Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2022 Volume 26 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2022 Volume 26 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways in vitro

  • Authors:
    • Tian Xie
    • Jun Yuan
    • Ling Mei
    • Ping Li
    • Ruijie Pan
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430014, P.R. China, College of Acupuncture and Bone Injury, Hubei University of Chinese Medicine, Wuhan, Hubei 430061, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 260
    |
    Published online on: June 20, 2022
       https://doi.org/10.3892/mmr.2022.12776
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intervertebral disc degeneration (IDD) is the main pathogenesis of numerous cases of chronic neck and back pain, and has become the leading cause of spinal‑related disability worldwide. Hyperoside is an active flavonoid glycoside that exhibits anti‑inflammation, anti‑oxidation and anti‑apoptosis effects. The purpose of the present study was to investigate the effect of hyperoside on tumor necrosis factor (TNF)‑α‑induced IDD progression in human nucleus pulposus cells (NPCs) and its potential mechanism. The activity and apoptosis of NPCs were detected by Cell Counting Kit‑8 and flow cytometry analyses, respectively. The expression of interleukin (IL)‑6 and IL‑1β was detected with ELISA kits. Western blotting was used to detect the expression levels of proteins. The results showed that hyperoside effectively alleviated TNF‑α‑induced NPC apoptosis, and hyperoside treatment inhibited the upregulation of inducible nitric oxide synthase, cyclooxygenase‑2, IL‑1β and IL‑6 in TNF‑α‑stimulated NPCs. Compared with the findings in the TNF‑α group, the intervention of hyperoside attenuated the upregulated expression of aggrecan and collagen II, and downregulated the expressions of matrix metalloproteinase (MMP) 3, MMP13 and a disintegrin and metalloproteinase with thrombospondin motifs 5. In addition, hyperoside upregulated sirtuin‑1 (SIRT1) and nuclear factor E2‑related factor 2 (Nrf2) protein expression, and inhibition of SIRT1 or Nrf2 signaling reversed the protective effect of hyperoside on TNF‑α‑induced NPCs. In summary, hyperoside ameliorated TNF‑α‑induced inflammation, extracellular matrix degradation, and endoplasmic reticulum stress‑mediated apoptosis, which may be associated with the regulation of the SIRT1/NF‑κB and Nrf2/antioxidant responsive element signaling pathways by hyperoside.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Risbud MV and Shapiro IM: Role of cytokines in intervertebral disc degeneration: Pain and disc content. Nat Rev Rheumatol. 10:44–56. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Kos N, Gradisnik L and Velnar T: A brief review of the degenerative intervertebral disc disease. Med Arch. 73:421–424. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Dowdell J, Erwin M, Choma T, Vaccaro A, Iatridis J and Cho SK: Intervertebral disk degeneration and repair. Neurosurgery. 80 (3 Suppl):S46–S54. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Li Z, Chen X, Xu D, Li S, Chan MTV and Wu WKK: Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 52:e127042019. View Article : Google Scholar : PubMed/NCBI

5 

Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X and Yang C: Exosomes from mesenchymal stem cells modulate ER stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics. 9:4084–4100. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Navone SE, Marfia G, Giannoni A, Beretta M, Guarnaccia L, Gualtierotti R, Nicoli D, Rampini P and Campanella R: Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histol Histopathol. 32:523–542. 2017.PubMed/NCBI

7 

Zhang GZ, Deng YJ, Xie QQ, Ren EH, Ma ZJ, He XG, Gao YC and Kang XW: Sirtuins and intervertebral disc degeneration: Roles in inflammation oxidative stress and mitochondrial function. Clin Chim Acta. 508:33–42. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Wang Y, Che M, Xin J, Zheng Z, Li J and Zhang S: The role of IL-1β and TNF-α in intervertebral disc degeneration. Biomed Pharmacother. 131:1106602020. View Article : Google Scholar : PubMed/NCBI

9 

Constable MD and Knoblich G: Sticking together? Re-binding previous other-associated stimuli interferes with self-verification but not partner-verification. Acta Psychol (Amst). 210:1031672020. View Article : Google Scholar : PubMed/NCBI

10 

Rosi IM, Bombardieri F, Steri D, Sternativo M and Rancati S: ‘Those plates that save me’: Experiences of Italian patients with implantable cardioverter defibrillator. Clin Nurs Res. 30:616–624. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Ku SK, Zhou W, Lee W, Han MS, Na M and Bae JS: Anti-inflammatory effects of hyperoside in human endothelial cells and in mice. Inflammation. 38:784–99. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM and Bishayee A: Dietary plants for the prevention and management of kidney stones: Preclinical and clinical evidence and molecular mechanisms. Int J Mol Sci. 19:7652018. View Article : Google Scholar : PubMed/NCBI

13 

Charachit N, Sukhamwang A, Dejkriengkraikul P and Yodkeeree S: Hyperoside and quercitrin in houttuynia cordata extract attenuate UVB-induced human keratinocyte cell damage and oxidative stress via modulation of MAPKs and Akt signaling pathway. Antioxidants (Basel). 11:2212022. View Article : Google Scholar : PubMed/NCBI

14 

Zhang J, Liu Y and Liu L: Hyperoside prevents sepsis–associated cardiac dysfunction through regulating cardiomyocyte viability and inflammation via inhibiting miR-21. Biomed Pharmacother. 138:1115242021. View Article : Google Scholar : PubMed/NCBI

15 

Hu X, Li H, Fu L, Liu F, Wang H, Li M, Jiang C and Yin B: The protective effect of hyperin on LPS-induced acute lung injury in mice. Microb Pathog. 127:116–120. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Huang C, Yang Y, Li WX, Wu XQ, Li XF, Ma TT, Zhang L, Meng XM and Li J: Hyperin attenuates inflammation by activating PPAR-γ in mice with acute liver injury (ALI) and LPS-induced RAW264.7 cells. Int Immunopharmacol. 29:440–447. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Han F, Li Z, Han S, Jia Y, Bai L, Li X and Hu D: SIRT1 suppresses burn injury-induced inflammatory response through activating autophagy in RAW264.7 macrophages. J Investig Med. 69:761–767. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Qi W, Ren D, Wang P, Song Z, Wu H, Yao S, Geng L, Su Y and Bai X: Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates ECM remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway. Int Immunopharmacol. 88:1069042020. View Article : Google Scholar : PubMed/NCBI

19 

Shen J, Fang J, Hao J, Zhong X, Wang D, Ren H and Hu Z: SIRT1 inhibits the catabolic effect of IL-1β through TLR2/SIRT1/NF-κB pathway in human degenerative nucleus pulposus cells. Pain Physician. 19:E215–E226. 2016.PubMed/NCBI

20 

Huang J, Zhou L, Chen J, Chen T, Lei B, Zheng N, Wan X, Xu J and Wang T: Hyperoside attenuate inflammation in HT22 cells via upregulating SIRT1 to activities Wnt/β-catenin and sonic hedgehog pathways. Neural Plast. 10:87064002021.PubMed/NCBI

21 

Xing HY, Cai YQ, Wang XF, Wang LL, Li P, Wang GY and Chen JH: The cytoprotective effect of hyperoside against oxidative stress is mediated by the Nrf2-ARE signaling pathway through GSK-3β inactivation. PLoS One. 10:e01451832015. View Article : Google Scholar : PubMed/NCBI

22 

Hou JY, Liu Y, Liu L and Li XM: Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling. Asian Pac J Trop Med. 9:76–80. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Edwards PD, Frenette-Ling C, Palme R and Boonstra R: A mechanism for population self-regulation: Social density suppresses GnRH expression and reduces reproductivity in voles. J Anim Ecol. 90:784–795. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Du L Qian X, Li Y, Li XZ, He LL, Xu L, Liu YQ, Li CC, Ma P, Shu FL, et al: Sirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in diabetic nephropathy. Acta Pharmacol Sin. 42:242–251. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Wang Z, Han N, Zhao K, Li Y, Chi Y and Wang B: Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway. Int Immunopharmacol. 72:445–453. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Roh EJ, Darai A, Kyung JW, Choi H, Kwon SY, Bhujel B, Kim KT and Han I: Genetic therapy for intervertebral disc degeneration. Int J Mol Sci. 22:15792021. View Article : Google Scholar : PubMed/NCBI

27 

Xue J, Hu B, Xing W, Li F, Huang Z, Zheng W, Wang B, Zhu Y and Yang X: Low expression of miR-142-3p promotes intervertebral disk degeneration. J Orthop Surg Res. 16:552021. View Article : Google Scholar : PubMed/NCBI

28 

Mascarenhas RO, Souza MB and Oliveira VC: Treatment of fibromyalgia in the 21st century-reply. JAMA Intern Med. 181:1011–1012. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Zhao Y, Qiu C, Wang W, Peng J, Cheng X, Shangguan Y, Xu M, Li J, Qu R, Chen X, et al: Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation. Theranostics. 10:7015–7033. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L, Bullock R, Isaacs RE, Brown C and Richardson WJ: Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum. 62:1974–1982. 2010.PubMed/NCBI

31 

Sive JI, Baird P, Jeziorsk M, Watkins A, Hoyland JA and Freemont AJ: Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol. 55:91–97. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Seguin CA, Pilliar RM, Roughley PJ and Kandel RA: Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine (Phila Pa 1976). 30:1940–1948. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Wang G, Yang ZQ and Zhang K: ER stress response in cancer: Molecular mechanism and therapeutic potential. Am J Transl Res. 2:65–74. 2010.PubMed/NCBI

34 

Fernandez A, Ordóñez R, Reiter RJ, González-Gallego J and Mauriz JL: Melatonin and ER stress: Relation to autophagy and apoptosis. J Pineal Res. 59:292–307. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Yang L, Guan G, Lei L, Lv Q, Liu S, Zhan X, Jiang Z and Gu X: Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via ER stress and autophagy. Cell Stress Chaperones. 23:1283–1294. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Yan J, Li S, Zhang Y, Deng Z, Wu J, Huang Z, Qin T, Xiao Y, Zhou J, Xu K and Ye W: Cholesterol induces pyroptosis and matrix degradation via mSREBP1-driven ER stress in intervertebral disc degeneration. Front Cell Dev Biol. 9:8031322021. View Article : Google Scholar : PubMed/NCBI

37 

Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F and Xu T: Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study. Phytomedicine. 80:1533872021. View Article : Google Scholar : PubMed/NCBI

38 

Li C, He Y, Yang Y, Gou Y, Li S, Wang R, Zeng S and Zhao X: Antioxidant and inflammatory effects of Nelumbo Nucifera Gaertn. Leaves. Oxid Med Cell Longev. 28:83759612021.PubMed/NCBI

39 

Piao MJ, Kang KA, Zhang R, Ko DO, Wang ZH, You HJ, Kim HS, Kim JS, Kang SS and Hyun JW: Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect. Biochim Biophys Acta. 1780:1448–1457. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Liu Z, Tao X, Zhang C, Lu Y and Wei D: Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Biomed Pharmacother. 59:481–490. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Chiu MC and Hsieh MC: Latent human error analysis and efficient improvement strategies by fuzzy TOPSIS in aviation maintenance tasks. Appl Ergon. 54:136–147. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Wan K, Lu C, Wang T, Qiao C, Lu L, Wu D, Lu M, Chen R, Fan L and Tang J: Hyperoside suppresses NLRP3 inflammasome in parkinson's disease via pituitary adenylate cyclase-activating polypeptide. Neurochem Int. 152:1052542022. View Article : Google Scholar : PubMed/NCBI

43 

Lou T, Huang Q, Su H, Zhao D and Li X: Targeting sirtuin 1 signaling pathway by ginsenosides. J Ethnopharmacol. 268:1136572021. View Article : Google Scholar : PubMed/NCBI

44 

Xu C, Song Y, Wang Z, Jiang J, Piao Y, Li L, Jin S, Li L, Zhu L and Yan G: Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways. Immun Inflamm Dis. 9:1406–1417. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Jiang Z, Wang J, Liu C, Wang X and Pan J: Hyperoside alleviated N-acetyl-para-amino-phenol-induced acute hepatic injury via Nrf2 activation. Int J Clin Exp Pathol. 12:64–76. 2019.PubMed/NCBI

46 

Shao Z, Wang B, Shi Y, Xie C, Huang C, Chen B, Zhang H, Zeng G, Liang H, Wu Y, et al: Senolytic agent quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. Osteoarthritis Cartilage. 29:413–422. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Song D, Ge J, Wang Y, Yan Q, Wu C, Yu H, Yang M, Yang H and Zou J: Tea polyphenol attenuates oxidative stress-induced degeneration of intervertebral discs by regulating the Keap1/Nrf2/ARE pathway. Oxid Med Cell Longev. 7:66841472021.PubMed/NCBI

48 

Chen D, Xia D, Pan Z, Xu D, Zhou Y, Wu Y, Cai N, Tang Q, Wang C, Yan M, et al: Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo. Cell Death Dis. 7:e24412016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie T, Yuan J, Mei L, Li P and Pan R: Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>. Mol Med Rep 26: 260, 2022.
APA
Xie, T., Yuan, J., Mei, L., Li, P., & Pan, R. (2022). Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>. Molecular Medicine Reports, 26, 260. https://doi.org/10.3892/mmr.2022.12776
MLA
Xie, T., Yuan, J., Mei, L., Li, P., Pan, R."Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>". Molecular Medicine Reports 26.2 (2022): 260.
Chicago
Xie, T., Yuan, J., Mei, L., Li, P., Pan, R."Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>". Molecular Medicine Reports 26, no. 2 (2022): 260. https://doi.org/10.3892/mmr.2022.12776
Copy and paste a formatted citation
x
Spandidos Publications style
Xie T, Yuan J, Mei L, Li P and Pan R: Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>. Mol Med Rep 26: 260, 2022.
APA
Xie, T., Yuan, J., Mei, L., Li, P., & Pan, R. (2022). Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>. Molecular Medicine Reports, 26, 260. https://doi.org/10.3892/mmr.2022.12776
MLA
Xie, T., Yuan, J., Mei, L., Li, P., Pan, R."Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>". Molecular Medicine Reports 26.2 (2022): 260.
Chicago
Xie, T., Yuan, J., Mei, L., Li, P., Pan, R."Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways <em>in vitro</em>". Molecular Medicine Reports 26, no. 2 (2022): 260. https://doi.org/10.3892/mmr.2022.12776
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team