Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2023 Volume 28 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2023 Volume 28 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages

  • Authors:
    • Chang-Lun Huang
    • Der-Yuan Chen
    • Chih-Chen Tzang
    • Jhen-Wei Lin
    • Bor-Show Tzang
    • Tsai-Ching Hsu
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Surgery, Department of Surgery, Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua 500, Taiwan, R.O.C., Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan, R.O.C., School of Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan, R.O.C.
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 193
    |
    Published online on: August 31, 2023
       https://doi.org/10.3892/mmr.2023.13080
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Human parvovirus B19 (B19V) has been strongly associated with a variety of inflammatory disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease and systemic lupus erythematosus. Non‑structural protein 1 (NS1) of B19V has been demonstrated to play essential roles in the pathological processes of B19V infection due to its regulatory properties on inflammatory cytokines. Celastrol, a quinone methide isolated from Tripterygium wilfordii, has displayed substantial potential in treating inflammatory diseases, such as psoriasis and RA. However, little is known about the effects of celastrol on B19V NS1‑induced inflammation. Therefore, cell viability assay, migration assay, phagocytosis analysis, zymography assay, ELISA and immunoblotting were conducted to verify the influences of celastrol on macrophages. The present study reported the attenuating effects of celastrol on B19V NS1‑induced inflammatory responses in macrophages derived from human acute monocytic leukemia cell lines, U937 and THP‑1. Although the migration was not significantly decreased by celastrol in both U937 and THP‑1 macrophages, significantly decreased viability, migration and phagocytosis were detected in both B19V NS1‑activated U937 and THP‑1 macrophages in the presence of celastrol. Additionally, celastrol significantly decreased MMP‑9 activity and the levels of inflammatory cytokines, including IL‑6, TNF‑α and IL‑1β, in B19V NS1‑activated U937 and THP‑1 cells. Notably, significantly decreased levels of NLR family pyrin domain‑containing 3, apoptosis‑associated speck‑like, caspase‑1 and IL‑18 proteins were observed in both B19V NS1‑activated U937 and THP‑1 cells in the presence of celastrol, indicating the involvement of the inflammasome pathway. To the best of our knowledge, the present study is the first to report on the attenuating effects of celastrol on B19V NS1‑induced inflammatory responses in macrophages, suggesting a therapeutic role for celastrol in B19V NS1‑related inflammatory diseases.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Cossart Y: Parvovirus B19 finds a disease. Lancet. 2:988–989. 1981. View Article : Google Scholar : PubMed/NCBI

2 

Qiu J, Söderlund-Venermo M and Young NS: Human parvoviruses. Clin Microbiol Rev. 30:43–113. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Cohen BJ and Buckley MM: The prevalence of antibody to human parvovirus B19 in England and Wales. J Med Microbiol. 25:151–153. 1988. View Article : Google Scholar : PubMed/NCBI

4 

Tsujimura M, Matsushita K, Shiraki H, Sato H, Okochi K and Maeda Y: Human parvovirus B19 infection in blood donors. Vox Sang. 69:206–212. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Brown KE and Young NS: Parvovirus B19 in human disease. Annu Rev Med. 48:59–67. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Heegaard ED and Brown KE: Human parvovirus B19. Clin Microbiol Rev. 15:485–505. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Lehmann HW, von Landenberg P and Modrow S: Parvovirus B19 infection and autoimmune disease. Autoimmun Rev. 2:218–223. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Young NS and Brown KE: Parvovirus B19. N Engl J Med. 350:586–597. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Page C, François C, Goëb V and Duverlie G: Human parvovirus B19 and autoimmune diseases. Review of the literature and pathophysiological hypotheses. J Clin Virol. 72:69–74. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Ros C, Bieri J and Leisi R: The VP1u of human parvovirus B19: A multifunctional capsid protein with biotechnological applications. Viruses. 12:14632020. View Article : Google Scholar : PubMed/NCBI

11 

Cotmore SF, McKie VC, Anderson LJ, Astell CR and Tattersall P: Identification of the major structural and nonstructural proteins encoded by human parvovirus B19 and mapping of their genes by procaryotic expression of isolated genomic fragments. J Virol. 60:548–557. 1986. View Article : Google Scholar : PubMed/NCBI

12 

Ozawa K and Young N: Characterization of capsid and noncapsid proteins of B19 parvovirus propagated in human erythroid bone marrow cell cultures. J Virol. 61:2627–2630. 1987. View Article : Google Scholar : PubMed/NCBI

13 

Kawase M, Momoeda M, Young NS and Kajigaya S: Most of the VP1 unique region of B19 parvovirus is on the capsid surface. Virology. 211:359–366. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Tzang BS, Tsay GJ, Lee YJ, Li C, Sun YS and Hsu TC: The association of VP1 unique region protein in acute parvovirus B19 infection and anti-phospholipid antibody production. Clin Chim Acta. 378:59–65. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Astell CR, Luo W, Brunstein J and St Amand J: B19 parvovirus: biochemical and molecular features. Human parvovirus B19. Anderson LJ and Young NS: Karger Publishers; Basel, Switzerland: pp. 16–41. 1997, View Article : Google Scholar

16 

Gareus R, Gigler A, Hemauer A, Leruez-Ville M, Morinet F, Wolf H and Modrow S: Characterization of cis-acting and NS1 protein responsive elements in the P6 promoter of parvovirus B19. J Virol. 72:609–616. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Mitchell LA: Parvovirus B19 nonstructural (NS1) protein as a transactivator of interleukin-6 synthesis: Common pathway in inflammatory sequelae of human parvovirus infections? J Med Virol. 67:267–274. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Jalali S, Farhadi A, Rafiei Dehbidi G, Farjadian S, Sharifzadeh S, Ranjbaran R, Seyyedi N, Namdari S and Behzad-Behbahani A: The pathogenic aspects of human parvovirus B19 NS1 protein in chronic and inflammatory diseases. Interdiscip Perspect Infect Dis. 2022:16399902022. View Article : Google Scholar : PubMed/NCBI

19 

Moffatt S, Tanaka N, Tada K, Nose M, Nakamura M, Muraoka O, Hirano T and Sugamura K: A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression. J Virol. 70:8485–8491. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Moffatt S, Yaegashi N, Tada K, Tanaka N and Sugamura K: Human parvovirus B19 nonstructural (NS1) protein induces apoptosis in erythroid lineage cells. J Virol. 72:3018–3028. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Hsu TC, Wu WJ, Chen MC and Tsay GJ: Human parvovirus B19 non-structural protein (NS1) induces apoptosis through mitochondria cell death pathway in COS-7 cells. Scand J Infect Dis. 36:570–577. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Poole BD, Kivovich V, Gilbert L and Naides SJ: Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis. Int J Med Sci. 8:88–96. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Fu Y, Ishii KK, Munakata Y, Saitoh T, Kaku M and Sasaki T: Regulation of Tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2. J Virol. 76:5395–5403. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Cascão R, Fonseca JE and Moita LF: Celastrol: A spectrum of treatment opportunities in chronic diseases. Front Med (Lausanne). 4:692017. View Article : Google Scholar : PubMed/NCBI

25 

Kun-Ming C, Chih-Hsien C, Chen-Fang L, Ting-Jung W, Hong-Shiue C and Wei-Chen L: Potential anticancer effect of celastrol on hepatocellular carcinoma by suppressing CXCR4-related signal and impeding tumor growth in vivo. Arch Med Res. 51:297–302. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Cui Y, Jiang X and Feng J: The therapeutic potential of triptolide and celastrol in neurological diseases. Front Pharmacol. 13:10249552022. View Article : Google Scholar : PubMed/NCBI

27 

Li Z, Zhang J, Duan X, Zhao G and Zhang M: Celastrol: A promising agent fighting against cardiovascular diseases. Antioxidants (Basel). 11:15972022. View Article : Google Scholar : PubMed/NCBI

28 

Tseng CK, Hsu SP, Lin CK, Wu YH, Lee JC and Young KC: Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells. Antiviral Res. 146:191–200. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Chen DY, Chen YM, Chen HH, Hsieh CW, Gung NR, Hung WT, Tzang BS and Hsu TC: Human parvovirus B19 nonstructural protein NS1 activates NLRP3 inflammasome signaling in adult-onset Still's disease. Mol Med Rep. 17:3364–3371. 2018.PubMed/NCBI

30 

Wu J, Chen X, Ye H, Yao M, Li S and Chen L: Nonstructural protein (NS1) of human parvovirus B19 stimulates host innate immunity and blunts the exogenous type I interferon signaling in vitro. Virus Res. 222:48–52. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Takasawa N, Munakata Y, Ishii KK, Takahashi Y, Takahashi M, Fu Y, Ishii T, Fujii H, Saito T, Takano H, et al: Human parvovirus B19 transgenic mice become susceptible to polyarthritis. J Immunol. 173:4675–4683. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Chisaka H, Morita E, Murata K, Ishii N, Yaegashi N, Okamura K and Sugamura K: A transgenic mouse model for non-immune hydrops fetalis induced by the NS1 gene of human parvovirus B19. J Gen Virol. 83((Pt 2)): 273–281. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Bachelier K, Biehl S, Schwarz V, Kindermann I, Kandolf R, Sauter M, Ukena C, Yilmaz A, Sliwa K, Bock CT, et al: Parvovirus B19-induced vascular damage in the heart is associated with elevated circulating endothelial microparticles. PLoS One. 12:e01763112017. View Article : Google Scholar : PubMed/NCBI

34 

Chen DY, Chen YM, Tzang BS, Lan JL and Hsu TC: Th17-related cytokines in systemic lupus erythematosus patients with dilated cardiomyopathies: A possible linkage to parvovirus B19 infection. PLoS One. 9:e1138892014. View Article : Google Scholar : PubMed/NCBI

35 

Nam NH: Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem. 6:945–951. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Dirsch VM, Kiemer AK, Wagner H and Vollmar AM: The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur J Pharmacol. 336:211–217. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Jin HZ, Hwang BY, Kim HS, Lee JH, Kim YH and Lee JJ: Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production. J Nat Prod. 65:89–91. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Kim Y, Kang H, Jang SW and Ko J: Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression. Cell Physiol Biochem. 28:175–184. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Venkatesha SH, Dudics S, Astry B and Moudgil KD: Control of autoimmune inflammation by celastrol, a natural triterpenoid. Pathog Dis. 74:ftw0592016. View Article : Google Scholar : PubMed/NCBI

40 

Zhou D, Li X, Xiao X, Wang G, Chen B, Song Y, Liu X, He Q, Zhang H, Wu Q, et al: Celastrol targets the ChREBP-TXNIP axis to ameliorates type 2 diabetes mellitus. Phytomedicine. 110:1546342023. View Article : Google Scholar : PubMed/NCBI

41 

Cascão R, Vidal B, Carvalho T, Lopes IP, Romão VC, Goncalves J, Moita LF and Fonseca JE: Celastrol efficacy by oral administration in the adjuvant-induced arthritis model. Front Med. (Lausanne). 7:4552020.

42 

Gao Q, Qin H, Zhu L, Li D and Hao X: Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats. Int Immunopharmacol. 84:1065272020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang C, Chen D, Tzang C, Lin J, Tzang B and Hsu T: Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages. Mol Med Rep 28: 193, 2023.
APA
Huang, C., Chen, D., Tzang, C., Lin, J., Tzang, B., & Hsu, T. (2023). Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages. Molecular Medicine Reports, 28, 193. https://doi.org/10.3892/mmr.2023.13080
MLA
Huang, C., Chen, D., Tzang, C., Lin, J., Tzang, B., Hsu, T."Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages". Molecular Medicine Reports 28.4 (2023): 193.
Chicago
Huang, C., Chen, D., Tzang, C., Lin, J., Tzang, B., Hsu, T."Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages". Molecular Medicine Reports 28, no. 4 (2023): 193. https://doi.org/10.3892/mmr.2023.13080
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Chen D, Tzang C, Lin J, Tzang B and Hsu T: Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages. Mol Med Rep 28: 193, 2023.
APA
Huang, C., Chen, D., Tzang, C., Lin, J., Tzang, B., & Hsu, T. (2023). Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages. Molecular Medicine Reports, 28, 193. https://doi.org/10.3892/mmr.2023.13080
MLA
Huang, C., Chen, D., Tzang, C., Lin, J., Tzang, B., Hsu, T."Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages". Molecular Medicine Reports 28.4 (2023): 193.
Chicago
Huang, C., Chen, D., Tzang, C., Lin, J., Tzang, B., Hsu, T."Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages". Molecular Medicine Reports 28, no. 4 (2023): 193. https://doi.org/10.3892/mmr.2023.13080
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team