Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2023 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2023 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells

  • Authors:
    • Hong Li
    • Licong Sun
    • Yuesen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
    |
    Published online on: April 5, 2023
       https://doi.org/10.3892/mmr.2023.12993
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Interleukin (IL)‑1β is a pathogenic factor associated with the destruction of periodontal tissue in periodontitis. IL‑1β processing is regulated by cytosolic machinery known as the inflammasome. Porphyromonas gingivalis infection and lipopolysaccharide (LPS) have an important role in the destruction of periodontal tissue in periodontitis. P. gingivalis infection and LPS have been reported to activate the NOD‑like receptor family pyrin domain‑containing protein 3 (NLRP3) inflammasome in human oral cells. Stem cell therapy exhibits anti‑inflammatory effects and stem cell‑conditioned culture media (SCM) shows similar beneficial effects. The present study tested the hypothesis that SCM inhibits activation of the inflammasome and protects human gingival epithelial cells (GECs) against LPS‑induced inflammatory damage. Human GECs were treated with or without LPS plus SCM or control cell media. NLPR3 inflammasome components and inflammatory factors were measured by western blotting and immunofluorescence. The present study revealed that LPS induced an increase in the expression of inflammasome components, NLRP3, apoptosis‑associated speck‑like protein containing a caspase recruitment domain (ASC) and caspase‑1. Co‑immunoprecipitation revealed increased binding of NLRP3 and ASC, and immunofluorescence showed an increased co‑localization of ASC and caspase‑1, suggesting that LPS stimulated assembly of the NLRP3 inflammasome. SCM inhibited the overexpression and assembly of NLRP3 inflammasome components induced by LPS. Furthermore, SCM blocked the increase in IL‑1β production induced by LPS and inhibited the translocation of the inflammatory factor, NF‑κB, into the nuclei. Consequently, SCM protected cells against LPS‑induced damage, as suggested by the recovery of disturbed E‑cadherin staining pattern, which indicates a disruption in epithelial integrity. In conclusion, treatment with SCM may attenuate LPS‑induced inflammatory damage in human GECs via inhibition of NLRP3 inflammasome activation, suggesting a potential therapeutic use for SCM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Nazir MA: Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 11:72–80. 2017.PubMed/NCBI

2 

Bascones A, Noronha S, Gomez M, Mota P, Moles MA and Dorrego MV: Tissue destruction in periodontitis: Bacteria or cytokines fault? Quintessence Int. 36:299–306. 2005.PubMed/NCBI

3 

Orozco A, Gemmell E, Bickel M and Seymour GJ: Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. Oral Microbiol Immunol. 21:256–260. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Pedra JH, Cassel SL and Sutterwala FS: Sensing pathogens and danger signals by the inflammasome. Curr Opin Immunol. 21:10–16. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Schroder K and Tschopp J: The inflammasomes. Cell. 140:821–832. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Broz P and Monack DM: Molecular mechanisms of inflammasome activation during microbial infections. Immunol Rev. 243:174–190. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Bostanci N, Emingil G, Saygan B, Turkoglu O, Atilla G, Curtis MA and Belibasakis GN: Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. Clin Exp Immunol. 157:415–422. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Park E, Na HS, Song YR, Shin SY, Kim YM and Chung J: Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection. Infect Immun. 82:112–123. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Picciolo G, Mannino F, Irrera N, Minutoli L, Altavilla D, Vaccaro M, Oteri G, Squadrito F and Pallio G: Reduction of oxidative stress blunts the NLRP3 inflammatory cascade in LPS stimulated human gingival fibroblasts and oral mucosal epithelial cells. Biomed Pharmacother. 146:1125252022. View Article : Google Scholar : PubMed/NCBI

10 

Huang X, Yang X, Ni J, Xie B, Liu Y, Xuan D and Zhang J: Hyperglucose contributes to periodontitis: Involvement of the NLRP3 pathway by engaging the innate immunity of oral gingival epithelium. J Periodontol. 86:327–335. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Yilmaz O: The chronicles of porphyromonas gingivalis: The microbium, the human oral epithelium and their interplay. Microbiology (Reading). 154:2897–2903. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Larijani B, Esfahani EN, Amini P, Nikbin B, Alimoghaddam K, Amiri S, Malekzadeh R, Yazdi NM, Ghodsi M, Dowlati Y, et al: Stem cell therapy in treatment of different diseases. Acta Med Iran. 50:79–96. 2012.PubMed/NCBI

13 

Malliaras K and Marban E: Cardiac cell therapy: Where we've been, where we are, and where we should be headed. Br Med Bull. 98:161–185. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Souidi N, Stolk M and Seifert M: Ischemia-reperfusion injury: Beneficial effects of mesenchymal stromal cells. Curr Opin Organ Transplant. 18:34–43. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Bi B, Schmitt R, Israilova M, Nishio H and Cantley LG: Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol. 18:2486–2496. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Mariani E and Facchini A: Clinical applications and biosafety of human adult mesenchymal stem cells. Curr Pharm Des. 18:1821–1845. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Ionescu L, Byrne RN, van Haaften T, Vadivel A, Alphonse RS, Rey-Parra GJ, Weissmann G, Hall A, Eaton F and Thébaud B: Stem cell conditioned medium improves acute lung injury in mice: In vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol. 303:L967–L977. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Walter MN, Wright KT, Fuller HR, MacNeil S and Johnson WE: Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res. 316:1271–1281. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Nguyen BK, Maltais S, Perrault LP, Tanguay JF, Tardif JC, Stevens LM, Borie M, Harel F, Mansour S and Noiseux N: Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors. J Cardiovasc Transl Res. 3:547–558. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Lee JW, Fang X, Gupta N, Serikov V and Matthay MA: Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA. 106:16357–16362. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Lepperdinger G, Brunauer R, Jamnig A, Laschober G and Kassem M: Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies? Exp Gerontol. 43:1018–1023. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, et al: Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation. PLoS One. 8:e767542013. View Article : Google Scholar : PubMed/NCBI

23 

Yilmaz O, Sater AA, Yao L, Koutouzis T, Pettengill M and Ojcius DM: ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis. Cell Microbiol. 12:188–198. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Kamo N, Ke B, Ghaffari AA, Shen XD, Busuttil RW, Cheng G and Kupiec-Weglinski JW: ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology. 58:351–362. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Li H, Zhou X and Zhang J: Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced inflammasome activation in human gingival epithelial cells. Int J Mol Med. 34:1039–1044. 2014. View Article : Google Scholar : PubMed/NCBI

26 

SHEN H, ZHANG D and LIU H: Mesenchymal stem cell conditioned medium azacytidine, panobinostat and GSK126 alleviate TGF-β-induced EMT in lung cancer. Food Sci Technol. 42:530212021. View Article : Google Scholar

27 

Wang L, Li Y, Zhang X, Liu N, Shen S, Sun S, Jiang Y, Li P, Jin H and Shen L: Paracrine interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration. Biosci Rep. 41:BSR202101982021. View Article : Google Scholar : PubMed/NCBI

28 

Zhang J, Gao Y, Chen P, Zhou Y, Guo S, Wang L and Chen J: Bone marrow-derived mesenchymal stem cells (BMSCs)-exosome carrying MiRNA-312 inhibits sevoflurane-induced cardiomyocyte apoptosis through activation of phosphatidylinositol 3-Kinase/Protein Kinase B (PI3K/AKT) pathway. J Biomaterials Tissue Engineering. 12:947–952. 2022. View Article : Google Scholar

29 

Yu F, Wu F, Li F, Liao X, Wang Y, Li X, Wang C, Shi Y and Ye L: Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells. Stem Cells. 38:1020–1033. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Liu MH, Bian BSJ, Cui X, Liu LT, Liu H, Huang B, Cui YH, Bian XW and Zhou Y: Mesenchymal stem cells regulate mechanical properties of human degenerated nucleus pulposus cells through SDF-1/CXCR4/AKT axis. Biochim Biophys Acta. 1863:1961–1968. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Lin H, Zhou Y, Lei Q, Lin D, Chen J and Wu C: Effect of inorganic phosphate on migration and osteogenic differentiation of bone marrow mesenchymal stem cells. BMC Dev Biol. 21:12021. View Article : Google Scholar : PubMed/NCBI

32 

Zhou B, Peng K, Wang G, Chen W and Kang Y: Polo like kinase 4 (PLK4) impairs human bone marrow mesenchymal stem cell (BMSC) viability and osteogenic differentiation. Biochem Biophys Res Commun. 549:221–228. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Wang W, Li S, Xu L, Jiang M, Li X, Zhang Y, Tighe S, Zhu Y and Li G: Differential gene expression between limbal niche progenitors and bone marrow derived mesenchymal stem cells. Int J Med Sci. 17:549–557. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Wang H, Meng Y, Cui Q, Qin F, Yang H, Chen Y, Cheng Y, Shi J and Guo Y: MiR-101 Targets the EZH2/Wnt/β-catenin the pathway to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Sci Rep. 6:369882016. View Article : Google Scholar : PubMed/NCBI

35 

Picciolo G, Mannino F, Irrera N, Altavilla D, Minutoli L, Vaccaro M, Arcoraci V, Squadrito V, Picciolo G, Squadrito F and Pallio G: PDRN, a natural bioactive compound, blunts inflammation and positively reprograms healing genes in an ‘in vitro’ model of oral mucositis. Biomed Pharmacother. 138:1115382021. View Article : Google Scholar : PubMed/NCBI

36 

D'Ascola A, Irrera N, Ettari R, Bitto A, Pallio G, Mannino F, Atteritano M, Campo GM, Minutoli L, Arcoraci V, et al: Exploiting curcumin synergy with natural products using quantitative analysis of dose-effect relationships in an experimental in vitro model of osteoarthritis. Front Pharmacol. 10:13472019. View Article : Google Scholar : PubMed/NCBI

37 

Picciolo G, Pallio G, Altavilla D, Vaccaro M, Oteri G, Irrera N and Squadrito F: β-Caryophyllene reduces the inflammatory phenotype of periodontal cells by targeting CB2 receptors. Biomedicines. 8:1642020. View Article : Google Scholar : PubMed/NCBI

38 

Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, Bai Y, Qin Y, Li J, Feng S and Zhao P: LPS-induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF-κB, STAT3 or AP-1 activation. Mol Med Rep. 17:5484–5491. 2018.PubMed/NCBI

39 

Li J, Qin Y, Chen Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Mao X and Li C: Mechanisms of the lipopolysaccharide-induced inflammatory response in alveolar epithelial cell/macrophage co-culture. Exp Ther Med. 20:762020. View Article : Google Scholar : PubMed/NCBI

40 

Han WQ, Zhu Q, Hu J, Li PL, Zhang F and Li N: Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim Biophys Acta. 1833:1454–1462. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Wang Z, Schley G, Turkoglu G, Burzlaff N, Amann KU, Willam C, Eckardt KU and Bernhardt WM: The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment. Nephrol Dial Transplant. 27:929–936. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Zhu Q, Wang Z, Xia M, Li PL, Zhang F and Li N: Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. Biochim Biophys Acta. 1822:936–941. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Zinchuk V, Zinchuk O and Okada T: Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: Pushing pixels to explore biological phenomena. Acta Histochem Cytochem. 40:101–111. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Tseng HC, Lee IT, Lin CC, Chi PL, Cheng SE, Shih RH, Hsiao LD and Yang CM: IL-1β promotes corneal epithelial cell migration by increasing MMP-9 expression through NF-kappaB- and AP-1-dependent pathways. PLoS One. 8:e579552013. View Article : Google Scholar : PubMed/NCBI

45 

Vinuales C, Gascon S, Barranquero C, Osada J and Rodriguez-Yoldi MJ: Interleukin-1beta reduces galactose transport in intestinal epithelial cells in a NF-kB and protein kinase C-dependent manner. Vet Immunol Immunopathol. 155:171–181. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Feng M, Wei S, Zhang S and Yang Y: Anti-inflammation and anti-pyroptosis activities of mangiferin via suppressing NF-κB/NLRP3/GSDMD signaling cascades. Int J Mol Sci. 23:101242022. View Article : Google Scholar : PubMed/NCBI

47 

Huang CH, Wang SC, Chen IC, Chen YT, Liu PL, Fang SH, Huang SP, Yeh HC, Liu CC and Lee PY: Protective effect of piplartine against LPS-induced sepsis through attenuating the MAPKs/NF-κB signaling pathway and NLRP3 inflammasome activation. Pharmaceuticals (Basel). 14:5882021. View Article : Google Scholar : PubMed/NCBI

48 

He D, Su Y, Usatyuk PV, Spannhake EW, Kogut P, Solway J, Natarajan V and Zhao Y: Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury. J Biol Chem. 284:24123–24132. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Marandi Y, Hashemzade S, Tayebinia H, Karimi J, Zamani A and Khodadadi I: NLRP3-inflammasome activation is associated with epithelial-mesenchymal transition and progression of colorectal cancer. Iran J Basic Med Sci. 24:483–492. 2021.PubMed/NCBI

50 

Tian R, Zhu Y, Yao J, Meng X, Wang J, Xie H and Wang R: NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis. Exp Cell Res. 357:328–334. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, et al: Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells. J Mol Endocrinol. 61:101–113. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J and Li M: Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway. Drug Des Devel Ther. 14:4901–4913. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Huang X, Shen H, Liu Y, Qiu S and Guo Y: Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway. Int Immunopharmacol. 95:1075052021. View Article : Google Scholar : PubMed/NCBI

54 

Yang D, Wang W, Li L, Peng Y, Chen P, Huang H, Guo Y, Xia X, Wang Y, Wang H, et al: The relative contribution of paracine effect versus direct differentiation on adipose-derived stem cell transplantation mediated cardiac repair. PLoS One. 8:e590202013. View Article : Google Scholar : PubMed/NCBI

55 

Pawitan JA: Prospect of stem cell conditioned medium in regenerative medicine. Biomed Res Int. 2014:9658492014. View Article : Google Scholar : PubMed/NCBI

56 

Taei AA, Khodabakhsh P, Nasoohi S, Farahmandfar M and Dargahi L: Paracrine effects of mesenchymal stem cells in ischemic stroke: Opportunities and challenges. Mol Neurobiol. 59:6281–6306. 2022. View Article : Google Scholar : PubMed/NCBI

57 

Tan KX, Chang T and Lin X: Secretomes as an emerging class of bioactive ingredients for enhanced cosmeceutical applications. Exp Dermatol. 31:674–688. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li H, Sun L and Wang Y: Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells. Mol Med Rep 27: 106, 2023.
APA
Li, H., Sun, L., & Wang, Y. (2023). Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells. Molecular Medicine Reports, 27, 106. https://doi.org/10.3892/mmr.2023.12993
MLA
Li, H., Sun, L., Wang, Y."Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells". Molecular Medicine Reports 27.5 (2023): 106.
Chicago
Li, H., Sun, L., Wang, Y."Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells". Molecular Medicine Reports 27, no. 5 (2023): 106. https://doi.org/10.3892/mmr.2023.12993
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Sun L and Wang Y: Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells. Mol Med Rep 27: 106, 2023.
APA
Li, H., Sun, L., & Wang, Y. (2023). Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells. Molecular Medicine Reports, 27, 106. https://doi.org/10.3892/mmr.2023.12993
MLA
Li, H., Sun, L., Wang, Y."Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells". Molecular Medicine Reports 27.5 (2023): 106.
Chicago
Li, H., Sun, L., Wang, Y."Inhibition of LPS‑induced NLRP3 inflammasome activation by stem cell‑conditioned culture media in human gingival epithelial cells". Molecular Medicine Reports 27, no. 5 (2023): 106. https://doi.org/10.3892/mmr.2023.12993
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team