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Construction of ceRNA regulatory networks for osteoporosis

  • Authors:
    • Hongtao Chen
    • Hailong Wang
    • Xu Liu
    • Long Li
    • Yiliyaer Abudusimu
    • Yilihamu Tuoheti
  • View Affiliations / Copyright

    Affiliations: Department of Sports Injuries, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, P.R. China, Department of Orthopedics, The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, P.R. China, Department of Orthopedics, The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 145
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    Published online on: June 13, 2023
       https://doi.org/10.3892/mmr.2023.13033
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Abstract

Osteoporosis increases the risk of fracture. Improving the diagnosis and treatment of osteoporosis has clinical applications. The differentially expressed genes (DEcircRs, DEmRs, DEmiRs) of osteoporotic patients and controls were analyzed using the GEO database, and enrichment analysis of DEmRs was performed. circRNAs and mRNAs, which were predicted to have a target relationship with DEmRs, were obtained to compare competing endogenous RNA (ceRNA) regulatory networks by comparison with differentially expressed genes. Molecular experiments were utilized to validate the expression of genes within the network. The interactions between genes within the ceRNA network were validated by luciferase reporter assays. Following overexpression of circ_0070304 in bone marrow mesenchymal stem cells (BMSCs), the osteogenic differentiation of the cells was assessed by Alizarin Red staining. A total of 110 intersectional DEmRs between patients with osteoporosis and controls from GSE35958 and GSE56815, which were mainly enriched in estrogen, the thyroid hormone signaling pathway, and adherens junctions were identified. A ceRNA network [circ_0070304/miR‑183‑5p/ring finger and CCCH‑type domains 2 (RC3H2)] was then constructed. Circ_0070304 acted as a sponge for miR‑183‑5p and regulated RC3H2 expression. Overexpression of circ_0070304 upregulated ROCK1 and induced osteogenic differentiation. The ceRNA regulatory network that was obtained is expected to be a new target for osteoporosis treatment and to provide new insights into the diagnosis and treatment of osteoporosis in greater depth.
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1 

Kanis JA, Cooper C, Rizzoli R and Reginster JY; Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF), : European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 30:3–44. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall S and Dawson-Hughes B: The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 29:2520–2526. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Liu T, Huang J, Xu D and Li Y: Identifying a possible new target for diagnosis and treatment of postmenopausal osteoporosis through bioinformatics and clinical sample analysis. Ann Transl Med. 9:11542021. View Article : Google Scholar : PubMed/NCBI

4 

Chandran M, Mitchell PJ, Amphansap T, Bhadada SK, Chadha M, Chan DC, Chung YS, Ebeling P, Gilchrist N, Habib Khan A, et al: Development of the Asia Pacific consortium on osteoporosis (APCO) framework: Clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region. Osteoporos Int. 32:1249–1275. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Zhang H, Wang A, Shen G, Wang X, Liu G, Yang F, Chen B, Wang M and Xu Y: Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis. Aging (Albany NY). 13:11296–11314. 2021. View Article : Google Scholar : PubMed/NCBI

6 

D'Amelio P and Sassi F: Gut microbiota, immune system, and bone. Calcif Tissue Int. 102:415–425. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S and Lindsay R; National Osteoporosis Foundation, : Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 25:2359–2381. 2014. View Article : Google Scholar : PubMed/NCBI

8 

De Martinis M, Ginaldi L, Allegra A, Sirufo MM, Pioggia G, Tonacci A and Gangemi S: The osteoporosis/microbiota linkage: The role of miRNA. Int J Mol Sci. 21:88872020. View Article : Google Scholar : PubMed/NCBI

9 

No authors listed. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO study group. World Health Organ Tech Rep Ser. 843:1–129. 1994.PubMed/NCBI

10 

Compston JE, McClung MR and Leslie WD: Osteoporosis. Lancet. 393:364–376. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Li R, Zhu X, Zhang M, Zong G and Zhang K: Association of serum periostin level with classical bone turnover markers and bone mineral density in shanghai chinese postmenopausal women with osteoporosis. Int J Gen Med. 14:7639–7646. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Pan X, Cen X, Zhang B, Pei F, Huang W, Huang X and Zhao Z: Circular RNAs as potential regulators in bone remodeling: A narrative review. Ann Transl Med. 9:15052021. View Article : Google Scholar : PubMed/NCBI

13 

Fu M, Fang L, Xiang X, Fan X, Wu J and Wang J: Microarray analysis of circRNAs sequencing profile in exosomes derived from bone marrow mesenchymal stem cells in postmenopausal osteoporosis patients. J Clin Lab Anal. 36:e239162022. View Article : Google Scholar : PubMed/NCBI

14 

Luo Y, Qiu G, Liu Y, Li S, Xu Y, Zhang Y, Cao Y and Wang Y: Circular RNAs in osteoporosis: Expression, functions and roles. Cell Death Discov. 7:2312021. View Article : Google Scholar : PubMed/NCBI

15 

Cui Q, Xing J, Yu M, Wang Y, Xu J, Gu Y, Nan X, Ma W, Liu H and Zhao H: Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway. Cell Death Dis. 10:1722019. View Article : Google Scholar : PubMed/NCBI

16 

Kerschan-Schindl K, Hackl M, Boschitsch E, Foger-Samwald U, Nägele O, Skalicky S, Weigl M, Grillari J and Pietschmann P: Diagnostic performance of a panel of miRNAs (OsteomiR) for osteoporosis in a cohort of postmenopausal women. Calcif Tissue Int. 108:725–737. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Alberti C, Manzenreither RA, Sowemimo I, Burkard TR, Wang J, Mahofsky K, Ameres SL and Cochella L: Cell-type specific sequencing of microRNAs from complex animal tissues. Nat Methods. 15:283–289. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Liang B, Burley G, Lin S and Shi YC: Osteoporosis pathogenesis and treatment: Existing and emerging avenues. Cell Mol Biol Lett. 27:722022. View Article : Google Scholar : PubMed/NCBI

19 

Benisch P, Schilling T, Klein-Hitpass L, Frey SP, Seefried L, Raaijmakers N, Krug M, Regensburger M, Zeck S, Schinke T, et al: The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One. 7:e451422012. View Article : Google Scholar : PubMed/NCBI

20 

Zhou Y, Gao Y, Xu C, Shen H, Tian Q and Deng HW: A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research. Sci Rep. 8:6682018. View Article : Google Scholar : PubMed/NCBI

21 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

22 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

23 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Gao Z, Yao K, Cai P, Long N, Cao Y, He F, Liu L and Xiao C: Establishment of a survival risk prediction model for adolescent and adult osteosarcoma patients. Biomed Res Int. 2022:95594962022. View Article : Google Scholar : PubMed/NCBI

25 

Liao X, Wang W, Yu B and Tan S: Thrombospondin-2 acts as a bridge between tumor extracellular matrix and immune infiltration in pancreatic and stomach adenocarcinomas: An integrative pan-cancer analysis. Cancer Cell Int. 22:2132022. View Article : Google Scholar : PubMed/NCBI

26 

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC and Müller M: pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 12:772011. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Lin C, Yu S, Jin R, Xiao Y, Pan M, Pei F, Zhu X, Huang H, Zhang Z, Chen S, et al: Circulating miR-338 Cluster activities on osteoblast differentiation: Potential diagnostic and therapeutic targets for postmenopausal osteoporosis. Theranostics. 9:3780–3797. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Manolagas SC: The quest for osteoporosis mechanisms and rational therapies: How far we've come, how much further we need to go. J Bone Miner Res. 33:371–385. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Almeida M, Laurent MR, Dubois V, Claessens F, O'Brien CA, Bouillon R, Vanderschueren D and Manolagas SC: Estrogens and androgens in skeletal physiology and pathophysiology. Physiol Rev. 97:135–187. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Williams GR and Bassett JHD: Thyroid diseases and bone health. J Endocrinol Invest. 41:99–109. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Bassett JH and Williams GR: Role of thyroid hormones in skeletal development and bone maintenance. Endocr Rev. 37:135–187. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zeng Y, Zhang L, Zhu W, He H, Sheng H, Tian Q, Deng FY, Zhang LS, Hu HG and Deng HW: Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis. Osteoporos Int. 28:3033–3042. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Jin D, Wu X, Yu H, Jiang L, Zhou P, Yao X, Meng J, Wang L, Zhang M and Zhang Y: Systematic analysis of lncRNAs, mRNAs, circRNAs and miRNAs in patients with postmenopausal osteoporosis. Am J Transl Res. 10:1498–1510. 2018.PubMed/NCBI

35 

Davis C, Dukes A, Drewry M, Helwa I, Johnson MH, Isales CM, Hill WD, Liu Y, Shi X, Fulzele S and Hamrick MW: MicroRNA-183-5p increases with age in bone-derived extracellular vesicles, suppresses bone marrow stromal (stem) cell proliferation, and induces stem cell senescence. Tissue Eng Part A. 23:1231–1240. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Weigl M, Kocijan R, Ferguson J, Leinfellner G, Heimel P, Feichtinger X, Pietschmann P, Grillari J, Zwerina J, Redl H and Hackl M: Longitudinal changes of circulating miRNAs during bisphosphonate and teriparatide treatment in an animal model of postmenopausal osteoporosis. J Bone Miner Res. 36:1131–1144. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Ji X, Chen X and Yu X: MicroRNAs in osteoclastogenesis and function: Potential therapeutic targets for osteoporosis. Int J Mol Sci. 17:3492016. View Article : Google Scholar : PubMed/NCBI

38 

Wang G, Zhang L, Yan C, Wang F and Zhang Y: Overexpression of miR125b promotes osteoporosis through miR-125b-TRAF6 pathway in postmenopausal ovariectomized rats. Diabetes Metab Syndr Obes. 14:671–682. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Hoefig KP, Reim A, Gallus C, Wong EH, Behrens G, Conrad C, Xu M, Kifinger L, Ito-Kureha T, Defourny KAY, et al: Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation. Nat Commun. 12:52082021. View Article : Google Scholar : PubMed/NCBI

40 

Maruyama T, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P, Ronai Z, Matsuzawa A and Ichijo H: Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Sci Signal. 7:ra82014. View Article : Google Scholar : PubMed/NCBI

41 

Zhang Q, Fan L, Hou F, Dong A, Wang YX and Tong Y: New insights into the RNA-binding and E3 ubiquitin ligase activities of Roquins. Sci Rep. 5:156602015. View Article : Google Scholar : PubMed/NCBI

42 

De Martinis M, Sirufo MM, Suppa M and Ginaldi L: IL-33/IL-31 axis in osteoporosis. Int J Mol Sci. 21:12392020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen H, Wang H, Liu X, Li L, Abudusimu Y and Tuoheti Y: Construction of ceRNA regulatory networks for osteoporosis. Mol Med Rep 28: 145, 2023.
APA
Chen, H., Wang, H., Liu, X., Li, L., Abudusimu, Y., & Tuoheti, Y. (2023). Construction of ceRNA regulatory networks for osteoporosis. Molecular Medicine Reports, 28, 145. https://doi.org/10.3892/mmr.2023.13033
MLA
Chen, H., Wang, H., Liu, X., Li, L., Abudusimu, Y., Tuoheti, Y."Construction of ceRNA regulatory networks for osteoporosis". Molecular Medicine Reports 28.2 (2023): 145.
Chicago
Chen, H., Wang, H., Liu, X., Li, L., Abudusimu, Y., Tuoheti, Y."Construction of ceRNA regulatory networks for osteoporosis". Molecular Medicine Reports 28, no. 2 (2023): 145. https://doi.org/10.3892/mmr.2023.13033
Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Wang H, Liu X, Li L, Abudusimu Y and Tuoheti Y: Construction of ceRNA regulatory networks for osteoporosis. Mol Med Rep 28: 145, 2023.
APA
Chen, H., Wang, H., Liu, X., Li, L., Abudusimu, Y., & Tuoheti, Y. (2023). Construction of ceRNA regulatory networks for osteoporosis. Molecular Medicine Reports, 28, 145. https://doi.org/10.3892/mmr.2023.13033
MLA
Chen, H., Wang, H., Liu, X., Li, L., Abudusimu, Y., Tuoheti, Y."Construction of ceRNA regulatory networks for osteoporosis". Molecular Medicine Reports 28.2 (2023): 145.
Chicago
Chen, H., Wang, H., Liu, X., Li, L., Abudusimu, Y., Tuoheti, Y."Construction of ceRNA regulatory networks for osteoporosis". Molecular Medicine Reports 28, no. 2 (2023): 145. https://doi.org/10.3892/mmr.2023.13033
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