, T., Liu, H., Li, P."Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/<em>lpr</em> mice". Molecular Medicine Reports 25.6 (2022): 211.
Chicago
Xie, T., Liu, H., Li, P."Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/<em>lpr</em> mice". Molecular Medicine Reports 25, no. 6 (2022): 211. https://doi.org/10.3892/mmr.2022.12727