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Prognostic and immunological potential of PPM1G in lung adenocarcinoma

  • Authors:
    • Rongjiang Yin
    • Li Qu
    • Zhanqing Wang
    • Jian Tang
    • Hua Gu
    • Xiaohui Wang
    • Donglin Yang
    • Pengchao Du
    • Menghua Dong
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003, P.R. China, School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 156
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    Published online on: June 30, 2023
       https://doi.org/10.3892/mmr.2023.13043
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Abstract

Lung cancer is one of the most common types of cancer worldwide, with the highest incidence and mortality rates. Protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G) is a serine/threonine phosphatase, which is involved in the proliferation, invasion and metastasis of tumor cells. However, there are few reports on the role of PPM1G in lung adenocarcinoma (LUAD). The present study used publicly available data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to evaluate the expression of PPM1G in LUAD, and to assess the relationship between PPM1G expression and the prognosis of patients with LUAD. Protein expression data of PPM1G obtained by immunohistochemical staining were collected from the Human Protein Atlas database. The correlation between PPM1G and immune cell infiltration and immune checkpoints was analyzed by single‑sample gene set enrichment analysis of TCGA data. The Kaplan‑Meier method was used for survival analysis, and univariate and multivariate Cox regression were used to analyze the effect of PPM1G on prognosis with data from TCGA database. The results showed that PPM1G was highly expressed in LUAD cancer tissues. The high expression of PPM1G was associated with poor clinical stage, T stage, N stage and overall survival in LUAD. The present study screened 29 genes related to PPM1G and closely related to the cell cycle in patients with LUAD. The expression of PPM1G was positively correlated with γδ‑Τ cells, T helper 2 cells and natural killer CD56dim cells, and was negatively correlated with B cells, mast cells, plasmacytoid dendritic cells, T helper cells, macrophages, T cells, CD8 T cells, central memory T cells, effector memory T cells, neutrophils and T follicular helper cells. In addition, PPM1G was positively correlated with immune detection points. In conclusion, PPM1G may be involved in the control of the lung cancer cell cycle, and could be associated with prognosis and immune infiltration in patients with LUAD.
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Copy and paste a formatted citation
Spandidos Publications style
Yin R, Qu L, Wang Z, Tang J, Gu H, Wang X, Yang D, Du P and Dong M: Prognostic and immunological potential of PPM1G in lung adenocarcinoma. Mol Med Rep 28: 156, 2023.
APA
Yin, R., Qu, L., Wang, Z., Tang, J., Gu, H., Wang, X. ... Dong, M. (2023). Prognostic and immunological potential of PPM1G in lung adenocarcinoma. Molecular Medicine Reports, 28, 156. https://doi.org/10.3892/mmr.2023.13043
MLA
Yin, R., Qu, L., Wang, Z., Tang, J., Gu, H., Wang, X., Yang, D., Du, P., Dong, M."Prognostic and immunological potential of PPM1G in lung adenocarcinoma". Molecular Medicine Reports 28.2 (2023): 156.
Chicago
Yin, R., Qu, L., Wang, Z., Tang, J., Gu, H., Wang, X., Yang, D., Du, P., Dong, M."Prognostic and immunological potential of PPM1G in lung adenocarcinoma". Molecular Medicine Reports 28, no. 2 (2023): 156. https://doi.org/10.3892/mmr.2023.13043
Copy and paste a formatted citation
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Spandidos Publications style
Yin R, Qu L, Wang Z, Tang J, Gu H, Wang X, Yang D, Du P and Dong M: Prognostic and immunological potential of PPM1G in lung adenocarcinoma. Mol Med Rep 28: 156, 2023.
APA
Yin, R., Qu, L., Wang, Z., Tang, J., Gu, H., Wang, X. ... Dong, M. (2023). Prognostic and immunological potential of PPM1G in lung adenocarcinoma. Molecular Medicine Reports, 28, 156. https://doi.org/10.3892/mmr.2023.13043
MLA
Yin, R., Qu, L., Wang, Z., Tang, J., Gu, H., Wang, X., Yang, D., Du, P., Dong, M."Prognostic and immunological potential of PPM1G in lung adenocarcinoma". Molecular Medicine Reports 28.2 (2023): 156.
Chicago
Yin, R., Qu, L., Wang, Z., Tang, J., Gu, H., Wang, X., Yang, D., Du, P., Dong, M."Prognostic and immunological potential of PPM1G in lung adenocarcinoma". Molecular Medicine Reports 28, no. 2 (2023): 156. https://doi.org/10.3892/mmr.2023.13043
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