Open Access

E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma

  • Authors:
    • Xianyong Jiang
    • Zhen Chen
    • Junping Zhu
    • Jun Han
    • Gaoliang You
    • Yonghong Li
    • Tiancheng Liu
    • Heng Ye
  • View Affiliations

  • Published online on: May 27, 2022     https://doi.org/10.3892/mmr.2022.12753
  • Article Number: 237
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Altered glucose metabolism is an important characteristic of cancer cells, which is referred to as Warburg effect or aerobic glycolysis. Ewing sarcoma (EWS) is a highly malignant tumor that occurs in children and adolescents. However, the functions of aerobic glycolysis in EWS remain to be elucidated. The present study identified a transcription factor, E2F transcription factor 1 (E2F1), as a new regulator of cancer the aerobic glycolysis and progression in EWS. The present study showed that E2F1 modulated aerobic glycolysis in EWS cells by effecting glucose uptake, lactate production and ATP generation. Altered E2F1 expression increased or decreased cell viability and invasion in EWS. Mechanistically, the results demonstrated that E2F1 may promote the Warburg effect and cancer progression in EWS via upregulating enolase 2 expression. Generally, these findings indicated that E2F1 involvement in the progression of EWS and could serve as a clinical therapeutic target in EWS.
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July-2022
Volume 26 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang X, Chen Z, Zhu J, Han J, You G, Li Y, Liu T and Ye H: E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma. Mol Med Rep 26: 237, 2022
APA
Jiang, X., Chen, Z., Zhu, J., Han, J., You, G., Li, Y. ... Ye, H. (2022). E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma. Molecular Medicine Reports, 26, 237. https://doi.org/10.3892/mmr.2022.12753
MLA
Jiang, X., Chen, Z., Zhu, J., Han, J., You, G., Li, Y., Liu, T., Ye, H."E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma". Molecular Medicine Reports 26.1 (2022): 237.
Chicago
Jiang, X., Chen, Z., Zhu, J., Han, J., You, G., Li, Y., Liu, T., Ye, H."E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma". Molecular Medicine Reports 26, no. 1 (2022): 237. https://doi.org/10.3892/mmr.2022.12753