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Article Open Access

Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process

  • Authors:
    • Chi-Jung Huang
    • Chi-Ming Pu
    • Su-Yi Su
    • Shih-Lun Lo
    • Cheng Hung Lee
    • Yu-Hsiu Yen
  • View Affiliations / Copyright

    Affiliations: Department of Medical Research, Cathay General Hospital, Taipei 10630, Taiwan, R.O.C., Division of Plastic Surgery, Department of Surgery, Cathay General Hospital, Taipei 10630, Taiwan, R.O.C., Division of Plastic Surgery, Department of Surgery, Cathay General Hospital, Taipei 10630, Taiwan, R.O.C., Division of Plastic Surgery, Department of Surgery, Cathay General Hospital, Taipei 10630, Tawain, R.O.C.
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 155
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    Published online on: June 30, 2023
       https://doi.org/10.3892/mmr.2023.13042
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Abstract

Wound healing is a complex biological process involving cytokines with four phases: Hemostasis, inflammation, proliferation and remodeling. Understanding the molecular mechanism of the inflammation phase could improve wound healing in the clinic as excess inflammation is a critical point for dysregulation of normal wound healing. Capsaicin (CAP), a major component of chili peppers, is known to exhibit anti‑inflammatory properties through a range of different pathways, such as the neurogenic inflammation and nociception pathways. To improve the understanding of the relationship between CAP and wound healing, it is crucial to elucidate the CAP‑related molecular panel involved in regulating inflammation. Therefore, the present study aimed to analyze the effects of CAP on wound healing using an in vitro cell model and an in vivo animal model. Cell migration, viability and inflammation were examined using fibroblasts, and wounds were evaluated in mice under CAP treatment. In the present study, it was found that 10 µM CAP increased cell migration and decreased interleukin 6 (IL‑6) expression in in vitro cell assays. In the in vivo animal experiments, the CAP‑treated wounds exhibited lower densities of polymorphonuclear neutrophils and monocytes/macrophages, as well as lower IL‑6 and C‑X‑C motif chemokine ligand 10 protein levels. Furthermore, in CAP‑treated wounds, CD31‑positive capillaries and collagen deposition at the late phase of wound healing were present at higher densities. In summary, an improvement in wound healing by CAP was shown through suppression of the inflammatory response and amelioration of the repair process. These findings suggest that CAP has potential as a natural therapeutic agent for the treatment of wound healing.
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Copy and paste a formatted citation
Spandidos Publications style
Huang C, Pu C, Su S, Lo S, Lee C and Yen Y: Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process. Mol Med Rep 28: 155, 2023.
APA
Huang, C., Pu, C., Su, S., Lo, S., Lee, C., & Yen, Y. (2023). Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process. Molecular Medicine Reports, 28, 155. https://doi.org/10.3892/mmr.2023.13042
MLA
Huang, C., Pu, C., Su, S., Lo, S., Lee, C., Yen, Y."Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process". Molecular Medicine Reports 28.2 (2023): 155.
Chicago
Huang, C., Pu, C., Su, S., Lo, S., Lee, C., Yen, Y."Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process". Molecular Medicine Reports 28, no. 2 (2023): 155. https://doi.org/10.3892/mmr.2023.13042
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Pu C, Su S, Lo S, Lee C and Yen Y: Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process. Mol Med Rep 28: 155, 2023.
APA
Huang, C., Pu, C., Su, S., Lo, S., Lee, C., & Yen, Y. (2023). Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process. Molecular Medicine Reports, 28, 155. https://doi.org/10.3892/mmr.2023.13042
MLA
Huang, C., Pu, C., Su, S., Lo, S., Lee, C., Yen, Y."Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process". Molecular Medicine Reports 28.2 (2023): 155.
Chicago
Huang, C., Pu, C., Su, S., Lo, S., Lee, C., Yen, Y."Improvement of wound healing by capsaicin through suppression of the inflammatory response and amelioration of the repair process". Molecular Medicine Reports 28, no. 2 (2023): 155. https://doi.org/10.3892/mmr.2023.13042
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