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NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells

  • Authors:
    • Yixian Wang
    • Chunhong Xin
    • Xiaokun Li
    • Xiaoxia Chang
    • Ru Jiang
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, Muping Hospital of Traditional Chinese Medicine, Yantai, Shandong 264100, P.R. China, Department of Hematopathology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Emergency Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Cardiology, Muping Hospital of Traditional Chinese Medicine, Yantai, Shandong 264100, P.R. China, Department of Laboratory Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 152
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    Published online on: June 21, 2023
       https://doi.org/10.3892/mmr.2023.13039
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Abstract

Acute myeloid leukemia (AML) is a clonal malignant proliferative disease. In recent years, with the use of all‑trans retinoic acid to induce cancer cell differentiation in acute promyelocytic leukemia, and its advantages of high efficacy and low toxic side effects, tumor differentiation therapy has become a research hotspot; however, the mechanisms underlying its role remain to be fully established. Nod‑like receptor family pyridine domain containing 3 (NLRP3) is the most extensively studied and well‑characterized inflammasome, is involved in a variety of inflammation‑related diseases, including cancer, and is a very attractive potential target for the study of novel therapeutic agents. Activation of the NLRP3 inflammasome is a double‑edged sword in tumor therapy, with evidence of protective anti‑tumor and pro‑tumor effects in different types of cancer. Whether the NLRP3 inflammasome promotes disease progression or exerts a protective anti‑tumor effect in hematological malignancies remains contested. In the present study, the protective anti‑tumor effects of NLRP3 on leukemia cells during their differentiation and maturation were investigated. It was found that the upregulation of NLRP3 expression induced using Phorbol 12‑Myristate 13‑Acetate played a role in promoting the differentiation and maturation of leukemia cells into monocytes/macrophages, and it was directly involved in the apoptosis of leukemia cells and the differentiation and maturation of CD11b+ cells. These results provide novel theoretical evidence for exploring the mechanism of differentiation therapy in leukemia and improves our understanding of the role of NLRP3 in hematologic tumors.
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View References

1 

Stahl M and Tallman MS: Acute promyelocytic leukemia (APL): Remaining challenges towards a cure for all. Leuk Lymphoma. 60:3107–3115. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Su R, Qing Y and Chen J: Targeting differentiation blockade in AML: New hope from cell-surface-based CRISPR screens. Cell Stem Cell. 28:585–587. 2021. View Article : Google Scholar : PubMed/NCBI

3 

He Y, Hara H and Núñez G: Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 41:1012–1021. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Martinon F, Burns K and Tschopp J: The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 10:417–426. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Vince JE and Silke J: The intersection of cell death and inflammasome activation. Cell Mol Life Sci. 73:2349–2367. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Gaidt MM and Hornung V: The NLRP3 inflammasome renders cell death Pro-inflammatory. J Mol Biol. 430:133–141. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Zheng M, Williams EP, Malireddi RKS, Karki R, Banoth B, Burton A, Webby R, Channappanavar R, Jonsson CB and Kanneganti TD: Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. J Biol Chem. 295:14040–14052. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, et al: Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun. 11:16592020. View Article : Google Scholar : PubMed/NCBI

9 

Liu Q, Hua M, Zhang C, Wang R, Liu J, Yang X, Han F, Hou M and Ma D: NLRP3-activated bone marrow dendritic cells play antileukemic roles via IL-1β/Th1/IFN-γ in acute myeloid leukemia. Cancer Lett. 520:109–120. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Sauter KA, Wood LJ, Wong J, Iordanov M and Magun BE: Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome. Cancer Biol Ther. 11:1008–1016. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Westbom C, Thompson JK, Leggett A, MacPherson M, Beuschel S, Pass H, Vacek P and Shukla A: Inflammasome modulation by chemotherapeutics in malignant mesothelioma. PLoS One. 10:e01454042015. View Article : Google Scholar : PubMed/NCBI

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Myou S, Zhu X, Boetticher E, Qin Y, Myo S, Meliton A, Lambertino A, Munoz NM, Hamann KJ and Leff AR: Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2. Immunology. 107:77–85. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Lam CF, Yeung HT, Lam YM and Ng RK: Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway. Leuk Res. 68:112–119. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3:730–737. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Yates JW, Wallace HJ Jr, Ellison RR and Holland JF: Cytosine arabinoside (NSC-63878) and daunorubicin (NSC-83142) therapy in acute nonlymphocytic leukemia. Cancer Chemother Rep. 57:485–488. 1973.PubMed/NCBI

17 

Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, Ferrara F, Fazi P, Cicconi L, Di Bona E, et al: Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 369:111–121. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Swanson KV, Deng M and Ting JP: The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol. 19:477–489. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Huang Y, Xu W and Zhou R: NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 18:2114–2127. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Heid ME, Keyel PA, Kamga C, Shiva S, Watkins SC and Salter RD: Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 191:5230–5238. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Sorbara MT and Girardin SE: Mitochondrial ROS fuel the inflammasome. Cell Res. 21:558–560. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, et al: A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 21:248–255. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Sharma BR and Kanneganti TD: NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. 22:550–559. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Guo B, Fu S, Zhang J, Liu B and Li Z: Targeting inflammasome/IL-1 pathways for cancer immunotherapy. Sci Rep. 6:361072016. View Article : Google Scholar : PubMed/NCBI

25 

Drexler SK, Bonsignore L, Masin M, Tardivel A, Jackstadt R, Hermeking H, Schneider P, Gross O, Tschopp J and Yazdi AS: Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci USA. 109:18384–18389. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Dunn JH, Ellis LZ and Fujita M: Inflammasomes as molecular mediators of inflammation and cancer: potential role in melanoma. Cancer Lett. 314:24–33. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Daley D, Mani VR, Mohan N, Akkad N, Pandian GSDB, Savadkar S, Lee KB, Torres-Hernandez A, Aykut B, Diskin B, et al: NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 214:1711–1724. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, et al: Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 15:1170–1178. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Dupaul-Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, Rodrigue-Gervais IG, Breton V, Colpitts SL, Beauchemin N and Saleh M: The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity. Immunity. 43:751–763. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, et al: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 491:259–263. 2012. View Article : Google Scholar : PubMed/NCBI

31 

van Deventer HW, Burgents JE, Wu QP, Woodford RM, Brickey WJ, Allen IC, McElvania-Tekippe E, Serody JS and Ting JP: The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells. Cancer Res. 70:10161–10169. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Karki R and Kanneganti TD: Diverging inflammasome signals in tumorigenesis and potential targeting. Nat Rev Cancer. 19:197–214. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Wang J, Liu L, Xie L, Xiang G and Zhou Y: Induction of differentiation-specific miRNAs in TPA-induced myeloid leukemia cells through MEK/ERK activation. Int J Mol Med. 31:59–66. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Daigneault M, Preston JA, Marriott HM, Whyte MK and Dockrell DH: The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One. 5:e86682010. View Article : Google Scholar : PubMed/NCBI

35 

Maeß MB, Wittig B, Cignarella A and Lorkowski S: Reduced PMA enhances the responsiveness of transfected THP-1 macrophages to polarizing stimuli. J Immunol Methods. 402:76–81. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Park EK, Jung HS, Yang HI, Yoo MC, Kim C and Kim KS: Correction to: Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res. 69:11572020. View Article : Google Scholar : PubMed/NCBI

37 

Aldo PB, Craveiro V, Guller S and Mor G: Effect of culture conditions on the phenotype of THP-1 monocyte cell line. Am J Reprod Immunol. 70:80–86. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Faria SS, Costantini S, de Lima VCC, de Andrade VP, Rialland M, Cedric R, Budillon A and Magalhães KG: NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer. J Biomed Sci. 28:262021. View Article : Google Scholar : PubMed/NCBI

39 

Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BY, Wong VK, Yu CL, et al: Polyphyllin VI induces Caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel). 12:1932020. View Article : Google Scholar : PubMed/NCBI

40 

Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J and Hu J: The role of pyroptosis in cancer: pro-cancer or pro-‘host’ ? Cell Death Dis. 10:6502019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Xin C, Li X, Chang X and Jiang R: NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Mol Med Rep 28: 152, 2023.
APA
Wang, Y., Xin, C., Li, X., Chang, X., & Jiang, R. (2023). NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Molecular Medicine Reports, 28, 152. https://doi.org/10.3892/mmr.2023.13039
MLA
Wang, Y., Xin, C., Li, X., Chang, X., Jiang, R."NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells". Molecular Medicine Reports 28.2 (2023): 152.
Chicago
Wang, Y., Xin, C., Li, X., Chang, X., Jiang, R."NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells". Molecular Medicine Reports 28, no. 2 (2023): 152. https://doi.org/10.3892/mmr.2023.13039
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Xin C, Li X, Chang X and Jiang R: NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Mol Med Rep 28: 152, 2023.
APA
Wang, Y., Xin, C., Li, X., Chang, X., & Jiang, R. (2023). NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Molecular Medicine Reports, 28, 152. https://doi.org/10.3892/mmr.2023.13039
MLA
Wang, Y., Xin, C., Li, X., Chang, X., Jiang, R."NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells". Molecular Medicine Reports 28.2 (2023): 152.
Chicago
Wang, Y., Xin, C., Li, X., Chang, X., Jiang, R."NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells". Molecular Medicine Reports 28, no. 2 (2023): 152. https://doi.org/10.3892/mmr.2023.13039
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