Open Access

Combination therapy with BMSCs‑exosomes and porous tantalum for the repair of femur supracondylar defects

  • Authors:
    • Fan Yang
    • Mingjian Wu
    • Haojie Chen
    • Shengli Ma
    • Jiahe Liu
    • Chenzhi Li
    • Yancheng Li
    • Jiahui Yang
    • Baoyi Liu
    • Dewei Zhao
  • View Affiliations

  • Published online on: May 18, 2023     https://doi.org/10.3892/mmr.2023.13017
  • Article Number: 130
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the field of orthopedics, defects in large bones have proven challenging to resolve. The aim of the present study was to address this problem through the combination of tantalum metal (pTa) with exosomes derived from bone marrow mesenchymal stem cells (BMSCs), which have the potential to enhance regeneration of full thickness femoral bone defects in rats. Cell culture results demonstrated that exosomes improved the proliferation and differentiation of BMSCs. Following establishment of a supracondylar femoral bone defect, exosomes and pTa were implanted into the defect area. Results demonstrated that pTa acts as a core scaffold for cell adhesion and exhibits good biocompatibility. Moreover, micro‑CT scan results as well as histological examination demonstrated that pTa had a significant effect on osteogenesis, with the addition of exosomes further promoting bone tissue regeneration and repair. In conclusion, this novel composite scaffold can effectively promote bone regeneration in large bone defect areas, providing a new approach for the treatment of large bone defects.
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July-2023
Volume 28 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang F, Wu M, Chen H, Ma S, Liu J, Li C, Li Y, Yang J, Liu B, Zhao D, Zhao D, et al: Combination therapy with BMSCs‑exosomes and porous tantalum for the repair of femur supracondylar defects. Mol Med Rep 28: 130, 2023
APA
Yang, F., Wu, M., Chen, H., Ma, S., Liu, J., Li, C. ... Zhao, D. (2023). Combination therapy with BMSCs‑exosomes and porous tantalum for the repair of femur supracondylar defects. Molecular Medicine Reports, 28, 130. https://doi.org/10.3892/mmr.2023.13017
MLA
Yang, F., Wu, M., Chen, H., Ma, S., Liu, J., Li, C., Li, Y., Yang, J., Liu, B., Zhao, D."Combination therapy with BMSCs‑exosomes and porous tantalum for the repair of femur supracondylar defects". Molecular Medicine Reports 28.1 (2023): 130.
Chicago
Yang, F., Wu, M., Chen, H., Ma, S., Liu, J., Li, C., Li, Y., Yang, J., Liu, B., Zhao, D."Combination therapy with BMSCs‑exosomes and porous tantalum for the repair of femur supracondylar defects". Molecular Medicine Reports 28, no. 1 (2023): 130. https://doi.org/10.3892/mmr.2023.13017