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Article Open Access

Placental proteome in late‑onset of fetal growth restriction

  • Authors:
    • Tomasz Gęca
    • Aleksandra Stupak
    • Robert Nawrot
    • Anna Goździcka‑Józefiak
    • Anna Kwaśniewska
    • Wojciech Kwaśniewski
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20‑081 Lublin, Poland, Department of Molecular Virology, Institute of Experimental Biology, Adam Mickiewicz University in Poznań, 61‑614 Poznan, Poland, Department of Gynecologic Oncology and Gynecology, Medical University of Lublin, 20‑081 Lublin, Poland
    Copyright: © Gęca et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 356
    |
    Published online on: October 14, 2022
       https://doi.org/10.3892/mmr.2022.12872
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Abstract

Fetal growth restriction (FGR) occurs when the fetus does not reach its genetically programmed intrauterine potential for growth and affects ~5‑10% of pregnancies. This condition is one of the leading causes of perinatal mortality and morbidity associated with obstetric and neonatal complications. Placental dysfunction in FGR causes an impairment in the transfer of nutrients and oxygen from the mother to the developing fetus. Maternal adaptations to placental insufficiency may also play a role in the pathophysiology of FGR. The present study aimed to compare the proteome of the placentas of 18 women with the physiological course of pregnancy and eutrophic fetus [estimated fetal weight (EFW) >10th percentile; control group] and 18 women with late FGR (EFW <10th percentile) diagnosed after 32 weeks of pregnancy, according to the Delphi consensus (study group). The U. Mann‑Whitney test was used to compare two independent groups. The R. Spearman correlation coefficient significance test was used to assess the existence of a relationship between the analyzed measurable parameters. P<0.05 was considered to indicate a statistically significant difference. The tests showed the presence of 356 different proteins which were responsible for the regulation of gene transcription control, inhibiting the activity of proteolytic enzymes, regulation of trophoblast proliferation and angiogenesis and inflammatory response. In the FGR placental proteome, other detected proteins were mostly involved in response to oxidative stress, cellular oxidation and detoxication, apoptosis, hemostatic and catabolic processes, energy transduction protein interactions, cell proliferation, differentiation and intracellular signaling. The present study used chromatographic mass‑spectrometry to compare the placental proteome profiles in pregnancies complicated by late‑onset FGR and normal pregnancy. Comparative analysis of proteomes from normal and FGR placentas showed significant differences. Further research is needed to clarify maternal and fetal adaptations to FGR.
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Copy and paste a formatted citation
Spandidos Publications style
Gęca T, Stupak A, Nawrot R, Goździcka‑Józefiak A, Kwaśniewska A and Kwaśniewski W: Placental proteome in late‑onset of fetal growth restriction. Mol Med Rep 26: 356, 2022.
APA
Gęca, T., Stupak, A., Nawrot, R., Goździcka‑Józefiak, A., Kwaśniewska, A., & Kwaśniewski, W. (2022). Placental proteome in late‑onset of fetal growth restriction. Molecular Medicine Reports, 26, 356. https://doi.org/10.3892/mmr.2022.12872
MLA
Gęca, T., Stupak, A., Nawrot, R., Goździcka‑Józefiak, A., Kwaśniewska, A., Kwaśniewski, W."Placental proteome in late‑onset of fetal growth restriction". Molecular Medicine Reports 26.6 (2022): 356.
Chicago
Gęca, T., Stupak, A., Nawrot, R., Goździcka‑Józefiak, A., Kwaśniewska, A., Kwaśniewski, W."Placental proteome in late‑onset of fetal growth restriction". Molecular Medicine Reports 26, no. 6 (2022): 356. https://doi.org/10.3892/mmr.2022.12872
Copy and paste a formatted citation
x
Spandidos Publications style
Gęca T, Stupak A, Nawrot R, Goździcka‑Józefiak A, Kwaśniewska A and Kwaśniewski W: Placental proteome in late‑onset of fetal growth restriction. Mol Med Rep 26: 356, 2022.
APA
Gęca, T., Stupak, A., Nawrot, R., Goździcka‑Józefiak, A., Kwaśniewska, A., & Kwaśniewski, W. (2022). Placental proteome in late‑onset of fetal growth restriction. Molecular Medicine Reports, 26, 356. https://doi.org/10.3892/mmr.2022.12872
MLA
Gęca, T., Stupak, A., Nawrot, R., Goździcka‑Józefiak, A., Kwaśniewska, A., Kwaśniewski, W."Placental proteome in late‑onset of fetal growth restriction". Molecular Medicine Reports 26.6 (2022): 356.
Chicago
Gęca, T., Stupak, A., Nawrot, R., Goździcka‑Józefiak, A., Kwaśniewska, A., Kwaśniewski, W."Placental proteome in late‑onset of fetal growth restriction". Molecular Medicine Reports 26, no. 6 (2022): 356. https://doi.org/10.3892/mmr.2022.12872
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