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Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)

  • Authors:
    • Yaccil Adilene Flores-Cortez
    • Martha I. Barragán-Bonilla
    • Juan M. Mendoza-Bello
    • Cecilia González-Calixto
    • Eugenia Flores-Alfaro
    • Mónica Espinoza-Rojo
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Biology and Genomic, Faculty of Biological Chemical Sciences, Autonomous University of Guerrero, Chilpancingo, Guerrero 39087, Mexico, Faculty of Nursing, Autonomous University of Guerrero, Acapulco, Guerrero 39610, Mexico, Laboratory of Clinical and Molecular Epidemiology, Faculty of Biological and Chemical Sciences, Autonomous University of Guerrero, Chilpancingo, Guerrero 39087, Mexico
    Copyright: © Flores-Cortez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 244
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    Published online on: June 1, 2022
       https://doi.org/10.3892/mmr.2022.12760
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Abstract

Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue. Adipose tissue is responsible for the production and secretion of numerous adipokines that induce metabolic disorders. Retinol‑binding protein 4 (RBP4) is an adipokine that transports vitamin A or retinol in the blood. High levels of RBP4 are associated with development of metabolic disease, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes (T2D). The present review summarizes the role of RBP4 in obesity and associated chronic alterations. Excessive synthesis of RBP4 contributes to inflammatory characteristic of obesity by activation of immune cells and release of proinflammatory cytokines, such as TNFα and ILs, via the Toll‑like receptor/JNK pathway. The retinol‑RBP4 complex inhibits insulin signaling directly in adipocytes by activating Janus kinase 2 (JAK2)/STAT5/suppressor of cytokine signaling 3 signaling. This mechanism is retinol‑dependent and requires vitamin A receptor stimulation by retinoic acid 6 (STRA6). In muscle, RBP4 is associated with increased serine 307 phosphorylation of insulin receptor substrate‑1, which decreases its affinity to PI3K and promotes IR. In the liver, RBP4 increases hepatic expression of phosphoenolpyruvate carboxykinase, which increases production of glucose. Elevated serum RBP4 levels are associated with β‑cell dysfunction in T2D via the STRA6/JAK2/STAT1/insulin gene enhancer protein 1 pathway. By contrast, RBP4 induces endothelial inflammation via the NF‑κB/nicotinamide adenine dinucleotide phosphate oxidase pathway independently of retinol and STRA6, which stimulates expression of proinflammatory molecules, such as vascular cell adhesion molecule 1, E‑selectin, intercellular adhesion molecule 1, monocyte chemoattractant protein 1 and TNFα. RBP4 promotes oxidative stress by decreasing endothelial mitochondrial function; overall, it may serve as a useful biomarker in the diagnosis of obesity and prognosis of associated disease, as well as a potential therapeutic target for treatment of these diseases.
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1 

Piché ME, Tchernof A and Després JP: Obesity phenotypes, diabetes, and cardiovascular diseases. Circ Res. 126:1477–1500. 2020. View Article : Google Scholar : PubMed/NCBI

2 

WHO: World Health Organization, . Obesity and overweight. 2021 July 20;https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

3 

Shamah-Levy T, Vielma-Orozco E, Heredia-Hernández O, Romero-Martínez M, Mojica-Cuevas J, Cuevas-Nasu L and Rivera-Dommarco J: Encuesta Nacional de Salud y Nutrición 2018–19: Resultados Nacionales. Pública IN: Instituto Nacional de Salud Pública; 2020

4 

Wu H and Ballantyne CM: Metabolic inflammation and insulin resistance in obesity. Circ Res. 126:1549–1564. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Wang L, Hu J and Zhou H: Macrophage and adipocyte mitochondrial dysfunction in obesity-induced metabolic diseases. World J Mens Health. 39:606–614. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P and Kahn BB: RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 19:512–526. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Nono Nankam PA and Blüher M: Retinol-binding protein 4 in obesity and metabolic dysfunctions. Mol Cell Endocrinol. 531:1113122021. View Article : Google Scholar : PubMed/NCBI

8 

Tsutsumi C, Okuno M, Tannous L, Piantedosi R, Allan M, Goodman DS and Blaner WS: Retinoids and retinoid-binding protein expression in rat adipocytes. J Biol Chem. 267:1805–1810. 1992. View Article : Google Scholar : PubMed/NCBI

9 

Fan J, Yin S, Lin D, Liu Y, Chen N, Bai X, Ke Q, Shen J, You L, Lin X, et al: Association of serum retinol-binding protein 4 Levels and the risk of incident type 2 diabetes in subjects with prediabetes. Diabetes Care. 42:1574–1581. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Grosjean F, Esposito P, Maccarrone R, Libetta C, Dal Canton A and Rampino T: RBP4: A culprit for insulin resistance in end stage renal disease that can be cleared by hemodiafiltration. BioMed Res Int. Nov 23–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

11 

Li G, Esangbedo IC, Xu L, Fu J, Li L, Feng D, Han L, Xiao X, Li M, Mi J, et al: Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: The BCAMS study. Cardiovasc Diabetol. 17:692018. View Article : Google Scholar : PubMed/NCBI

12 

Grzegorczyk EA, Harasim-Symbor E, Lukaszuk B, Harasiuk D, Choromanska B, Mysliwiec P, Zendzian-Piotrowska M and Chabowski A: Lack of pronounced changes in the expression of fatty acid handling proteins in adipose tissue and plasma of morbidly obese humans. Nutr Diabetes. 8:32018. View Article : Google Scholar : PubMed/NCBI

13 

Chen Y, Lv P, Du M, Liang Z, Zhou M and Chen D: Increased retinol-free RBP4 contributes to insulin resistance in gestational diabetes mellitus. Arch Gynecol Obstet. 296:53–61. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Abbas NAT and El Salem A: Metformin, sitagliptin, and liraglutide modulate serum retinol-binding protein-4 level and adipocytokine production in type 2 diabetes mellitus rat model. Can J Physiol Pharmacol. 96:1226–1231. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Steinhoff JS, Lass A and Schupp M: Biological functions of RBP4 and its relevance for human diseases. Front Physiol. 12:6599772021. View Article : Google Scholar : PubMed/NCBI

16 

Fairulnizal Md, Noh M, Devi Nair Gunasegavan R and Mustar S: Vitamin A in health and disease. Vitamin A. 2019. View Article : Google Scholar

17 

Olsen T and Blomhoff R: Retinol, retinoic acid, and retinol-binding protein 4 are differentially associated with cardiovascular disease, type 2 diabetes, and obesity: An overview of human studies. Adv Nutr. 11:644–666. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Zabetian-Targhi F, Mahmoudi MJ, Rezaei N and Mahmoudi M: Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases. Adv Nutr. 6:748–762. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Noy N: Vitamin A in regulation of insulin responsiveness: Mini review. Proc Nutr Soc. 75:212–215. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D and Sun H: A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 315:820–825. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Napoli JL: Functions of intracellular retinoid binding-proteins. Subcell Biochem. 81:21–76. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Saari JC: Vitamin A metabolism in rod and cone visual cycles. Annu Rev Nutr. 32:125–145. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Dowling JE: Vitamin A: Its many roles-from vision and synaptic plasticity to infant mortality. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 206:389–399. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Chelstowska S, Widjaja-Adhi MA, Silvaroli JA and Golczak M: Molecular basis for vitamin A uptake and storage in vertebrates. Nutrients. 8:6762016. View Article : Google Scholar : PubMed/NCBI

25 

Wright CB, Redmond TM and Nickerson JM: A history of the classical visual cycle. Prog Mol Biol Transl Sci. 134:433–448. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Yang FC, Xu F, Wang TN and Chen GX: Roles of vitamin A in the regulation of fatty acid synthesis. World J Clin Cases. 9:4506–4519. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Iskakova M, Karbyshev M, Piskunov A and Rochette-Egly C: Nuclear and extranuclear effects of vitamin A. Can J Physiol Pharmacol. 93:1065–1075. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Ghyselinck NB and Duester G: Retinoic acid signaling pathways. Development. 146:dev1675022019. View Article : Google Scholar : PubMed/NCBI

29 

Balmer JE and Blomhoff R: Gene expression regulation by retinoic acid. J Lipid Res. 43:1773–1808. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Smith JE, Borek C, Gawinowicz MA and Goodman DS: Structure-function relationships of retinoids in their effects on retinol-binding protein metabolism in cultured H4II EC3 liver cells. Arch Biochem Biophys. 238:1–9. 1985. View Article : Google Scholar : PubMed/NCBI

31 

Bellovino D, Lanyau Y, Garaguso I, Amicone L, Cavallari C, Tripodi M and Gaetani S: MMH cells: An in vitro model for the study of retinol-binding protein secretion regulated by retinol. J Cell Physiol. 181:24–32. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Boaghi A, Pop RM, Vasilache SL, Banescu C, Hutanu A, Marginean OC and Pascanu IM: Plasma RBP4 level in association with body composition, metabolic profile, STRA6 and RBP4 gene polymorphisms in obese Romanian children. Diabetes Metab Syndr Obes. 13:4643–4650. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L and Kahn BB: Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 436:356–362. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Codoñer-Franch P, Mora-Herranz A, Simó-Jordá R, Pérez-Rambla C, Boix-García L and Faus-Pérez A: Retinol-binding protein 4 levels are associated with measures of liver and renal function and oxidant/antioxidant status in obese children. J Pediatr. 163:593–595. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Wessel H, Saeed A, Heegsma J, Connelly MA, Faber KN and Dullaart RPF: Plasma levels of retinol binding protein 4 relate to large VLDL and small LDL particles in subjects with and without type 2 diabetes. J Clin Med. 8:17922019. View Article : Google Scholar : PubMed/NCBI

36 

Korek E, Gibas-Dorna M, Chęcińska-Maciejewska Z, Krauss H, Łagiedo-Żelazowska M, Kołodziejczak B and Bogdański P: Serum RBP4 positively correlates with triglyceride level but not with BMI, fat mass and insulin resistance in healthy obese and non-obese individuals. Biomarkers. 23:683–688. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Mateo-Gallego R, Lamiquiz-Moneo I, Perez-Calahorra S, Marco-Benedí V, Bea AM, Baila-Rueda L, Laclaustra M, Peñalvo JL, Civeira F and Cenarro A: Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women. Nutr Metab Cardiovasc Dis. 28:133–142. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Comerford KB, Buchan W and Karakas SE: The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res. 46:224–231. 2014.PubMed/NCBI

39 

Numao S, Sasai H, Nomata Y, Matsuo T, Eto M, Tsujimoto T and Tanaka K: Effects of exercise training on circulating retinol-binding protein 4 and cardiovascular disease risk factors in obese men. Obes Facts. 5:845–855. 2012. View Article : Google Scholar : PubMed/NCBI

40 

López-Domènech S, Abad-Jiménez Z, Iannantuoni F, de Marañón AM, Rovira-Llopis S, Morillas C, Bañuls C, Víctor VM and Rocha M: Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity. Mol Metab. 19:24–33. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Kwanbunjan K, Panprathip P, Phosat C, Chumpathat N, Wechjakwen N, Puduang S, Auyyuenyong R, Henkel I and Schweigert FJ: Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk. BMC Endocr Disord. 18:262018. View Article : Google Scholar : PubMed/NCBI

42 

Zhou W, Ye SD, Chen C and Wang W: Involvement of RBP4 in diabetic atherosclerosis and the role of vitamin D intervention. J Diabetes Res. 2018:73298612018. View Article : Google Scholar : PubMed/NCBI

43 

Weiss K, Mihály J, Liebisch G, Marosvölgyi T, Schmitz G, Decsi T and Rühl R: Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice. Lipids. 46:1013–1020. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Rosell M, Hondares E, Iwamoto S, Gonzalez FJ, Wabitsch M, Staels B, Olmos Y, Monsalve M, Giralt M, Iglesias R and Villarroya F: Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue. Endocrinology. 153:1162–1173. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Moraes-Vieira PM, Yore MM, Sontheimer-Phelps A, Castoldi A, Norseen J, Aryal P, Simonyté Sjödin K and Kahn BB: Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4. Proc Natl Acad Sci USA. 117:31309–31318. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Yesudhas D, Gosu V, Anwar MA and Choi S: Multiple roles of toll-like receptor 4 in colorectal cancer. Front Immunol. 5:3342014. View Article : Google Scholar : PubMed/NCBI

47 

Kilicarslan M, de Weijer BA, Simonyté Sjödin K, Aryal P, Ter Horst KW, Cakir H, Romijn JA, Ackermans MT, Janssen IM, Berends FJ, et al: RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women. FASEB J. 34:6099–6110. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Grant RW and Stephens JM: Fat in flames: Influence of cytokines and pattern recognition receptors on adipocyte lipolysis. Am J Physiol Endocrinol Metab. 309:E205–E213. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Morigny P, Houssier M, Mouisel E and Langin D: Adipocyte lipolysis and insulin resistance. Biochimie. 125:259–266. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Farjo KM, Farjo RA, Halsey S, Moiseyev G and Ma JX: Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 32:5103–5115. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, et al: Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 32:2010–2019. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Pandey GK, Balasubramanyam J, Balakumar M, Deepa M, Anjana RM, Abhijit S, Kaviya A, Velmurugan K, Miranda P, Balasubramanyam M, et al: Altered circulating levels of retinol binding protein 4 and transthyretin in relation to insulin resistance, obesity, and glucose intolerance in Asian Indians. Endocr Pract. 21:861–869. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Grundy SM: Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol. 83:25F–29F. 1999. View Article : Google Scholar : PubMed/NCBI

54 

Yousefi MR and TaheriChadorneshin H: The effect of moderate endurance training on gastrocnemius retinol-binding protein 4 and insulin resistance in streptozotocin-induced diabetic rats. Interv Med Appl Sci. 10:59–63. 2018.PubMed/NCBI

55 

Marschner RA, Pinto G, Borges J, Markoski MM, Schaan BD and Lehnen AM: Short-term detraining does not change insulin sensitivity and RBP4 in rodents previously submitted to aerobic exercise. Horm Metab Res. 49:58–63. 2017.PubMed/NCBI

56 

Sapra A and Bhandari P: Diabetes mellitus. StatPearls. StatPearls Publishing; Treasure Island, FL: 2022

57 

Huang R, Bai X, Li X, Wang X and Zhao L: Retinol-binding protein 4 activates STRA6, provoking pancreatic β-cell dysfunction in type 2 diabetes. Diabetes. 70:449–463. 2021. View Article : Google Scholar : PubMed/NCBI

58 

Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA and May CL: Islet-1 Is essential for pancreatic β-cell function. Diabetes. 63:4206–4217. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Li JY, Chen XX, Lu XH, Zhang CB, Shi QP and Feng L: Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes. Biosci Rep. 38:BSR201811002018. View Article : Google Scholar : PubMed/NCBI

60 

Han W, Wei H, Kong W, Wang J, Yang L and Wu H: Association between retinol binding protein 4 and diabetic retinopathy among type 2 diabetic patients: A meta-analysis. Acta Diabetol. 57:1203–1218. 2020. View Article : Google Scholar : PubMed/NCBI

61 

Behl T, Kaur I and Kotwani A: Implication of oxidative stress in progression of diabetic retinopathy. Surv Ophthalmol. 61:187–196. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Zhang L, Cheng YL, Xue S and Xu ZG: The role of circulating RBP4 in the type 2 diabetes patients with kidney diseases: A systematic review and meta-analysis. Dis Markers. 2020:88304712020. View Article : Google Scholar : PubMed/NCBI

63 

Mahfouz MH, Assiri AM and Mukhtar MH: Assessment of neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein 4 (RBP4) in type 2 diabetic patients with nephropathy. Biomark Insights. 11:31–40. 2016. View Article : Google Scholar : PubMed/NCBI

64 

Zachariah JP, Hwang S, Hamburg NM, Benjamin EJ, Larson MG, Levy D, Vita JA, Sullivan LM, Mitchell GF and Vasan RS: Circulating adipokines and vascular function: Cross-sectional associations in a community-based cohort. Hypertension. 67:294–300. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Zhang JX, Zhu GP, Zhang BL and Cheng YY: Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese. J Hum Hypertens. 31:611–615. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Liu G, Ding M, Chiuve SE, Rimm EB, Franks PW, Meigs JB, Hu FB and Sun Q: Plasma levels of fatty acid-binding protein 4, retinol-binding protein 4, high-molecular-weight adiponectin, and cardiovascular mortality among men with type 2 diabetes: A 22-year prospective study. Arterioscler Thromb Vasc Biol. 36:2259–2267. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Liu Y, Zhong Y, Chen H, Wang D, Wang M, Ou JS and Xia M: Retinol-binding protein-dependent cholesterol uptake regulates macrophage foam cell formation and promotes atherosclerosis. Circulation. 135:1339–1354. 2017. View Article : Google Scholar : PubMed/NCBI

68 

Rychter AM, Skrzypczak-Zielińska M, Zielińska A, Eder P, Souto EB, Zawada A, Ratajczak AE, Dobrowolska A and Krela-Kaźmierczak I: Is the retinol-binding protein 4 a possible risk factor for cardiovascular diseases in obesity? Int J Mol Sci. 21:52292020. View Article : Google Scholar : PubMed/NCBI

69 

Yaribeygi H, Sathyapalan T, Atkin SL and Sahebkar A: Molecular mechanisms linking oxidative stress and diabetes mellitus. Oxid Med Cell Longev. 2020:86092132020. View Article : Google Scholar : PubMed/NCBI

70 

Papachristoforou E, Lambadiari V, Maratou E and Makrilakis K: Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications. J Diabetes Res. 2020:74897952020. View Article : Google Scholar : PubMed/NCBI

71 

Daneshzad E, Farsad-Naeimi A, Heshmati J, Mirzaei K, Maghbooli Z and Keshavarz SA: The association between dietary antioxidants and adipokines level among obese women. Diabetes Metab Syndr. 13:1369–1373. 2019. View Article : Google Scholar : PubMed/NCBI

72 

Liu Y, Wang D, Li D, Sun R and Xia M: Associations of retinol-binding protein 4 with oxidative stress, inflammatory markers, and metabolic syndrome in a middle-aged and elderly Chinese population. Diabetol Metab Syndr. 6:252014. View Article : Google Scholar : PubMed/NCBI

73 

Wang J, Chen H, Liu Y, Zhou W, Sun R and Xia M: Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage. Atherosclerosis. 240:335–344. 2015. View Article : Google Scholar : PubMed/NCBI

74 

Umeno A, Sakashita M, Sugino S, Murotomi K, Okuzawa T, Morita N, Tomii K, Tsuchiya Y, Yamasaki K, Horie M, et al: Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids. Biosci Rep. 40:BSR201937672020. View Article : Google Scholar : PubMed/NCBI

75 

Makino S, Fujiwara M, Suzukawa K, Handa H, Fujie T, Ohtaka Y, Komatsu Y, Aoki Y, Maruyama H, Terada Y, et al: Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome. Horm Metab Res. 41:221–226. 2009. View Article : Google Scholar : PubMed/NCBI

76 

Nena E, Steiropoulos P, Tzouvelekis A, Tsara V, Hatzizisi O, Kyriazis G, Froudarakis M, Trakada G, Papanas N and Bouros D: Reduction of serum retinol-binding protein-4 levels in nondiabetic obstructive sleep apnea patients under continuous positive airway pressure treatment. Respiration. 80:517–523. 2010. View Article : Google Scholar : PubMed/NCBI

77 

Karamfilova V, Gateva A, Alexiev A, Zheleva N, Velikova T, Ivanova-Boyanova R, Ivanova R, Cherkezov N, Kamenov Z and Mateva L: The association between retinol-binding protein 4 and prediabetes in obese patients with nonalcoholic fatty liver disease. Arch Physiol Biochem. 128:217–222. 2022. View Article : Google Scholar : PubMed/NCBI

78 

Saeed A, Bartuzi P, Heegsma J, Dekker D, Kloosterhuis N, de Bruin A, Jonker JW, van de Sluis B and Faber KN: Impaired hepatic vitamin A metabolism in NAFLD mice leading to vitamin A accumulation in hepatocytes. Cell Mol Gastroenterol Hepatol. 11:309–325.e3. 2021. View Article : Google Scholar : PubMed/NCBI

79 

Wang X, Chen X, Zhang H, Pang J, Lin J, Xu X, Yang L, Ma J, Ling W and Chen Y: Circulating retinol-binding protein 4 is associated with the development and regression of non-alcoholic fatty liver disease. Diabetes Metab. 46:119–128. 2020. View Article : Google Scholar : PubMed/NCBI

80 

Tsai YL, Liu CW, Huang SF, Yang YY, Lin MW, Huang CC, Li TH, Huang YH, Hou MC and Lin HC: Urinary fatty acid and retinol binding protein-4 predict CKD progression in severe NAFLD patients with hypertension: 4-Year study with clinical and experimental approaches. Medicine (Baltimore). 99:e186262020. View Article : Google Scholar : PubMed/NCBI

81 

Toussirot E, Aubin F, Desmarets M, Wendling D, Augé B, Gillard J, Messica O, Guillot X, Laheurte C, Monnet E and Dumoulin G: Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk. Rheumatology (Oxford). 60:2816–2825. 2021. View Article : Google Scholar : PubMed/NCBI

82 

Scotece M, Koskinen-Kolasa A, Pemmari A, Leppänen T, Hämäläinen M, Moilanen T, Moilanen E and Vuolteenaho K: Novel adipokine associated with OA: Retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients. Inflamm Res. 69:415–421. 2020. View Article : Google Scholar : PubMed/NCBI

83 

Fan J, Zhu J, Sun L and Li Y, Wang T and Li Y: Causal association of adipokines with osteoarthritis: A Mendelian randomization study. Rheumatology (Oxford). 60:2808–2815. 2021. View Article : Google Scholar : PubMed/NCBI

84 

Li M, Wang Z, Zhu L, Shui Y, Zhang S and Guo W: Down-regulation of RBP4 indicates a poor prognosis and correlates with immune cell infiltration in hepatocellular carcinoma. Biosci Rep. 41:BSR202103282021. View Article : Google Scholar : PubMed/NCBI

85 

Papiernik D, Urbaniak A, Kłopotowska D, Nasulewicz-Goldeman A, Ekiert M, Nowak M, Jarosz J, Cuprych M, Strzykalska A, Ugorski M, et al: Retinol-binding protein 4 accelerates metastatic spread and increases impairment of blood flow in mouse mammary gland tumors. Cancers (Basel). 12:6232020. View Article : Google Scholar : PubMed/NCBI

86 

Wu M, Li Q and Wang H: Identification of novel biomarkers associated with the prognosis and potential pathogenesis of breast cancer via integrated bioinformatics analysis. Technol Cancer Res Treat. 20:15330338219920812021. View Article : Google Scholar : PubMed/NCBI

87 

Tsakogiannis D, Kalogera E, Zagouri F, Zografos E, Balalis D and Bletsa G: Determination of FABP4, RBP4 and the MMP-9/NGAL complex in the serum of women with breast cancer. Oncol Lett. 21:852021. View Article : Google Scholar : PubMed/NCBI

88 

Hu X, Huang W, Wang F, Dai Y, Hu X, Yue D and Wang S: Serum levels of retinol-binding protein 4 and the risk of non-small cell lung cancer: A case-control study. Medicine (Baltimore). 99:e212542020. View Article : Google Scholar : PubMed/NCBI

89 

Komor MA, Bosch LJ, Coupé VM, Rausch C, Pham TV, Piersma SR, Mongera S, Mulder CJ, Dekker E, Kuipers EJ, et al: Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression. J Pathol. 250:288–298. 2020. View Article : Google Scholar : PubMed/NCBI

90 

Wang Y, Wang Y and Zhang Z: Adipokine RBP4 drives ovarian cancer cell migration. J Ovarian Res. 11:292018. View Article : Google Scholar : PubMed/NCBI

91 

Preitner F, Mody N, Graham TE, Peroni OD and Kahn BB: Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. Am J Physiol Endocrinol Metab. 297:E1420–E1429. 2009. View Article : Google Scholar : PubMed/NCBI

92 

Cioffi CL, Racz B, Varadi A, Freeman EE, Conlon MP, Chen P, Zhu L, Kitchen DB, Barnes KD, Martin WH, et al: Design, synthesis, and preclinical efficacy of novel nonretinoid antagonists of retinol-binding protein 4 in the mouse model of hepatic steatosis. J Med Chem. 62:5470–5500. 2019. View Article : Google Scholar : PubMed/NCBI

93 

Kim N and Priefer R: Retinol binding protein 4 antagonists and protein synthesis inhibitors: Potential for therapeutic development. Eur J Med Chem. 226:1138562021. View Article : Google Scholar : PubMed/NCBI

94 

Zhu C, Xiao Y, Liu X, Han J, Zhang J, Wei L and Jia W: Pioglitazone lowers serum retinol binding protein 4 by suppressing its expression in adipose tissue of obese rats. Cell Physiol Biochem. 35:778–788. 2015. View Article : Google Scholar : PubMed/NCBI

95 

Hu H, Xu M, Qi R, Wang Y, Wang C, Liu J, Luo L, Xia L and Fang Z: Sitagliptin downregulates retinol-binding protein 4 and upregulates glucose transporter type 4 expression in a type 2 diabetes mellitus rat model. Int J Clin Exp Med. 8:17902–17911. 2015.PubMed/NCBI

96 

Miller AP, Black M and Amengual J: Fenretinide inhibits vitamin A formation from β-carotene and regulates carotenoid levels in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 1867:1590702022. View Article : Google Scholar : PubMed/NCBI

97 

Blaner WS: Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders. Pharmacol Ther. 197:153–178. 2019. View Article : Google Scholar : PubMed/NCBI

98 

Racz B, Varadi A, Kong J, Allikmets R, Pearson PG, Johnson G, Cioffi CL and Petrukhin K: A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle. J Biol Chem. 293(29): 11574–11588. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Flores-Cortez YA, Barragán-Bonilla MI, Mendoza-Bello JM, González-Calixto C, Flores-Alfaro E and Espinoza-Rojo M: Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). Mol Med Rep 26: 244, 2022.
APA
Flores-Cortez, Y.A., Barragán-Bonilla, M.I., Mendoza-Bello, J.M., González-Calixto, C., Flores-Alfaro, E., & Espinoza-Rojo, M. (2022). Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). Molecular Medicine Reports, 26, 244. https://doi.org/10.3892/mmr.2022.12760
MLA
Flores-Cortez, Y. A., Barragán-Bonilla, M. I., Mendoza-Bello, J. M., González-Calixto, C., Flores-Alfaro, E., Espinoza-Rojo, M."Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)". Molecular Medicine Reports 26.1 (2022): 244.
Chicago
Flores-Cortez, Y. A., Barragán-Bonilla, M. I., Mendoza-Bello, J. M., González-Calixto, C., Flores-Alfaro, E., Espinoza-Rojo, M."Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)". Molecular Medicine Reports 26, no. 1 (2022): 244. https://doi.org/10.3892/mmr.2022.12760
Copy and paste a formatted citation
x
Spandidos Publications style
Flores-Cortez YA, Barragán-Bonilla MI, Mendoza-Bello JM, González-Calixto C, Flores-Alfaro E and Espinoza-Rojo M: Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). Mol Med Rep 26: 244, 2022.
APA
Flores-Cortez, Y.A., Barragán-Bonilla, M.I., Mendoza-Bello, J.M., González-Calixto, C., Flores-Alfaro, E., & Espinoza-Rojo, M. (2022). Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). Molecular Medicine Reports, 26, 244. https://doi.org/10.3892/mmr.2022.12760
MLA
Flores-Cortez, Y. A., Barragán-Bonilla, M. I., Mendoza-Bello, J. M., González-Calixto, C., Flores-Alfaro, E., Espinoza-Rojo, M."Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)". Molecular Medicine Reports 26.1 (2022): 244.
Chicago
Flores-Cortez, Y. A., Barragán-Bonilla, M. I., Mendoza-Bello, J. M., González-Calixto, C., Flores-Alfaro, E., Espinoza-Rojo, M."Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)". Molecular Medicine Reports 26, no. 1 (2022): 244. https://doi.org/10.3892/mmr.2022.12760
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