Open Access

Curcumin improves the function of umbilical vein endothelial cells by inhibiting H2O2‑induced pyroptosis

  • Authors:
    • Yulin Yuan
    • Caiping Zhang
    • Yunwu He
    • Lingzhi Yuan
    • Qian Zhao
    • Yuhe Liu
    • Shiyin Long
  • View Affiliations

  • Published online on: May 9, 2022     https://doi.org/10.3892/mmr.2022.12730
  • Article Number: 214
  • Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endothelial cell (EC) dysfunction is one of the initiating factors of atherosclerosis. EC dysfunction is primarily caused by oxidative damage and inflammation. As a classic non‑specific antioxidant and anti‑inflammatory drug, curcumin has been widely used in studies of lipid metabolism disorders. However, whether curcumin is able to alleviate H2O2‑induced EC damage and its related mechanisms has remained to be elucidated. The present study confirmed the protective effects of curcumin on human umbilical vein endothelial cells (HUVECs). A HUVEC injury model was established using H2O2 and the optimal concentrations and time of curcumin to achieve therapeutic effects were explored. Curcumin was observed to inhibit H2O2‑induced pyroptosis by inhibiting the activation of NOD‑, LRR‑ and pyrin domain‑containing protein 3. In addition, curcumin improved HUVEC function by restoring αvβ3 and reducing endothelin‑1 expression. In conclusion, the results of the present study revealed the mechanism through which curcumin inhibits pyroptosis and indicated that curcumin may have a potential utility in treating diseases of EC dysfunction.

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June-2022
Volume 25 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yuan Y, Zhang C, He Y, Yuan L, Zhao Q, Liu Y and Long S: Curcumin improves the function of umbilical vein endothelial cells by inhibiting H<sub>2</sub>O<sub>2</sub>‑induced pyroptosis. Mol Med Rep 25: 214, 2022
APA
Yuan, Y., Zhang, C., He, Y., Yuan, L., Zhao, Q., Liu, Y., & Long, S. (2022). Curcumin improves the function of umbilical vein endothelial cells by inhibiting H<sub>2</sub>O<sub>2</sub>‑induced pyroptosis. Molecular Medicine Reports, 25, 214. https://doi.org/10.3892/mmr.2022.12730
MLA
Yuan, Y., Zhang, C., He, Y., Yuan, L., Zhao, Q., Liu, Y., Long, S."Curcumin improves the function of umbilical vein endothelial cells by inhibiting H<sub>2</sub>O<sub>2</sub>‑induced pyroptosis". Molecular Medicine Reports 25.6 (2022): 214.
Chicago
Yuan, Y., Zhang, C., He, Y., Yuan, L., Zhao, Q., Liu, Y., Long, S."Curcumin improves the function of umbilical vein endothelial cells by inhibiting H<sub>2</sub>O<sub>2</sub>‑induced pyroptosis". Molecular Medicine Reports 25, no. 6 (2022): 214. https://doi.org/10.3892/mmr.2022.12730