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Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression

  • Authors:
    • Xiaoling Li
    • Runqi Chen
    • Lina Wang
    • Zengxue Lu
    • Yangjie Li
    • Dun Tang
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, Guilin People's Hospital, Xiangshan 541002, P.R. China, Department of Gastroenterology, Xing'an County People's Hospital, Xing'an, Guilin, Guangxi 541300, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 270
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    Published online on: July 4, 2022
       https://doi.org/10.3892/mmr.2022.12786
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Abstract

In recent years, the global incidence and mortality of myocardial infarction (MI) has increased and become one of the important diseases threatening public health. Long non‑coding (lnc)RNAs are a type of ncRNA that serve critical roles in the progression of various types of disease. The present study aimed to investigate the effect and mechanism of lncRNA cardiac autophagy inhibitory factor (CAIF) on cardiac ischemia/reperfusion (I/R) injury. CAIF was downregulated in the myocardium of I/R rats and cardiomyocytes treated with hydrogen peroxide (H2O2). Further experiments demonstrated that CAIF overexpression inhibited I/R‑induced cardiac infarction and apoptosis in vivo. CAIF decreased H2O2‑induced apoptosis and oxidative stress of cardiomyocytes. Mechanistically, CAIF sponged microRNA (miR)‑488‑5p; this interaction was confirmed by rescue experiments. Moreover, miR‑488‑5p targeted apoptosis and caspase activation inhibitor (AVEN) and inhibited its expression. In summary, the present data identified a novel CAIF/miR‑488‑5p/AVEN signaling axis as a key regulator of myocyte apoptosis, which may be a potential therapeutic target for the treatment of MI.
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View References

1 

Barnett R: Acute myocardial infarction. Lancet. 393:25802019. View Article : Google Scholar : PubMed/NCBI

2 

Ketchum ES, Dickstein K, Kjekshus J, Pitt B, Wong MF, Linker DT and Levy WC: The seattle post myocardial infarction model (SPIM): Prediction of mortality after acute myocardial infarction with left ventricular dysfunction. Eur Heart J Acute Cardiovasc Care. 3:46–55. 2014. View Article : Google Scholar : PubMed/NCBI

3 

De Villiers C and Riley PR: Mouse models of myocardial infarction: Comparing permanent ligation and ischaemia-reperfusion. Dis Model Mech. 13:dmm0465652020. View Article : Google Scholar : PubMed/NCBI

4 

Blankenberg S, Neumann JT and Westermann D: Diagnosing myocardial infarction: A highly sensitive issue. Lancet. 392:893–894. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Isaaz K and Gerbay A: Deferred stenting in acute ST elevation myocardial infarction. Lancet. 388:13712016. View Article : Google Scholar : PubMed/NCBI

6 

Hombach S and Kretz M: Non-coding RNAs: Classification, biology and functioning. Adv Exp Med Biol. 937:3–17. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Yu BY and Dong B: LncRNA H19 regulates cardiomyocyte apoptosis and acute myocardial infarction by targeting miR-29b. Int J Cardiol. 271:252018. View Article : Google Scholar : PubMed/NCBI

8 

Yin Y, Lv L and Wang W: Expression of miRNA-214 in the sera of elderly patients with acute myocardial infarction and its effect on cardiomyocyte apoptosis. Exp Ther Med. 17:4657–4662. 2019.PubMed/NCBI

9 

Xin B, Liu Y, Li G, Xu Y and Cui W: The role of lncRNA SNHG16 in myocardial cell injury induced by acute myocardial infarction and the underlying functional regulation mechanism. Panminerva Med. 63:388–389. 2019.PubMed/NCBI

10 

Zhang Y, Jiao L, Sun L, Li Y, Gao Y, Xu C, Shao Y, Li M, Li C, Lu Y, et al: LncRNA ZFAS1 as a SERCA2a inhibitor to cause intracellular Ca(2+) overload and contractile dysfunction in a mouse model of myocardial infarction. Circ Res. 122:1354–1368. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Liao J, He Q, Li M, Chen Y, Liu Y and Wang J: LncRNA MIAT: Myocardial infarction associated and more. Gene. 578:158–161. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Hao K, Lei W, Wu H, Wu J, Yang Z, Yan S, Lu XA, Li J, Xia X, Han X, et al: LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction. Theranostics. 9:7282–7297. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Viereck J, Bührke A, Foinquinos A, Chatterjee S, Kleeberger JA, Xiao K, Janssen-Peters H, Batkai S, Ramanujam D, Kraft T, et al: Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy. Eur Heart J. 41:3462–3474. 2020.PubMed/NCBI

14 

Yang J, Huang X, Hu F, Fu X, Jiang Z and Chen K: LncRNA ANRIL knockdown relieves myocardial cell apoptosis in acute myocardial infarction by regulating IL-33/ST2. Cell Cycle. 18:3393–3403. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Yu SY, Dong B, Fang ZF, Hu XQ, Tang L and Zhou SH: Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy. J Cell Mol Med. 22:4886–4898. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Wang SM, Liu GQ, Xian HB, Si JL, Qi SX and Yu YP: LncRNA NEAT1 alleviates sepsis-induced myocardial injury by regulating the TLR2/NF-κB signaling pathway. Eur Rev Med Pharmacol Sci. 23:4898–4907. 2019.PubMed/NCBI

17 

Wang Y and Zhang Y: LncRNA CAIF suppresses LPS-induced inflammation and apoptosis of cardiomyocytes through regulating miR-16 demethylation. Immun Inflamm Dis. 9:1468–1478. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Liu CY, Zhang YH, Li RB, Zhou LY, An T, Zhang RC, Zhai M, Huang Y, Yan KW, Dong YH, et al: LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription. Nat Commun. 9:292018. View Article : Google Scholar : PubMed/NCBI

19 

Leads from the MMWR. Recommendations for protection against viral hepatitis. JAMA. 254:197–198. 1985. View Article : Google Scholar : PubMed/NCBI

20 

Cramer DW and Elias KM: A prognostically relevant miRNA signature for epithelial ovarian cancer. Lancet Oncol. 17:1032–1033. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Krell J, Stebbing J, Frampton AE, Carissimi C, Harding V, De Giorgio A, Fulci V, Macino G, Colombo T and Castellano L: The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network. Lancet. 385 (Suppl 1):S152015. View Article : Google Scholar : PubMed/NCBI

22 

Feng R, Sang Q, Zhu Y, Fu W, Liu M, Xu Y, Shi H, Xu Y, Qu R, Chai R, et al: MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro. Sci Rep. 5:86892015. View Article : Google Scholar : PubMed/NCBI

23 

Collignon J: miRNA in embryonic development: The taming of Nodal signaling. Dev Cell. 13:458–460. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Zhong YX, Li WS, Liao LS and Liang L: LncRNA CCAT1 promotes cell proliferation and differentiation via negative modulation of miRNA-218 in human DPSCs. Eur Rev Med Pharmacol Sci. 23:3575–3583. 2019.PubMed/NCBI

25 

Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK and Kuboki T: miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells. PLoS One. 8:e835452013. View Article : Google Scholar : PubMed/NCBI

26 

Shen N, Liu S, Cui J, Li Q, You Y, Zhong Z, Cheng F, Guo AY, Zou P, Yuan G and Zhu X: Tumor necrosis factor α knockout impaired tumorigenesis in chronic myeloid leukemia cells partly by metabolism modification and miRNA regulation. Onco Targets Ther. 12:2355–2364. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Wu A, Lou L, Zhai J, Zhang D, Chai L, Nie B, Zhu H, Gao Y, Shang H and Zhao M: miRNA expression profile and effect of Wenxin granule in rats with ligation-induced myocardial infarction. Int J Genomics. 2017:21758712017. View Article : Google Scholar : PubMed/NCBI

28 

Wang ZH, Sun XY, Li CL, Sun YM, Li J, Wang LF and Li ZQ: miRNA-21 expression in the serum of elderly patients with acute myocardial infarction. Med Sci Monit. 23:5728–5734. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Zhang L and Jia X: Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven. Cell Mol Biol Lett. 24:612019. View Article : Google Scholar : PubMed/NCBI

30 

American Veterinary Medical Association, . AVMA guidelines for complementary and alternative veterinary medicine. J Am Vet Med Assoc. 218:17312001.PubMed/NCBI

31 

Zeng J, Zhu L, Liu J, Zhu T, Xie Z, Sun X and Zhang H: Metformin protects against oxidative stress injury induced by ischemia/reperfusion via regulation of the lncRNA-H19/miR-148a-3p/Rock2 axis. Oxid Med Cell Longev. 2019:87683272019. View Article : Google Scholar : PubMed/NCBI

32 

Dhalla NS, Elmoselhi AB, Hata T and Makino N: Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res. 47:446–456. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Yang D, Yu J, Liu HB, Yan XQ, Hu J, Yu Y, Guo J, Yuan Y and Du ZM: The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5. Cell Death Dis. 10:9082019. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Kroeze A, van Hoeven V, Verheij MW, Turksma AW, Weterings N, van Gassen S, Zeerleder SS, Blom B, Voermans C and Hazenberg MD: Presence of innate lymphoid cells in allogeneic hematopoietic grafts correlates with reduced graft-versus-host disease. Cytotherapy. 24:302–310. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Yoshimura C, Nagasaka A, Kurose H and Nakaya M: Efferocytosis during myocardial infarction. J Biochem. 168:1–6. 2020. View Article : Google Scholar : PubMed/NCBI

37 

González A, Fortuño MA, Querejeta R, Ravassa S, López B, López N and Díez J: Cardiomyocyte apoptosis in hypertensive cardiomyopathy. Cardiovasc Res. 59:549–562. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Zhuo LA, Wen YT, Wang Y, Liang ZF, Wu G, Nong MD and Miao L: LncRNA SNHG8 is identified as a key regulator of acute myocardial infarction by RNA-seq analysis. Lipids Health Dis. 18:2012019. View Article : Google Scholar : PubMed/NCBI

39 

Su Q, Lv XW, Xu YL, Cai RP, Dai RX, Yang XH, Zhao WK and Kong BH: Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial I/R injury via p53-mediated autophagy and apoptosis. Mol Ther Nucleic Acids. 23:1304–1322. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Zhou T, Qin G, Yang L, Xiang D and Li S: LncRNA XIST regulates myocardial infarction by targeting miR-130a-3p. J Cell Physiol. 234:8659–8667. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Zhang G, Sun H, Zhang Y, Zhao H, Fan W, Li J, Lv Y, Song Q, Li J, Zhang M and Shi H: Characterization of dysregulated lncRNA-mRNA network based on ceRNA hypothesis to reveal the occurrence and recurrence of myocardial infarction. Cell Death Discov. 4:352018. View Article : Google Scholar : PubMed/NCBI

42 

Sun F, Zhuang Y, Zhu H, Wu H, Li D, Zhan L, Yang W, Yuan Y, Xie Y, Yang S, et al: LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction. J Mol Cell Cardiol. 133:188–198. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Zhang Y, Hou YM, Gao F, Xiao JW, Li CC and Tang Y: lncRNA GAS5 regulates myocardial infarction by targeting the miR-525-5p/CALM2 axis. J Cell Biochem. 120:18678–186788. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Su T and Shao X, Zhang X, Yang C and Shao X: Value of circulating miRNA-1 detected within 3 h after the onset of acute chest pain in the diagnosis and prognosis of acute myocardial infarction. Int J Cardiol. 307:146–151. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Yaoita H, Ogawa K, Maehara K and Maruyama Y: Apoptosis in relevant clinical situations: Contribution of apoptosis in myocardial infarction. Cardiovasc Res. 45:630–641. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Song Y, Zhang C, Zhang J, Jiao Z, Dong N, Wang G, Wang Z and Wang L: Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction. Theranostics. 9:2346–2360. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Fan PC, Chen CC, Peng CC, Chang CH, Yang CH, Yang C, Chu LJ, Chen YC, Yang CW, Chang YS and Chu PH: A circulating miRNA signature for early diagnosis of acute kidney injury following acute myocardial infarction. J Transl Med. 17:1392019. View Article : Google Scholar : PubMed/NCBI

48 

Bejerano T, Etzion S, Elyagon S, Etzion Y and Cohen S: Nanoparticle delivery of miRNA-21 mimic to cardiac macrophages improves myocardial remodeling after myocardial infarction. Nano Lett. 18:5885–5891. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Gidlöf O, van der Brug M, Ohman J, Gilje P, Olde B, Wahlestedt C and Erlinge D: Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression. Blood. 121:39083917S1–S26. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Bao XL, Zhang L and Song WP: LncRNA SNHG1 overexpression regulates the proliferation of acute myeloid leukemia cells through miR-488-5p/NUP205 axis. Eur Rev Med Pharmacol Sci. 23:5896–5903. 2019.PubMed/NCBI

51 

Arnold J, Engelmann JC, Schneider N, Bosserhoff AK and Kuphal S: miR-488-5p and its role in melanoma. Exp Mol Pathol. 112:1043482020. View Article : Google Scholar : PubMed/NCBI

52 

Jing R, Zhong QQ, Long TY, Pan W and Qian ZX: Downregulated miRNA-26a-5p induces the apoptosis of endothelial cells in coronary heart disease by inhibiting PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 23:4940–4947. 2019.PubMed/NCBI

53 

Dahiya N and Atreya C: MiRNA-103b downregulates ITGB3 and mediates apoptosis in ex vivo stored human platelets. Microrna. 10:123–129. 2021. View Article : Google Scholar : PubMed/NCBI

54 

Melzer IM, Fernández SB, Bösser S, Lohrig K, Lewandrowski U, Wolters D, Kehrloesser S, Brezniceanu ML, Theos AC, Irusta PM, et al: The Apaf-1-binding protein aven is cleaved by cathepsin D to unleash its anti-apoptotic potential. Cell Death Differ. 19:1435–1445. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Chen R, Wang L, Lu Z, Li Y and Tang D: Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Mol Med Rep 26: 270, 2022.
APA
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., & Tang, D. (2022). Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Molecular Medicine Reports, 26, 270. https://doi.org/10.3892/mmr.2022.12786
MLA
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., Tang, D."Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression". Molecular Medicine Reports 26.2 (2022): 270.
Chicago
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., Tang, D."Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression". Molecular Medicine Reports 26, no. 2 (2022): 270. https://doi.org/10.3892/mmr.2022.12786
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Chen R, Wang L, Lu Z, Li Y and Tang D: Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Mol Med Rep 26: 270, 2022.
APA
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., & Tang, D. (2022). Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Molecular Medicine Reports, 26, 270. https://doi.org/10.3892/mmr.2022.12786
MLA
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., Tang, D."Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression". Molecular Medicine Reports 26.2 (2022): 270.
Chicago
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., Tang, D."Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression". Molecular Medicine Reports 26, no. 2 (2022): 270. https://doi.org/10.3892/mmr.2022.12786
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