Open Access

Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death

  • Authors:
    • Xu Chen
    • Jie Chen
    • Chunbao Miao
    • Guangrong Yin
    • Zhuangzhuang Zhang
    • Rongbin Sun
    • Su Ni
  • View Affiliations

  • Published online on: September 11, 2023     https://doi.org/10.3892/mmr.2023.13089
  • Article Number: 202
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is a degenerative disease that ultimately leads to joint deformity. The pathogenesis of OA is believed to involve abnormal chondrocyte death, with ferroptosis serving a key role in chondrocyte damage. The present study investigated whether acetyl zingerone (AZ), a newly identified antioxidant derived from curcumin, can alleviate the progression of OA. To investigate this, the present study performed various experiments, including crystal violet staining, flow cytometry, immunofluorescence and western blot analysis. In addition, dual validation was performed using in vivo and in vitro experiments; a mouse OA model was constructed for the in vivo experiments, and chondrocytes were used for the in vitro experiments. Destabilization of the medial meniscus (DMM) surgery was performed to establish an OA model in mice and IL‑1β was used to induce an OA model in vitro. The results indicated that AZ may promote chondrocyte viability and the expression of extracellular matrix components. Furthermore, AZ reduced the occurrence of ferroptosis by promoting the expression of glutathione peroxidase 4, inhibiting cartilage destruction and osteophyte formation, and alleviating damage to articular cartilage caused by DMM surgery. Mechanistically, the activation of nuclear factor erythroid 2‑related factor 2 and heme oxygenase‑1 may be responsible for the anti‑ferroptosis effects of AZ on chondrocytes. These findings indicated that AZ may be considered a promising candidate for OA therapy.
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November-2023
Volume 28 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R and Ni S: Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death. Mol Med Rep 28: 202, 2023
APA
Chen, X., Chen, J., Miao, C., Yin, G., Zhang, Z., Sun, R., & Ni, S. (2023). Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death. Molecular Medicine Reports, 28, 202. https://doi.org/10.3892/mmr.2023.13089
MLA
Chen, X., Chen, J., Miao, C., Yin, G., Zhang, Z., Sun, R., Ni, S."Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death". Molecular Medicine Reports 28.5 (2023): 202.
Chicago
Chen, X., Chen, J., Miao, C., Yin, G., Zhang, Z., Sun, R., Ni, S."Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death". Molecular Medicine Reports 28, no. 5 (2023): 202. https://doi.org/10.3892/mmr.2023.13089